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RU2001131570A - The method of obtaining L-amino acids using bacteria belonging to the genus Escherichia - Google Patents

The method of obtaining L-amino acids using bacteria belonging to the genus Escherichia

Info

Publication number
RU2001131570A
RU2001131570A RU2001131570/13A RU2001131570A RU2001131570A RU 2001131570 A RU2001131570 A RU 2001131570A RU 2001131570/13 A RU2001131570/13 A RU 2001131570/13A RU 2001131570 A RU2001131570 A RU 2001131570A RU 2001131570 A RU2001131570 A RU 2001131570A
Authority
RU
Russia
Prior art keywords
bacterium
amino acid
increased
amino acids
activity
Prior art date
Application number
RU2001131570/13A
Other languages
Russian (ru)
Other versions
RU2229513C2 (en
Inventor
Виталий Аркадьевич Лившиц
Мария Вячеславовна Витушкина
Михаил Маркович Гусятинер
Михаил Харисович Зиятдинов
Валерий Завенович Ахвердян
Екатерина Алексеевна Саврасова
Вера Георгиевна Дорошенко
Сергей Владимирович Машко
Original Assignee
Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Filing date
Publication date
Application filed by Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" filed Critical Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика"
Priority claimed from RU2001131570/13A external-priority patent/RU2229513C2/en
Priority to RU2001131570/13A priority Critical patent/RU2229513C2/en
Priority to PL369776A priority patent/PL207851B1/en
Priority to AT02788635T priority patent/ATE334190T1/en
Priority to BRPI0214329-1A priority patent/BR0214329B1/en
Priority to CA2468178A priority patent/CA2468178C/en
Priority to DK02788635T priority patent/DK1449917T3/en
Priority to EP06009979A priority patent/EP1688482A1/en
Priority to EP02788635A priority patent/EP1449917B1/en
Priority to AU2002355021A priority patent/AU2002355021C1/en
Priority to JP2003545812A priority patent/JP4305183B2/en
Priority to ES02788635T priority patent/ES2269788T3/en
Priority to CNB028274784A priority patent/CN100469875C/en
Priority to DE60213456T priority patent/DE60213456T2/en
Priority to KR1020047007782A priority patent/KR101023924B1/en
Priority to MXPA04004872A priority patent/MXPA04004872A/en
Priority to PCT/JP2002/012202 priority patent/WO2003044191A1/en
Priority to ARP020104507A priority patent/AR037583A1/en
Priority to US10/302,983 priority patent/US7259003B2/en
Publication of RU2001131570A publication Critical patent/RU2001131570A/en
Publication of RU2229513C2 publication Critical patent/RU2229513C2/en
Application granted granted Critical
Priority to US11/761,465 priority patent/US7531332B2/en

Links

Claims (8)

