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RS53350B - Substituted imidazo[1,2b] pyridazine compounds as trk kinase inhibitors - Google Patents

Substituted imidazo[1,2b] pyridazine compounds as trk kinase inhibitors

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Publication number
RS53350B
RS53350B RS20140259A RSP20140259A RS53350B RS 53350 B RS53350 B RS 53350B RS 20140259 A RS20140259 A RS 20140259A RS P20140259 A RSP20140259 A RS P20140259A RS 53350 B RS53350 B RS 53350B
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Serbia
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alkyl
ring
optionally substituted
independently selected
group
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RS20140259A
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Serbian (sr)
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Steven W. Andrews
Julia Haas
Yutong Jiang
Gan Zhang
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Array Biopharma, Inc.
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Publication of RS53350B publication Critical patent/RS53350B/en

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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Jedinjenje opše formule Iili njena farmaceutski prihvatljiva so, naznačen time, što:R1 predstavlja H ili (1-6C alkil);R2 je NRbRc, (1-4C)alkil, (1-4C)fluoroalkil, CF3, (1-4C)hidroksialkil, -(1-4C alkil)hetAr1, -(1-4Calkil)NH(l-4Calkil, hetAr2, hetCyc1, hetCyc2, fenil koji je po slobodnom izboru supstituisan sa NHS02(1-4C alkil), ili (3-6C)cikloalkil koji je po slobodnom izboru supstituisan sa (1-4C alkil), CN, OH, CF3, CO2(1-4C alkil) ili CO2H;gde Rb može da bude H ili (1-6C alkil);gde Rc može da bude H, (1-4C)alkil, (1-4C)hidroksialkil, hetAr3, ili fenil, gde je pomenuti fenil po slobodnom izboru supstituisan sa jednim ili više supstituenata koji su nezavisno odabrani iz grupe koju čine halogen, CN, CF3 i -O(1-4C alkil),ili NRbRc gradi 4-očlani heterociklični prsten koji ima atom azota, gde je pomenuti heterociklični prsten po slobodnom izboru supstituisan sa jednim ili više supstituenata koji su nezavisno odabrani iz grupe koju čine halogen, OH, (1-4C alkil), (1-4 C) alkoksi, -OC(=O)(1-4C alkil), NH2, -NHC(=O)O(1-4C alkil) i (1-4C)hidroksialkil, ili NRbRcgradi 5-6-očlani heterociklični prsten koji ima heteroatom u prstenu koji predstavlja azot i opciono ima drugi heteroatom u prstenu ili grupu koja je odabrana izmedju N, O i SO2, gde je heterociklični prsten po slobodnom izboru supstituisan sa jednim ili više supstituenata koji su nezavisno odabrani iz grupe koju čine OH, halogen, CF3, (1-4C)alkil, CO2(1-4C alkil), CO2H, NH2, NHC(=O)O(1-4C alkil) i okso,ili NRbRc gradi 7-8-očlani spojeni heterociklični prsten koji ima 1-2 atoma azota u prstenu, gde je pomenuti prsten po slobodnom izboru supstituisan sa CO2(1-4Calkil);hetAr1 je 5-očlani heteroarilni prsten sa 1-3 atoma azota u prstenu;hetAr2 je 5-6 očlani heteroarilni prsten sa najmanje jednim atomom azota u prstenu i koji po slobodnom izboru ima drugi heteroatom u prstenu koji je nezavisno odabran izmedju N i S, gde je pomenuti heteroarilni prsten po slobodnom izboru supstituisan sa jednim ili više supstituenata koji su nezavisno odabrani iz grupe koju čine (1-4C alkil), halogen, -(1-4 C)alkoksi, i NH(1-4C alkil);gde hetCyc1 predstavlja 4-6-očlani azaciklični prsten vezan preko ugljenika koji je po slobodnom izboru supstituisan sa jednim ili više supstituenata koji su nezavisno odabrani izmedju (1-4C alkil), i CO2(1-4C alkil);hetCyc2 predstavlja piridinonski ili piridazinonski prsten koji je po slobodnom izboru supstituisan sa supstituentom koji je odabran od (1-4C) alkil;hetAr3 predstavlja 5-6-očlani heteroarilni prsten sa 1-2 heteroatoma u prstenu koji su svaki za sebe odabrani od N i O i po slobodnom izboru supstituisani sa jednim ili više supstituenata koji su nezavisno odabrani od (l-4C)alkil;Y predstavlja fenilni prsten po slobodnom izboru supstituisan sa jednim ili više supstituenatanezavisno odabranih iz grupe koju čine halogen, (1-4C) alkoksi, CF3 i CHF2, ili 5-6-očlaniheteroarilni prsten koji ima heteroatom odabran izmedju N i S;gde je X nula, -CH2-, -CHA compound of general formula or a pharmaceutically acceptable salt thereof, wherein: R1 represents H or (1-6C alkyl); R2 is NRbRc, (1-4C) alkyl, (1-4C) fluoroalkyl, CF3, (1-4C) hydroxyalkyl, - (1-4C alkyl) hetAr1, - (1-4Calkyl) NH (1-4Calkyl, hetAr2, hetCyc1, hetCyc2, phenyl which is optionally substituted by NHSO2 (1-4C alkyl), or (3-6C ) cycloalkyl which is optionally substituted by (1-4C alkyl), CN, OH, CF3, CO2 (1-4C alkyl) or CO2H; where Rb may be H or (1-6C alkyl); where Rc may be is H, (1-4C) alkyl, (1-4C) hydroxyalkyl, hetAr3, or phenyl, wherein said phenyl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, CN, CF3 and - O (1-4C alkyl) or NRbRc forms a 4-membered heterocyclic ring having a nitrogen atom, wherein said heterocyclic ring is optionally substituted with one or more substituents independently selected from the group consisting of halogen, OH, (1 -4C alkyl), (1-4C) alkoxy, -OC (= O) (1-4C alkyl), NH2, -NHC (= O) O (1-4C alkyl) and (1-4C) hydroxyalkyl, or NRbRc is a 5-6 membered heterocyclic ring having a ring heteroatom represented by nitrogen and optionally