PT771794E - Compostos heterociclicos contendo oxigenio - Google Patents
Compostos heterociclicos contendo oxigenioInfo
- Publication number
- PT771794E PT771794E PT96915194T PT96915194T PT771794E PT 771794 E PT771794 E PT 771794E PT 96915194 T PT96915194 T PT 96915194T PT 96915194 T PT96915194 T PT 96915194T PT 771794 E PT771794 E PT 771794E
- Authority
- PT
- Portugal
- Prior art keywords
- bond
- cyano
- combined
- compounds containing
- containing oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12153795 | 1995-05-19 | ||
| JP25865195 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT771794E true PT771794E (pt) | 2006-09-29 |
Family
ID=26458881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT96915194T PT771794E (pt) | 1995-05-19 | 1996-05-20 | Compostos heterociclicos contendo oxigenio |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0771794B1 (pt) |
| JP (1) | JP4172817B2 (pt) |
| KR (1) | KR100445356B1 (pt) |
| CN (1) | CN1163493C (pt) |
| AT (1) | ATE325110T1 (pt) |
| AU (1) | AU705690B2 (pt) |
| CA (1) | CA2195755A1 (pt) |
| DE (1) | DE69636086T2 (pt) |
| DK (1) | DK0771794T3 (pt) |
| ES (1) | ES2258775T3 (pt) |
| HK (1) | HK1000785A1 (pt) |
| NO (1) | NO317631B1 (pt) |
| PT (1) | PT771794E (pt) |
| WO (1) | WO1996036624A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11505539A (ja) * | 1995-05-18 | 1999-05-21 | ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクロヘキシルジヒドロベンゾフラン |
| DE59610077D1 (de) * | 1995-05-18 | 2003-02-27 | Altana Pharma Ag | Phenyldihydrobenzofurane |
| JP2000501411A (ja) * | 1995-12-05 | 2000-02-08 | ダーウィン・ディスカバリー・リミテッド | ベンゾフランカルボキサミドおよびスルホンアミド |
| EP0901482B1 (en) * | 1996-05-20 | 2003-05-02 | Darwin Discovery Limited | Benzofuran carboxamides and their therapeutic use |
| AU4454597A (en) * | 1996-08-19 | 1998-03-06 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzofuran-4-carboxamides |
| WO1998022455A1 (fr) * | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Composes heterocycliques d'oxygene |
| EP1029860B1 (en) * | 1997-10-01 | 2003-04-16 | Kyowa Hakko Kogyo Co., Ltd. | Benzofuran derivatives |
| EP1054884A1 (en) * | 1998-02-09 | 2000-11-29 | Darwin Discovery Limited | Benzofuran-4-carboxamides and their therapeutic use |
| ATE263166T1 (de) * | 1998-07-06 | 2004-04-15 | Altana Pharma Ag | Neue benzoxazole mit pde-hemmender wirkung |
| EP1110961B1 (en) | 1998-09-03 | 2004-07-14 | Kyowa Hakko Kogyo Co., Ltd. | Oxygenic heterocyclic compounds |
| WO2000040714A2 (en) * | 1998-12-30 | 2000-07-13 | Oligos Etc. Inc. | Therapeutic phosphodiesterase inhibitors |
| WO2001007031A1 (fr) * | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Derives de benzene, compositions immunostimulantes ou agents de retablissement de la pharmacosensibilite les contenant |
| WO2003000697A1 (fr) * | 2001-06-22 | 2003-01-03 | Takeda Chemical Industries, Ltd. | Derive de furo-isoquinoline, procede de production de ce compose et utilisation de ce compose |
| DE10205274A1 (de) * | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