1. Бактерия - продуцент L-аминокислоты, принадлежащая к роду Escherichia, в которой продукция L-аминокислоты упомянутой бактерией увеличена за счет повышения активности белков, описанных в пунктах (А) или (В), в клетке упомянутой бактерии:1. A bacterium is an L-amino acid producer belonging to the genus Escherichia, in which the production of an L-amino acid by said bacterium is increased by increasing the activity of the proteins described in (A) or (B) in the cell of said bacterium: (A) белок, который представлен аминокислотной последовательностью, приведенной в списке последовательностей под номером 2;(A) a protein that is represented by the amino acid sequence shown in sequence listing number 2; (B) белок, который представлен аминокислотной последовательностью, включающей делеции, замены, вставки или добавление одной или нескольких аминокислот в аминокислотную последовательность, приведенную в списке последовательностей под номером 2, и который обладает активностью, придающей бактерии повышенную устойчивость к L-аминокислотам, таким как фенилаланин, треонин, гомосерин или цистеин, и/или их аналогам, таким как п-фторфенилаланин, 5-фтор-DL-триптофан, S-(2-аминоэтил)цистеин или 4-аза-DL-лейцин;(B) a protein that is represented by an amino acid sequence including deletions, substitutions, insertions, or the addition of one or more amino acids to the amino acid sequence listed in sequence number 2, and which has an activity that confers bacteria an increased resistance to L-amino acids, such as phenylalanine, threonine, homoserine or cysteine, and / or their analogues, such as p-fluorophenylalanine, 5-fluoro-DL-tryptophan, S- (2-aminoethyl) cysteine or 4-aza-DL-leucine; 2. Бактерия по п.1, отличающаяся тем, что активности белков, описанных в пунктах (А) или (В), повышены путем трансформации бактерии с помощью ДНК, кодирующей белки, описанные в пунктах (А) или (В), или путем изменения регуляции экспрессии указанной ДНК в хромосоме упомянутой бактерии.2. The bacterium according to claim 1, characterized in that the activity of the proteins described in points (A) or (B) is increased by transforming the bacterium using DNA encoding the proteins described in points (A) or (B), or by changes in the regulation of expression of said DNA in the chromosome of said bacterium. 3. Бактерия по п.2, отличающаяся тем, что трансформация осуществляется с использованием многокопийного вектора.3. The bacterium according to claim 2, characterized in that the transformation is carried out using a multi-copy vector. 4. Способ получения L-аминокислоты, включающий стадии: выращивания бактерии по любому из пп.1-3 в питательной среде, и выделения из культуральной жидкости полученной и накопленной в ней L-аминокислоты.4. A method for producing an L-amino acid, comprising the steps of: growing a bacterium according to any one of claims 1 to 3 in a nutrient medium, and isolating the obtained and accumulated L-amino acid from the culture fluid. 5. Способ по п.4, отличающийся тем, что L-аминокислотой является L-фенилаланин.5. The method according to claim 4, characterized in that the L-amino acid is L-phenylalanine. 6. Способ по п.5, отличающийся тем, что у указанной бактерии повышена экспрессия генов биосинтеза фенилаланина.6. The method according to claim 5, characterized in that said bacterium has increased expression of phenylalanine biosynthesis genes. 7. Способ по п.4, отличающийся тем, что L-аминокислотой является L-треонин.7. The method according to claim 4, characterized in that the L-amino acid is L-threonine. 8. Способ по п.7, отличающийся тем, что у указанной бактерии повышена экспрессия генов треонинового оперона.8. The method according to claim 7, characterized in that said bacterium has increased expression of threonine operon genes.
RU2001131570/13A 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants) RU2229513C2 (en)

Priority Applications (19)

Application Number Priority Date Filing Date Title
RU2001131570/13A RU2229513C2 (en) 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
ES02788635T ES2269788T3 (en) 2001-11-23 2002-11-21 PROCEDURE FOR THE PRODUCTION OF L-AMINO ACIDS USING ESCHERICHIA.
DE60213456T DE60213456T2 (en) 2001-11-23 2002-11-21 PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
BRPI0214329-1A BR0214329B1 (en) 2001-11-23 2002-11-21 L-AMINO ACID PRODUCING BACTERIA, AND METHODS FOR THE PRODUCTION OF L-AMINO ACID AND LOWER ALTERINE ALPHA-L-PHENYL-ALANINE ALTERIN ESTER
CA2468178A CA2468178C (en) 2001-11-23 2002-11-21 Method for producing l-amino acid using bacteria belonging to the genus escherichia
DK02788635T DK1449917T3 (en) 2001-11-23 2002-11-21 Process for L-Amino Acid Preparation Using Escherichia
EP06009979A EP1688482A1 (en) 2001-11-23 2002-11-21 Method for producing L-amino acid using bacteria belonging to the genus Escherichia
EP02788635A EP1449917B1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
AU2002355021A AU2002355021C1 (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using escherichia
JP2003545812A JP4305183B2 (en) 2001-11-23 2002-11-21 Method for producing L-amino acid using Escherichia bacterium
PL369776A PL207851B1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
CNB028274784A CN100469875C (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using escherichia
AT02788635T ATE334190T1 (en) 2001-11-23 2002-11-21 PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
KR1020047007782A KR101023924B1 (en) 2001-11-23 2002-11-21 Process for producing L-amino acid using Escherichia
MXPA04004872A MXPA04004872A (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia.
PCT/JP2002/012202 WO2003044191A1 (en) 2001-11-23 2002-11-21 Process for producing l-amino acid using escherichia
ARP020104507A AR037583A1 (en) 2001-11-23 2002-11-22 METHOD TO PRODUCE L-AMINO ACIDS USING BACTERIA THAT BELONG TO THE GENERO ESCHERICHIA
US10/302,983 US7259003B2 (en) 2001-11-23 2002-11-25 Escherichia bacteria transformed with a yedA homolog to enhance L-amino acid producing activity, and methods for producing an L-amino acid using same
US11/761,465 US7531332B2 (en) 2001-11-23 2007-06-12 Method for producing a lower alkyl ester of α-L-aspartyl-L-phenylalanine using Escherichia bacteria