having a second ring heteroatom or a group selected from N, O and SO2, wherein the heterocyclic ring is optionally substituted with one or more substituents which are independently selected from the group consisting of OH, halogen, CF3, (1-4C) alkyl, CO2 (1-4C alkyl), CO2H, NH2, NHC (= O) O (1-4C alkyl) and oxo, or NRbRc forms 7 -8-membered fused heterocyclic ring having 1-2 ring nitrogen atoms, wherein said ring is optionally substituted with CO2 (1-4Calkyl); hetAr1 is a 5-membered heteroaryl ring with 1-3 ring nitrogen; hetAr2 is a 5-6 membered heteroaryl ring with at least one nitrogen atom in the ring and optionally having a second heteroatom in the ring independently selected from N and S, wherein said heteroaryl ring is s optionally substituted with one or more substituents independently selected from the group consisting of (1-4C alkyl), halogen, - (1-4C) alkoxy, and NH (1-4C alkyl); where hetCyc1 represents 4-6- a membered azacyclic carbon bond optionally substituted by one or more substituents independently selected from (1-4C alkyl) and CO2 (1-4C alkyl); hetCyc2 represents a pyridinone or pyridazinone optionally substituted ring with a substituent selected from (1-4C) alkyl; hetAr3 represents a 5-6-membered heteroaryl ring with 1-2 ring heteroatoms each independently selected from N and O and optionally substituted by one or more substituents which are independently selected from (1-4C) alkyl; Y represents an optionally substituted phenyl ring substituted by one or more substituents independently selected from the group consisting of halogen, (1-4C) alkoxy, CF3 and CHF2, or a 5-6 membered heteroaryl ring whichhas a heteroatom selected from N and S; where X is zero, -CH 2 -, -CH

RS20140259A 2008-09-22 2009-09-21 Substituted imidazo[1,2b] pyridazine compounds as trk kinase inhibitors RS53350B (en)

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PCT/US2009/057729 WO2010033941A1 (en) 2008-09-22 2009-09-21 Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors

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Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101600718B (en) * 2006-11-06 2013-07-03 特雷罗药物股份有限公司 Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
EA019507B1 (en) 2008-05-13 2014-04-30 Айрм Ллк Fused nitrogen containing heterocycles and compounds thereof as kinase inhibitors
SI2350075T1 (en) 2008-09-22 2014-06-30 Array Biopharma, Inc. Substituted imidazoš1,2bćpyridazine compounds as trk kinase inhibitors
EP2350071B1 (en) 2008-10-22 2014-01-08 Array Biopharma, Inc. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
EP2571883B1 (en) 2010-05-20 2015-01-07 Array Biopharma, Inc. Macrocyclic compounds as trk kinase inhibitors
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
PL2712358T3 (en) 2011-05-13 2017-05-31 Array Biopharma, Inc. Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
EP2731439A4 (en) 2011-07-12 2014-12-03 Merck Sharp & Dohme TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
ES2671748T3 (en) 2011-07-21 2018-06-08 Tolero Pharmaceuticals, Inc. Heterocyclic protein kinase inhibitors
AU2013230119B2 (en) * 2012-03-09 2017-02-23 Lexicon Pharmaceuticals, Inc. Imidazo [1, 2 - b] pyridazine - based compounds, compositions comprising them, and uses thereof
WO2013176970A1 (en) 2012-05-22 2013-11-28 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
TWI585088B (en) * 2012-06-04 2017-06-01 第一三共股份有限公司 Imidazo[1,2-b]pyridazine analogues as kinase inhibitors
WO2014078417A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078325A1 (en) * 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078378A1 (en) * 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
MY178262A (en) 2012-11-13 2020-10-07 Array Biopharma Inc Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078322A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078408A1 (en) * 2012-11-13 2014-05-22 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
JP6345684B2 (en) 2012-11-13 2018-06-20 アレイ バイオファーマ、インコーポレイテッド Bicyclic urea, thiourea, guanidine, and cyanoguanidine compounds useful for the treatment of pain
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078328A1 (en) * 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2015039333A1 (en) 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
WO2015039334A1 (en) 2013-09-22 2015-03-26 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
CN106170289B (en) 2014-01-24 2019-07-23 特普医药公司 The huge ring of the diaryl of regulator as protein kinase
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143654A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
WO2015143653A1 (en) 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
RU2719489C2 (en) 2014-05-15 2020-04-17 Эррэй Биофарма Инк. 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1n-pyrazol-5-yl)urea as a trka kinase inhibitor
RS64122B1 (en) * 2014-11-16 2023-05-31 Array Biopharma Inc Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
CN104672121B (en) * 2015-02-16 2017-10-24 上海华默西医药科技有限公司 The preparation method of 2R (2,5 difluorophenyl) pyrrolidine hydrochloride
WO2016161572A1 (en) 2015-04-08 2016-10-13 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
MX2017015461A (en) 2015-06-01 2018-08-15 Loxo Oncology Inc Methods of diagnosing and treating cancer.
