RS63074B1 - Inhibitori lizin specifične demetilaze-1 - Google Patents

Inhibitori lizin specifične demetilaze-1

Info

Publication number: RS63074B1
Authority: RS; Serbia
Prior art keywords: inhibitors; specific demethylase; lysine specific; lysine; demethylase
Prior art date: 2014-07-03

Application number

RS20220311A

Other languages

English (en)

Inventor

Young K Chen

Toufike Kanouni

Zhe Nie

Jeffrey Alan Stafford

James Marvin Veal

Original Assignee

Celgene Quanticel Research Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-07-03

Filing date

2015-06-29

Publication date

2022-04-29

2015-06-29 Application filed by Celgene Quanticel Research Inc filed Critical Celgene Quanticel Research Inc

2022-04-29 Publication of RS63074B1 publication Critical patent/RS63074B1/sr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polyamides (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

RS20220311A 2014-07-03 2015-06-29 Inhibitori lizin specifične demetilaze-1 RS63074B1 (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201462020886P	2014-07-03	2014-07-03
EP15814038.4A EP3164380B1 (en)	2014-07-03	2015-06-29	Inhibitors of lysine specific demethylase-1
PCT/US2015/038345 WO2016003917A1 (en)	2014-07-03	2015-06-29	Inhibitors of lysine specific demethylase-1

Publications (1)

Publication Number	Publication Date
RS63074B1 true RS63074B1 (sr)	2022-04-29

Family

ID=55019883

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RS20220311A RS63074B1 (sr)	2014-07-03	2015-06-29	Inhibitori lizin specifične demetilaze-1
RS20230452A RS64423B1 (sr)	2014-07-03	2015-06-29	Inhibitori lizin specifične demetilaze-1

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
RS20230452A RS64423B1 (sr)	2014-07-03	2015-06-29	Inhibitori lizin specifične demetilaze-1

Country Status (28)

Country	Link
US (3)	US9902719B2 (sr)
EP (2)	EP3164380B1 (sr)
JP (2)	JP6663866B2 (sr)
KR (1)	KR102475498B1 (sr)
CN (2)	CN108530424B (sr)
AU (1)	AU2015284383B2 (sr)
BR (1)	BR112017000043A2 (sr)
CA (1)	CA2954049A1 (sr)
CL (1)	CL2016003422A1 (sr)
CO (1)	CO2017000549A2 (sr)
CY (1)	CY1125127T1 (sr)
DK (2)	DK3164380T3 (sr)
EA (2)	EA201891526A3 (sr)
EC (1)	ECSP17006821A (sr)
ES (2)	ES2907676T3 (sr)
FI (1)	FI3511319T3 (sr)
HR (2)	HRP20220414T1 (sr)
HU (2)	HUE058852T2 (sr)
IL (2)	IL249881B (sr)
LT (2)	LT3511319T (sr)
MX (2)	MX2020010900A (sr)
PL (2)	PL3164380T3 (sr)
PT (2)	PT3511319T (sr)
RS (2)	RS63074B1 (sr)
SA (1)	SA517380651B1 (sr)
SG (2)	SG10201802501RA (sr)
SI (2)	SI3164380T1 (sr)
WO (1)	WO2016003917A1 (sr)

