[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

RU2018124345A - Способ и система для сенсорного обнаружения - Google Patents

Способ и система для сенсорного обнаружения Download PDF

Info

Publication number
RU2018124345A
RU2018124345A RU2018124345A RU2018124345A RU2018124345A RU 2018124345 A RU2018124345 A RU 2018124345A RU 2018124345 A RU2018124345 A RU 2018124345A RU 2018124345 A RU2018124345 A RU 2018124345A RU 2018124345 A RU2018124345 A RU 2018124345A
Authority
RU
Russia
Prior art keywords
nanostructure
gate electrode
functional fragment
redox
fragment
Prior art date
Application number
RU2018124345A
Other languages
English (en)
Other versions
RU2018124345A3 (ru
Inventor
Фернандо ПАТОЛЬСКИ
Вадим КРИВИТСКИ
Марина ЗВЕРЖИНЕТСКИ
Original Assignee
Рамот Ат Тель-Авив Юниверсити Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рамот Ат Тель-Авив Юниверсити Лтд. filed Critical Рамот Ат Тель-Авив Юниверсити Лтд.
Publication of RU2018124345A publication Critical patent/RU2018124345A/ru
Publication of RU2018124345A3 publication Critical patent/RU2018124345A3/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4866—Evaluating metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L23/00—Details of semiconductor or other solid state devices
    • H01L23/52—Arrangements for conducting electric current within the device in operation from one component to another, i.e. interconnections, e.g. wires, lead frames
    • H01L23/522—Arrangements for conducting electric current within the device in operation from one component to another, i.e. interconnections, e.g. wires, lead frames including external interconnections consisting of a multilayer structure of conductive and insulating layers inseparably formed on the semiconductor body
    • H01L23/532—Arrangements for conducting electric current within the device in operation from one component to another, i.e. interconnections, e.g. wires, lead frames including external interconnections consisting of a multilayer structure of conductive and insulating layers inseparably formed on the semiconductor body characterised by the materials
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D62/00—Semiconductor bodies, or regions thereof, of devices having potential barriers
    • H10D62/10—Shapes, relative sizes or dispositions of the regions of the semiconductor bodies; Shapes of the semiconductor bodies
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D62/00—Semiconductor bodies, or regions thereof, of devices having potential barriers
    • H10D62/10—Shapes, relative sizes or dispositions of the regions of the semiconductor bodies; Shapes of the semiconductor bodies
    • H10D62/117—Shapes of semiconductor bodies
    • H10D62/118—Nanostructure semiconductor bodies
    • H10D62/119—Nanowire, nanosheet or nanotube semiconductor bodies
    • H10D62/121—Nanowire, nanosheet or nanotube semiconductor bodies oriented parallel to substrates
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D62/00—Semiconductor bodies, or regions thereof, of devices having potential barriers
    • H10D62/80—Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials
    • H10D62/83—Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group IV materials, e.g. B-doped Si or undoped Ge
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K10/00—Organic devices specially adapted for rectifying, amplifying, oscillating or switching; Organic capacitors or resistors having potential barriers
    • H10K10/40—Organic transistors
    • H10K10/46—Field-effect transistors, e.g. organic thin-film transistors [OTFT]
    • H10K10/462—Insulated gate field-effect transistors [IGFETs]
    • H10K10/466—Lateral bottom-gate IGFETs comprising only a single gate
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K10/00—Organic devices specially adapted for rectifying, amplifying, oscillating or switching; Organic capacitors or resistors having potential barriers
    • H10K10/40—Organic transistors
    • H10K10/46—Field-effect transistors, e.g. organic thin-film transistors [OTFT]
    • H10K10/462—Insulated gate field-effect transistors [IGFETs]
    • H10K10/484—Insulated gate field-effect transistors [IGFETs] characterised by the channel regions
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10K—ORGANIC ELECTRIC SOLID-STATE DEVICES
    • H10K85/00—Organic materials used in the body or electrodes of devices covered by this subclass
    • H10K85/20—Carbon compounds, e.g. carbon nanotubes or fullerenes
    • H10K85/221—Carbon nanotubes
    • H10K85/225—Carbon nanotubes comprising substituents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Power Engineering (AREA)
  • Computer Hardware Design (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Optics & Photonics (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)

