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RU2008143015A - Многокартриджное устройство для введения жидкости - Google Patents

Многокартриджное устройство для введения жидкости Download PDF

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RU2008143015A
RU2008143015A RU2008143015/14A RU2008143015A RU2008143015A RU 2008143015 A RU2008143015 A RU 2008143015A RU 2008143015/14 A RU2008143015/14 A RU 2008143015/14A RU 2008143015 A RU2008143015 A RU 2008143015A RU 2008143015 A RU2008143015 A RU 2008143015A
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drug
drive mechanism
bolus
reservoir
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Роберт ГОННЕЛЛИ (US)
Роберт ГОННЕЛЛИ
Стивен Ф. ЛЕВЕСК (US)
Стивен Ф. ЛЕВЕСК
Роналд В. НАРДИ (US)
Роналд В. НАРДИ
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ВАЛЕРИТАС, ЭлЭлСи (US)
ВАЛЕРИТАС, ЭлЭлСи
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
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    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1454—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons spring-actuated, e.g. by a clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
    • A61M5/3298—Needles arranged in parallel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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Abstract

1. Устройство для введения жидкости для введения первого лекарственного препарата и второго лекарственного препарата, включающее ! корпус, ! первый резервуар в корпусе и сконфигурированный для содержания первого лекарственного препарата, ! второй резервуар в корпусе и сконфигурированный для содержания второго лекарственного препарата, и ! иглу, имеющую первый конец, сконфигурированный для жидкостной связи с первым резервуаром, и второй конец, выполненный выступающим наружу из корпуса. ! 2. Устройство по п.1, кроме того, включающее базальный приводной механизм для обеспечения базального введения первого лекарственного препарата. ! 3. Устройство по п.2, в котором базальный приводной механизм обеспечивает базальное введение второго лекарственного препарата. ! 4. Устройство по п.2, в котором базальный приводной механизм представляет собой первый базальный приводной механизм, и, кроме того, включающее второй базальный приводной механизм для обеспечения базального введения второго лекарственного препарата. ! 5. Устройство по п.4, в котором каждый из первого и второго базальных пусковых механизмов включает цилиндрическую пружину, базальный приводной поршень и резервуар гидравлической жидкости. ! 6. Устройство по п.5, кроме того, включающее первую насосную камеру в жидкостной связи с резервуаром гидравлической жидкости первого базального приводного механизма посредством первого ограничителя потока и вторую насосную камеру в жидкостной связи с резервуаром гидравлической жидкости второго базального приводного механизма посредством второго ограничителя потока. ! 7. Устройство по п.6, кроме того, включающее первы�

Claims (46)

