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RU2017128289A - MULTI-FLUID DELIVERY SYSTEM WITH A REUSABLE CONSUMPTION KIT AND ITS DESIGN FEATURES - Google Patents

MULTI-FLUID DELIVERY SYSTEM WITH A REUSABLE CONSUMPTION KIT AND ITS DESIGN FEATURES Download PDF

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Publication number
RU2017128289A
RU2017128289A RU2017128289A RU2017128289A RU2017128289A RU 2017128289 A RU2017128289 A RU 2017128289A RU 2017128289 A RU2017128289 A RU 2017128289A RU 2017128289 A RU2017128289 A RU 2017128289A RU 2017128289 A RU2017128289 A RU 2017128289A
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Prior art keywords
syringe
valve
fluid
port
manifold
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RU2017128289A
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Russian (ru)
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RU2017128289A3 (en
RU2714926C2 (en
Inventor
Джон А. ХАУРИ
Майкл СУОНТНЕР
Ричард Соколов
Бенджамин Джеймс КАЛЛЕН
Элисон Рут НОРКОТТ
Эрнесто Хуэсо МОНИС
Камман ЛО
Марк Сильвио ПРОФАКА
Патрик Спенс
Брайан Е. КЕЙН
Майкл А. СПОН
Кевин П. КОУЭН
Джастин ЭНГЕРТ
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БАЙЕР ХелсКер ЛЛСи
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Publication of RU2017128289A3 publication Critical patent/RU2017128289A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/002Compounding apparatus specially for enteral or parenteral nutritive solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • A61M5/1408Infusion of two or more substances in parallel, e.g. manifolds, sequencing valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10Tube connectors; Tube couplings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22Valves or arrangement of valves
    • A61M39/24Check- or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/008Racks for supporting syringes or needles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1413Modular systems comprising interconnecting elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14212Pumping with an aspiration and an expulsion action
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804Flow controllers
    • A61M5/16827Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877Adjusting flow; Devices for setting a flow rate
    • A61M5/16881Regulating valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/3146Priming, e.g. purging, reducing backlash or clearance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M2005/14208Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/14Detection of the presence or absence of a tube, a connector or a container in an apparatus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3306Optical measuring means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (84)

1. Многоразовый расходный комплект (МРК), включающий:1. Reusable consumable kit (MRK), including: множество шприцев, причем каждый шприц имеет проксимальный конец и дистальный конец, отстоящий от проксимального конца по продольной оси, и плунжер, выполненный с возможностью возвратно-поступательного движения во внутренней полости шприца между проксимальным концом и дистальным концом;a plurality of syringes, each syringe having a proximal end and a distal end spaced from the proximal end along the longitudinal axis, and a plunger configured to reciprocate in the inner cavity of the syringe between the proximal end and the distal end; коллектор, сообщающийся по текучей среде с дистальным концом каждого из множества шприцев;a manifold in fluid communication with the distal end of each of the plurality of syringes; по меньшей мере один клапан, сообщающийся по текучей среде с дистальным концом по меньшей мере одного из множества шприцев, причем этот по меньшей мере один клапан выполнен с возможностью перехода между положением заполнения для заполнения внутренней полости указанного по меньшей мере одного из множества шприцев через коллектор и положением выдачи для выдачи флюида из внутренней полости по меньшей мере одного из множества шприцев через коллектор; иat least one valve in fluid communication with the distal end of at least one of the plurality of syringes, the at least one valve being configured to transition between the filling position to fill the internal cavity of the at least one of the plurality of syringes through a manifold and a dispensing position for dispensing fluid from the inner cavity of at least one of the plurality of syringes through the manifold; and по меньшей мере один соединительный порт, сообщающийся по текучей среде с коллектором, когда указанный по меньшей мере один клапан находится в положении выдачи.at least one connecting port in fluid communication with the manifold when said at least one valve is in the dispensing position. 2. МРК по п. 1, в котором указанный по меньшей мере один соединительный порт установлен на каркасе, соединенном по меньшей мере с одним из множества шприцев.2. RTOs according to claim 1, wherein said at least one connecting port is mounted on a frame connected to at least one of the plurality of syringes. 