PT625197E - Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacao - Google Patents
Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacaoInfo
- Publication number
- PT625197E PT625197E PT93902110T PT93902110T PT625197E PT 625197 E PT625197 E PT 625197E PT 93902110 T PT93902110 T PT 93902110T PT 93902110 T PT93902110 T PT 93902110T PT 625197 E PT625197 E PT 625197E
- Authority
- PT
- Portugal
- Prior art keywords
- mammal
- human
- expression system
- dna sequence
- casein
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108020005029 5' Flanking Region Proteins 0.000 abstract 2
- 108010076119 Caseins Proteins 0.000 abstract 2
- 101710087237 Whey acidic protein Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 210000004602 germ cell Anatomy 0.000 abstract 2
- 210000001161 mammalian embryo Anatomy 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000282836 Camelus dromedarius Species 0.000 abstract 1
- 241000283707 Capra Species 0.000 abstract 1
- 102000011632 Caseins Human genes 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 235000017274 Diospyros sandwicensis Nutrition 0.000 abstract 1
- 101000793859 Homo sapiens Kappa-casein Proteins 0.000 abstract 1
- 241000282838 Lama Species 0.000 abstract 1
- 108010011756 Milk Proteins Proteins 0.000 abstract 1
- 241000699666 Mus <mouse, genus> Species 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 241000282898 Sus scrofa Species 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 235000013350 formula milk Nutrition 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 210000001082 somatic cell Anatomy 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 235000021247 β-casein Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK9288A DK8892D0 (da) | 1992-01-23 | 1992-01-23 | Humant proteingen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT625197E true PT625197E (pt) | 2003-04-30 |
Family
ID=8089602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT93902110T PT625197E (pt) | 1992-01-23 | 1993-01-25 | Adn que codifica a k-cseina, processo para a obtencao da proteina e sua utilizacao |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6222094B1 (pt) |
| EP (1) | EP0625197B1 (pt) |
| JP (1) | JP3467272B2 (pt) |
| AT (1) | ATE229071T1 (pt) |
| AU (1) | AU3346493A (pt) |
| CA (1) | CA2128110A1 (pt) |
| DE (1) | DE69332537T2 (pt) |
| DK (2) | DK8892D0 (pt) |
| ES (1) | ES2188592T3 (pt) |
| PT (1) | PT625197E (pt) |
| WO (1) | WO1993015196A1 (pt) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025567A1 (en) * | 1992-06-15 | 1993-12-23 | Gene Pharming Europe B.V. | Production of recombinant polypeptides by bovine species and transgenic methods |
| US5633076A (en) * | 1989-12-01 | 1997-05-27 | Pharming Bv | Method of producing a transgenic bovine or transgenic bovine embryo |
| WO1995024494A1 (en) * | 1994-03-09 | 1995-09-14 | Abbott Laboratories | Humanized milk |
| US6204431B1 (en) | 1994-03-09 | 2001-03-20 | Abbott Laboratories | Transgenic non-human mammals expressing heterologous glycosyltransferase DNA sequences produce oligosaccharides and glycoproteins in their milk |
| NZ281041A (en) * | 1994-03-09 | 1998-04-27 | Abbott Lab | Non-human mammals transformed with a catalytic entity of enzymes or antibodies to produce a heterologous product in the animals milk |
| US5750176A (en) * | 1994-03-09 | 1998-05-12 | Abbott Laboratories | Transgenic non-human mammal milk comprising 2'-fucosyl-lactose |
| US5712250A (en) * | 1994-09-16 | 1998-01-27 | Abbott Laboratories | Product for inhibition of human rotavirus infection |
| US5576300A (en) * | 1994-09-16 | 1996-11-19 | Abbott Laboratories | Method for inhibition of human rotavirus infection |
| JPH10505828A (ja) * | 1994-09-16 | 1998-06-09 | アボツト・ラボラトリーズ | ヒトロタウイルス感染の阻害 |
