RO82739B - Procedeu pentru prepararea unor derivati de fluoerena - Google Patents
Procedeu pentru prepararea unor derivati de fluoerenaInfo
- Publication number
- RO82739B RO82739B RO104045A RO10404581A RO82739B RO 82739 B RO82739 B RO 82739B RO 104045 A RO104045 A RO 104045A RO 10404581 A RO10404581 A RO 10404581A RO 82739 B RO82739 B RO 82739B
- Authority
- RO
- Romania
- Prior art keywords
- derivatives
- fluoerene
- preparing
- carbamoylfluorene
- permeation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
- C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Inventia se refera la un procedeu pentru perpararea unor derivati de fluorena cu formula generala I: (vezi formula) în care R1 si R2 reprezinta un atom de hidrogen sau un radical alchil C1....C6 prin reactia dintre 9-carbamoilfluorena si acrilonitril în prezenta unei baze, de preferinta hidroxid de benziltrimetilamoniu, în medi de solvent organic ales dintre dioxan si tetrahidrofuran la temperaturi cuprinse între 0 si 100 degree C de preferinta între 35 si 75 degree C.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/141,229 US4282170A (en) | 1980-04-17 | 1980-04-17 | 9-Carbamoyl-9-(2-cyanoethyl)fluorenes |
Publications (2)
Publication Number | Publication Date |
---|---|
RO82739A RO82739A (ro) | 1984-01-14 |
RO82739B true RO82739B (ro) | 1984-01-30 |
Family
ID=22494758
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO104045A RO82739B (ro) | 1980-04-17 | 1981-04-16 | Procedeu pentru prepararea unor derivati de fluoerena |
Country Status (26)
Country | Link |
---|---|
US (1) | US4282170A (ro) |
EP (1) | EP0038676B1 (ro) |
JP (2) | JPS574954A (ro) |
KR (1) | KR840001071B1 (ro) |
AR (1) | AR228596A1 (ro) |
AT (1) | ATE9897T1 (ro) |
AU (1) | AU543345B2 (ro) |
BG (1) | BG35464A3 (ro) |
CA (1) | CA1172646A (ro) |
CS (1) | CS225833B2 (ro) |
DD (1) | DD158395A5 (ro) |
DE (1) | DE3166679D1 (ro) |
DK (1) | DK172181A (ro) |
ES (1) | ES8302632A1 (ro) |
FI (1) | FI75337C (ro) |
GB (1) | GB2074161B (ro) |
GR (1) | GR73824B (ro) |
IE (1) | IE51221B1 (ro) |
IL (1) | IL62669A (ro) |
NZ (1) | NZ196814A (ro) |
PH (1) | PH15857A (ro) |
PL (1) | PL131122B1 (ro) |
PT (1) | PT72854B (ro) |
RO (1) | RO82739B (ro) |
SU (1) | SU1297724A3 (ro) |
ZA (1) | ZA812482B (ro) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4552982A (en) * | 1983-08-01 | 1985-11-12 | Eli Lilly And Company | Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes |
US4508735A (en) * | 1983-09-21 | 1985-04-02 | Eli Lilly And Company | Anti-arrhythmic N-alkanoylaminoalkyl fluorenes |
FI844067L (fi) * | 1983-10-19 | 1985-04-20 | Lilly Co Eli | Foerfarande foer framstaellning av 9-karbamoylfluorenderivat. |
US4486592A (en) * | 1983-10-19 | 1984-12-04 | Eli Lilly And Company | 9-Carbamoylfluorene derivatives |
US4585894A (en) * | 1983-10-19 | 1986-04-29 | Eli Lilly And Company | Process for producing 9-carbamoyl fluorene derivatives |
US4842420A (en) * | 1987-12-14 | 1989-06-27 | Mobil Oil Corporation | Variable-width draw tape for thermoplastic bags |
US5736578A (en) * | 1995-06-06 | 1998-04-07 | Bristol-Myers Squibb Company | Ethylamido fluorenes and improved method of making same |
NZ330216A (en) * | 1996-01-16 | 2000-09-29 | Bristol Myers Squibb Co | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and use in treatment of atherosclerosis |
US5760246A (en) | 1996-12-17 | 1998-06-02 | Biller; Scott A. | Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method |
CN100463249C (zh) * | 2006-01-24 | 2009-02-18 | 吉林大学 | 电化学沉积制备有机发光薄膜的方法及在发光器件中的应用 |
US7520124B2 (en) * | 2006-09-12 | 2009-04-21 | United Technologies Corporation | Asymmetric serrated nozzle for exhaust noise reduction |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2280058A (en) * | 1942-04-21 | Cyanoethylation of carbocycijc | ||
GB960758A (en) | 1962-12-21 | 1964-06-17 | Boehringer & Soehne Gmbh | Basic fluorene derivatives |
US3325544A (en) * | 1965-06-10 | 1967-06-13 | Upjohn Co | 9-(2-amino-1-methylethyl) fluoren-9-ol and salts thereof |
US3660485A (en) * | 1970-10-05 | 1972-05-02 | Searle & Co | Fluorene-9-carboxylic acid hydrazides |
US3843657A (en) * | 1972-12-08 | 1974-10-22 | Searle & Co | 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides |
-
1980
- 1980-04-17 US US06/141,229 patent/US4282170A/en not_active Expired - Lifetime
-
1981
- 1981-04-14 ES ES501339A patent/ES8302632A1/es not_active Expired
- 1981-04-14 NZ NZ196814A patent/NZ196814A/en unknown
- 1981-04-14 AR AR284966A patent/AR228596A1/es active
- 1981-04-14 CA CA000375408A patent/CA1172646A/en not_active Expired
- 1981-04-14 PH PH25498A patent/PH15857A/en unknown
- 1981-04-14 ZA ZA00812482A patent/ZA812482B/xx unknown
- 1981-04-14 PT PT72854A patent/PT72854B/pt not_active IP Right Cessation
- 1981-04-14 CS CS812820A patent/CS225833B2/cs unknown
- 1981-04-14 GR GR64688A patent/GR73824B/el unknown
- 1981-04-15 AT AT81301666T patent/ATE9897T1/de active
- 1981-04-15 EP EP81301666A patent/EP0038676B1/en not_active Expired
- 1981-04-15 FI FI811176A patent/FI75337C/fi not_active IP Right Cessation
- 1981-04-15 DK DK172181A patent/DK172181A/da active IP Right Grant
- 1981-04-15 DE DE8181301666T patent/DE3166679D1/de not_active Expired
- 1981-04-15 GB GB8111886A patent/GB2074161B/en not_active Expired
- 1981-04-16 PL PL1981230714A patent/PL131122B1/pl unknown
- 1981-04-16 DD DD81229304A patent/DD158395A5/de not_active IP Right Cessation
- 1981-04-16 AU AU69611/81A patent/AU543345B2/en not_active Ceased
- 1981-04-16 RO RO104045A patent/RO82739B/ro unknown
- 1981-04-16 IE IE873/81A patent/IE51221B1/en not_active IP Right Cessation
- 1981-04-16 SU SU813310061A patent/SU1297724A3/ru active
- 1981-04-16 JP JP5835681A patent/JPS574954A/ja active Granted
- 1981-04-16 BG BG051701A patent/BG35464A3/xx unknown
- 1981-04-17 KR KR1019810001317A patent/KR840001071B1/ko active
- 1981-04-17 IL IL62669A patent/IL62669A/xx unknown
-
1988
- 1988-10-04 JP JP63251711A patent/JPH01125363A/ja active Granted
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