3. МРК по п. 1, в котором указанный по меньшей мере один соединительный порт сообщается по текучей среде с коллектором через линию выдачи.3. RTO according to claim 1, wherein said at least one connecting port is in fluid communication with the collector through the issuing line. 4. МРК по п. 1, дополнительно включающий порт для отходов, сообщающийся по текучей среде с резервуаром для отходов.4. RTOs according to claim 1, further comprising a waste port communicating in fluid with the waste tank. 5. МРК по п. 1, в котором каждый из множества шприцев включает линию заполнения с острием, выполненным с возможностью соединения с крупноразмерным флюидным источником, и в котором каждая флюидная линия выполнена с возможностью заполнения внутренней полости шприца через коллектор, когда указанный по меньшей мере один клапан находится в положении заполнения.5. RTO according to claim 1, in which each of the plurality of syringes includes a filling line with a tip configured to connect to a large-sized fluid source, and in which each fluid line is configured to fill the internal cavity of the syringe through the manifold when at least one valve is in the filling position. 6. МРК по любому из пп. 1-5, в котором указанный по меньшей мере один клапан включает канавку для вхождения в зацепление с крылом, которое поворачивает канавку между положением заполнения и положением выдачи.6. RTOs according to any one of paragraphs. 1-5, wherein said at least one valve includes a groove for engaging with a wing that rotates the groove between the filling position and the dispensing position. 7. Многофлюидная инъекционная система, включающая:7. A multifluid injection system, including: механизированный инъектор, включающий корпус, вмещающий множество поршневых элементов, выполненных с возможностью возвратно-поступательного движения;a mechanized injector comprising a housing accommodating a plurality of piston elements configured to reciprocate; приемную полость, выполненную для приема с возможностью удаления множества шприцев многоразового расходного комплекта (МРК), причем приемная полость включает нижнюю пластину и верхнюю пластину, отделенную от нижней пластины посредством задней боковой стенки, так что множество шприцев МРК поддерживается в осевом направлении между верхней пластиной и нижней пластиной; иa receiving cavity configured to receive, with the possibility of removing, a plurality of syringes of a refillable consumable kit (MRC), wherein the receiving cavity includes a lower plate and an upper plate separated from the lower plate by a rear side wall, so that a plurality of syringes of the MRC are supported axially between the upper plate and bottom plate; and по меньшей мере одну направляющую, связанную с приемной полостью,at least one guide associated with the receiving cavity, причем по меньшей мере указанная одна направляющая сужается в направлении ввода к задней боковой стенке для направления МРК в приемную полость.moreover, at least one guide is tapering in the direction of entry to the rear side wall to direct the RTOs into the receiving cavity. 8. Многофлюидная инъекционная система по п. 7, дополнительно включающая множество крупноразмерных флюидных соединителей, выполненных с возможностью соединения МРК с по меньшей мере одним крупноразмерным флюидным источником.8. The multifluidic injection system according to claim 7, further comprising a plurality of large-sized fluid connectors configured to couple the RTOs to at least one large-sized fluid source. 9. Многофлюидная инъекционная система по п. 7, в которой верхняя пластина образует множество прорезей, выполненных с возможностью приема по меньшей мере одного из множества шприцев МРК, и в которой каждая из множества прорезей образует сочленяемое углубление для приема конического дистального конца указанного по меньшей мере одного шприца, так что конический дистальный конец входит в зацепление с сочленяемым углублением, когда МРК введен в приемную полость.9. The multifluid injection system according to claim 7, in which the upper plate forms a plurality of slots configured to receive at least one of the plurality of RTO syringes, and in which each of the plurality of slots forms an articulated recess for receiving a conical distal end of the at least one syringe, so that the conical distal end engages with an articulated recess when an MRC is inserted into the receiving cavity. 10. Многофлюидная инъекционная система по п. 7, в которой верхняя пластина выполнена с возможностью перемещения между первым положением, выполненным с возможностью установки МРК в приемную полость и извлечения из нее, и вторым положением, выполненным с возможностью запирания МРК в приемной полости.10. The multifluid injection system according to claim 7, in which the upper plate is arranged to move between the first position configured to install RTOs in the receiving cavity and extract from it, and the second position configured to lock the RTOs in the receiving cavity. 