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2001131570/13A RU2229513C2 (en) 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)

Publications (2)

Publication Number Publication Date
RU2001131570A true RU2001131570A (en) 2003-08-20
RU2229513C2 RU2229513C2 (en) 2004-05-27

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RU2001131570/13A RU2229513C2 (en) 2001-11-23 2001-11-23 Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)

Country Status (17)

Country Link
US (2) US7259003B2 (en)
EP (2) EP1688482A1 (en)
JP (1) JP4305183B2 (en)
KR (1) KR101023924B1 (en)
CN (1) CN100469875C (en)
AR (1) AR037583A1 (en)
AT (1) ATE334190T1 (en)
AU (1) AU2002355021C1 (en)
BR (1) BR0214329B1 (en)
CA (1) CA2468178C (en)
DE (1) DE60213456T2 (en)
DK (1) DK1449917T3 (en)
ES (1) ES2269788T3 (en)
MX (1) MXPA04004872A (en)
PL (1) PL207851B1 (en)
RU (1) RU2229513C2 (en)
WO (1) WO2003044191A1 (en)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976843A (en) * 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
US20060040364A1 (en) * 1998-10-13 2006-02-23 Livshits Vitaly A DNA coding for a protein which imparts L-homoserine resistance to Escherichia coli bacterium, and a method for producing L-amino acids
RU2144564C1 (en) * 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Dna fragment rhtb encoding synthesis of protein rhtb that determines resistance of bacterium escherichia coli to l-homoserine and method of l-amino acid producing
RU2175351C2 (en) 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Escherichia coli dna fragment determining enhanced production of l-amino acids (variants) and method of l-amino acid producing
RU2212447C2 (en) * 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Strain escherichia coli as producer of amino acid (variants) and method for preparing amino acid (variants)
DE60219968T2 (en) * 2001-02-13 2008-01-17 Ajinomoto Co., Inc. Process for the production of L-amino acids by means of bacteria of the genus Escherichia
DE60236684D1 (en) 2001-11-23 2010-07-22 Ajinomoto Kk PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
RU2229513C2 (en) * 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
RU2244007C2 (en) * 2002-02-27 2005-01-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-threonine, strain escherichia coli as producer of threonine (variants)
RU2273666C2 (en) * 2003-02-26 2006-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-amino acids by fermentation of mixture of glucose and pentoses
EP1604023A2 (en) * 2003-03-12 2005-12-14 Ajinomoto Co., Inc. Optimization of bacterial sucab expression by promoter mutagenesis for efficient l-glutamic acid production
US7312058B2 (en) * 2003-07-16 2007-12-25 Ajinomoto Co., Ltd. Mutant serine acetyltransferase
RU2275425C2 (en) * 2003-11-03 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Bacterium belonging to genus escherichia as producer of l-cysteine and method for preparing l-cysteine
US20050176033A1 (en) * 2003-11-10 2005-08-11 Klyachko Elena V. Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine
RU2275424C2 (en) * 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method for preparing l-threonine by using bacterium belonging to genus escherichia
US7005333B2 (en) * 2003-12-30 2006-02-28 Infineon Technologies Ag Transistor with silicon and carbon layer in the channel region
DK1664318T3 (en) * 2004-01-30 2010-01-25 Ajinomoto Kk L-amino acid-producing microorganism and method for producing L-amino acid
US20050181488A1 (en) * 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
JP4604537B2 (en) * 2004-03-31 2011-01-05 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
KR101089559B1 (en) * 2004-03-31 2011-12-06 아지노모토 가부시키가이샤 Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus Bacillus or Escherichia
