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RU2009127302A - Способ изготовления твердого, орально применимого фармацевтического состава - Google Patents

Способ изготовления твердого, орально применимого фармацевтического состава Download PDF

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RU2009127302A
RU2009127302A RU2009127302/15A RU2009127302A RU2009127302A RU 2009127302 A RU2009127302 A RU 2009127302A RU 2009127302/15 A RU2009127302/15 A RU 2009127302/15A RU 2009127302 A RU2009127302 A RU 2009127302A RU 2009127302 A RU2009127302 A RU 2009127302A
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Клаус БЕНКЕ (DE)
Клаус БЕНКЕ
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Байер Шеринг Фарма Акциенгезельшафт (DE)
Байер Шеринг Фарма Акциенгезельшафт
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Abstract

1. Твердый, орально применимый фармацевтический состав, содержащий гидролизованную форму 5-хлор-N-({(5S)-2-оксо-3-[4-(3-оксо-4-морфолинил)фенил]-1,3-оксазолидин-5-ил}метил)-2-тиофенкарбокс-амида (I). ! 2. Фармацевтический состав по п.1, содержащий действующее вещество (I) в кристаллической форме. ! 3. Фармацевтический состав по п.2, содержащий действующее вещество (I) в микрокристаллической форме. ! 4. Фармацевтический состав по одному из пп.1-3, отличающийся тем, что действующее вещество (I) содержится в концентрации от 1 до 60% в пересчете на общую массу препарата. ! 5. Фармацевтический состав по одному из пп.1-3, содержащий в качестве смачивающего средства лаурилсульфат натрия. ! 6. Фармацевтический состав по п.4, содержащий в качестве смачивающего средства лаурилсульфат натрия. !7. Фармацевтический состав по п.5, содержащий лаурилсульфат натрия в концентрации от 0,1 до 5% в пересчете на общую массу. ! 8. Фармацевтический состав по п.6, содержащий лаурилсульфат натрия в концентрации от 0,1 до 5% в пересчете на общую массу. ! 9. Фармацевтический состав по одному из пп.1-3 или 6-8, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу. ! 10. Фармацевтический состав по п.4, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу. ! 11. Фармацевтический состав по п.5, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу. ! 12. Фармацевтический состав по п.9, содержащий гидроксипропилметилцеллюлозу в концентрации от 1 до 15% в пересчете на общую массу. ! 13. Фармацевтический состав по п.9, содержащий гидроксипропилметилцеллюлозу в концентрации от 1 до 15% в пересчете на общую массу. ! 14. Фармацевтич�

Claims (17)

1. Твердый, орально применимый фармацевтический состав, содержащий гидролизованную форму 5-хлор-N-({(5S)-2-оксо-3-[4-(3-оксо-4-морфолинил)фенил]-1,3-оксазолидин-5-ил}метил)-2-тиофенкарбокс-амида (I).
2. Фармацевтический состав по п.1, содержащий действующее вещество (I) в кристаллической форме.
3. Фармацевтический состав по п.2, содержащий действующее вещество (I) в микрокристаллической форме.
4. Фармацевтический состав по одному из пп.1-3, отличающийся тем, что действующее вещество (I) содержится в концентрации от 1 до 60% в пересчете на общую массу препарата.
5. Фармацевтический состав по одному из пп.1-3, содержащий в качестве смачивающего средства лаурилсульфат натрия.
6. Фармацевтический состав по п.4, содержащий в качестве смачивающего средства лаурилсульфат натрия.
7. Фармацевтический состав по п.5, содержащий лаурилсульфат натрия в концентрации от 0,1 до 5% в пересчете на общую массу.
8. Фармацевтический состав по п.6, содержащий лаурилсульфат натрия в концентрации от 0,1 до 5% в пересчете на общую массу.
9. Фармацевтический состав по одному из пп.1-3 или 6-8, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу.
10. Фармацевтический состав по п.4, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу.
11. Фармацевтический состав по п.5, содержащий в качестве гидрофильного связующего гидроксипропилметилцеллюлозу.
12. Фармацевтический состав по п.9, содержащий гидроксипропилметилцеллюлозу в концентрации от 1 до 15% в пересчете на общую массу.
13. Фармацевтический состав по п.9, содержащий гидроксипропилметилцеллюлозу в концентрации от 1 до 15% в пересчете на общую массу.
14. Фармацевтический состав по п.11, содержащий гидроксипропилметилцеллюлозу в концентрации от 1 до 15% в пересчете на общую массу.
15. Фармацевтический состав по п.1 в форме таблетки.
16. Фармацевтический состав по п.15 в форме быстро высвобождающей действующее вещество таблетки.
17. Фармацевтический состав по п.15 или 16, отличающийся тем, что таблетка покрыта лаком.
RU2009127302/15A 2003-11-27 2009-07-16 Способ изготовления твердого, орально применимого фармацевтического состава RU2493850C2 (ru)

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DE10355461.0 2003-11-27
DE10355461A DE10355461A1 (de) 2003-11-27 2003-11-27 Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung

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RU2009127302/15A RU2493850C2 (ru) 2003-11-27 2009-07-16 Способ изготовления твердого, орально применимого фармацевтического состава

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DE10129725A1 (de) * 2001-06-20 2003-01-02 Bayer Ag Kombinationstherapie substituierter Oxazolidinone
DE10300111A1 (de) * 2003-01-07 2004-07-15 Bayer Healthcare Ag Verfahren zur Herstellung von 5-Chlor-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophencarboxamid
DE10355461A1 (de) 2003-11-27 2005-06-23 Bayer Healthcare Ag Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung
DE102004062475A1 (de) * 2004-12-24 2006-07-06 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit modifizierter Freisetzung
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DE102005047561A1 (de) 2005-10-04 2007-04-05 Bayer Healthcare Ag Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung
KR101364400B1 (ko) 2005-10-04 2014-02-17 바이엘 인텔렉쳐 프로퍼티 게엠베하 5-클로로-ｎ-(｛(5ｓ)-2-옥소-3-［4-(3-옥소-4-모르폴리닐)-페닐］-1,3-옥사졸리딘-5-일｝-메틸)-2-티오펜 카르복사미드의 신규 다형체 및 무정형 형태
DE102005048824A1 (de) 2005-10-10 2007-04-12 Bayer Healthcare Ag Behandlung und Prophylaxe von Mikroangiopathien
DE102006034916A1 (de) 2006-07-28 2008-01-31 Bayer Healthcare Ag Beschichtung künstlicher Oberflächen von medizinischen Hilfsmitteln und Geräten sowie Reinigung und/oder Vorbehandlung von Kathetern und anderen medizinischen Hilfsmitteln und Geräten
DE102006051625A1 (de) 2006-11-02 2008-05-08 Bayer Materialscience Ag Kombinationstherapie substituierter Oxazolidinone

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UA85693C2 (ru) 2009-02-25
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SI1689370T2 (sl) 2017-01-31
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US20170007612A1 (en) 2017-01-12
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KR20060117330A (ko) 2006-11-16
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