11. Многофлюидная инъекционная система по п. 10, в которой верхняя пластина включает защелку для.запирания верхней пластины во втором положении.11. The multifluid injection system of claim 10, wherein the upper plate includes a latch for locking the upper plate in a second position. 12. Многофлюидная инъекционная система по любому из пп. 7-11, дополнительно включающая по меньшей мере одну муфту, выполненную с возможностью вхождения в зацепление с по меньшей мере одним клапаном МРК.12. The multifluid injection system according to any one of paragraphs. 7-11, further comprising at least one sleeve configured to engage with at least one RTO valve. 13. Многофлюидная инъекционная система по п. 12, в которой указанная по меньшей мере одна муфта представляет собой поворотную муфту, имеющую крыло, выполненное с возможностью самосовмещения с канавкой, выполненной на указанном по меньшей мере одном клапане МРК.13. The multifluid injection system according to claim 12, wherein said at least one sleeve is a rotary sleeve having a wing configured to self-align with a groove made on said at least one MRC valve. 14. Многоразовый расходный комплект (МРК), включающий:14. Reusable consumable kit (MRK), including: по меньшей мере один шприц, имеющий проксимальный конец и дистальный конец, отстоящий от проксимального конца по продольной оси, и плунжер, выполненный с возможностью возвратно-поступательного движения во внутренней полости шприца между проксимальным концом и дистальным концом;at least one syringe having a proximal end and a distal end spaced from the proximal end along the longitudinal axis, and a plunger configured to reciprocate in the inner cavity of the syringe between the proximal end and the distal end; коллектор, сообщающийся по текучей среде с дистальным концом указанного по меньшей мере одного шприца;a manifold in fluid communication with the distal end of said at least one syringe; по меньшей мере один клапан, сообщающийся по текучей среде с внутренней полостью шприца, причем указанный по меньшей мере один клапан выполнен с возможностью перехода между положением заполнения для заполнения внутренней полости шприца флюидом и положением выдачи для выдачи флюида из внутренней полости шприца; иat least one valve in fluid communication with the inner cavity of the syringe, wherein said at least one valve is configured to transition between a filling position for filling the inner cavity of the syringe with fluid and a dispensing position for dispensing fluid from the inner cavity of the syringe; and по меньшей мере один соединительный порт, сообщающийся по текучей среде с коллектором и внутренней полостью шприца, когда указанный по меньшей мере один клапан находится в положении выдачи.at least one connecting port in fluid communication with the manifold and the internal cavity of the syringe when said at least one valve is in the dispensing position. 15. МРК по п. 14, в котором указанный по меньшей мере один клапан имеет головку клапана с канавкой, углубленной в головку клапана.15. MRK according to claim 14, wherein said at least one valve has a valve head with a groove recessed into the valve head. 16. МРК по п. 15, в котором канавка имеет форму, подходящую для приема по меньшей мере части соединительного механизма для поворота указанного по меньшей мере одного клапана между положением заполнения и положением выдачи, когда соединительный механизм входит в зацепление с канавкой указанного по меньшей мере одного клапана.16. RTO according to claim 15, in which the groove has a shape suitable for receiving at least a portion of the connecting mechanism for rotating said at least one valve between the filling position and the dispensing position when the connecting mechanism engages with the groove of said at least one valve. 17. МРК по п. 15, в котором канавка сужается в направлении от дистального конца клапана к проксимальному концу клапана.17. RTO according to claim 15, in which the groove tapers in the direction from the distal end of the valve to the proximal end of the valve. 18. МРК по п. 14, в котором указанный по меньшей мере один клапан выполнен с возможностью поворота между положением заполнения и положением выдачи.18. RTO according to claim 14, wherein said at least one valve is rotatable between the filling position and the dispensing position. 19. МРК по п. 14, в котором в положении заполнения указанный по меньшей мере один клапан обеспечивает заполнение внутренней полости шприца через заливной порт, сообщающийся по текучей среде с крупноразмерным флюидным источником, и выдачу флюида из внутренней полости шприца через выпускное отверстие, сообщающееся по текучей среде с коллектором.19. RTO according to claim 14, in which at least one valve indicates filling the inner cavity of the syringe through the filling port in fluid communication with a large-sized fluid source, and dispensing fluid from the inner cavity of the syringe through the outlet in communication fluid with manifold. 