1. Устройство для введения жидкости для введения первого лекарственного препарата и второго лекарственного препарата, включающее
корпус,
первый резервуар в корпусе и сконфигурированный для содержания первого лекарственного препарата,
второй резервуар в корпусе и сконфигурированный для содержания второго лекарственного препарата, и
иглу, имеющую первый конец, сконфигурированный для жидкостной связи с первым резервуаром, и второй конец, выполненный выступающим наружу из корпуса.
2. Устройство по п.1, кроме того, включающее базальный приводной механизм для обеспечения базального введения первого лекарственного препарата.
3. Устройство по п.2, в котором базальный приводной механизм обеспечивает базальное введение второго лекарственного препарата.
4. Устройство по п.2, в котором базальный приводной механизм представляет собой первый базальный приводной механизм, и, кроме того, включающее второй базальный приводной механизм для обеспечения базального введения второго лекарственного препарата.
5. Устройство по п.4, в котором каждый из первого и второго базальных пусковых механизмов включает цилиндрическую пружину, базальный приводной поршень и резервуар гидравлической жидкости.
6. Устройство по п.5, кроме того, включающее первую насосную камеру в жидкостной связи с резервуаром гидравлической жидкости первого базального приводного механизма посредством первого ограничителя потока и вторую насосную камеру в жидкостной связи с резервуаром гидравлической жидкости второго базального приводного механизма посредством второго ограничителя потока.
7. Устройство по п.6, кроме того, включающее первый поршень для введения, расположенный в первом жидкостном резервуаре для воздействия на первый лекарственный препарат в первом жидкостном резервуаре, и второй поршень для введения, расположенный во втором жидкостном резервуаре для воздействия на второй лекарственный препарат во втором жидкостном резервуаре.
8. Устройство по п.3, кроме того, включающее болюсный приводной механизм для обеспечения болюсного введения первого лекарственного препарата.
9. Устройство по п.8, в котором болюсный приводной механизм обеспечивает болюсное введение второго лекарственного препарата.
10. Устройство по п.8, в котором болюсный приводной механизм представляет собой первый болюсный приводной механизм, и где устройство для введения жидкости, кроме того, включает второй болюсный приводной механизм для обеспечения болюсного введения второго лекарственного препарата.
11. Устройство по п.8, в котором болюсный приводной механизм включает защелку и болюсный поршень, связанный с защелкой.
12. Устройство по п.11, кроме того, включающее насосную камеру, связанную с первым жидкостным резервуаром, и где болюсный поршень расположен в резервуаре болюсной жидкости в жидкостной связи с насосной камерой.
13. Устройство по п.1, кроме того, включающее вторую иглу, имеющую первый конец, выполненный для жидкостной связи со вторым резервуаром, и второй конец, выполненный выступающим наружу из корпуса.
14. Устройство по п.13, в котором первая игла расположена на первом конце оболочки, и вторая игла расположена на втором конце оболочки.
15. Устройство по п.13, в котором плечо введения первой иглы длиннее, чем плечо введения второй иглы.
16. Устройство по п.1, в котором игла включает третий конец, выполненный для жидкостной связи со вторым резервуаром.
17. Устройство по п.16, в котором игла обычно имеет «Y-образную» форму.
18. Устройство для введения жидкости по п.1, в котором игла обычно имеет «J-образную» форму.
19. Устройство по п.18, в котором «J-образная» игла включает первый конец, выполненный для введения в первый резервуар, и второй конец, выполненный для введения пациенту обычно одновременно с введением первого конца в первый резервуар.
20. Устройство по п.1, кроме того, включающее третий резервуар в корпусе, сконфигурированный для содержания третьего лекарственного препарата.
21. Устройство по любому из предшествующих пунктов, кроме того, включающее первый лекарственный препарат, содержащийся в первом резервуаре, и второй лекарственный препарат, содержащийся во втором резервуаре.
22. Устройство по п.21, в котором один из первого или второго лекарственных препаратов представляет собой инсулин или аналог инсулина, и другой из первого или второго лекарственных препаратов включает компонент, выбираемый из группы, состоящей из инкретинов, миметиков инкретина, аналогов инкретина, амилинов, стимуляторов секреции инсулина, препаратов, повышающих чувствительность к инсулину, ингибиторов продукции глюкозы печени, ингибиторов глюкозидазы, блокаторов АТФ-зависимых калиевых каналов, агонистов рецептора, активируемого пролифератором пероксисом, ингибиторов абсорбции глюкозы в желудочно-кишечном тракте и их комбинаций.
23. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает бигуанид.
24. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает Глюкагоно-подобный пептид-1.
25. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает ингибитор глюкозидазы.
26. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает препарат сульфонилмочевины.
27. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает меглитинид.
28. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает агонист рецептора активируемого пролифератором пероксисом.
29. Устройство по п.28, в котором агонистом рецептора активируемого пролифератором пероксисом является тиазолидиндион.
30. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает С-пептид.
31. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает глюкагон.
32. Устройство по п.22, в котором другой из первого или второго лекарственных препаратов включает инсулиноподобный фактор роста.
33. Способ введения первого и второго лекарственных препаратов из устройства для введения жидкости, содержащий
введение первой базальной дозы первого лекарственного препарата, и
введение второй базальной дозы второго лекарственного препарата.
34. Способ по п.33, в котором первое базальное введение приблизительно равно второму базальному введению.
35. Способ по п.33, в котором первое базальное введение больше, чем второе базальное введение.
36. Способ по п.33, в котором введение первой базальной дозы включает активацию первого базального приводного механизма, и введение второй базальной дозы включает активацию первого базального приводного механизма.
37. Способ по п.33, в котором введение первой базальной дозы включает активацию первого базального приводного механизма, и введение второй базальной дозы включает активацию второго базального приводного механизма.
38. Способ по п.33, кроме того, включающий введение первой болюсной дозы первого лекарственного препарата и введение второй болюсной дозы второго лекарственного препарата.
39. Способ по п.38, в котором первое болюсное введение является таким же, как второе болюсное введение.
40. Способ по п.38, в котором первое болюсное введение является большим, чем второе болюсное введение.
41. Способ по п.38, в котором введение первой болюсной дозы включает активацию первого болюсного приводного механизма, и введение второй болюсной дозы включает активацию первого болюсного приводного механизма.
42. Способ по п.38, в котором введение первой болюсной дозы включает активацию первого болюсного приводного механизма, и введение второй болюсной дозы включает активацию второго болюсного приводного механизма.
43. Способ по п.33, кроме того, включающий введение болюсной дозы первого лекарственного препарата.
44. Способ введения первого и второго лекарственных препаратов из устройства для введения жидкости, включающий
(i) выталкивание гидравлической жидкости из резервуара гидравлической жидкости в первую насосную камеру для оказания воздействия на первый подвижный барьер,
(ii) выталкивание гидравлической жидкости из резервуара для гидравлической жидкости во вторую насосную камеру для оказания воздействия на второй подвижный барьер,
(iii) оказание воздействия на первый поршень для выталкивания по меньшей мере части первого лекарственного препарата через отверстие первого жидкостного резервуара, и
(iv) оказание воздействия на второй поршень для выталкивания по меньшей мере части второго лекарственного препарата через отверстие второго жидкостного резервуара.
45. Способ по п.44, в котором выталкивание гидравлической жидкости из резервуара гидравлической жидкости включает воздействие силы сжатия пружины на поршень в резервуаре гидравлической жидкости.
46. Способ по п.44, в котором выталкивание гидравлической жидкости из резервуара включает выталкивание гидравлической жидкости из резервуара гидравлической жидкости через дроссель и в первую и вторую насосные камеры.
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