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RS101304A - Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi - Google Patents

Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi

Info

Publication number
RS101304A
RS101304A YU101304A YUP101304A RS101304A RS 101304 A RS101304 A RS 101304A YU 101304 A YU101304 A YU 101304A YU P101304 A YUP101304 A YU P101304A RS 101304 A RS101304 A RS 101304A
Authority
RS
Serbia
Prior art keywords
alkenyl
piperadine
azaindole
indole
amides
Prior art date
Application number
YU101304A
Other languages
English (en)
Inventor
Tao Wang
John Kadow
Nicholas Meanwell
Kap-Sun Yeung
Zhongxing Zhang
Zhiwei Yin
Zhilei Qiu
Daniel Deon
Clint James
Edward Ruediger
Carol Bachand
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32312411&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS101304(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of RS101304A publication Critical patent/RS101304A/sr
Publication of RS53021B publication Critical patent/RS53021B/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ovaj pronalazak daje jedinjenja koja imaju lekovita i bioafektujuća svojstva, njihove farmaceutske smeše i metod korišćenja. Preciznije, ovaj pronalazak se bavi novim piperidinskim 4-alkenil derivatima koji poseduju jedinstvenu antivirusnu aktivnost. Još preciznije, predmetni pronalazak se odnosi na jedinjenja korisna za lečenje HIV-a i AIDS-a. Jedinjenja pronalaska su opšte Formule I: (I) gde: Z je; Q je odabrano iz grupe koja sadrži: ; -W- je.
YU101304A 2002-05-28 2003-04-30 Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi RS53021B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38350902P 2002-05-28 2002-05-28
PCT/US2003/013324 WO2004043337A2 (en) 2002-05-28 2003-04-30 Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

Publications (2)

Publication Number Publication Date
RS101304A true RS101304A (sr) 2006-10-27
RS53021B RS53021B (sr) 2014-04-30

Family

ID=32312411

Family Applications (1)

Application Number Title Priority Date Filing Date
YU101304A RS53021B (sr) 2002-05-28 2003-04-30 Indolni, azaindolni i srodni heterociklični 4-alkenil piperidinski amidi

Country Status (31)

Country Link
US (1) US20040063744A1 (sr)
EP (1) EP1513832B1 (sr)
JP (1) JP4446889B2 (sr)
KR (1) KR101001811B1 (sr)
CN (1) CN100528866C (sr)
AR (1) AR040230A1 (sr)
AU (1) AU2003301958B2 (sr)
BR (2) BRPI0311541B1 (sr)
CA (1) CA2487542C (sr)
CL (1) CL2003001087A1 (sr)
CO (1) CO5631440A2 (sr)
DK (1) DK1513832T3 (sr)
ES (1) ES2460728T3 (sr)
GE (1) GEP20074152B (sr)
HR (1) HRP20041137B1 (sr)
IL (1) IL165200A (sr)
IS (1) IS2945B (sr)
MX (1) MXPA04011670A (sr)
MY (1) MY139058A (sr)
NO (1) NO329691B1 (sr)
NZ (1) NZ536661A (sr)
PE (1) PE20040526A1 (sr)
PL (1) PL216388B1 (sr)
PT (1) PT1513832E (sr)
RS (1) RS53021B (sr)
RU (1) RU2323934C2 (sr)
SI (1) SI1513832T1 (sr)
TW (1) TWI310381B (sr)
UA (1) UA79470C2 (sr)
WO (1) WO2004043337A2 (sr)
ZA (1) ZA200409504B (sr)