| CA2491464A1 (en) * | 2002-07-03 | 2004-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives |
| CA2519026A1 (en) * | 2003-03-17 | 2004-09-30 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic and/or preventive agent for chronic skin disease |
| JPWO2004087146A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 微粒子混合物の製造方法 |
| JPWO2004087147A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 肺疾患の治療および／または予防剤 |
| JPWO2004087150A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 医薬組成物 |
| CN1767828A (zh) * | 2003-03-31 | 2006-05-03 | 协和发酵工业株式会社 | 医药组合物 |
| JPWO2004096274A1 (ja) * | 2003-03-31 | 2006-07-13 | 協和醗酵工業株式会社 | 気道内投与剤 |
| CN1767827A (zh) * | 2003-03-31 | 2006-05-03 | 协和发酵工业株式会社 | 肺部疾病的治疗及/或预防剂 |
| JPWO2004087151A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 医薬組成物 |
| JPWO2004112791A1 (ja) * | 2003-06-23 | 2006-07-27 | 協和醗酵工業株式会社 | 肺疾患の治療および／または予防剤 |
| EP1504756A1 (en) * | 2003-08-06 | 2005-02-09 | Kyowa Hakko Kogyo Co., Ltd | Medicament compositions comprising a heterocyclic compound and an anticholinergic |
| EP1813284A1 (en) * | 2004-10-13 | 2007-08-01 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical composition |
| US20070287689A1 (en) * | 2004-10-13 | 2007-12-13 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic And/Or Preventive Agents For Chronic Skin Diseases |
| WO2006123726A1 (ja) * | 2005-05-18 | 2006-11-23 | Kyowa Hakko Kogyo Co., Ltd. | 医薬組成物 |
| CA2661850A1 (en) * | 2006-09-01 | 2008-03-06 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
| EP2060572A4 (en) * | 2006-09-06 | 2010-11-17 | Kyorin Seiyaku Kk | PYRAZOLOPYRIDINE DERIVATIVE AND THIS ACTIVE PHOSPHODIESTERASE (PDE) INHIBITOR |
| KR101507717B1 (ko) * | 2006-12-22 | 2015-04-08 | 레오 파마 에이/에스 | Ｐｄｅ4 억제제로서 유용한 치환된 아세토페논 |
| ES2478670T3 (es) | 2007-02-28 | 2014-07-22 | Leo Pharma A/S | Nuevos inhibidores de la fosfodiesterasa |
| ATE540037T1 (de) | 2007-04-16 | 2012-01-15 | Leo Pharma As | Triazolopyridine als phosphodiesterasehemmer zur behandlung von hautkrankheiten |
| NZ593595A (en) | 2008-12-19 | 2013-07-26 | Leo Pharma As | Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases |
| DK3070091T3 (da) | 2010-06-24 | 2019-07-08 | Leo Pharma As | Benzodioxolderivater som phosphodiesterasehæmmere |
| RU2630699C2 (ru) | 2011-12-21 | 2017-09-12 | Лео Фарма А/С | [1,2,4]триазолопиридины и их применение в качестве ингибиторов фосфодиэстеразы |
| PT3157930T (pt) * | 2014-06-23 | 2018-12-24 | Leo Pharma As | Métodos para a preparação de compostos heterocíclicos de 1,3-benzodioxole |
| CN106588841B (zh) * | 2015-10-19 | 2019-01-25 | 富乐马鸿凯（大连）医药有限公司 | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 |
| CN106588900A (zh) * | 2015-10-20 | 2017-04-26 | 北京康辰医药科技有限公司 | 一种苯并双环化合物或其药学上可接受的盐、药物组合物及其应用 |
| CN106905336B (zh) * | 2017-01-22 | 2019-04-09 | 浙江工业大学 | 一种手性吡唑螺呋喃类化合物的不对称合成方法 |
| CN107325067B (zh) * | 2017-05-03 | 2020-05-12 | 广州中医药大学 | 磷酸二酯酶4抑制剂桑辛素m衍生物及其用途 |
| BR112019025028A2 (pt) | 2017-06-20 | 2020-06-16 | Leo Pharma A/S | Método para preparar um composto. |
| CN109721580B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 3-苯基-7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