Claims (23)

1. Система для обнаружения изменений электрического свойства, содержащая
сенсорный элемент, содержащий транзистор, имеющий электрод затвора и полупроводниковую наноструктуру, соединяющую электрод истока с электродом затвора и модифицированную функциональным фрагментом, ковалентно прикрепленным к ней; а также
источник напряжения, подключенный к указанному электроду затвора;
контроллер, выполненный с возможностью управления напряжением затвора, приложенным указанным источником напряжения к указанному электроду затвора, таким как обратная окислительно-восстановительная реакция, возникающая, когда указанный фрагмент контактирует с редокс-активным веществом, а также
схему для обнаружения изменений электрического свойства указанной наноструктуры.
2. Система по п. 1, в которой указанный функциональный фрагмент представляет собой редокс-активный фрагмент.
3. Система по п. 1 или 2, в которой указанный функциональный фрагмент содержит по меньшей мере одну функциональную группу, способную к обратимому изменению степени окисления или состояния окисления по меньшей мере одного из ее атомов.
4. Система по п. 1 или 2, в которой указанный функциональный фрагмент содержит хинон.
5. Система по п. 1 или 2, в которой указанный функциональный фрагмент содержит ароматический хинон.
6. Система по п. 1 или 2, в которой указанный функциональный фрагмент представляет собой или содержит функциональную группу, выбранную из группы, состоящей из хинона, бензохинона, антрахинона и фенантренхинона, каждый из которых является замещенным или незамещенным.
7. Система по п. 1 или 2, в которой указанное электрическое свойство предусматривает плотность электронов или заряда на поверхности указанной наноструктуры.
8. Система по п. 1 или 2, в которой указанная наноструктура представляет собой нанопроволоку.
9. Система по п. 1 или 2, в которой указанная полупроводниковая наноструктура содержит кремний.
10. Система по п. 1 или 2, в которой указанный сенсорный элемент содержит по меньшей мере один дополнительный транзистор, имеющий наноструктуру, модифицированную нередокс-активным фрагментом, причем указанная схема детектора выполнена с возможностью вычитания сигналов, принятых от указанной наноструктуры, модифицированной указанным редокс-активным фрагментом, из сигналов, полученных от указанной наноструктуры, модифицированных указанным нередокс-активным фрагментом.
11. Система по п. 1 или 2, содержащаяся в наклейке, прикрепляемой к коже.
12. Система по п. 1 или 2, содержащаяся в имплантируемом в живое тело корпусе.
13. Способ сенсорного обнаружения метаболической активности в живом организме, предусматривающий
контактирование живого организма с сенсорным элементом, содержащим транзистор с электродом затвора и полупроводниковой наноструктурой, соединяющей электрод истока с электродом затвора, и модифицированный функциональным фрагментом, ковалентно прикрепленным к ней;
обнаружение изменений электрического свойства указанной наноструктуры в результате окислительно-восстановительной реакции, возникающей во время указанного контакта; а также
подача напряжения затвора на указанный электрод затвора для отмены указанной окислительно-восстановительной реакции.
14. Способ по п. 13, в котором указанное напряжение затвора выбрано так, чтобы поддерживать обычную постоянную популяцию указанного функционального фрагмента на указанной наноструктуре.
15. Способ по любому из пп. 13, 14, в котором указанное напряжение затвора является постоянным.
16. Способ по любому из пп. 13, 14, в котором указанное напряжение затвора составляет от приблизительно -3 вольт до приблизительно +3 вольт.
RU2018124345A 2015-12-09 2016-12-08 Способ и система для сенсорного обнаружения RU2018124345A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562264944P 2015-12-09 2015-12-09
US201562264913P 2015-12-09 2015-12-09
US62/264,913 2015-12-09
US62/264,944 2015-12-09
PCT/IL2016/051320 WO2017098518A1 (en) 2015-12-09 2016-12-08 Method and system for sensing

Publications (2)

Publication Number Publication Date
RU2018124345A true RU2018124345A (ru) 2020-01-09
RU2018124345A3 RU2018124345A3 (ru) 2020-02-25