JP6871903B2 (en) * 2015-07-02 2021-05-19 ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Chiral diallyl macrocyclic molecule as a modulator of protein kinase
DK3319969T3 (en) 2015-07-06 2024-07-08 Turning Point Therapeutics Inc DIARYL MACROCYCLE POLYMORPH
CA2992586A1 (en) 2015-07-16 2017-01-19 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
KR20180033194A (en) 2015-07-21 2018-04-02 티피 테라퓨틱스, 인크. Chiral Diaryl Macrocycles and Their Uses
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
KR102400423B1 (en) 2016-04-04 2022-05-19 록쏘 온콜로지, 인코포레이티드 (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidine-3- Liquid formulation of yl)-3-hydroxypyrrolidine-1-carboxamide
DK3439663T3 (en) 2016-04-04 2024-08-26 Loxo Oncology Inc ADVANCES IN THE TREATMENT OF PEDIATRIC CANCER
LT3458456T (en) 2016-05-18 2021-02-25 Loxo Oncology, Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
BR112019001607A2 (en) 2016-07-28 2019-04-30 Tp Therapeutics, Inc. macrocyclic kinase inhibitors
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
CN108003161B (en) * 2016-10-28 2020-10-09 正大天晴药业集团股份有限公司 Neurotrophic factor tyrosine kinase receptor inhibitors
AU2017348826B2 (en) 2016-10-28 2021-12-02 Centaurus Biopharma Co., Ltd. Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor
CN106632353A (en) * 2016-11-18 2017-05-10 山东友帮生化科技有限公司 Synthesis method of 3-nitro-6- chloroimidazo[1,2-b] pyridazine
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
TWI808958B (en) 2017-01-25 2023-07-21 美商特普醫葯公司 Combination therapy involving diaryl macrocyclic compounds
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
CN107286070B (en) * 2017-07-19 2019-07-16 浙江师范大学 (R) synthetic method and intermediate of -2- (2,5- difluorophenyl) pyrrolidines
JP7224334B2 (en) 2017-07-28 2023-02-17 ターニング・ポイント・セラピューティクス・インコーポレイテッド Macrocyclic compounds and uses thereof
CN111542522B (en) * 2017-08-11 2021-10-15 苏州韬略生物科技有限公司 Substituted pyrazolopyrimidines useful as kinase inhibitors
FI3674307T3 (en) 2017-08-23 2023-09-11 Chia Tai Tianqing Pharmaceutical Group Co Ltd Macrocycle containing aminopyrazole and pyrimidine and pharmaceutical composition and use thereof
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
WO2019084285A1 (en) 2017-10-26 2019-05-02 Qian Zhao Formulations of a macrocyclic trk kinase inhibitor
HRP20221502T1 (en) 2017-12-19 2023-03-31 Turning Point Therapeutics, Inc. Macrocyclic compounds for treating diseases
WO2019143991A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
CN111971286B (en) 2018-01-18 2023-04-14 阿雷生物药品公司 Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors
CA3087972C (en) 2018-01-18 2023-01-10 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors
CN108218754B (en) * 2018-01-23 2021-05-07 广东赛烽医药科技有限公司 Preparation method of 2- (2,5-difluorophenyl) pyrrolidine
JP7294677B2 (en) 2018-03-14 2023-06-20 フォチョン・ファーマシューティカルズ・リミテッド Substituted (2-azabicyclo[3.1.0]hexane-2-yl)pyrazolo[1,5-a]pyrimidine compounds and substituted (2-azabicyclo[3.1.0]hexane-2 as TRK kinase inhibitors -yl)imidazo[1,2-b]pyridazine compounds
MA52218A (en) 2018-03-29 2021-02-17 Loxo Oncology Inc TREATMENT OF CANCERS ASSOCIATED WITH TRK
EP3786167B1 (en) 2018-04-25 2024-08-21 Primegene (Beijing) Co., Ltd. Diaryl macrocyclic compound and pharmaceutical composition, and use thereof
GB201811825D0 (en) * 2018-07-19 2018-09-05 Benevolentai Bio Ltd Organic compounds
KR102653681B1 (en) 2018-07-31 2024-04-03 록쏘 온콜로지, 인코포레이티드 SPRAY-DRIED DISPERSIONS AND FORMULATIONS OF (S)-5-AMINO-3-(4-((5-FLUORO-2-METHOXYBENZAMIDO)METHYL)PHENYL)-1-(1,1,1-TRIFLUORO PROPAN-2-YL)-lH-PYRAZOLE-4-CARBOXAMIDE
CN110857304B (en) * 2018-08-24 2021-05-18 北京富龙康泰生物技术有限公司 Trk inhibitor, preparation method and application thereof
AU2019335450B2 (en) 2018-09-03 2024-11-14 Tyligand Bioscience (Shanghai) Limited TRK inhibitor as anti-cancer drug
US11964988B2 (en) 2018-09-10 2024-04-23 Array Biopharma Inc. Fused heterocyclic compounds as RET kinase inhibitors
CN111039947A (en) * 2018-10-15 2020-04-21 上海轶诺药业有限公司 Preparation and application of protein receptor kinase inhibitor
CN111171019A (en) * 2018-11-13 2020-05-19 上海轶诺药业有限公司 Five-membered and six-membered heterocyclic compounds and application thereof as protein receptor kinase inhibitors
CN111269233A (en) * 2018-12-05 2020-06-12 上海轶诺药业有限公司 Preparation and application of imidazo aromatic ring compounds
CN109354578A (en) * 2018-12-06 2019-02-19 浙江师范大学 It is a kind of for Buddhist nun's intermediate and for the synthetic method of Buddhist nun
EP3898615A1 (en) 2018-12-19 2021-10-27 Array Biopharma, Inc. 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer
EP3898626A1 (en) 2018-12-19 2021-10-27 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