20. МРК по п. 14, в котором указанный по меньшей мере один соединительный порт установлен на каркасе, соединенном по меньшей мере с одним из множества шприцев.20. The RTO according to claim 14, wherein said at least one connecting port is mounted on a chassis connected to at least one of the plurality of syringes. 21. МРК по п. 14, в котором указанный по меньшей мере один соединительный порт сообщается по текучей среде с коллектором через линию выдачи.21. The RTO according to claim 14, wherein said at least one connecting port is in fluid communication with the collector through a delivery line. 22. МРК по п. 14, в котором указанный по меньшей мере один соединительный порт имеет порт для отходов, сообщающийся по текучей среде с резервуаром для отходов.22. The RTO according to claim 14, wherein said at least one connecting port has a waste port in fluid communication with the waste reservoir. 23. МРК по любому из пп. 14-22, дополнительно включающий линию заполнения, имеющую острие для соединения с крупноразмерным флюидным источником, причем флюидная линия заполняет внутреннюю полость шприца флюидом через коллектор, когда указанный по меньшей мере один клапан находится в положении заполнения.23. RTOs according to any one of paragraphs. 14-22, further comprising a filling line having a tip for connecting to a large fluid source, the fluid line filling the interior of the syringe with fluid through the manifold when said at least one valve is in the filling position. 24. Многофлюидная инъекционная система, включающая:24. A multifluid injection system, including: механизированный инъектор, включающий корпус, вмещающий по меньшей мере один поршневой элемент, выполненный с возможностью осуществления возвратно-поступательного движения;a mechanized injector comprising a housing accommodating at least one piston element configured to reciprocate; многоразовый расходный комплект (МРК), выполненный с возможностью подключения к механизированному инъектору флюида, причем МРК включает:a reusable consumable kit (MRK), made with the possibility of connecting to a mechanized fluid injector, and MRK includes: по меньшей мере один шприц с проксимальным концом и дистальным концом, отстоящим от проксимального конца по продольной оси, и плунжер с возможностью возвратно-поступательного движения под действием указанного по меньшей мере одного поршневого элемента во внутренней полости шприца между проксимальным концом и дистальным концом;at least one syringe with a proximal end and a distal end spaced from the proximal end along the longitudinal axis, and a plunger with the possibility of reciprocating movement under the action of the specified at least one piston element in the inner cavity of the syringe between the proximal end and the distal end; коллектор, сообщающийся по текучей среде с дистальным концом указанного по меньшей мере одного шприца;a manifold in fluid communication with the distal end of said at least one syringe; по меньшей мере один клапан, сообщающийся по текучей среде с внутренней полостью шприца, причем указанный по меньшей мере один клапан выполнен с возможностью перехода между положением заполнения для заполнения внутренней полости шприца флюидом и положением выдачи для выдачи флюида из внутренней полости шприца; иat least one valve in fluid communication with the inner cavity of the syringe, wherein said at least one valve is configured to transition between a filling position for filling the inner cavity of the syringe with fluid and a dispensing position for dispensing fluid from the inner cavity of the syringe; and по меньшей мере один соединительный порт, сообщающийся по текучей среде с коллектором и внутренней полостью шприца, когда указанный по меньшей мере один клапан находится в положении выдачи; иat least one connecting port in fluid communication with the manifold and the internal cavity of the syringe when said at least one valve is in the dispensing position; and соединительный механизм для перехода указанного по меньшей мере одного клапана между положением заполнения и положением выдачи.a connecting mechanism for transitioning said at least one valve between the filling position and the dispensing position. 25. Многофлюидная инъекционная система по п. 24, в которой соединительный механизм содержит крыло и в которой указанный по меньшей мере один клапан имеет канавку, имеющую форму, подходящую для приема крыла соединительного механизма.25. The multifluid injection system of claim 24, wherein the connecting mechanism comprises a wing and wherein said at least one valve has a groove having a shape suitable for receiving a wing of the connecting mechanism. 26. Многофлюидная инъекционная система по п. 25, в которой, когда крыло соединительного механизма введено в канавку указанного по меньшей мере одного клапана, поворот соединительного механизма приводит к повороту указанного по меньшей мере одного клапана.26. The multifluid injection system according to claim 25, wherein when the wing of the connecting mechanism is inserted into the groove of said at least one valve, rotation of the connecting mechanism causes the rotation of said at least one valve. 