RS61016B1 - Prolekovi inhibitora hiv reverzne transkriptaze - Google Patents
Prolekovi inhibitora hiv reverzne transkriptazeInfo
- Publication number
- RS61016B1 RS61016B1 RS20201323A RSP20201323A RS61016B1 RS 61016 B1 RS61016 B1 RS 61016B1 RS 20201323 A RS20201323 A RS 20201323A RS P20201323 A RSP20201323 A RS P20201323A RS 61016 B1 RS61016 B1 RS 61016B1
- Authority
- RS
- Serbia
- Prior art keywords
- prodrugs
- reverse transcriptase
- transcriptase inhibitors
- hiv reverse
- hiv
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461973689P | 2014-04-01 | 2014-04-01 | |
EP15774282.6A EP3125894B1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
PCT/US2015/022868 WO2015153304A1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS61016B1 true RS61016B1 (sr) | 2020-12-31 |
Family
ID=54241131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20201323A RS61016B1 (sr) | 2014-04-01 | 2015-03-27 | Prolekovi inhibitora hiv reverzne transkriptaze |
Country Status (21)
Country | Link |
---|---|
US (1) | US10004740B2 (sr) |
EP (2) | EP3125894B1 (sr) |
JP (1) | JP6342011B2 (sr) |
KR (1) | KR102440843B1 (sr) |
CN (1) | CN106456639B (sr) |
AU (1) | AU2015241247B2 (sr) |
BR (1) | BR112016022722B8 (sr) |
CA (1) | CA2944187C (sr) |
CY (1) | CY1123582T1 (sr) |
DK (1) | DK3125894T3 (sr) |
ES (1) | ES2828951T3 (sr) |
HR (1) | HRP20201780T1 (sr) |
HU (1) | HUE051848T2 (sr) |
LT (1) | LT3125894T (sr) |
MX (1) | MX2016012915A (sr) |
PL (1) | PL3125894T3 (sr) |
PT (1) | PT3125894T (sr) |
RS (1) | RS61016B1 (sr) |
RU (1) | RU2693622C2 (sr) |
SI (1) | SI3125894T1 (sr) |
WO (1) | WO2015153304A1 (sr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
AU2015241247B2 (en) | 2014-04-01 | 2017-09-14 | Merck Sharp & Dohme Llc | Prodrugs of HIV reverse transcriptase inhibitors |
CN106008362B (zh) * | 2016-05-24 | 2018-08-10 | 杰达维(上海)医药科技发展有限公司 | 一种嘧啶衍生物的制备方法 |
CA3086303A1 (en) | 2017-12-22 | 2019-06-27 | Sumitomo Chemical Company, Limited | Heterocyclic compound and harmful arthropod controlling agent containing same |
JOP20210149A1 (ar) * | 2018-12-18 | 2023-01-30 | Merck Sharp & Dohme | مشتقات بيريميدين تعمل كعوامل انتقائية ضد الخلايا المصابة بفيروس نقص المناعة البشرية |
EP3928834A4 (en) | 2019-02-20 | 2022-10-12 | Sumitomo Chemical Company Limited | ETHER COMPOUND AND HARMFUL ARTHROPOD CONTROL COMPOSITION CONTAINING THE SAME |
MX2021014247A (es) | 2019-05-22 | 2022-01-06 | Merck Sharp & Dohme Llc | Derivados piridinona como agentes citotoxicos selectivos contra celulas infectadas con virus de inmunodeficiencia humana (vih). |
KR20220034853A (ko) | 2019-07-16 | 2022-03-18 | 브리스톨-마이어스 스큅 컴퍼니 | 인터류킨의 조정에서의 전구약물 |
TW202304919A (zh) | 2021-03-31 | 2023-02-01 | 印度商皮埃企業有限公司 | 稠合雜環化合物及其作為害蟲控制劑之用途 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5519021A (en) | 1992-08-07 | 1996-05-21 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
EA011164B1 (ru) | 2003-02-07 | 2009-02-27 | Янссен Фармацевтика Н. В. | Производные пиримидина для профилактики вич-инфекции |
TW200423930A (en) | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
TW200505441A (en) | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
EP1608629A1 (en) | 2003-03-24 | 2005-12-28 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7288942B2 (en) * | 2003-10-02 | 2007-10-30 | Naoyuki Sato | Plasma potential measuring method and apparatus, and plasma potential measuring probe |
WO2005070901A2 (en) | 2004-01-12 | 2005-08-04 | Gilead Sciences, Inc. | Pyrimidyl phosphonate antiviral compounds and methods of use |