Family

ID=59012779

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2018124339A RU2018124339A (ru) 2015-12-09 2016-12-08 Способ и система для сенсорного обнаружения посредством модифицированной наноструктуры
RU2018124345A RU2018124345A (ru) 2015-12-09 2016-12-08 Способ и система для сенсорного обнаружения

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RU2018124339A RU2018124339A (ru) 2015-12-09 2016-12-08 Способ и система для сенсорного обнаружения посредством модифицированной наноструктуры

Country Status (8)

Country Link
US (2) US10667750B2 (ru)
EP (2) EP3386911B1 (ru)
JP (2) JP2018538535A (ru)
KR (2) KR20180091053A (ru)
CN (2) CN109476477A (ru)
CA (2) CA3007599A1 (ru)
RU (2) RU2018124339A (ru)
WO (2) WO2017098518A1 (ru)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2774307C1 (ru) * 2021-11-23 2022-06-17 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Биосенсор для индикации биопатогенов

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006116362A2 (en) 2005-04-25 2006-11-02 The Trustees Of Boston University Structured substrates for optical surface profiling
MX2016005273A (es) 2013-10-22 2017-01-05 Ramot At Tel-Aviv Univ Ltd Procedimiento y sistema de deteccion.
EP3353528B1 (en) 2015-09-22 2023-11-29 Trustees of Boston University Multiplexed phenotyping of nanovesicles
JP2018538535A (ja) 2015-12-09 2018-12-27 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． 検知のための方法及びシステム
CA3012212A1 (en) 2016-02-05 2017-08-10 Nanoview Diagnostics Inc. Detection of exosomes having surface markers
US11432750B2 (en) * 2016-03-14 2022-09-06 Abbott Diabetes Care Inc. In vivo enzyme activity sensors and methods
WO2017171736A1 (en) * 2016-03-30 2017-10-05 Intel Corporation Nanowire for transistor integration
US11002737B2 (en) * 2016-09-29 2021-05-11 Worcester Polytechnic Institute Micro-array devices for capturing cells in blood and methods of their use
WO2018178992A1 (en) 2017-03-29 2018-10-04 Ramot At Tel-Aviv University Ltd. Method and system for separating biomolecules from a mixture containing same
MX2019015117A (es) 2017-06-15 2020-02-17 Univ Ramot Deteccion electroquimica de compuestos que contienen peroxido.
IL260057B (en) 2017-06-15 2020-04-30 Filanovsky Boris Electrochemical detection of substances containing a nitro group
BR112019028104B1 (pt) * 2017-08-01 2021-10-26 Illumina, Inc Sensores de efeito de campo
WO2019081679A1 (en) * 2017-10-25 2019-05-02 Skindicator Ab DEVICE AND METHOD FOR DETECTING CHANGES IN TISSUE
FR3074489B1 (fr) * 2017-12-05 2023-04-21 Centre Nat Rech Scient Plateforme de nanostructures pour l’interfacage cellulaire et procede de fabrication correspondant
JP2019124651A (ja) * 2018-01-19 2019-07-25 株式会社日立製作所 人工嗅覚センシングシステムおよびその製造方法
EP3768159B1 (en) * 2018-03-20 2025-01-01 Graphwear Technologies Inc. Replaceable sensor systems
JP7188091B2 (ja) * 2018-04-24 2022-12-13 トヨタ自動車株式会社 窒素酸化物吸蔵材及び排ガス浄化方法
CN108957007B (zh) * 2018-07-24 2021-08-17 无锡市人民医院 一种联合透析装置和硅纳米线场效应管的生物传感器
CN109998488B (zh) * 2019-04-13 2022-08-02 中国医学科学院北京协和医院 克罗恩病和肠道溃疡型淋巴瘤的鉴别模型及构建方法
WO2021009559A1 (en) 2019-07-12 2021-01-21 Qulab Medical Ltd. Electrochemical fet sensor
CN113025477B (zh) * 2020-06-17 2023-12-15 山东大学 双色荧光双重检测的微流控芯片及方法
CA3201918A1 (en) * 2020-12-17 2022-06-23 Crystal EMERY Screening of fluorescent microbes using microfabricated device
US20240094158A1 (en) * 2021-01-20 2024-03-21 Richard Postrel Processes and methods for fabrication and use of carbon nanotubule and graphene matrices
US12061165B2 (en) * 2021-01-25 2024-08-13 University Of Central Florida Research Foundation, Inc. Plasmonic organic electrochemical transistor
US12178979B2 (en) 2021-10-13 2024-12-31 Satio, Inc. Dermal patch for delivering a pharmaceutical
US20220369957A1 (en) * 2021-05-19 2022-11-24 Satio, Inc. Self-contained dermal patch for blood analysis
US12214346B2 (en) 2021-10-13 2025-02-04 Satio, Inc. Dermal patch with a diagnostic test strip
WO2024042531A1 (en) * 2022-08-26 2024-02-29 Ramot At Tel-Aviv University Ltd. Method and system for detecting a bioanalyte in the blood