27. Многофлюидная инъекционная система по п. 25, в которой соединительный механизм самосовмещается с указанным по меньшей мере одним клапаном для введения крыла соединительного механизма в канавку указанного по меньшей мере одного клапана.27. The multifluid injection system according to claim 25, wherein the connecting mechanism is self-aligning with said at least one valve for introducing a wing of the connecting mechanism into the groove of said at least one valve. 28. Многофлюидная инъекционная система по п. 25, в которой соединительный механизм подпружинен, для поддержки контакта с указанным по меньшей мере одним клапаном, когда крыло соединительного механизма поворачивается в положение совмещения с канавкой указанного по меньшей мере одного клапана.28. The multifluid injection system according to claim 25, wherein the connecting mechanism is spring loaded to maintain contact with said at least one valve when the wing of the connecting mechanism is rotated to align with the groove of said at least one valve. 29. Многофлюидная инъекционная система по п. 25, в которой, когда крыло соединительного механизма совмещено с канавкой указанного по меньшей мере одного клапана, крыло вталкивается в канавку под действием возвратного движения упругого элемента.29. The multifluid injection system according to claim 25, wherein when the wing of the connecting mechanism is aligned with the groove of said at least one valve, the wing is pushed into the groove under the action of the return movement of the elastic member. 30. Многофлюидная инъекционная система по п. 24, дополнительно включающая приводной механизм для управления соединительным механизмом.30. The multifluid injection system according to claim 24, further comprising a drive mechanism for controlling the connecting mechanism. 31. Многофлюидная инъекционная система по п. 30, в которой приводной механизм вращает соединительный механизм.31. The multifluid injection system of claim 30, wherein the drive mechanism rotates the coupling mechanism. 32. Многофлюидная инъекционная система по любому из пп. 25-31, в которой крыло имеет по меньшей мере одну наклонную поверхность, расположенную под углом относительно продольной оси указанного по меньшей мере одного клапана.32. The multifluid injection system according to any one of paragraphs. 25-31, in which the wing has at least one inclined surface located at an angle relative to the longitudinal axis of the specified at least one valve. 33. Многоразовый расходный комплект (МРК), включающий:33. Reusable consumable kit (MRK), including: множество шприцев, причем каждый шприц имеет проксимальный конец и дистальный конец, отстоящий от проксимального конца по продольной оси, и плунжер, выполненный с возможностью возвратно-поступательного движения во внутренней полости шприца между проксимальным концом и дистальным концом;a plurality of syringes, each syringe having a proximal end and a distal end spaced from the proximal end along the longitudinal axis, and a plunger configured to reciprocate in the inner cavity of the syringe between the proximal end and the distal end; коллектор, соединенный с дистальным концом каждого из множества шприцев;a manifold connected to the distal end of each of the plurality of syringes; по меньшей мере один клапан, - связанный с коллектором, причем указанный по меньшей мере один клапан выполнен с возможностью перехода между положением заполнения для заполнения внутренней полости по меньшей мере одного из множества шприцев через коллектор и положением выдачи для выдачи флюида из внутренней полости по меньшей мере одного из множества шприцев через коллектор;at least one valve connected to the manifold, said at least one valve being configured to transition between the filling position to fill the inner cavity of at least one of the plurality of syringes through the manifold and the dispensing position for dispensing fluid from the inner cavity of at least one of a plurality of syringes through a manifold; по меньшей мере одну линию заполнения, сообщающуюся по текучей среде с внутренней полостью и внутренней полостью шприца по меньшей мере одного из множества шприцев, когда указанный по меньшей мере один клапан находится в положении заполнения; иat least one filling line in fluid communication with the internal cavity and internal cavity of the syringe of at least one of the plurality of syringes when said at least one valve is in the filling position; and по меньшей мере один соединительный порт, сообщающийся по текучей среде с коллектором и внутренней полостью по меньшей мере одного из множества шприцев, когда указанный по меньшей мере один клапан находится в положении выдачи,at least one connecting port in fluid communication with the manifold and the internal cavity of at least one of the plurality of syringes when said at least one valve is in the dispensing position, причем указанный по меньшей мере один клапан имеет головку клапана с канавкой, углубленной в головку клапана,wherein said at least one valve has a valve head with a groove recessed into the valve head, причем прорезь имеет форму, подходящую для приема по меньшей мере части соединительного механизма для поворота указанного по меньшей мере одного клапана между положением заполнения и положением выдачи, когда соединительный механизм входит в зацепление с канавкой указанного по меньшей мере одного клапана.moreover, the slot has a shape suitable for receiving at least part of the connecting mechanism for rotation of the specified at least one valve between the filling position and the issuing position, when the connecting mechanism is engaged with the groove of the specified at least one valve. 