JP2022520361A (en) 2019-02-12 2022-03-30 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド Pharmaceuticals containing heterocyclic protein kinase inhibitors
WO2020187291A1 (en) 2019-03-19 2020-09-24 华中师范大学 Pyrazolopyrimidine compound, pharmaceutical composition, and application therefor
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021047584A1 (en) * 2019-09-11 2021-03-18 Fochon Pharmaceuticals, Ltd. SUBSTITUTED (2-AZABICYCLO [3.1.0] HEXAN-2-YL) PYRAZOLO [1, 5-a] PYRIMIDINE AND IMIDAZO [1, 2-b] PYRIDAZINE COMPOUNDS AS TRK KINASES INHIBITORS
JP2023500906A (en) 2019-11-08 2023-01-11 インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） Methods of treating cancers with acquired resistance to kinase inhibitors
CN112812118A (en) * 2019-11-18 2021-05-18 上海轶诺药业有限公司 Preparation and application of protein receptor kinase inhibitor
AU2021209418A1 (en) * 2020-01-22 2022-07-21 Benevolentai Bio Limited Topical pharmaceutical compositions comprising imidazo[1,2-b]pyridazine compounds
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN113563343B (en) * 2020-07-27 2022-05-24 杭州邦顺制药有限公司 Substituted pyrazolo [1,5-a ] pyrimidine compounds and uses thereof
US20240309007A1 (en) * 2021-07-01 2024-09-19 Anheart Therapeutics (Hangzhou) Co., Ltd. Crystalline forms of 3-{4-[(2r)-2-aminopropoxy]phenyl}-n-[(1r)- 1-(3-fluorophenyl) ethyl]imidazo[1,2-b]pyridazin-6-amine and salts thereof

Family Cites Families (188)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ536355A (en) 1993-11-30 2006-08-31 Searle & Co Method of treating inflammation using substituted pyrazolyl benzenesulfonamides
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5430021A (en) 1994-03-18 1995-07-04 Pharmavene, Inc. Hydrophobic drug delivery systems
US5844092A (en) 1994-03-18 1998-12-01 Genentech, Inc. Human TRK receptors and neurotrophic factor inhibitors
CA2206201A1 (en) 1996-05-29 1997-11-29 Yoshiaki Isobe Pyrazole derivatives and their pharmaceutical use
CA2285264A1 (en) 1997-04-25 1998-11-05 Michiyo Gyoten Condensed pyridazine derivatives, their production and use
US6534085B1 (en) 1999-09-23 2003-03-18 Bioresponse L.L.C. Phytochemicals for promoting weight loss
CA2412494C (en) 2000-06-22 2012-10-23 Genentech, Inc. Agonist anti-trk-c monoclonal antibodies
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
CA2448956C (en) 2001-05-30 2017-10-03 Genentech, Inc. Anti-ngf antibodies for the treatment of various disorders
US20030199525A1 (en) 2002-03-21 2003-10-23 Hirst Gavin C. Kinase inhibitors
US7449488B2 (en) 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
ITMI20021620A1 (en) 2002-07-23 2004-01-23 Novuspharma Spa ANTI-TUMORAL ACTIVITY COMPOUND
JP4024624B2 (en) 2002-08-26 2007-12-19 富士通株式会社 Semiconductor device manufacturing method and manufacturing apparatus
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
JP4881558B2 (en) 2002-09-04 2012-02-22 シェーリング コーポレイション Pyrazolopyrimidines as cyclin-dependent kinase inhibitors
WO2004052286A2 (en) 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7550470B2 (en) 2002-12-11 2009-06-23 Merck & Co. Inc. Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors
ATE433447T1 (en) 2003-02-20 2009-06-15 Smithkline Beecham Corp PYRIMIIDINE COMPOUNDS
GB0303910D0 (en) 2003-02-20 2003-03-26 Merck Sharp & Dohme Therapeutic agents
WO2004082458A2 (en) 2003-02-21 2004-09-30 The Johns Hopkins University Tyrosine kinome
JP2004277337A (en) 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE
EP1608652A1 (en) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidine compounds and their use in medicine
EP1615697A2 (en) 2003-04-11 2006-01-18 Novo Nordisk A/S New pyrazolo[1,5-a] pyrimidine derivatives and pharmaceutical use thereof
US20060094699A1 (en) 2003-04-11 2006-05-04 Kampen Gita Camilla T Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy
WO2004089415A2 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S COMBINATIONS OF AN 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITOR AND A GLUCOCORTICOID RECEPTOR AGONIST
KR20060011977A (en) 2003-04-28 2006-02-06 가르파마 컴퍼니 리미티드 Galetin 9-inducing factor
JO2785B1 (en) 2003-05-27 2014-03-15 شركة جانسين فارماسوتيكا ان. في Quinazoline derivatives
JP2005008581A (en) 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd NEW PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME AND APPLICATION THEREOF
EA009517B1 (en) 2003-06-27 2008-02-28 Байер Кропсайенс Аг Pyrazolopyrimidines
GEP20196963B (en) 2003-07-15 2019-04-10 Inc Amgen Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
JP4936897B2 (en) 2003-12-18 2012-05-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Pyrido- and pyrimidopyrimidine derivatives as antiproliferative agents
