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PT983275E - Novos derivados do triptolido vantajosos para o tratamento de doencas autoimunes - Google Patents

Novos derivados do triptolido vantajosos para o tratamento de doencas autoimunes

Info

Publication number
PT983275E
PT983275E PT98919928T PT98919928T PT983275E PT 983275 E PT983275 E PT 983275E PT 98919928 T PT98919928 T PT 98919928T PT 98919928 T PT98919928 T PT 98919928T PT 983275 E PT983275 E PT 983275E
Authority
PT
Portugal
Prior art keywords
triptolido
diseases
automatic
treatment
new derivatives
Prior art date
Application number
PT98919928T
Other languages
English (en)
Inventor
Michael J Jung
Mahinda Wickramaratne
Michael Hepperle
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PT983275E publication Critical patent/PT983275E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT98919928T 1997-05-23 1998-04-27 Novos derivados do triptolido vantajosos para o tratamento de doencas autoimunes PT983275E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86248897A 1997-05-23 1997-05-23

Publications (1)

Publication Number Publication Date
PT983275E true PT983275E (pt) 2003-01-31

Family

ID=25338616

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98919928T PT983275E (pt) 1997-05-23 1998-04-27 Novos derivados do triptolido vantajosos para o tratamento de doencas autoimunes

Country Status (21)

Country Link
EP (1) EP0983275B1 (pt)
JP (1) JP2001525851A (pt)
KR (1) KR20010012822A (pt)
CN (1) CN1257507A (pt)
AR (1) AR012723A1 (pt)
AT (1) ATE222910T1 (pt)
AU (1) AU741917B2 (pt)
BR (1) BR9809678A (pt)
CA (1) CA2287977A1 (pt)
DE (1) DE69807466T2 (pt)
DK (1) DK0983275T3 (pt)
ES (1) ES2178207T3 (pt)
HK (1) HK1026096A1 (pt)
HU (1) HUP0003398A3 (pt)
IL (1) IL133088A0 (pt)
NO (1) NO995723L (pt)
NZ (1) NZ500762A (pt)
PT (1) PT983275E (pt)
TW (1) TW434235B (pt)
WO (1) WO1998052951A1 (pt)
ZA (1) ZA984174B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6329148B1 (en) 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
US6569893B2 (en) * 2001-03-15 2003-05-27 Pharmagenesis, Inc. Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents
EP1511478A4 (en) * 2002-05-31 2009-12-02 Pharmagenesis Inc TRIPTOLIDE DERIVATIVES FOR MODULATING APOPTOSIS AND IMMUNOSUPPRESSION
CN100398544C (zh) * 2002-09-18 2008-07-02 成都达远药物有限公司 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用
CA2508217A1 (en) * 2002-12-17 2004-07-15 Pharmagenesis, Inc. Triptolide derivatives as immunomodulators and anticancer agents
CN1223595C (zh) * 2002-12-27 2005-10-19 中国科学院上海药物研究所 雷公藤内酯醇衍生物及其应用
US6943259B2 (en) * 2003-02-25 2005-09-13 Pharmagenesis, Inc. Halogenated triptolide derivatives as immunomodulators and anticancer agents
US7820834B2 (en) 2003-12-24 2010-10-26 Pharmagenesis, Inc. Triptolide 5,6-derivatives as immunomodulators and anticancer agents
WO2005077008A2 (en) 2004-02-09 2005-08-25 Pharmagenesis, Inc. Methods for isolation of triptolide compounds from tripterygium wilfordii
JP5057966B2 (ja) 2004-03-02 2012-10-24 ファーマジェネシス， インコーポレイテッド 免疫調節剤および抗癌剤としてのトリプトライドラクトン環誘導体
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US8617906B2 (en) 2004-10-13 2013-12-31 Pharmagenesis, Inc. Identification and screening of triptolide target molecules
CN104387406A (zh) * 2009-02-05 2015-03-04 药物起源公司 作为抗癌药和免疫调制剂的雷公藤内酯 c-环衍生物
CA2977559C (en) * 2015-10-29 2022-04-12 Hangzhou Weben Pharmaceuticals Inc C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof
CN114716503B (zh) * 2022-03-23 2024-03-12 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种雷公藤氯内酯醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4005108A (en) * 1973-04-03 1977-01-25 Research Corporation Novel anti-leukemic diterpenoid triepoxides
US5430054A (en) * 1989-12-22 1995-07-04 Jiangsu Family Planning Institute Preparation methods of diterpene lactone compounds and application of the same to antifertility
US5663335A (en) * 1996-03-01 1997-09-02 Pharmagenesis, Inc. Immunosuppressive compounds and methods

Also Published As

Publication number Publication date
IL133088A0 (en) 2001-03-19
WO1998052951A1 (en) 1998-11-26
ATE222910T1 (de) 2002-09-15
NZ500762A (en) 2001-08-31
AU741917B2 (en) 2001-12-13
NO995723L (no) 2000-01-21
JP2001525851A (ja) 2001-12-11
HK1026096A1 (en) 2000-12-01
DK0983275T3 (da) 2002-12-23
BR9809678A (pt) 2000-07-11
EP0983275B1 (en) 2002-08-28
CA2287977A1 (en) 1998-11-26
CN1257507A (zh) 2000-06-21
DE69807466D1 (de) 2002-10-02
ES2178207T3 (es) 2002-12-16
AR012723A1 (es) 2000-11-08
TW434235B (en) 2001-05-16
HUP0003398A3 (en) 2001-09-28
HUP0003398A2 (en) 2001-03-28
KR20010012822A (ko) 2001-02-26
DE69807466T2 (de) 2003-04-24
AU7260798A (en) 1998-12-11
EP0983275A1 (en) 2000-03-08
ZA984174B (en) 1998-11-23
NO995723D0 (no) 1999-11-22

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