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RO84456B - Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita - Google Patents

Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita

Info

Publication number
RO84456B
RO84456B RO108573A RO10857382A RO84456B RO 84456 B RO84456 B RO 84456B RO 108573 A RO108573 A RO 108573A RO 10857382 A RO10857382 A RO 10857382A RO 84456 B RO84456 B RO 84456B
Authority
RO
Romania
Prior art keywords
carbon atoms
furopyridinium
thieno
group
cephalosporin derivatives
Prior art date
Application number
RO108573A
Other languages
English (en)
Other versions
RO84456A (ro
Inventor
William Henry Walker Lunn
Robert Theodore Vasileff
Original Assignee
Eli Lilly And Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co filed Critical Eli Lilly And Co
Publication of RO84456A publication Critical patent/RO84456A/ro
Publication of RO84456B publication Critical patent/RO84456B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita cu formula generala I: (vezi formula) în care R reprezinta o grupa alchil cu 1...4 atomi de carbon sau o grupa carboxialchil cu 1...4 atomi de carbon si R1 reprezinta o grupa biciclopiridiniu, aleasa dintre tienopiridiniu [2,3 -b], [3,2 - b], [2,3 -c], [3,2 -c] si furipiridiniu [2,3 -b], [3,2 -b], [2,3 -c], [3,2 -c] eventual substituita cu unul sau doi substituenti, alesi dintre alchil cu 1...4 atomi de carbon, halogen, carboxi, alcoxi cu 1...4 atomi de carbon, constînd din aceea ca un compus cu formula generala II: (vezi formula) în care R are semnificatia de mai sus, grupa carboxil este protejata sub forma de ester si L este un atom de halogen, se trateaza cu un tieno sau furoderivat de piridina, cu structura corespunzatoare radicalului R1, într-un amestec de acetonitril si tetrahidrofuran ca solvent, la temperatura camerei, dupa care se îndeparteaza grupele de protectie.
RO108573A 1981-09-08 1982-09-06 Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita RO84456B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30035781A 1981-09-08 1981-09-08
US34062882A 1982-01-19 1982-01-19

Publications (2)

Publication Number Publication Date
RO84456A RO84456A (ro) 1984-06-21
RO84456B true RO84456B (ro) 1984-08-30

Family

ID=26971737

Family Applications (1)

Application Number Title Priority Date Filing Date
RO108573A RO84456B (ro) 1981-09-08 1982-09-06 Procedeu pentru prepararea unor derivati de cefalosporina tieno si furopiridiniu substituita

Country Status (17)

Country Link
EP (1) EP0074268A3 (ro)
KR (1) KR840001585A (ro)
CS (1) CS232735B2 (ro)
DD (1) DD209633A5 (ro)
DK (1) DK399282A (ro)
ES (2) ES8404361A1 (ro)
FI (1) FI823088L (ro)
GB (1) GB2105719A (ro)
GR (1) GR76701B (ro)
HU (1) HU187575B (ro)
IL (1) IL66726A0 (ro)
NZ (1) NZ201833A (ro)
PH (1) PH19756A (ro)
PL (1) PL238158A1 (ro)
PT (1) PT75518B (ro)
RO (1) RO84456B (ro)
SU (1) SU1169542A3 (ro)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE30724T1 (de) * 1982-06-28 1987-11-15 Bristol Myers Co Cephalosporinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten.
US4480098A (en) * 1982-11-12 1984-10-30 Eli Lilly And Company Preparation of alkali metal thieno(furo)pyridines
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
EP0137442A3 (de) * 1983-10-08 1986-01-15 Hoechst Aktiengesellschaft Cephalosporinderivate und Verfahren zu ihrer Herstellung
GB2148289B (en) * 1983-10-17 1987-09-23 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
EP0187456A1 (en) * 1984-11-29 1986-07-16 Ici Pharma Cephalosporin derivatives
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
US4918067A (en) * 1986-07-24 1990-04-17 Beecham Group P.L.C. Heterocyclic substituted penicillin antibiotics
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
MXPA02007719A (es) * 2000-02-10 2002-10-11 Upjohn Co Tioamidas de oxazolidinona con sustituyentes de piperazina y amida.
DE602004028111D1 (de) 2003-04-16 2010-08-26 Sandoz Ag Verfahren zur herstellung von cefepim
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2440738A1 (fr) * 1978-11-13 1980-06-06 Parcor Medicament a base de derives des thieno (2,3-c) et (3,2-c) pyridines
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"

Also Published As

Publication number Publication date
GR76701B (ro) 1984-08-29
ES527763A0 (es) 1985-05-16
EP0074268A3 (en) 1984-05-23
PH19756A (en) 1986-06-26
ES515548A0 (es) 1984-04-16
RO84456A (ro) 1984-06-21
HU187575B (en) 1986-01-28
CS650582A2 (en) 1984-06-18
PL238158A1 (en) 1984-11-19
ES8404361A1 (es) 1984-04-16
CS232735B2 (en) 1985-02-14
SU1169542A3 (ru) 1985-07-23
ES8505374A1 (es) 1985-05-16
FI823088A0 (fi) 1982-09-07
EP0074268A2 (en) 1983-03-16
DK399282A (da) 1983-03-09
NZ201833A (en) 1985-09-13
IL66726A0 (en) 1982-12-31
FI823088L (fi) 1983-03-09
PT75518A (en) 1982-10-01
DD209633A5 (de) 1984-05-16
GB2105719A (en) 1983-03-30
KR840001585A (ko) 1984-05-07
PT75518B (en) 1985-11-12

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