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EP3430015A1 (en)	2016-03-16	2019-01-23	Oryzon Genomics, S.A.	Methods to determine kdm1a target engagement and chemoprobes useful therefor
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KR20240122847A (ko)	2017-08-03	2024-08-13	오리존 지노믹스 에스.에이.	행동 변경 치료 방법
BR112021002327A2 (pt) *	2018-08-10	2021-05-04	Navire Pharma, Inc.	derivados de 6-(4-amino-3-metil-2-oxa-8-azaespiro[4,5]decan-8-il)-3-(2,3-diclorofenil)-2-metilpirimidin-4(3h)-ona e compostos relacionados como inibidores de ptpn11(shp2) para o tratamento do câncer
CN113365996B (zh) *	2019-02-01	2024-09-03	韩美药品株式会社	咪唑吡啶衍生化合物以及药物组成物
SG11202109159VA (en)	2019-03-20	2021-10-28	Oryzon Genomics Sa	Methods of treating borderline personality disorder
US20220151999A1 (en)	2019-03-20	2022-05-19	Oryzon Genomics, S.A.	Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
JP2022546908A (ja)	2019-07-05	2022-11-10	オリゾン・ゲノミクス・ソシエダッド・アノニマ	Ｋｄｍ１ａ阻害剤を使用した小細胞肺がんの個別化された処置のためのバイオマーカーおよび方法
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CN114105950B (zh) *	2020-08-31	2022-09-06	南京明德新药研发有限公司	吡唑类化合物及其应用
WO2022199662A1 (zh) *	2021-03-24	2022-09-29	四川汇宇制药股份有限公司	一种多环化合物及其应用
CA3231846A1 (en)	2021-04-08	2022-10-13	Tamara Maes	Combinations of lsd1 inhibitors for treating myeloid cancers
CN116102533A (zh) *	2021-11-11	2023-05-12	中国科学院上海药物研究所	一种芳杂环类化合物及其应用
WO2023217784A1 (en)	2022-05-09	2023-11-16	Oryzon Genomics, S.A.	Methods of treating nf1-mutant tumors using lsd1 inhibitors
WO2023217758A1 (en)	2022-05-09	2023-11-16	Oryzon Genomics, S.A.	Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
WO2024110649A1 (en)	2022-11-24	2024-05-30	Oryzon Genomics, S.A.	Combinations of lsd1 inhibitors and menin inhibitors for treating cancer

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MX2017000170A (es) *	2014-07-03	2017-05-01	Celgene Quanticel Res Inc	Inhibidores de demetilasa-1 especifica de lisina.

2015
- 2015-06-29 LT LTEP19156976.3T patent/LT3511319T/lt unknown
- 2015-06-29 SG SG10201802501RA patent/SG10201802501RA/en unknown
- 2015-06-29 MX MX2020010900A patent/MX2020010900A/es unknown
- 2015-06-29 AU AU2015284383A patent/AU2015284383B2/en not_active Ceased
- 2015-06-29 PL PL15814038T patent/PL3164380T3/pl unknown
- 2015-06-29 FI FIEP19156976.3T patent/FI3511319T3/fi active
- 2015-06-29 CN CN201810425583.0A patent/CN108530424B/zh not_active Expired - Fee Related
- 2015-06-29 HU HUE15814038A patent/HUE058852T2/hu unknown
- 2015-06-29 CN CN201580047448.1A patent/CN106795103B/zh not_active Expired - Fee Related
- 2015-06-29 DK DK15814038.4T patent/DK3164380T3/da active
- 2015-06-29 DK DK19156976.3T patent/DK3511319T3/da active
- 2015-06-29 ES ES15814038T patent/ES2907676T3/es active Active
- 2015-06-29 US US15/323,277 patent/US9902719B2/en active Active
- 2015-06-29 PT PT191569763T patent/PT3511319T/pt unknown
- 2015-06-29 BR BR112017000043-1A patent/BR112017000043A2/pt not_active Application Discontinuation
- 2015-06-29 HU HUE19156976A patent/HUE062558T2/hu unknown
- 2015-06-29 KR KR1020177003162A patent/KR102475498B1/ko active IP Right Grant
- 2015-06-29 SI SI201531797T patent/SI3164380T1/sl unknown
- 2015-06-29 PL PL19156976.3T patent/PL3511319T3/pl unknown
- 2015-06-29 EA EA201891526A patent/EA201891526A3/ru unknown
- 2015-06-29 LT LTEPPCT/US2015/038345T patent/LT3164380T/lt unknown
- 2015-06-29 WO PCT/US2015/038345 patent/WO2016003917A1/en active Application Filing
- 2015-06-29 HR HRP20220414TT patent/HRP20220414T1/hr unknown
- 2015-06-29 EP EP15814038.4A patent/EP3164380B1/en active Active
- 2015-06-29 SG SG11201610975RA patent/SG11201610975RA/en unknown
- 2015-06-29 RS RS20220311A patent/RS63074B1/sr unknown
- 2015-06-29 EP EP19156976.3A patent/EP3511319B1/en active Active
- 2015-06-29 SI SI201531948T patent/SI3511319T1/sl unknown
- 2015-06-29 EA EA201790085A patent/EA033698B1/ru not_active IP Right Cessation
- 2015-06-29 MX MX2017000168A patent/MX2017000168A/es active IP Right Grant
- 2015-06-29 CA CA2954049A patent/CA2954049A1/en not_active Abandoned
- 2015-06-29 JP JP2016575768A patent/JP6663866B2/ja active Active
- 2015-06-29 PT PT158140384T patent/PT3164380T/pt unknown
- 2015-06-29 HR HRP20230595TT patent/HRP20230595T1/hr unknown
- 2015-06-29 ES ES19156976T patent/ES2948782T3/es active Active
- 2015-06-29 RS RS20230452A patent/RS64423B1/sr unknown
2016
- 2016-12-30 CL CL2016003422A patent/CL2016003422A1/es unknown
2017
- 2017-01-01 IL IL249881A patent/IL249881B/en active IP Right Grant
- 2017-01-02 SA SA517380651A patent/SA517380651B1/ar unknown
- 2017-01-23 CO CONC2017/0000549A patent/CO2017000549A2/es unknown
- 2017-02-01 EC ECIEPI20176821A patent/ECSP17006821A/es unknown
2018
- 2018-01-10 US US15/867,397 patent/US10100046B2/en active Active
- 2018-09-05 US US16/122,703 patent/US20190002456A1/en not_active Abandoned
2019
- 2019-02-21 JP JP2019029856A patent/JP6768857B2/ja not_active Expired - Fee Related
2020
- 2020-01-19 IL IL272130A patent/IL272130B/en active IP Right Grant
2022
- 2022-04-11 CY CY20221100269T patent/CY1125127T1/el unknown