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2214442C3 (de) 1972-03-24 1981-09-10 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Überführung von Glucose in Gluconsäure
GB2294808B (en) 1991-10-21 1996-07-10 Holm Kennedy James W Method and device for biochemical sensing
KR100991573B1 (ko) 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서
US7303875B1 (en) * 2002-10-10 2007-12-04 Nanosys, Inc. Nano-chem-FET based biosensors
US7910064B2 (en) 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
US7416911B2 (en) 2003-06-24 2008-08-26 California Institute Of Technology Electrochemical method for attaching molecular and biomolecular structures to semiconductor microstructures and nanostructures
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
JP2005077210A (ja) * 2003-08-29 2005-03-24 National Institute For Materials Science 生体分子検出素子及びそれを用いた核酸解析方法
WO2006137899A2 (en) * 2004-09-30 2006-12-28 E. I. Du Pont De Nemours And Company Nanosensors for detecting analytes and method of detecting analyteshave been developed in which the redox potential of a redox effector in solution is altered thereby causing changes in the carbon nanotube (30) conductance. the analyte may be detected in solution, eliminating the need for immobilizing the analyte on a support.
US20100227382A1 (en) * 2005-05-25 2010-09-09 President And Fellows Of Harvard College Nanoscale sensors
KR100718144B1 (ko) * 2006-01-09 2007-05-14 삼성전자주식회사 이온 물질 검출용 ｆｅｔ 기반 센서, 그를 포함하는 이온물질 검출 장치 및 그를 이용한 이온 물질 검출 방법
US20090299213A1 (en) 2006-03-15 2009-12-03 President And Fellows Of Harvard College Nanobioelectronics
WO2008030395A1 (en) 2006-09-07 2008-03-13 California Institute Of Technology Apparatus and method for quantitative determination of target molecules
EP2125605A1 (en) 2007-01-12 2009-12-02 Environmental Biotechnology CRC Pty Limited Sample handling device
IL189576A0 (en) 2008-02-18 2008-12-29 Technion Res & Dev Foundation Chemically sensitive field effect transistors for explosive detection
CN102239409A (zh) 2008-12-05 2011-11-09 纳诺维德公司 用于及时护理分析仪的基于微流的实验室测试卡
WO2010115143A1 (en) * 2009-04-03 2010-10-07 University Of Southern California Surface modification of nanosensor platforms to increase sensitivity and reproducibility
GB2471470A (en) 2009-06-30 2011-01-05 Hewlett Packard Development Co Quantum repeater and system and method for creating extended entanglements utilising cyclic synchronised control signals at repeater relay nodes
DE102010002915B4 (de) 2010-03-16 2012-10-18 Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh Mikrofluidischer Sensor
EP2652508B1 (en) 2010-12-14 2018-02-07 Jyant Technologies, Inc. The use of anti-cxcl13 and anti-cxcr5 antibodies for the treatment or detection of cancer
CA2832031C (en) 2011-04-06 2019-09-17 Ramot At Tel-Aviv University Ltd. Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same
CN103323516A (zh) 2013-05-28 2013-09-25 西北师范大学 一种基于离子液体功能化的碳纳米管和银纳米复合物的无酶h2o2传感器的制备方法
MX2016005273A (es) 2013-10-22 2017-01-05 Ramot At Tel-Aviv Univ Ltd Procedimiento y sistema de deteccion.
US20170181669A1 (en) * 2014-06-12 2017-06-29 The Trustees Of Columbia University In The City Of New York Graphene-based nanosensor for identifying target analytes
WO2016157117A1 (en) * 2015-03-31 2016-10-06 Rg Smart Pte. Ltd. Nanoelectronic sensor pixel
US20180088079A1 (en) * 2015-04-03 2018-03-29 President And Fellows Of Harvard College Nanoscale wires with external layers for sensors and other applications
JP2018538535A (ja) 2015-12-09 2018-12-27 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． 検知のための方法及びシステム
US10436746B2 (en) * 2016-08-29 2019-10-08 The Regents Of The University Of California High performance chemical and bio sensors using metal oxide semiconductors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2774307C1 (ru) * 2021-11-23 2022-06-17 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Биосенсор для индикации биопатогенов