AU2004308299B2 (en) 2003-12-19 2011-11-24 Plexxikon, Inc. Compounds and methods for development of Ret modulators
WO2005068424A1 (en) 2004-01-20 2005-07-28 Cell Therapeutics Europe S.R.L. Indolinone derivatives as receptor tyrosine kinase ihibitors
US20050222171A1 (en) 2004-01-22 2005-10-06 Guido Bold Organic compounds
WO2005099363A2 (en) 2004-03-26 2005-10-27 Whitehead Institute For Biomedical Research Methods of diagnosing, preventing and treating cancer metastasis
CN1938311A (en) 2004-03-30 2007-03-28 因特蒙公司 Macrocyclic compounds as inhibitors of viral replication
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
PE20060664A1 (en) 2004-09-15 2006-08-04 Novartis Ag BICYCLE AMIDAS AS KINASE INHIBITORS
AU2005304784B2 (en) 2004-11-04 2011-03-24 Vertex Pharmaceuticals Incorporated Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
JO3088B1 (en) 2004-12-08 2017-03-15 Janssen Pharmaceutica Nv Macrocyclic Quinazoline derivatives and their use as MTKI
DE102005003687A1 (en) 2005-01-26 2006-07-27 Sphingo Tec Gmbh Immunodiagnostic determination of neurotensin in mammal blood, comprises injecting immune active N-terminal mammal proneurotensin in to the serum- or plasma- sample
MX2007009842A (en) 2005-02-16 2007-08-23 Astrazeneca Ab Chemical compounds.
CN101119996A (en) 2005-02-16 2008-02-06 阿斯利康(瑞典)有限公司 chemical compound
US7612067B2 (en) 2005-03-21 2009-11-03 Eli Lilly And Company Imidazopyridazine compounds
WO2006115452A1 (en) 2005-04-27 2006-11-02 Astrazeneca Ab Use of pyrazolyl-pyrimidine derivatives in the treatment of pain
JP2008540622A (en) 2005-05-16 2008-11-20 アストラゼネカ アクチボラグ Compound
CN100406650C (en) 2005-06-05 2008-07-30 徐斌 Modular comb type expansion joint installation of girder capable of resisting super displacement
ITRM20050290A1 (en) 2005-06-07 2006-12-08 Lay Line Genomics Spa USE OF MOLECULES ABLE TO INHIBIT THE BOND BETWEEN NGF AND ITS TRKA RECEPTOR AS AN EXTENDED EFFECT ANALGESICS.
US20070025540A1 (en) 2005-07-07 2007-02-01 Roger Travis Call center routing based on talkativeness
CN101263156A (en) 2005-07-25 2008-09-10 因特蒙公司 Novel macrocyclic inhibitors of hepatitis C virus replication
JP2009502734A (en) * 2005-07-29 2009-01-29 アステラス製薬株式会社 Fused heterocycles as Lck inhibitors
EP1909760A1 (en) 2005-08-03 2008-04-16 Eastman Chemical Company Tocopheryl polyethylene glycol succinate powder and process for preparing same
AU2006283592A1 (en) 2005-08-22 2007-03-01 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
WO2007025090A2 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Heterobicyclic and - tricyclic inhibitors of mapk/erk kinase
WO2007022999A1 (en) 2005-08-25 2007-03-01 Creabilis Therapeutics S.P.A. Polymer conjugates of k-252a and derivatives thereof
DE102005042742A1 (en) 2005-09-02 2007-03-08 Schering Ag Substituted imidazo [1,2b] pyridazines as kinase inhibitors, their production and use as pharmaceuticals
US20070078136A1 (en) 2005-09-22 2007-04-05 Bristol-Myers Squibb Company Fused heterocyclic compounds useful as kinase modulators
CN101316847A (en) 2005-10-06 2008-12-03 先灵公司 Pyrazolo(1, 5A) pyrimidines as protein kinase inhibitors
CN101360499B (en) 2005-10-06 2015-10-07 默沙东公司 The purposes of pyrazolo [1,5-A] pyrimidine derivatives in the kinase whose medicine of preparation Profilin
EP1948633B1 (en) 2005-10-11 2011-08-10 Centre National De La Recherche Scientifique (Cnrs) 3 -hydroxyflavone derivatives for the detection and the quantification of cell apoptosis
UA93990C2 (en) 2005-10-11 2011-03-25 Интермюн, Инк. Compounds and methods for inhibiting hepatitis c viral replication
US8372851B2 (en) 2005-10-21 2013-02-12 Exelixis, Inc. Pyrazolo pyrimidines as casein kinase II (CK2) modulators
GB0524436D0 (en) 2005-11-30 2006-01-11 Novartis Ag Organic compounds
EP1968579A1 (en) 2005-12-30 2008-09-17 Astex Therapeutics Limited Pharmaceutical compounds
US20080108611A1 (en) 2006-01-19 2008-05-08 Battista Kathleen A Substituted thienopyrimidine kinase inhibitors
WO2007102679A1 (en) 2006-03-06 2007-09-13 Je Il Pharmaceutical Co., Ltd. Novel thienopyrimidine derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same
EP2001880A2 (en) 2006-03-07 2008-12-17 Array Biopharma, Inc. Heterobicyclic pyrazole compounds and methods of use
GB0606805D0 (en) 2006-04-04 2006-05-17 Novartis Ag Organic compounds
CL2007001165A1 (en) 2006-04-26 2008-01-25 Hoffmann La Roche 2- (1h-indazol-4-yl) -6- (4-methanesulfonyl-piperazin-1-ylmethyl) -4-morpholin-4-yl-thieno [3,2-d] pyrimidine; preparation procedure; pharmaceutical composition; process of preparing said composition; pharmaceutical kit; and use to treat diseases such as cancer, immune disorders and cardiovascular diseases.