RU2306338C2 (en) * 2004-06-24 2007-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Mob'-DERIVED RSF1010 PLASMID CONTAINING NO ANTIBIOTIC-RESISTANCE GENES, BACTERIUM CONTAINING SUCH PLASMID AND METHOD FOR PRODUCTION OF USEFUL METABOLITES
US7915018B2 (en) 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family
WO2006088235A1 (en) 2005-02-18 2006-08-24 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
EP1883704B1 (en) * 2005-05-16 2010-07-07 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the kefb gene
EP1976994A1 (en) * 2006-01-26 2008-10-08 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of enterobacteriaceae family with attenuated expression of the aldh gene
WO2007086618A1 (en) 2006-01-30 2007-08-02 Ajinomoto Co., Inc. L-amino acid producing bacterium and method of producing l-amino acid
JP2009095237A (en) * 2006-02-02 2009-05-07 Ajinomoto Co Inc Method for producing l-amino acid
JP2009118740A (en) 2006-03-03 2009-06-04 Ajinomoto Co Inc Method for producing l-amino acid
EP2184348B1 (en) 2006-03-23 2013-11-27 Ajinomoto Co., Inc. A method for producing an L-amino acid using bacterium of the Enterobacteriaceae family with attenuated expression of a gene coding for small RNA
WO2007119890A1 (en) * 2006-04-18 2007-10-25 Ajinomoto Co., Inc. A METHOD FOR PRODUCING AN L-AMINO ACID USING A BACTERIUM OF THE ENTEROBACTERIACEAE FAMILY WITH ATTENUATED EXPRESSION OF THE sfmACDFH-fimZ CLUSTER OR THE fimZ GENE
JP2009165355A (en) 2006-04-28 2009-07-30 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
WO2007139219A1 (en) 2006-06-01 2007-12-06 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene
RU2337961C2 (en) * 2006-07-04 2008-11-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) METHOD OF OBTAINING L-THREONINE USING BACTERIUM, BELONGING TO GENUS Escherichia, IN WHICH OPERON rspAB IS INACTIVATED
RU2006129690A (en) 2006-08-16 2008-02-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACID USING BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH EXPRESSION OF THE ydiN GENE, ydiB GENE OR THEIR COMBINATION IS DECREASED
JP2010017082A (en) * 2006-10-10 2010-01-28 Ajinomoto Co Inc Method for producing l-amino acid
RU2006143864A (en) * 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED
JP2010041920A (en) 2006-12-19 2010-02-25 Ajinomoto Co Inc Method for producing l-amino acid
RU2365622C2 (en) 2006-12-22 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) METHOD OF PURINE NUCLEOZIDES AND NUCLEOTIDES PRODUCTION BY FERMENTATION WITH APPLICATION OF BACTERIA BELONGING TO GENUS Escherichia OR Bacillus
KR101730837B1 (en) 2007-01-22 2017-04-27 아지노모토 가부시키가이샤 Microorganism capable of producing L-amino acid, and method for production of L-amino acid
JP2010110216A (en) 2007-02-20 2010-05-20 Ajinomoto Co Inc Method for producing l-amino acid or nucleic acid
JP2010110217A (en) 2007-02-22 2010-05-20 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
BRPI0816429A2 (en) 2007-09-04 2019-09-24 Ajinomoto Kk microorganism, and method for producing an 1-amino acid.
RU2396336C2 (en) 2007-09-27 2010-08-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) METHOD OF PRODUCING AMINO ACIDS USING Escherichia GENUS BACTERIA
JP2011067095A (en) 2008-01-10 2011-04-07 Ajinomoto Co Inc Method for producing target substance by fermentation process
EP2248906A4 (en) 2008-01-23 2012-07-11 Ajinomoto Kk Method of producing l-amino acid
RU2008105793A (en) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR DESIGNING OPERONS CONTAINING TRANSLATION-CONJUGATED GENES, BACTERIA CONTAINING SUCH OPERON, METHOD FOR PRODUCING USEFUL METABOLITIS AND METHOD FOR EXPRESS MONITORING
KR101627095B1 (en) 2008-09-08 2016-06-03 아지노모토 가부시키가이샤 Microorganism capable of producing L-amino acid, and method for producing L-amino acid
RU2008148283A (en) * 2008-12-09 2010-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-ARGININE USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF THE ARTI GENE WAS DECREASED
