[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

RS20050045A - Microbiological method for the production of 7alpha- substituted 11 alpha-hydroxysteroids - Google Patents

Microbiological method for the production of 7alpha- substituted 11 alpha-hydroxysteroids

Info

Publication number
RS20050045A
RS20050045A YUP-2005/0045A YUP4505A RS20050045A RS 20050045 A RS20050045 A RS 20050045A YU P4505 A YUP4505 A YU P4505A RS 20050045 A RS20050045 A RS 20050045A
Authority
RS
Serbia
Prior art keywords
production
hydroxysteroids
7alpha
alpha
substituted
Prior art date
Application number
YUP-2005/0045A
Other languages
Serbian (sr)
Inventor
Ludwig Zorn
Rolf Bohlmann
Norbert Gallus
Hermann Kunzer
Hans Peter Muhn
Reinhard Nubbemeyer
Original Assignee
Schering Aktiengesellschaft,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10233723A external-priority patent/DE10233723A1/en
Application filed by Schering Aktiengesellschaft, filed Critical Schering Aktiengesellschaft,
Publication of RS20050045A publication Critical patent/RS20050045A/en
Publication of RS51855B publication Critical patent/RS51855B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/12—Acting on D ring
    • C12P33/16—Acting at 17 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed is a new synthetic pathway for the production of precursors for the production of compounds having general formula (8,10,12). During said synthesis, compounds of general formal (4,B) are produced in a microbiological reaction. The meanings of radicals R7, R10, R11, R13, R17 and R17' and group U-V-W-X-Y-Z are defined in the patent claims.
YU20050045A 2002-07-24 2003-07-24 Microbiological method for the production of 7alpha- substituted 11 alpha-hydroxysteroids RS51855B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10233723A DE10233723A1 (en) 2002-07-24 2002-07-24 Preparation of 7 alpha-substituted 11 alpha-hydroxy-steroids, useful as precursors for new androgenic 7 alpha,17 alpha-substituted 11 beta-halo-steroids, by microbiological conversion of 7 alpha-substituted steroids
US40295302P 2002-08-14 2002-08-14
PCT/EP2003/008111 WO2004011663A2 (en) 2002-07-24 2003-07-24 Microbiological method for the production of 7 alpha-substituted 11 alpha-hydroxysteroids

Publications (2)

Publication Number Publication Date
RS20050045A true RS20050045A (en) 2007-06-04
RS51855B RS51855B (en) 2012-02-29

Family

ID=31189296

Family Applications (1)

Application Number Title Priority Date Filing Date
YU20050045A RS51855B (en) 2002-07-24 2003-07-24 Microbiological method for the production of 7alpha- substituted 11 alpha-hydroxysteroids

Country Status (20)

Country Link
EP (1) EP1523568A2 (en)
JP (1) JP4417838B2 (en)
KR (1) KR101041328B1 (en)
CN (1) CN100339486C (en)
BR (1) BR0313210A (en)
CA (1) CA2492079C (en)
CO (1) CO5690563A2 (en)
CR (1) CR7672A (en)
EA (2) EA010572B1 (en)
EC (1) ECSP055630A (en)
HK (1) HK1081999A1 (en)
HR (1) HRP20050172A2 (en)
IL (1) IL166358A0 (en)
MX (1) MXPA05001024A (en)
NO (1) NO20050980L (en)
NZ (2) NZ537871A (en)
PH (1) PH12005500143B1 (en)
PL (1) PL373808A1 (en)
RS (1) RS51855B (en)
WO (1) WO2004011663A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100982540B1 (en) * 2005-10-27 2010-09-16 다이호야쿠힌고교 가부시키가이샤 Process for production of steroid compound
CN103834712B (en) * 2012-11-26 2016-03-30 复旦大学 The optimization method of desogestrel intermediate nanometer liposome bio-transformation
CN103214543B (en) * 2012-12-25 2015-09-02 中国人民解放军海军医学研究所 New Crategolic acid derivative, its preparation method and the application in antitumor drug thereof
CN104862323B (en) * 2015-06-02 2018-01-16 中国农业科学院生物技术研究所 Modify the '-hydroxylase gene of diphenol compounds
PL442098A1 (en) * 2022-08-26 2024-03-04 Uniwersytet Przyrodniczy we Wrocławiu Method of producing 11α-hydroxy-19-nortestosterone