EP2036557B1 (en) 2006-05-18 2015-10-21 Eisai R&D Management Co., Ltd. Antitumor agent for thyroid cancer
US7389632B2 (en) 2006-06-10 2008-06-24 Uhlmann Pac-Systeme Gmbh & Co. Kg Apparatus for distributing small objects in a fill station
EP1873157A1 (en) 2006-06-21 2008-01-02 Bayer Schering Pharma Aktiengesellschaft Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
TWI419889B (en) 2006-07-05 2013-12-21 Mitsubishi Tanabe Pharma Corp A pyrazolo [1,5-a] pyrimidine compound
WO2008016131A1 (en) * 2006-08-04 2008-02-07 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US7531539B2 (en) 2006-08-09 2009-05-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP2063962A2 (en) 2006-09-07 2009-06-03 Biogen Idec MA Inc. Irak modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder
US20090286779A1 (en) 2006-09-29 2009-11-19 Novartis Ag Pyrazolopyrimidines as lipid kinase inhibitors
WO2008052734A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
CN101600718B (en) 2006-11-06 2013-07-03 特雷罗药物股份有限公司 Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
PE20081581A1 (en) 2006-12-21 2008-11-12 Plexxikon Inc PIRROLO [2,3-b] PYRIDINES COMPOUNDS AS KINASE MODULATORS
US20080234267A1 (en) 2007-03-20 2008-09-25 Karen Elizabeth Lackey Compounds and Methods of Treatment
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
CN101801972A (en) 2007-03-28 2010-08-11 英诺瓦西亚公司 Pyrazolo [1,5-A]pyrimidines as inhibitors of stearoyl-coA desaturase
ES2420113T3 (en) 2007-04-03 2013-08-22 Array Biopharma, Inc. Imidazo [1,2-a] pyridine compounds as receptor tyrosine kinase inhibitors
JP5160637B2 (en) 2007-05-04 2013-03-13 アイアールエム・リミテッド・ライアビリティ・カンパニー Compounds and compositions as c-kit and PDGFR kinase inhibitors
US8338422B2 (en) 2007-06-21 2012-12-25 Janssen Pharmaceutica Nv Indolin-2-ones and aza-indolin-2-ones
SG183049A1 (en) 2007-07-20 2012-08-30 Nerviano Medical Sciences Srl Substituted indazole derivatives active as kinase inhibitors
ME00977B (en) 2007-08-10 2012-06-20 Regeneron Pharma High affinity human antibodies to human nerve growth factor
CA2702838A1 (en) 2007-10-16 2009-04-23 Wyeth Llc Thienopyrimidine and pyrazolopyrimidine compounds and their use as mtor kinase and pi3 kinase inhibitors
AU2008316474A1 (en) 2007-10-23 2009-04-30 Novartis Ag Use of TrkB antibodies for the treatment of respiratory disorders
WO2009060197A1 (en) 2007-11-08 2009-05-14 Centro Nacional De Investigaciones Oncologicas (Cnio) Imidazopyridazines for use as protein kinase inhibitors
EP2235062A1 (en) 2008-01-17 2010-10-06 Irm Llc Improved anti-trkb antibodies
JP2009203226A (en) 2008-01-31 2009-09-10 Eisai R & D Management Co Ltd Receptor tyrosine kinase inhibitor containing pyridine derivative and pyrimidine derivative
EA019507B1 (en) * 2008-05-13 2014-04-30 Айрм Ллк Fused nitrogen containing heterocycles and compounds thereof as kinase inhibitors
US8158636B2 (en) 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN102036963B (en) 2008-05-23 2013-08-21 诺瓦提斯公司 Derivatives of quinolines and quinoxalines as protein tyrosine kinase inhibitors
WO2010012733A1 (en) 2008-07-29 2010-02-04 Nerviano Medical Sciences S.R.L. Use of a cdk inhibitor for the treatment of glioma
SI2350075T1 (en) * 2008-09-22 2014-06-30 Array Biopharma, Inc. Substituted imidazoš1,2bćpyridazine compounds as trk kinase inhibitors
EP2350071B1 (en) 2008-10-22 2014-01-08 Array Biopharma, Inc. SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS
WO2010051549A1 (en) 2008-10-31 2010-05-06 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
WO2010058006A1 (en) 2008-11-24 2010-05-27 Nerviano Medical Sciences S.R.L. Cdk inhibitor for the treatment of mesothelioma
JO3265B1 (en) 2008-12-09 2018-09-16 Novartis Ag Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease
CA2744236C (en) 2009-02-12 2021-03-16 Cell Signaling Technology, Inc. Mutant ros expression in human cancer
AR077468A1 (en) 2009-07-09 2011-08-31 Array Biopharma Inc PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS
WO2011101408A1 (en) 2010-02-18 2011-08-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for preventing cancer metastasis
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
TWI619713B (en) 2010-04-21 2018-04-01 普雷辛肯公司 Compounds and methods for kinase modulation, and indications therefor