BRPI1007069A2 (en) 2009-01-23 2015-08-25 Ajinomoto Kk Method for producing an 1-amino acid.
JPWO2011013707A1 (en) 2009-07-29 2013-01-10 味の素株式会社 Method for producing L-amino acid
JP2012223092A (en) 2009-08-28 2012-11-15 Ajinomoto Co Inc Method for producing l-amino acid
JP2013013329A (en) 2009-11-06 2013-01-24 Ajinomoto Co Inc Method for producing l-amino acid
RU2460793C2 (en) 2010-01-15 2012-09-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Method for producing l-amino acids with use of bacteria of enterobacteriaceae family
JP2013074795A (en) 2010-02-08 2013-04-25 Ajinomoto Co Inc MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID
RU2471868C2 (en) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Mutant adenylate cyclase, dna coding it, bacteria of enterobacteriaceae family containing said dan and method for preparing l-amino acids
RU2471870C2 (en) 2010-06-03 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR PRODUCING L-ARGININE AND L-CITRULLINE WITH USE OF BACTERIA OF ENTEROBACTERIACEAE FAMILY WITH ATTENUATED pepA GENE EXPRESSION
RU2497943C2 (en) * 2010-07-15 2013-11-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD OF PRODUCTION OF L-AMINO ACIDS USING BACTERIA OF FAMILY Enterobacteriaceae
RU2501858C2 (en) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR OBTAINING L-AMINOACID USING BACTERIUM OF Enterobacteriaceae FAMILY
RU2482188C2 (en) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR PREPARING L-ARGININE WITH USE OF BACTERIA OF GENUS Escherichia WHEREIN astCADBE OPERON IS INACTIVATED
JP2014036576A (en) 2010-12-10 2014-02-27 Ajinomoto Co Inc Method for producing l-amino acids
RU2011134436A (en) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY
RU2013118637A (en) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE
RU2013140115A (en) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED
JP2016192903A (en) 2013-09-17 2016-11-17 味の素株式会社 Method for manufacturing l-amino acid from biomass derived from seaweed
RU2013144250A (en) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF A GENE CODING A PHOSPHATE TRANSPORTER IS DECREASED
ES2761596T3 (en) 2013-10-02 2020-05-20 Ajinomoto Kk Ammonia control apparatus and ammonia control method
ES2694011T3 (en) 2013-10-21 2018-12-17 Ajinomoto Co., Inc. Method to produce L-amino acid
RU2014105547A (en) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. METHOD FOR PRODUCING L-AMINO ACIDS USING THE ENTEROBACTERIACEAE FAMILY HAVING A SUPER EXPRESSED GENE yajL
RU2015120052A (en) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. A method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family in which gshA gene expression is weakened
WO2017122747A1 (en) 2016-01-12 2017-07-20 Ajinomoto Co., Inc. Method for producing benzaldehyde
CN109121422B (en) 2016-02-25 2021-12-21 味之素株式会社 Method for producing L-amino acids using bacteria of the Enterobacteriaceae family overexpressing genes coding for iron exporters
JP7066977B2 (en) 2017-04-03 2022-05-16 味の素株式会社 Manufacturing method of L-amino acid
KR101968317B1 (en) * 2018-02-23 2019-04-11 씨제이제일제당 주식회사 Novel L-tryptophan export protein and the method of producing L-tryptophan usingthe same
EP3861109A1 (en) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
JP7491314B2 (en) 2019-02-22 2024-05-28 味の素株式会社 Method for producing L-amino acids using bacteria belonging to the Enterobacteriaceae family that overexpress the ydiJ gene
JP7524909B2 (en) 2019-04-05 2024-07-30 味の素株式会社 Method for producing L-amino acids
CN110592084B (en) * 2019-08-28 2023-07-28 内蒙古伊品生物科技有限公司 Recombinant strain transformed by rhtA gene promoter, construction method and application thereof
JP2022550084A (en) 2019-09-25 2022-11-30 味の素株式会社 Method for producing L-amino acid by bacterial fermentation
WO2021085405A1 (en) 2019-10-28 2021-05-06 味の素株式会社 Benzaldehyde production method
WO2023195475A1 (en) 2022-04-04 2023-10-12 味の素株式会社 Method for controlling parasitic plants