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL75841C (en) 1949-06-11
US2658023A (en) * 1953-04-21 1953-11-03 Pfizer & Co C Oxygenation of steroids
US2985563A (en) * 1958-11-13 1961-05-23 Schering Corp 11alpha-hydroxylation of steroids by glomerella
US3004047A (en) * 1959-03-13 1961-10-10 Olin Mathieson 6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en) * 1961-06-05 1967-09-12 Upjohn Co 7-methyltestosterones
US3203869A (en) * 1962-10-11 1965-08-31 Syntex Corp 11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en) 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
EP1167380A3 (en) * 1995-12-11 2004-12-08 G.D. Searle & Co. 11.alpha.-hydroxy-steroid-4,6-dien-3-one compounds and a process for their preparation
GB9525194D0 (en) 1995-12-12 1996-02-07 Zeneca Ltd Pharmaceutical composition
JP2000501940A (en) * 1995-12-12 2000-02-22 アクゾ・ノベル・エヌ・ベー 11α-Hydroxylation of steroids by microorganisms
US6767902B2 (en) 1997-09-17 2004-07-27 The Population Council, Inc. Androgen as a male contraceptive and non-contraceptive androgen replacement
US20020012694A1 (en) * 1997-09-17 2002-01-31 Alfred J. Moo-Young Transdermal administration of ment
US5952319A (en) 1997-11-26 1999-09-14 Research Triangle Institute Androgenic steroid compounds and a method of making and using the same
IL151219A0 (en) 2000-02-15 2003-04-10 Schering Ag Male contraceptive formulation comprising norethisterone
DE10104327A1 (en) * 2001-01-24 2002-07-25 Schering Ag New 11beta-halo-testosterone derivatives useful in male hormone replacement therapy and in male fertility control
KR20050025985A (en) * 2002-07-25 2005-03-14 쉐링 악티엔게젤샤프트 Composition Containing an Androgenous 11β-Halogen Steroid and a Progestational Hormone, and Male Contraceptive Based on Said Composition

Also Published As

Publication number Publication date
AU2003281677A1 (en) 2004-02-16
CA2492079A1 (en) 2004-02-05
NO20050980L (en) 2005-02-23
CA2492079C (en) 2012-01-10
IL166358A0 (en) 2006-01-16
EA008147B1 (en) 2007-04-27
MX260952B (en) 2008-10-01
WO2004011663A9 (en) 2004-05-06
EA010572B1 (en) 2008-10-30
NZ549529A (en) 2008-04-30
ECSP055630A (en) 2005-04-18
MXPA05001024A (en) 2005-05-16
EA200500224A1 (en) 2005-08-25
CO5690563A2 (en) 2006-10-31
HK1081999A1 (en) 2006-05-26
BR0313210A (en) 2005-06-28
WO2004011663A2 (en) 2004-02-05
EA200601030A1 (en) 2006-10-27
JP4417838B2 (en) 2010-02-17
WO2004011663A3 (en) 2004-07-15
NZ537871A (en) 2006-10-27
PL373808A1 (en) 2005-09-19
CR7672A (en) 2006-05-29
KR101041328B1 (en) 2011-06-14
HRP20050172A2 (en) 2005-04-30
JP2006503813A (en) 2006-02-02
EP1523568A2 (en) 2005-04-20
KR20050026507A (en) 2005-03-15
PH12005500143B1 (en) 2011-03-25
CN100339486C (en) 2007-09-26
RS51855B (en) 2012-02-29
CN1671858A (en) 2005-09-21

Similar Documents

Publication Publication Date Title
HK1089444A1 (en) Dihydropteridinones, method for the production and use thereof in the form of drugs
MXPA04002067A (en) Novel dihydropteridinones, method for producing the same and the use thereof as medicaments.
MXPA02011458A (en) Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament.
CA2346796A1 (en) Benzoylcyclohexanediones, process for their preparation and their use as herbicides and plant growth regulators
TW200500339A (en) Pyrrolidine derivatives, and process for the preparation
TW200505879A (en) Process for the preparation of valsartan
MX9800412A (en) Process for producing n-substituted 3-hydroxypyrazoles.
IL172015A (en) Pyrimidine compounds having phosphonate groups, method for their preparation and their use in the manufacture of medicaments for treating viral infection
RS20050045A (en) Microbiological method for the production of 7alpha- substituted 11 alpha-hydroxysteroids
MXPA03001356A (en) Novel beta-amyloid inhibitors, method for producing the same and the use thereof as medicaments.
MY138550A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MY136938A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
NO20062149L (en) Bengamide derivatives, methods of preparation and use thereof for the treatment of cancer
RS20110079A (en) Microbiological procedure for obtaining 7alpha-substituted 11alpha-hydroxysteroids
GB0113232D0 (en) Chemical process
MXPA05008440A (en) Method for the production of bicyclic aromatic amino acids and intermediate products thereof.
MY135359A (en) New process for the synthesis of perindopril and pharmaceutically acceptable salts thereof
MY139348A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
MXPA02001406A (en) Substituted heterocyclyl-2h-chromenes.
MY136288A (en) New process for the synthesis of perindopril and its pharmaceutically acceptable salts
IL177388A0 (en) Method for preparing pyrrolidine oximes
RS20050018A (en) Acyloxypyrrolidine derivatives and use thereof as ligands of v1b or both v1b and v1a receptors
AU2926199A (en) Method for the production of polymers from n-vinyl compounds
MXPA05013649A (en) Nematicidal thiazoline-containing fluorobutenes.
MY139289A (en) Process for the synthesis of perindopril and pharmaceutically acceptable salts thereof