[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PT87073A - 4-]4-]4-]4-]]2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl"methoxy"phenyl"-1-piperazinyl"phenyl"triazolones - Google Patents

4-]4-]4-]4-]]2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl"methoxy"phenyl"-1-piperazinyl"phenyl"triazolones

Info

Publication number
PT87073A
PT87073A PT87073A PT8707388A PT87073A PT 87073 A PT87073 A PT 87073A PT 87073 A PT87073 A PT 87073A PT 8707388 A PT8707388 A PT 8707388A PT 87073 A PT87073 A PT 87073A
Authority
PT
Portugal
Prior art keywords
phenyl
6alkyl
azolylmethyl
triazolones
dioxolan
Prior art date
Application number
PT87073A
Other languages
English (en)
Other versions
PT87073B (pt
Inventor
Jan Heeres
Leo Jacobus Jozef Backx
Louis Jozef Elisabeth Va Veken
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PT87073A publication Critical patent/PT87073A/pt
Publication of PT87073B publication Critical patent/PT87073B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
PT87073A 1987-03-25 1988-03-24 Processo para a preparacao de 4-{4-{4-{4{{2-(2,4-di-fluoro-fenil)-2-(1h-azol-il-metil-1,3-dioxolan-4-il}metoxi}fenil}-1-piperazinil}fenil}triazolonas e de composicoes antimicrobianas que as contem PT87073B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3020787A 1987-03-25 1987-03-25

Publications (2)

Publication Number Publication Date
PT87073A true PT87073A (pt) 1988-04-01
PT87073B PT87073B (pt) 1992-07-31

Family

ID=21853062

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87073A PT87073B (pt) 1987-03-25 1988-03-24 Processo para a preparacao de 4-{4-{4-{4{{2-(2,4-di-fluoro-fenil)-2-(1h-azol-il-metil-1,3-dioxolan-4-il}metoxi}fenil}-1-piperazinil}fenil}triazolonas e de composicoes antimicrobianas que as contem

Country Status (25)

Country Link
EP (1) EP0283992B1 (pt)
JP (1) JPH0667929B2 (pt)
KR (1) KR960012370B1 (pt)
CN (1) CN1038588C (pt)
AT (1) ATE80626T1 (pt)
AU (1) AU600107B2 (pt)
CA (1) CA1313875C (pt)
CY (1) CY1837A (pt)
DE (1) DE3874576T2 (pt)
DK (1) DK168336B1 (pt)
ES (1) ES2044991T3 (pt)
FI (1) FI89798C (pt)
GR (1) GR3006420T3 (pt)
HK (1) HK50395A (pt)
HU (1) HU204819B (pt)
IE (1) IE61802B1 (pt)
IL (1) IL85823A (pt)
MA (1) MA21227A1 (pt)
NO (1) NO168476C (pt)
NZ (1) NZ223799A (pt)
PH (1) PH25023A (pt)
PT (1) PT87073B (pt)
SU (1) SU1635900A3 (pt)
TN (1) TNSN88025A1 (pt)
ZA (1) ZA882118B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1331757C (en) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
US5075309A (en) * 1989-06-09 1991-12-24 Janssen Pharmaceutica N.V. Antifungal 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones and imidazolones
NZ233502A (en) * 1989-06-09 1991-11-26 Janssen Pharmaceutica Nv 4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
WO1993007847A1 (en) * 1991-10-15 1993-04-29 Kenneth Vincent Mason Anti-seborrhoeic formulation
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals
TW218017B (pt) * 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
PH30929A (en) * 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
PT741737E (pt) * 1994-01-24 2000-04-28 Janssen Pharmaceutica Nv Antifungicos do tipo azole soluveis em agua
RO118715B1 (ro) * 1994-10-27 2003-09-30 Janssen Pharmaceutica Nv Inhibitori ai sintezei apolipoproteinei-b
US5625064A (en) * 1995-04-19 1997-04-29 Schering Corporation Process for the preparation of triazolones
TW457240B (en) * 1995-04-20 2001-10-01 Janssen Pharmaceutica Nv Novel triazolones as apolipoprotein-B synthesis inhibitors
US7078526B2 (en) 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
IL163846A0 (en) 2002-03-01 2005-12-18 Univ South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
CN100360117C (zh) 2002-06-21 2008-01-09 转化医药公司 具有提高的溶出度的药物组合物
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1742941A1 (en) * 2004-04-22 2007-01-17 Transform Pharmaceuticals, Inc. Novel saperconazole crystalline forms and related processes, pharmaceutical compositions and methods
WO2011144653A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Process for the preparation of chiral triazolones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles

Also Published As

Publication number Publication date
HU204819B (en) 1992-02-28
HK50395A (en) 1995-04-13
DK163288D0 (da) 1988-03-24
EP0283992B1 (en) 1992-09-16
IE880893L (en) 1988-09-25
ES2044991T3 (es) 1994-01-16
ZA882118B (en) 1989-11-29
FI881404A (fi) 1988-09-26
GR3006420T3 (pt) 1993-06-21
FI89798B (fi) 1993-08-13
IE61802B1 (en) 1994-11-30
DK163288A (da) 1988-09-26
EP0283992A3 (en) 1989-06-14
JPS63277674A (ja) 1988-11-15
CN1038588C (zh) 1998-06-03
MA21227A1 (fr) 1988-10-01
CN88101660A (zh) 1988-11-09
DE3874576T2 (de) 1993-02-18
DK168336B1 (da) 1994-03-14
NO168476B (no) 1991-11-18
AU1358588A (en) 1988-09-29
FI89798C (fi) 1993-11-25
EP0283992A2 (en) 1988-09-28
AU600107B2 (en) 1990-08-02
CY1837A (en) 1995-12-01
CA1313875C (en) 1993-02-23
KR960012370B1 (ko) 1996-09-20
ATE80626T1 (de) 1992-10-15
SU1635900A3 (ru) 1991-03-15
JPH0667929B2 (ja) 1994-08-31
NZ223799A (en) 1989-12-21
HUT50333A (en) 1990-01-29
TNSN88025A1 (fr) 1990-07-10
IL85823A0 (en) 1988-09-30
PH25023A (en) 1991-01-28
FI881404A0 (fi) 1988-03-24
DE3874576D1 (de) 1992-10-22
NO168476C (no) 1992-02-26
NO881306D0 (no) 1988-03-24
NO881306L (no) 1988-09-26
KR880011147A (ko) 1988-10-26
IL85823A (en) 1993-05-13
PT87073B (pt) 1992-07-31

Similar Documents

Publication Publication Date Title
PT87073A (pt) 4-]4-]4-]4-]]2-(2,4-difluorophenyl)-2-(1h-azolylmethyl)-1,3-dioxolan-4-yl"methoxy"phenyl"-1-piperazinyl"phenyl"triazolones
DK625586A (da) Derivater af ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1h-imidazoler og -1h-1,2,4-triazoler
ES2087886T3 (es) 4-(4-(4-(4-((2-(2,4-difluorofenil)-2-(1h-azolilmetil)-1,3-dioxolan-4-il)metoxi)fenil)-1-piperazinil)fenil)triazolonas e imidazolonas antifungicas.

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920103

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040705