Also Published As

Publication number	Publication date
IL272130A (en)	2020-03-31
PT3511319T (pt)	2023-06-29
DK3164380T3 (da)	2022-03-28
CY1125127T1 (el)	2024-02-16
SI3511319T1 (sl)	2023-10-30
SG10201802501RA (en)	2018-05-30
IL249881B (en)	2020-01-30
LT3164380T (lt)	2022-06-27
EP3511319A1 (en)	2019-07-17
WO2016003917A1 (en)	2016-01-07
JP2019108346A (ja)	2019-07-04
EA201891526A2 (ru)	2018-12-28
EP3164380B1 (en)	2022-02-09
LT3511319T (lt)	2023-08-25
US9902719B2 (en)	2018-02-27
DK3511319T3 (da)	2023-07-31
IL272130B (en)	2021-03-25
ES2907676T3 (es)	2022-04-26
CN106795103B (zh)	2019-07-12
SA517380651B1 (ar)	2020-09-30
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IL249881A0 (en)	2017-03-30
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FI3511319T3 (fi)	2023-07-20
KR102475498B1 (ko)	2022-12-07
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CL2016003422A1 (es)	2017-11-10
HRP20220414T1 (hr)	2022-05-27
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AU2015284383B2 (en)	2019-04-18
US20190002456A1 (en)	2019-01-03
PT3164380T (pt)	2022-03-02

Publication	Publication Date	Title
IL272130B (en)	2021-03-25	Inhibitors of specific lysine demethylase-1
ZA201607613B (en)	2017-11-29	Inhibitors of lysine specific demethylase-1
IL250876B (en)	2021-09-30	Inhibitors of specific lysine demethylase-1
ZA201700069B (en)	2018-04-25	Inhibitors of lysine specific demethylase-1
ZA201700072B (en)	2018-04-25	Inhibitors of lysine specific demethylase-1