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RU2015142245A - Иммуномодифицирующие частицы для лечения воспаления - Google Patents

Иммуномодифицирующие частицы для лечения воспаления Download PDF

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Publication number
RU2015142245A
RU2015142245A RU2015142245A RU2015142245A RU2015142245A RU 2015142245 A RU2015142245 A RU 2015142245A RU 2015142245 A RU2015142245 A RU 2015142245A RU 2015142245 A RU2015142245 A RU 2015142245A RU 2015142245 A RU2015142245 A RU 2015142245A
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Russia
Prior art keywords
particles
negatively charged
subject
charged particles
microns
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RU2015142245A
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English (en)
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Даниэль ГЕТТЗ
Николас КИНГ
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Кур Фармасьютикалз Дивелопмент Компани
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Publication of RU2015142245A publication Critical patent/RU2015142245A/ru

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Claims (29)

1. Способ индуцирования апоптоза моноцитов и/или нейтрофилов у субъекта, включающий введение указанному субъекту фармацевтической композиции, содержащей отрицательно заряженные частицы, причем указанные частицы не имеют присоединенных к ним пептидных или антигенных фрагментов, и носитель.
2. Способ по п. 1, в котором указанные отрицательно заряженные частицы представляют собой частицы полистирола, частицы алмаза, частицы стабилизированного полипропиленсульфида PLURONICS или частицы сополимера молочной и гликолевой кислоты (PLGA).
3. Способ по п. 1, в котором частицы являются карбоксилированными.
4. Способ по п. 1, в котором частицы имеют дзета-потенциал в диапазоне от -75 мВ до 0 мВ.
5. Способ по п. 1, в котором диаметр указанных отрицательно заряженных частиц находится в диапазоне от приблизительно 0,1 мкм до приблизительно 10 мкм.
6. Способ по п. 1, в котором субъект имеет аутоиммунное расстройство, является реципиентом трансплантата, имеет ишемическое реперфузионное повреждение, атеросклероз, перенес инфаркт миокарда, имеет аллергическое нарушение или бактериальную или вирусную инфекцию.
7. Способ удаления провоспалительных медиаторов из среды воспаления у субъекта с воспалительным расстройством, включающий введение указанному субъекту фармацевтической композиции, содержащей отрицательно заряженные частицы, причем указанные частицы не имеют присоединенных к ним пептидных или антигенных фрагментов, и носитель.
8. Способ по п. 7, в котором указанные отрицательно заряженные частицы представляют собой частицы полистирола, частицы алмаза, частицы стабилизированного полипропиленсульфида PLURONICS или частицы сополимера молочной и гликолевой кислоты (PLGA).
9. Способ по п. 7, в котором указанные частицы являются карбоксилированными.
10. Способ по п. 7, в котором частицы имеют дзета-потенциал в диапазоне от -75 мВ до 0 мВ.
11. Способ по п. 7, в котором диаметр указанных отрицательно заряженных частиц находится в диапазоне от приблизительно 0,1 мкм до приблизительно 10 мкм.
12. Способ по п. 7, в котором субъект имеет аутоиммунное расстройство, является реципиентом трансплантата, имеет ишемическое реперфузионное повреждение, атеросклероз, перенес инфаркт миокарда, имеет аллергическое нарушение или бактериальную или вирусную инфекцию.
13. Способ концентрации регуляторных белков из сыворотки или плазмы у субъекта с воспалительным расстройством, включающий введение указанному субъекту фармацевтической композиции, содержащей отрицательно заряженные частицы, причем указанные частицы не имеют присоединенных к ним пептидных или антигенных фрагментов, и носитель.
14. Способ по п. 13, в котором указанные отрицательно заряженные частицы представляют собой частицы полистирола, частицы алмаза, частицы стабилизированного полипропиленсульфида PLURONICS или частицы сополимера молочной и гликолевой кислоты (PLGA).
15. Способ по п. 13, в котором указанные частицы являются карбоксилированными.
16. Способ по п. 13, в котором частицы имеют дзета-потенциал в диапазоне от -75 мВ до 0 мВ.
17. Способ по п. 13, в котором диаметр указанных отрицательно заряженных частиц находится в диапазоне от приблизительно 0,1 мкм до приблизительно 10 мкм.
18. Способ по п. 13, в котором субъект имеет аутоиммунное расстройство, является реципиентом трансплантата, имеет ишемическое реперфузионное повреждение, атеросклероз, перенес инфаркт миокарда, имеет аллергическое нарушение или бактериальную или вирусную инфекцию.
19. Способ диагностики состояния воспаления у субъекта, включающий:
(a) отбор крови у указанного субъекта;
(b) разделение крови для выделения сыворотки и/или плазмы;
(c) инкубацию сыворотки и/или плазмы с отрицательно заряженными частицами в течение некоторого периода времени;
(d) выделение или очищение белков, связанных с указанными отрицательно заряженными частицами; и
(e) определение наличия состояния воспаления у субъекта, если белки, очищенные от отрицательно заряженных частиц на стадии (d), содержат один или более из белков, перечисленных в таблице 6.
20. Способ диагностики состояния воспаления у субъекта, включающий:
(a) внутривенное введение указанному субъекту композиции, содержащей отрицательно заряженные частицы, причем отрицательно заряженные частицы не имеют присоединенных к ним пептидных или антигенных фрагментов;
(b) удаление отрицательно заряженных частиц, введенных на стадии (a) из крови субъекта;
(c) выделение или очищение белков, связанных с указанными отрицательно заряженными частицами; и
(d) определение наличия состояния воспаления у субъекта, если белки, очищенные от отрицательно заряженных частиц на стадии (c), содержат один или более из белков, перечисленных в таблице 6.
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