| CN109721579B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
| CN114478413B (zh) * | 2022-01-14 | 2023-06-23 | 北京富盛嘉华医药科技有限公司 | 2-(2′-羟基-3′-甲代烯丙基-5′-甲基苯基)苯并三氮唑的制备方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2507604A2 (fr) * | 1977-04-19 | 1982-12-17 | Delalande Sa | Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique |
| CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
| JPS62234083A (ja) * | 1986-02-28 | 1987-10-14 | アーバモント インク ディビーエイ アドリヤ ラボラトリーズ | 鎮吐薬または精神病治療薬として有用なカルボキサミド類 |
| JPH01207267A (ja) * | 1987-03-05 | 1989-08-21 | Yamanouchi Pharmaceut Co Ltd | ピリジン誘導体及び該化合物を含有する肝疾患治療剤 |
| ZA886585B (en) * | 1987-09-08 | 1990-05-30 | Lilly Co Eli | Specific 5-ht,antagonists |
| US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| ES2102036T3 (es) * | 1992-06-15 | 1997-07-16 | Celltech Therapeutics Ltd | Derivados con grupo fenilo trisustituido utilizados como inhibidores selectivos de la fosfodiesterasa iv. |
| JP4146894B2 (ja) * | 1994-07-22 | 2008-09-10 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロベンゾフラン |
| DE59610077D1 (de) * | 1995-05-18 | 2003-02-27 | Altana Pharma Ag | Phenyldihydrobenzofurane |
-
1996
- 1996-05-20 PT PT96915194T patent/PT771794E/pt unknown
- 1996-05-20 AU AU57029/96A patent/AU705690B2/en not_active Ceased
- 1996-05-20 WO PCT/JP1996/001327 patent/WO1996036624A1/ja active IP Right Grant
- 1996-05-20 CN CNB961905298A patent/CN1163493C/zh not_active Expired - Fee Related
- 1996-05-20 ES ES96915194T patent/ES2258775T3/es not_active Expired - Lifetime
- 1996-05-20 DE DE69636086T patent/DE69636086T2/de not_active Expired - Fee Related
- 1996-05-20 AT AT96915194T patent/ATE325110T1/de not_active IP Right Cessation
- 1996-05-20 KR KR1019970700326A patent/KR100445356B1/ko not_active IP Right Cessation
- 1996-05-20 DK DK96915194T patent/DK0771794T3/da active
- 1996-05-20 JP JP53470896A patent/JP4172817B2/ja not_active Expired - Fee Related
- 1996-05-20 EP EP96915194A patent/EP0771794B1/en not_active Expired - Lifetime
- 1996-05-20 CA CA002195755A patent/CA2195755A1/en not_active Abandoned
-
1997
- 1997-01-14 NO NO19970151A patent/NO317631B1/no unknown
- 1997-11-28 HK HK97102285A patent/HK1000785A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5702996A (en) | 1996-11-29 |
| AU705690B2 (en) | 1999-05-27 |
| KR100445356B1 (ko) | 2004-11-12 |
| CA2195755A1 (en) | 1996-11-21 |
| NO970151L (no) | 1997-03-06 |
| ATE325110T1 (de) | 2006-06-15 |
| CN1154697A (zh) | 1997-07-16 |
| HK1000785A1 (en) | 2006-06-30 |
| EP0771794A1 (en) | 1997-05-07 |
| CN1163493C (zh) | 2004-08-25 |
| KR970704724A (ko) | 1997-09-06 |
| DK0771794T3 (da) | 2006-09-11 |
| ES2258775T3 (es) | 2006-09-01 |
| EP0771794B1 (en) | 2006-05-03 |
| DE69636086D1 (de) | 2006-06-08 |
| WO1996036624A1 (fr) | 1996-11-21 |
| NO970151D0 (no) | 1997-01-14 |
| NO317631B1 (no) | 2004-11-29 |
| EP0771794A4 (en) | 1998-09-02 |
| JP4172817B2 (ja) | 2008-10-29 |
| DE69636086T2 (de) | 2006-11-30 |
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