34. Конфигурация шприц/коллектор, включающая:34. A syringe / manifold configuration including: по меньшей мере один шприц, имеющий конический дистальный конец со шприцевым флюидным портом; иat least one syringe having a conical distal end with a syringe fluid port; and коллектор, включающий по меньшей мере одну коллекторную трубку, причем указанная коллекторная трубка сообщается по текучей среде с главным флюидным каналом и трубчатым концом крепления шприца, при этом трубчатый конец крепления шприца сообщается по текучей среде со шприцевым флюидным портом указанного по меньшей мере одного шприца,a manifold comprising at least one collection tube, wherein said collection tube is in fluid communication with the main fluid channel and the tubular end of the syringe mount, wherein the tubular end of the syringe mount is in fluid communication with the syringe fluid port of the at least one syringe, причем трубчатый конец крепления шприца указанного по меньшей мере одной коллекторной трубки герметично соединен со шприцевым флюидным портом указанного по меньшей мере одного шприца.moreover, the tubular end of the mounting of the syringe of the specified at least one collector tube is hermetically connected to the syringe fluid port of the specified at least one syringe. 35. Конфигурация шприц/коллектор по п. 34, в которой указанная по меньшей мере одна коллекторная трубка включает заливной порт, выполненный с возможностью сообщения по текучей среде с флюидной линией МРК, выпускное отверстие, сообщающееся по текучей среде с главным флюидным каналом, и полость приема клапана, причем выпускное отверстие и заливной порт сообщаются по текучей среде с внутренней полостью указанного по меньшей мере одного шприца через клапанный узел в полости приема клапана.35. The syringe / manifold configuration according to claim 34, wherein said at least one collection tube includes an inlet port configured to fluidly communicate with an MRI fluid line, an outlet in fluid communication with the main fluid channel, and a cavity receiving valve, and the outlet and the inlet port are in fluid communication with the internal cavity of the specified at least one syringe through the valve assembly in the cavity of the valve receiving. 36. Конфигурация шприц/коллектор по п. 35, в которой клапанный узел выполнен с возможностью перехода между положением заполнения для заполнения внутренней полости шприца флюидом и положением выдачи для выдачи флюида из внутренней полости шприца.36. The syringe / manifold configuration of claim 35, wherein the valve assembly is configured to transition between a filling position to fill the inner cavity of the syringe with fluid and a dispensing position for dispensing fluid from the inner cavity of the syringe. 37. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой трубчатый конец крепления шприца указанной по меньшей мере одной коллекторной трубки находится в герметичном соединении со шприцевым флюидным портом посредством крепежного механизма со стяжной гайкой.37. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the tubular end of the mounting of the syringe of the specified at least one collector tube is sealed to the syringe fluid port by means of a fastening mechanism with a coupling nut. 38. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой трубчатый конец крепления шприца указанной по меньшей мере одной коллекторной трубки включает сформированную поверх полимерную оболочку, которая образует герметичное соединение посредством связи растворителя с внутренней поверхностью шприцевого флюидного порта.38. The configuration of the syringe / collector according to any one of paragraphs. 34-36, wherein the tubular end of the syringe attachment of said at least one collection tube includes a polymer sheath formed over it that forms a sealed connection by bonding the solvent to the inner surface of the syringe fluid port. 39. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой шприцевый флюидный порт включает сформированную поверх полимерную оболочку, образующую герметичное соединение посредством связи растворителя с внутренней поверхностью трубчатого конца крепления шприца указанной по меньшей мере одной коллекторной трубки.39. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the syringe fluid port includes a over-molded polymer sheath forming an airtight connection by bonding the solvent to the inner surface of the tubular end of the syringe attachment of the at least one collection tube. 40. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой каждая из поверхностей, внутренней поверхности шприцевого флюидного порта и внутренней поверхности трубчатого конца крепления шприца, включают запирающий фланец, простирающийся радиально внутрь, а клапанный узел включает канавку запирания шприца и канавку запирания коллектора, соответственно выполненных с возможностью образования запирающего зацепления с запирающими фланцами шприцевого флюидного порта и трубчатым концом крепления шприца.40. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which each of the surfaces, the inner surface of the syringe fluid port and the inner surface of the tubular end of the attachment of the syringe, include a locking flange extending radially inward, and the valve assembly includes a groove for locking the syringe and a groove for locking the manifold, respectively configured to form a locking engagement with locking flanges of the syringe fluid port and the tubular end of the syringe mount. 41. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой внешняя цилиндрическая поверхность трубчатого конца крепления шприца соединена с внутренней цилиндрической поверхностью шприцевого флюидного порта с помощью УФ-активируемого адгезива, и41. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the outer cylindrical surface of the tubular end of the mounting of the syringe is connected to the inner cylindrical surface of the syringe fluid port using UV-activated adhesive, and в которой заливной порт шприца включает множество боковых прорезей, обеспечивающих возможность расширения УФ-активируемого адгезива в процессе отверждения.in which the filler port of the syringe includes many lateral slots, allowing expansion of the UV-activated adhesive during the curing process. 42. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой внешняя цилиндрическая поверхность шприцевого флюидного порта соединена с внутренней цилиндрической поверхностью трубчатого конца крепления шприца с помощью УФ-активируемого адгезива, и42. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the outer cylindrical surface of the syringe fluid port is connected to the inner cylindrical surface of the tubular end of the syringe mount using a UV-activated adhesive, and в которой трубчатый конец крепления шприца включает множество боковых прорезей, обеспечивающих возможность расширения УФ-активируемого адгезива в процессе отверждения.in which the tubular end of the mounting of the syringe includes many lateral slots, allowing expansion of the UV-activated adhesive in the curing process. 43. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой конический дистальный конец шприца включает множество обращенных в дистальном направлении гибких зажимов, выполненных с возможностью зацепления с радиальным фланцем на внешней окружности трубчатого конца крепления шприца.43. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the conical distal end of the syringe includes a plurality of distally-facing flexible clamps adapted to engage with a radial flange on the outer circumference of the tubular end of the syringe mount. 44. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой шприцевый флюидный порт включает продольную прорезь, а трубчатый конец крепления шприца включает радиальный фланец, в которой трубчатый конец крепления шприца вставлен в шприцевый флюидный порт, где радиальный фланец расположен непосредственно проксимально к продольной прорези, и44. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the syringe fluid port includes a longitudinal slot, and the tubular end of the syringe mount includes a radial flange, in which the tubular end of the syringe mount is inserted into the syringe fluid port, where the radial flange is located directly proximal to the longitudinal slot, and в которой соединение между трубчатым концом крепления шприца и шприцевым флюидным портом поддерживается с помощью С-образного зажима, вставленного в продольную прорезь.in which the connection between the tubular end of the syringe mount and the syringe fluid port is supported by a C-shaped clamp inserted into the longitudinal slot. 45. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой один из шприцевого флюидного порта и трубчатого конца крепления шприца, включает радиальный фланец, а другой из шприцевого флюидного порта и трубчатого конца крепления шприца включает дополняющий радиальный приемный фланец, который принимает радиальный фланец, и45. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which one of the syringe fluid port and the tubular end of the syringe mount includes a radial flange, and the other of the syringe fluid port and the tubular end of the syringe mount includes a complementary radial receiving flange that receives the radial flange, and в которой радиальный фланец и дополняющий радиальный принимающий фланец соединены лазерной сваркой.in which the radial flange and the complementary radial receiving flange are connected by laser welding. 46. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой один из шприцевого флюидного порта и трубчатого конца крепления шприца, включает кольцеобразную приемную прорезь, включающую средство направления энергии, а другой из шприцевого флюидного порта и трубчатого конца крепления шприца, включает оконечную часть, которая входит в зацепление и вставлена в кольцеобразную приемную канавку, и46. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which one of the syringe fluid port and the tubular end of the syringe mount includes an annular receiving slot including means for directing energy, and the other of the syringe fluid port and the tubular end of the syringe mount includes an end portion that engages and is inserted into annular receiving groove, and в которой оконечная часть и кольцеобразная приемная прорезь соединены ультразвуковой сваркой.in which the end part and the annular receiving slot are connected by ultrasonic welding. 47. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой шприцевый флюидный порт содержит гнездовой соединитель Люэра, образующий герметичное соединение с штыревым соединителем Люэра на трубчатом конце крепления шприца, и в которой шприцевый флюидный порт дополнительно содержит дистальную кольцевую канавку между шприцевым флюидным портом и трубчатым концом крепления шприца, выполненную с возможностью приема в нее УФ-активированного адгезива.47. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the syringe fluid port comprises a Luer female connector forming a tight connection with the Luer male connector on the tubular end of the syringe mount, and in which the syringe fluid port further comprises a distal annular groove between the syringe fluid port and the tubular end of the syringe mount made with the possibility of receiving UV-activated adhesive therein. 48. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой зацепление между шприцевым флюидным портом и трубчатым концом крепления шприца образует трубчатое пространство между внутренней поверхностью шприцевого флюидного порта и внешней поверхностью трубчатого конца крепления шприца, и в котором трубчатое пространство выполнено с возможностью приема УФ-активированного адгезива.48. The configuration of the syringe / collector according to any one of paragraphs. 34-36, wherein the engagement between the syringe fluid port and the tubular end of the syringe attachment forms a tubular space between the inner surface of the syringe fluid port and the outer surface of the tubular end of the syringe attachment, and in which the tubular space is configured to receive UV-activated adhesive. 49. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой зацепление между шприцевым флюидным портом и трубчатым концом крепления шприца образует трубчатое пространство между внутренней поверхностью трубчатого конца крепления шприца и внешней поверхностью шприцевого флюидного порта, и в которой трубчатое пространство выполнено с возможностью приема УФ-активированного адгезива.49. The configuration of the syringe / collector according to any one of paragraphs. 34-36, in which the engagement between the syringe fluid port and the tubular end of the syringe attachment forms a tubular space between the inner surface of the tubular end of the syringe attachment and the outer surface of the syringe fluid port, and in which the tubular space is adapted to receive UV-activated adhesive. 50. Конфигурация шприц/коллектор по любому из пп. 34-36, в которой шприцевый флюидный порт включает гнездовой соединитель Люэра, который формирует герметичное соединение со штыревым соединителем Люэра на трубчатом конце крепления шприца, и в которой шприцевый флюидный порт приварен к трубчатому концу крепления шприца прихваточным швом стежками, выполненным с помощью лазера.50. The configuration of the syringe / collector according to any one of paragraphs. 34-36, wherein the syringe fluid port includes a Luer male connector that forms a tight connection to the Luer male connector on the tubular end of the syringe attachment, and in which the syringe fluid port is welded to the tubular end of the syringe attachment with a laser tack stitch seam.
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JP2018501035A (en) 2018-01-18
TW201641096A (en) 2016-12-01
US20230166095A1 (en) 2023-06-01
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TWI619490B (en) 2018-04-01
CA2973257A1 (en) 2016-07-14
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US11491318B2 (en) 2022-11-08
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EP3242649A1 (en) 2017-11-15
TW201725026A (en) 2017-07-16
AU2016205275B2 (en) 2020-11-12
CA3207200A1 (en) 2016-07-14
CN113069635B (en) 2023-06-23
RU2017128289A3 (en) 2019-08-01
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WO2016112163A1 (en) 2016-07-14

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