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US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
US20040110785A1 (en) * 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US20050075364A1 (en) * 2003-07-01 2005-04-07 Kap-Sun Yeung Indole, azaindole and related heterocyclic N-substituted piperazine derivatives
US20050124623A1 (en) 2003-11-26 2005-06-09 Bender John A. Diazaindole-dicarbonyl-piperazinyl antiviral agents
US7087610B2 (en) * 2004-06-03 2006-08-08 Bristol-Myers Squibb Company Benzothiazole antiviral agents
WO2005121140A1 (en) 2004-06-09 2005-12-22 Glaxo Group Limited Pyrrolopyridine derivatives
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US7601715B2 (en) * 2005-06-22 2009-10-13 Bristol-Myers Squibb Company Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein
AR055601A1 (es) * 2005-08-09 2007-08-29 Glaxo Group Ltd Compuestos derivados de imidazopiridina como ligandos de receptores canabinoides
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
US7572810B2 (en) * 2006-06-08 2009-08-11 Bristol-Myers Squibb Company Alkene piperidine derivatives as antiviral agents
US7504399B2 (en) * 2006-06-08 2009-03-17 Bristol-Meyers Squibb Company Piperazine enamines as antiviral agents
BRPI0812163A2 (pt) * 2007-05-25 2014-12-16 Abbott Gmbh & Co Kg Compostos heterocíclicos como moduladores positivos do receptor metabotrópico de glutamato 2 (receptor mglu2)
WO2009011912A1 (en) * 2007-07-18 2009-01-22 Bristol-Myers Squibb Company A composition for treating hiv comprising virus-like particles
US8242124B2 (en) * 2008-06-25 2012-08-14 Bristol-Myers Squibb Company Diketopiperidine derivatives as HIV attachment inhibitors
US7960406B2 (en) 2008-06-25 2011-06-14 Bristol-Myers Squibb Company Diketo substituted pyrrolo[2,3-c] pyridines
EP2323633B1 (en) * 2008-09-04 2012-03-21 Bristol-Myers Squibb Company Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor
AU2010218152B2 (en) * 2009-02-27 2015-04-09 Siga Technologies, Inc. Thienopyridine derivatives for the treatment and prevention of Dengue virus infections
EP2414332B1 (en) 2009-04-02 2013-10-23 Shionogi&Co., Ltd. Acrylamide compounds and the use thereof
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
US8450361B2 (en) * 2010-08-06 2013-05-28 Bristol-Myers Squibb Company Substituted indole and azaindole oxoacetyl piperazinamide derivatives
EP2646439B1 (en) 2010-12-02 2016-05-25 Bristol-Myers Squibb Company Alkyl amides as hiv attachment inhibitors
ES2636312T3 (es) 2011-04-12 2017-10-05 VIIV Healthcare UK (No.5) Limited Derivados de tioamida, amidoxima y amidrazona como inhibidores de la fijación del VIH
US8664213B2 (en) 2011-08-29 2014-03-04 Bristol-Myers Squibb Company Spiro bicyclic diamine derivatives as HIV attachment inhibitors
ES2616268T3 (es) 2011-08-29 2017-06-12 VIIV Healthcare UK (No.5) Limited Derivados condensados de diamina bicíclica como inhibidores de la unión de VIH
MX352320B (es) * 2012-02-08 2017-11-21 Viiv Healthcare Uk No 4 Ltd Metodos para la preparacion del compuesto profarmaco de piperazina inhibidor de la union de virus de inmunodeficiencia humana.
US9193725B2 (en) 2012-03-14 2015-11-24 Bristol-Meyers Squibb Company Cyclic hydrazine derivatives as HIV attachment inhibitors
EP2895472B1 (en) * 2012-08-09 2016-11-23 VIIV Healthcare UK (No.5) Limited Tricyclic alkene derivatives as HIV attachment inhibitors
US9505752B2 (en) * 2012-08-09 2016-11-29 Viiv Healthcare Uk (No. 5) Limited Piperidine amide derivatives as HIV attachment inhibitors
WO2017112576A1 (en) * 2015-12-21 2017-06-29 Dow Global Technologies Llc Methods for external base-free suzuki couplings
CN108059611A (zh) * 2018-01-22 2018-05-22 济南舜景医药科技有限公司 一种用于治疗心率不齐药物中间体的合成方法
CN109053575A (zh) * 2018-08-24 2018-12-21 遵义医学院 3-环丙基-1-甲基-1h-吡唑-4-甲醛的制备工艺

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US5023265A (en) * 1990-06-01 1991-06-11 Schering Corporation Substituted 1-H-pyrrolopyridine-3-carboxamides
US5124327A (en) * 1991-09-06 1992-06-23 Merck & Co., Inc. HIV reverse transcriptase
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US6476034B2 (en) * 2000-02-22 2002-11-05 Bristol-Myers Squibb Company Antiviral azaindole derivatives
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US6573262B2 (en) * 2000-07-10 2003-06-03 Bristol-Myers Sqibb Company Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives

Also Published As

Publication number Publication date
NO20045064L (no) 2005-02-23
PL216388B1 (pl) 2014-03-31
CL2003001087A1 (es) 2005-02-11
MY139058A (en) 2009-08-28
WO2004043337A2 (en) 2004-05-27
CN100528866C (zh) 2009-08-19
ES2460728T3 (es) 2014-05-14
JP2006507326A (ja) 2006-03-02
SI1513832T1 (sl) 2014-04-30
IS2945B (is) 2016-05-15
RS53021B (sr) 2014-04-30
AR040230A1 (es) 2005-03-23
UA79470C2 (en) 2007-06-25
PT1513832E (pt) 2014-05-22
EP1513832B1 (en) 2014-03-05
BR0311541A (pt) 2006-06-06
DK1513832T3 (da) 2014-05-26
KR20050013558A (ko) 2005-02-04
TWI310381B (en) 2009-06-01
PL373603A1 (en) 2005-09-05
RU2004138565A (ru) 2005-07-20
KR101001811B1 (ko) 2010-12-15
ZA200409504B (en) 2006-05-31
BRPI0311541B1 (pt) 2018-04-24
HRP20041137A2 (en) 2005-06-30
IL165200A (en) 2011-01-31
IL165200A0 (en) 2005-12-18
NO329691B1 (no) 2010-11-29
WO2004043337A3 (en) 2004-11-11
CN1671697A (zh) 2005-09-21
CA2487542C (en) 2011-09-27
JP4446889B2 (ja) 2010-04-07
NZ536661A (en) 2007-12-21
AU2003301958B2 (en) 2009-10-01
EP1513832A2 (en) 2005-03-16
IS7546A (is) 2004-11-22
CO5631440A2 (es) 2006-04-28
MXPA04011670A (es) 2005-03-07
HRP20041137B1 (hr) 2014-11-21
US20040063744A1 (en) 2004-04-01
EP1513832A4 (en) 2010-03-10
AU2003301958A1 (en) 2004-06-03
PE20040526A1 (es) 2004-08-28
RU2323934C2 (ru) 2008-05-10
CA2487542A1 (en) 2004-05-27
GEP20074152B (en) 2007-07-10
TW200406397A (en) 2004-05-01

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