US8543395B2 (en) 2010-05-18 2013-09-24 Shazam Entertainment Ltd. Methods and systems for performing synchronization of audio with corresponding textual transcriptions and determining confidence values of the synchronization
EP2571883B1 (en) 2010-05-20 2015-01-07 Array Biopharma, Inc. Macrocyclic compounds as trk kinase inhibitors
SI3333188T1 (en) 2010-08-19 2022-04-29 Zoetis Belgium S.A. Anti-ngf antibodies and their use
US8637516B2 (en) * 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012075340A2 (en) 2010-12-01 2012-06-07 Alderbio Holdings Llc Anti-ngf compositions and use thereof
MA34969B1 (en) 2011-02-25 2014-03-01 Irm Llc COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
PL2712358T3 (en) 2011-05-13 2017-05-31 Array Biopharma, Inc. Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
WO2013059740A1 (en) 2011-10-21 2013-04-25 Foundation Medicine, Inc. Novel alk and ntrk1 fusion molecules and uses thereof
SG11201402221XA (en) 2011-11-14 2014-06-27 Tesaro Inc Modulating certain tyrosine kinases
KR20140105508A (en) 2011-12-12 2014-09-01 닥터 레디스 레보러터리즈 리미티드 Substituted pyrazolo[1,5-a]pyridine as tropomyosin receptor kinase (trk) inhibitors
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
EP2842955B1 (en) 2012-04-26 2016-10-05 ONO Pharmaceutical Co., Ltd. Trk-inhibiting compound
NZ716487A (en) 2012-05-23 2017-01-27 Nerviano Medical Sciences Srl Process for the preparation of n-[5-(3,5-difluoro-benzyl)-1h-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide
TWI585088B (en) 2012-06-04 2017-06-01 第一三共股份有限公司 Imidazo[1,2-b]pyridazine analogues as kinase inhibitors
US20150218652A1 (en) 2012-08-31 2015-08-06 The Regents Of The Unversity Of Colorado, A Body Corporate Methods for diagnosis and treatment of cancer
WO2014039971A1 (en) 2012-09-07 2014-03-13 Exelixis, Inc. Inhibitors of met, vegfr and ret for use in the treatment of lung adenocarcinoma
US20140084039A1 (en) 2012-09-24 2014-03-27 Electro Scientific Industries, Inc. Method and apparatus for separating workpieces
JP2014082984A (en) 2012-10-23 2014-05-12 Astellas Pharma Inc Method for detecting novel ntrk2 activating mutation
US11230589B2 (en) 2012-11-05 2022-01-25 Foundation Medicine, Inc. Fusion molecules and uses thereof
WO2014071358A2 (en) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
US9790178B2 (en) 2012-11-13 2017-10-17 Array Biopharma Inc. Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
JP6345684B2 (en) 2012-11-13 2018-06-20 アレイ バイオファーマ、インコーポレイテッド Bicyclic urea, thiourea, guanidine, and cyanoguanidine compounds useful for the treatment of pain
WO2014078408A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078417A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
MY178262A (en) 2012-11-13 2020-10-07 Array Biopharma Inc Pyrrolidinyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
US9969694B2 (en) 2012-11-13 2018-05-15 Array Biopharma Inc. N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
WO2014078328A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-bicyclic aryl,n'-pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078325A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. N-(monocyclic aryl),n'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
WO2014078322A1 (en) 2012-11-13 2014-05-22 Array Biopharma Inc. Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors
AU2013350721A1 (en) 2012-11-29 2015-01-29 Yeda Research And Development Co. Ltd. Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
US9447135B2 (en) 2012-12-14 2016-09-20 University Of Kentucky Research Foundation Semi-synthetic mithramycin derivatives with anti-cancer activity
US9127055B2 (en) 2013-02-08 2015-09-08 Astellas Pharma Inc. Method of treating pain with anti-human NGF antibody
ES2710556T3 (en) 2013-02-19 2019-04-25 Ono Pharmaceutical Co Trk inhibitor compound
EP2981613A4 (en) 2013-02-22 2016-11-02 Boris C Bastian Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets
US20140243332A1 (en) 2013-02-27 2014-08-28 Oregon Health & Science University Methods of treating cancers characterized by aberrent ros1 activity
EP3421613B1 (en) 2013-03-15 2020-08-19 The Board of Trustees of the Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
JP2016515508A (en) 2013-03-15 2016-05-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Fusion protein and method thereof