Also Published As

Publication number Publication date
CA3007599A1 (en) 2017-06-15
KR20180091053A (ko) 2018-08-14
EP3386911B1 (en) 2023-09-20
EP3387420A4 (en) 2019-08-14
CN108700547A (zh) 2018-10-23
CA3007606A1 (en) 2017-06-15
EP3386911A4 (en) 2019-08-07
EP3387420A1 (en) 2018-10-17
RU2018124345A3 (ru) 2020-02-25
JP2019501383A (ja) 2019-01-17
KR20180091882A (ko) 2018-08-16
EP3387420B1 (en) 2023-11-15
JP2018538535A (ja) 2018-12-27
WO2017098518A1 (en) 2017-06-15
CN109476477A (zh) 2019-03-15
EP3386911A1 (en) 2018-10-17
US10667750B2 (en) 2020-06-02
RU2018124339A (ru) 2020-01-09
WO2017098517A1 (en) 2017-06-15
US20180372678A1 (en) 2018-12-27
US11275078B2 (en) 2022-03-15
US20190200923A1 (en) 2019-07-04

Similar Documents

Publication Publication Date Title
RU2018124345A (ru) Способ и система для сенсорного обнаружения
RU2019108155A (ru) Способ и система для подкожного сенсорного определения
Liang et al. PEDOT: PSS‐based bioelectronic devices for recording and modulation of electrophysiological and biochemical cell signals
Khodagholy et al. Organic electrochemical transistor incorporating an ionogel as a solid state electrolyte for lactate sensing
Ohno et al. Electrolyte-gated graphene field-effect transistors for detecting pH and protein adsorption
ES2960443T3 (es) Método y unidad electrónica para detectar propiedades in vivo de un biosensor
Zong et al. ZnO nanorod-based FET biosensor for continuous glucose monitoring
Leleux et al. Organic electrochemical transistors for clinical applications
Giordani et al. Specific dopamine sensing based on short-term plasticity behavior of a whole organic artificial synapse
WO2007079015A3 (en) Method of and system for stabilization of sensors
Zhang et al. Liquid–solid dual-gate organic transistors with tunable threshold voltage for cell sensing
US20110137200A1 (en) Compensation of motion artifacts in capacitive measurement of electrophysiological signals
Zhang et al. Carbon nanofiber electrode for neurochemical monitoring
CN104780837B (zh) 改进的电生理学分析系统
JP2012256052A5 (ja) 液晶表示装置
BR0215201A (pt) Sistema e método minimamente invasivos para monitorar nìveis de analito
FR2982758B1 (fr) Procede d'analyse physiologique de fiabilite accrue
US20230349894A1 (en) Reduced electronic sampling of aptamer sensors
WO2021016465A1 (en) Minimally invasive continuous analyte monitoring for closed-loop treatment applications
WO2012030436A3 (en) Symmetrical physiological signal sensing with a medical device
Aggas et al. Wien Oscillator Using Organic Enzyme‐Chemiresistors for Fused Measurement of Glucose and Lactate
Jiang et al. Flexible piezo-electrocatalytic uric acid sensor
JP2016036642A (ja) 電極およびウェアラブル電極
Park et al. Highly sensitive biosensors based on All-PEDOT: PSS organic electrochemical transistors with laser-induced micropatterning
KR101427001B1 (ko) 결합촉진 장치와 이를 이용한 결합 촉진 방법 및 바이오 센서와 이를 이용한 센싱 방법

Legal Events

Date Code Title Description
FA94 Acknowledgement of application withdrawn (non-payment of fees)

Effective date: 20210422