| US6455280B1 (en) | 1998-12-22 | 2002-09-24 | Genset S.A. | Methods and compositions for inhibiting neoplastic cell growth |
| US6514825B1 (en) * | 2000-06-28 | 2003-02-04 | Conexant Systems, Inc. | Technique for reducing 1/f noise in MOSFETs |
| PT2279755E (pt) | 2001-10-10 | 2014-06-04 | Ratiopharm Gmbh | Remodelação e glicoconjugação do factor de crescimento de fibroblastos (fgf) |
| EP2298354B1 (en) | 2001-10-10 | 2014-03-19 | ratiopharm GmbH | Remodelling and glycoconjugation of interferon-beta |
| WO2003100074A2 (en) * | 2002-05-24 | 2003-12-04 | A2 Corporation Limited | Animal genotyping method |
| US7011949B2 (en) * | 2002-09-30 | 2006-03-14 | Agilent Technologies, Inc. | Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications |
| CA2507051C (en) * | 2002-11-27 | 2015-04-07 | Dmi Biosciences, Inc. | Treatment of diseases and conditions mediated by increased phosphorylation |
| MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
| EP1720888A4 (en) | 2004-02-20 | 2009-09-16 | Burnham Inst | ANTIMICROBIAL GLUCOSE AND METHODS OF MAKING |
| US7968762B2 (en) * | 2004-07-13 | 2011-06-28 | Van Andel Research Institute | Immune-compromised transgenic mice expressing human hepatocyte growth factor (hHGF) |
| PL1851323T3 (pl) * | 2005-02-24 | 2017-02-28 | Dsm Ip Assets B.V. | Enzymatyczny sposób otrzymywania l-P-P z kappa kazeiny |
| BRPI0616323A2 (pt) * | 2005-09-20 | 2011-06-14 | Prolacta Bioscience Inc | mÉtodo para determinar se um fluido mamÁrio doado foi obtido a partir de um indivÍduo especÍfico |
| WO2010119088A2 (en) * | 2009-04-15 | 2010-10-21 | Bodo Melnik | Milk and milk-based products modified to exhibit a reduced insulinemic index and/or reduced mitogenic activity |
| EP2693883B1 (en) * | 2011-04-07 | 2018-12-26 | Cornell University | Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same |
| PL2764565T3 (pl) | 2011-10-05 | 2023-06-05 | Oned Material, Inc. | Materiały aktywne z nanostrukturami krzemowymi do baterii litowo-jonowych oraz powiązane z nimi procesy, kompozycje, komponenty i urządzenia |
| EA023387B1 (ru) * | 2012-10-08 | 2016-05-31 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK3, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL3, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-Blue/pFK3 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL3 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ |
| EA023475B1 (ru) * | 2012-10-08 | 2016-06-30 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pFK4, ОБЕСПЕЧИВАЮЩАЯ СИНТЕЗ РЕКОМБИНАНТНОГО ПЕПТИДА RL4, ЯВЛЯЮЩЕГОСЯ АНАЛОГОМ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, РЕКОМБИНАНТНЫЙ ШТАММ БАКТЕРИЙ ESCHERICHIA COLI XL1-BLUE/pFK4 И РЕКОМБИНАНТНЫЙ ПЕПТИД RL4 - АНАЛОГ ФРАГМЕНТА КАППА-КАЗЕИНА ЧЕЛОВЕКА, ОБЛАДАЮЩИЙ АПОПТОТИЧЕСКОЙ АКТИВНОСТЬЮ ПО ОТНОШЕНИЮ К РАКОВЫМ КЛЕТКАМ |
| BR112017003414B1 (pt) | 2014-08-21 | 2022-08-09 | Perfect Day, Inc | Composições alimentícias substitutas de laticínios |
| CN109922662A (zh) | 2016-08-25 | 2019-06-21 | 完美日股份有限公司 | 包含乳蛋白和非动物蛋白的食物产品及其生产方法 |
| JP2022531390A (ja) * | 2019-05-02 | 2022-07-06 | ニュー カルチャー インコーポレイテッド | チーズおよびヨーグルト様組成物ならびに関連する方法 |
| EP4213635A1 (en) | 2020-09-18 | 2023-07-26 | Standing Ovation | Method for producing cheese substitutes |
| EP3970501A1 (en) | 2020-09-18 | 2022-03-23 | Baio | Method for producing cheese substitutes |
| US10947552B1 (en) | 2020-09-30 | 2021-03-16 | Alpine Roads, Inc. | Recombinant fusion proteins for producing milk proteins in plants |
| US10894812B1 (en) | 2020-09-30 | 2021-01-19 | Alpine Roads, Inc. | Recombinant milk proteins |
| CA3191387A1 (en) | 2020-09-30 | 2022-04-07 | Nobell Foods, Inc. | Recombinant milk proteins and food compositions comprising the same |