WO2014152777A2 (en) 2013-03-15 2014-09-25 Insight Genetics, Inc. Methods and compositions for the diagnosis and treatment of cancers resistant to ros1 inhibitors
US8937071B2 (en) 2013-03-15 2015-01-20 Glaxosmithkline Intellectual Property Development Limited Compounds as rearranged during transfection (RET) inhibitors
AU2014254394B2 (en) 2013-04-17 2020-06-18 Life Technologies Corporation Gene fusions and gene variants associated with cancer
US10072298B2 (en) 2013-04-17 2018-09-11 Life Technologies Corporation Gene fusions and gene variants associated with cancer
RU2656591C2 (en) 2013-07-11 2018-06-06 Бетта Фармасьютикалз Ко., Лтд Protein tyrosine kinase modulators and methods of use
US10705087B2 (en) 2013-07-26 2020-07-07 Japanese Foundation For Cancer Research Detection method for NTRK3 fusion
WO2015017533A1 (en) 2013-07-30 2015-02-05 Blueprint Medicines Corporation Ntrk2 fusions
EP3060207A4 (en) 2013-10-24 2017-04-12 Georgetown University Methods and compositions for treating cancer
JPWO2015064621A1 (en) 2013-10-29 2017-03-09 公益財団法人がん研究会 Novel fusion and detection method thereof
CN106170289B (en) 2014-01-24 2019-07-23 特普医药公司 The huge ring of the diaryl of regulator as protein kinase
WO2015120136A1 (en) 2014-02-05 2015-08-13 VM Oncology LLC Compositions of compounds and uses thereof
TWI672141B (en) 2014-02-20 2019-09-21 美商醫科泰生技 Molecules for administration to ros1 mutant cancer cells
RU2719489C2 (en) 2014-05-15 2020-04-17 Эррэй Биофарма Инк. 1-((3s,4r)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1n-pyrazol-5-yl)urea as a trka kinase inhibitor
WO2015183837A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
US20170114415A1 (en) 2014-05-30 2017-04-27 The Regents Of The University Of Colorado, A Body Corporate Activating ntrk1 gene fusions predictive of kinase inhibitor therapy
SG11201700774UA (en) 2014-08-01 2017-02-27 Pharmacyclics Llc Biomarkers for predicting response of dlbcl to treatment with a btk inhibitor
CA2958423A1 (en) 2014-08-18 2016-02-25 Ono Pharmaceutical Co., Ltd. Acid-addition salt of trk-inhibiting compound
ES2952717T3 (en) 2014-10-14 2023-11-03 Novartis Ag Antibody molecules against PD-L1 and uses thereof
RS64122B1 (en) 2014-11-16 2023-05-31 Array Biopharma Inc Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate
RU2708674C2 (en) 2014-12-15 2019-12-11 СиЭмДжи ФАРМАСЬЮТИКАЛ КО., ЛТД. Condensed ring heteroaryl compounds and use thereof as trk inhibitors
US10835585B2 (en) 2015-05-20 2020-11-17 The Broad Institute, Inc. Shared neoantigens
WO2016196141A1 (en) 2015-05-29 2016-12-08 Ignyta, Inc. Compositions and methods for treating patients with rtk mutant cells
MX2017015461A (en) 2015-06-01 2018-08-15 Loxo Oncology Inc Methods of diagnosing and treating cancer.
AU2015101722A4 (en) 2015-06-19 2016-05-19 Macau University Of Science And Technology Oncogenic ros1 and alk kinase inhibitor
US9782400B2 (en) 2015-06-19 2017-10-10 Macau University Of Science And Technology Oncogenic ROS1 and ALK kinase inhibitor
GB201511546D0 (en) 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
JP6871903B2 (en) 2015-07-02 2021-05-19 ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Chiral diallyl macrocyclic molecule as a modulator of protein kinase
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
WO2017127835A2 (en) 2016-01-22 2017-07-27 The Medicines Company Aqueous formulations and methods of preparation and use thereof
TW201733580A (en) 2016-03-11 2017-10-01 小野藥品工業股份有限公司 Treating agent for cancer having TrK inhibitor resistance
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
KR102400423B1 (en) 2016-04-04 2022-05-19 록쏘 온콜로지, 인코포레이티드 (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidine-3- Liquid formulation of yl)-3-hydroxypyrrolidine-1-carboxamide
EP3445361A1 (en) 2016-04-19 2019-02-27 Exelixis, Inc. Triple negative breast cancer treatment method
LT3458456T (en) 2016-05-18 2021-02-25 Loxo Oncology, Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
WO2017201156A1 (en) 2016-05-18 2017-11-23 Duke University Method of treating kras wild-type metastatic colorectal cell carcinoma using cabozantinib plus panitumumab
JOP20190092A1 (en) 2016-10-26 2019-04-25 Array Biopharma Inc PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
WO2019084285A1 (en) 2017-10-26 2019-05-02 Qian Zhao Formulations of a macrocyclic trk kinase inhibitor

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