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786039A (en) * 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
SU974817A1 (en) 1981-06-16 1990-08-23 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Method of producing l-treonin
DE3891417C5 (en) 1988-10-25 2006-01-05 Ajinomoto Co., Inc. A method of altering a L-threonine producing microorganism and using a microorganism thus obtained to produce L-threonine
US5976843A (en) 1992-04-22 1999-11-02 Ajinomoto Co., Inc. Bacterial strain of Escherichia coli BKIIM B-3996 as the producer of L-threonine
US5705371A (en) 1990-06-12 1998-01-06 Ajinomoto Co., Inc. Bacterial strain of escherichia coli BKIIM B-3996 as the producer of L-threonine
US5534421A (en) 1991-05-30 1996-07-09 Ajinomoto Co., Inc. Production of isoleucine by escherichia coli having isoleucine auxotrophy and no negative feedback inhibition of isoleucine production
US6132999A (en) 1992-09-21 2000-10-17 Ajinomoto Co., Inc. L-threonine-producing microbacteria and a method for the production of L-threonine
EP0828718A1 (en) * 1995-06-02 1998-03-18 G.D. SEARLE & CO. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
JP4032441B2 (en) * 1995-08-30 2008-01-16 味の素株式会社 Method for producing L-amino acid
DE19548222A1 (en) 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Process for the microbial production of amino acids through increased activity of export carriers
DE19726083A1 (en) 1997-06-19 1998-12-24 Consortium Elektrochem Ind Microorganisms and processes for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine or thiazolidine derivatives
RU2144564C1 (en) 1998-10-13 2000-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Dna fragment rhtb encoding synthesis of protein rhtb that determines resistance of bacterium escherichia coli to l-homoserine and method of l-amino acid producing
RU2148642C1 (en) * 1998-12-23 2000-05-10 ЗАО "Научно-исследовательский институт АДЖИНОМОТО-Генетика" (ЗАО "АГРИ") Dna rhtc fragment encoding synthesis of rhtc protein that determines enhanced resistance of bacterium escherichia coli to l-threonine and method of l-amino acid producing
RU2175351C2 (en) * 1998-12-30 2001-10-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО "АГРИ") Escherichia coli dna fragment determining enhanced production of l-amino acids (variants) and method of l-amino acid producing
RU2209246C2 (en) * 2000-01-26 2003-07-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Small subunit of isozyme iii and isozyme iii of acetohydroxyacid synthetase from escherichia coli, dna fragment (variants), strain of bacterium escherichia coli as producer of l-valine (variants) and method for preparing l-valine
AU2001249345A1 (en) 2000-03-21 2001-10-03 Elitra Pharmaceuticals, Inc. Identification of essential genes in prokaryotes
RU2212447C2 (en) * 2000-04-26 2003-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Strain escherichia coli as producer of amino acid (variants) and method for preparing amino acid (variants)
DE60219968T2 (en) * 2001-02-13 2008-01-17 Ajinomoto Co., Inc. Process for the production of L-amino acids by means of bacteria of the genus Escherichia
DE60236684D1 (en) * 2001-11-23 2010-07-22 Ajinomoto Kk PROCESS FOR L-AMINO ACID PRODUCTION WITH ESCHERICHIA
RU2229513C2 (en) * 2001-11-23 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-amino acids, strain escherichia coli as producer of l-amino acids (variants)
RU2244007C2 (en) * 2002-02-27 2005-01-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Method for preparing l-threonine, strain escherichia coli as producer of threonine (variants)
EP1604023A2 (en) * 2003-03-12 2005-12-14 Ajinomoto Co., Inc. Optimization of bacterial sucab expression by promoter mutagenesis for efficient l-glutamic acid production
RU2268300C2 (en) * 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" METHOD FOR PREPARING L-AMINO ACIDS BY USING MICROORGANISMS POSSESSING ENHANCED EXPRESSION OF pckA GENE
US7312058B2 (en) * 2003-07-16 2007-12-25 Ajinomoto Co., Ltd. Mutant serine acetyltransferase
RU2275424C2 (en) * 2003-12-05 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method for preparing l-threonine by using bacterium belonging to genus escherichia
US20050181488A1 (en) * 2004-02-12 2005-08-18 Akhverdian Valery Z. Method for producing L-threonine using bacteria belonging to the genus Escherichia
US20050191684A1 (en) * 2004-02-25 2005-09-01 Zimenkov Danila V. Method for producing L-amino acids
US8003367B2 (en) * 2004-03-16 2011-08-23 Ajinomoto Co., Inc. Method for producing L-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes
RU2306338C2 (en) * 2004-06-24 2007-09-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Mob'-DERIVED RSF1010 PLASMID CONTAINING NO ANTIBIOTIC-RESISTANCE GENES, BACTERIUM CONTAINING SUCH PLASMID AND METHOD FOR PRODUCTION OF USEFUL METABOLITES
US7915018B2 (en) * 2004-10-22 2011-03-29 Ajinomoto Co., Inc. Method for producing L-amino acids using bacteria of the Enterobacteriaceae family

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