| US11771105B2 (en) | 2021-08-17 | 2023-10-03 | New Culture Inc. | Dairy-like compositions and related methods |
| WO2023197003A2 (en) * | 2022-04-08 | 2023-10-12 | Mozza Foods, Inc. | Making cheese with soy proteins |
| EP4328240A1 (en) * | 2022-08-25 | 2024-02-28 | Real Deal Milk S.L. | Recombinant protein production |
| WO2024102436A1 (en) * | 2022-11-10 | 2024-05-16 | The Johns Hopkins University | System for modulating receptor tyrosine kinase signaling and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982004443A1 (en) | 1981-06-12 | 1982-12-23 | Ohio Univ | Genetic transformation of zygotes |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| EP0181634A3 (en) * | 1984-11-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Synthetic gene for human lysozyme |
| ATE141646T1 (de) * | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
| EP0247494B1 (en) | 1986-05-20 | 1996-07-31 | The General Hospital Corporation | Method for evaluating the effect of a heterologous agent on an animal |
| GB8615942D0 (en) | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
| WO1988001648A1 (en) | 1986-08-28 | 1988-03-10 | Immunex Corporation | Expression of heterologous proteins by transgenic lactating mammals |
| EP0832981A1 (en) | 1987-02-17 | 1998-04-01 | Pharming B.V. | DNA sequences to target proteins to the mammary gland for efficient secretion |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US6020015A (en) * | 1988-09-22 | 2000-02-01 | Gaull; Gerald E. | Infant formula compositions and nutrition containing genetically engineered human milk proteins |
| WO1991003551A1 (en) | 1989-09-11 | 1991-03-21 | Tsi-Mason Research Institute | Production of growth hormone in transgenic animal milk |
| ES2090299T3 (es) | 1989-12-01 | 1996-10-16 | Pharming Bv | Produccion de polipeptidos recombinantes mediante especies bovinas y metodos transgenicos. |
| US5795611A (en) * | 1989-12-20 | 1998-08-18 | Slattery; Charles W. | Human infant formulas containing recombinant human alpha-lactalbumin and beta-casein |
| US5391497A (en) | 1992-10-13 | 1995-02-21 | University Of Colorado Foundation, Inc. | Human k-casein |
-
1992
- 1992-01-23 DK DK9288A patent/DK8892D0/da not_active Application Discontinuation
-
1993
- 1993-01-25 ES ES93902110T patent/ES2188592T3/es not_active Expired - Lifetime
- 1993-01-25 CA CA002128110A patent/CA2128110A1/en not_active Abandoned
- 1993-01-25 AU AU33464/93A patent/AU3346493A/en not_active Abandoned
- 1993-01-25 PT PT93902110T patent/PT625197E/pt unknown
- 1993-01-25 US US08/256,799 patent/US6222094B1/en not_active Expired - Fee Related
- 1993-01-25 JP JP51286793A patent/JP3467272B2/ja not_active Expired - Fee Related
- 1993-01-25 AT AT93902110T patent/ATE229071T1/de not_active IP Right Cessation
- 1993-01-25 EP EP93902110A patent/EP0625197B1/en not_active Expired - Lifetime
- 1993-01-25 WO PCT/DK1993/000024 patent/WO1993015196A1/en active IP Right Grant
- 1993-01-25 DE DE69332537T patent/DE69332537T2/de not_active Expired - Fee Related
- 1993-01-25 DK DK93902110T patent/DK0625197T3/da active
-
1995
- 1995-06-05 US US08/462,437 patent/US6232094B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE229071T1 (de) | 2002-12-15 |
| DK0625197T3 (da) | 2003-03-24 |
| US6222094B1 (en) | 2001-04-24 |
| US6232094B1 (en) | 2001-05-15 |
| CA2128110A1 (en) | 1993-08-05 |
| JPH07503136A (ja) | 1995-04-06 |
| EP0625197A1 (en) | 1994-11-23 |
| AU3346493A (en) | 1993-09-01 |
| JP3467272B2 (ja) | 2003-11-17 |
| DE69332537T2 (de) | 2003-09-04 |
| DE69332537D1 (de) | 2003-01-16 |
| ES2188592T3 (es) | 2003-07-01 |
| EP0625197B1 (en) | 2002-12-04 |
| WO1993015196A1 (en) | 1993-08-05 |
| DK8892D0 (da) | 1992-01-23 |
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