CA2559552A1 (en) | 2004-03-23 | 2005-09-29 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors |
ES2333802T3 (es) | 2004-04-23 | 2010-03-01 | F. Hoffmann-La Roche Ag | Inhibidores no nucleicos de transcriptasa inversa. |
US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
CA2592092A1 (en) | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
DE602006005699D1 (de) | 2005-10-19 | 2009-04-23 | Hoffmann La Roche | N-phenyl-phenylacetamid-nichtnukleosidinhibitoren reverser transkriptase |
BRPI0617720A2 (pt) | 2005-10-19 | 2011-08-02 | Hoffmann La Roche | compostos inibidores de nnrt de fenil-acetamida, usos dos referidos compostos e composição farmacêutica que os contém |
BRPI0719060A2 (pt) | 2006-11-24 | 2014-02-04 | Takeda Pharmaceutical | Composto, prodroga, agente farmacêutico, métodos para inibir um receptor de angiotensina ii e/ou ativar um receptor ativado com proliferador de peroxisoma, e para prevenir ou tratar doenças ou condições, e, uso de um composto |
US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
US8404253B2 (en) | 2006-12-28 | 2013-03-26 | Newport Laboratories, Inc. | Modified live (JMSO strain) Haemophilus parasuis vaccine |
DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
RU2010125220A (ru) * | 2007-11-20 | 2011-12-27 | Мерк Шарп Энд Домэ Корп. (Us) | Ненуклеозидные ингибиторы обратной транскриптазы |
CN103254138A (zh) * | 2008-01-08 | 2013-08-21 | 默沙东公司 | 用于制备n-取代的羟基嘧啶酮羧酰胺类化合物的方法 |
WO2011120133A1 (en) * | 2010-03-30 | 2011-10-06 | Merck Frosst Canada Ltd. | Non-nucleoside reverse transcriptase inhibitors |
WO2011126969A1 (en) | 2010-04-08 | 2011-10-13 | Merck Sharp & Dohme Corp. | Prodrugs of an hiv reverse transcriptase inhibitor |
JO3470B1 (ar) * | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
AU2015241247B2 (en) | 2014-04-01 | 2017-09-14 | Merck Sharp & Dohme Llc | Prodrugs of HIV reverse transcriptase inhibitors |
-
2015
- 2015-03-27 AU AU2015241247A patent/AU2015241247B2/en active Active
- 2015-03-27 RS RS20201323A patent/RS61016B1/sr unknown
- 2015-03-27 KR KR1020167030064A patent/KR102440843B1/ko active IP Right Grant
- 2015-03-27 ES ES15774282T patent/ES2828951T3/es active Active
- 2015-03-27 SI SI201531408T patent/SI3125894T1/sl unknown
- 2015-03-27 MX MX2016012915A patent/MX2016012915A/es active IP Right Grant
- 2015-03-27 HU HUE15774282A patent/HUE051848T2/hu unknown
- 2015-03-27 CN CN201580029171.XA patent/CN106456639B/zh active Active
- 2015-03-27 DK DK15774282.6T patent/DK3125894T3/da active
- 2015-03-27 JP JP2016559867A patent/JP6342011B2/ja active Active
- 2015-03-27 US US15/300,405 patent/US10004740B2/en active Active
- 2015-03-27 WO PCT/US2015/022868 patent/WO2015153304A1/en active Application Filing
- 2015-03-27 EP EP15774282.6A patent/EP3125894B1/en active Active
- 2015-03-27 LT LTEP15774282.6T patent/LT3125894T/lt unknown
- 2015-03-27 PT PT157742826T patent/PT3125894T/pt unknown
- 2015-03-27 BR BR112016022722A patent/BR112016022722B8/pt active IP Right Grant
- 2015-03-27 EP EP20194453.5A patent/EP3785714A1/en active Pending
- 2015-03-27 RU RU2016142611A patent/RU2693622C2/ru active
- 2015-03-27 PL PL15774282T patent/PL3125894T3/pl unknown
- 2015-03-27 CA CA2944187A patent/CA2944187C/en active Active
-
2020
- 2020-11-04 HR HRP20201780TT patent/HRP20201780T1/hr unknown
- 2020-11-11 CY CY20201101068T patent/CY1123582T1/el unknown
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