[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PT3956332T - Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários - Google Patents

Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários

Info

Publication number
PT3956332T
PT3956332T PT207191602T PT20719160T PT3956332T PT 3956332 T PT3956332 T PT 3956332T PT 207191602 T PT207191602 T PT 207191602T PT 20719160 T PT20719160 T PT 20719160T PT 3956332 T PT3956332 T PT 3956332T
Authority
PT
Portugal
Prior art keywords
diasteroselective
thiol
intermediates
disulfide
preparation
Prior art date
Application number
PT207191602T
Other languages
English (en)
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of PT3956332T publication Critical patent/PT3956332T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT207191602T 2019-04-18 2020-04-09 Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários PT3956332T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19170052 2019-04-18

Publications (1)

Publication Number Publication Date
PT3956332T true PT3956332T (pt) 2023-04-24

Family

ID=66396993

Family Applications (1)

Application Number Title Priority Date Filing Date
PT207191602T PT3956332T (pt) 2019-04-18 2020-04-09 Processo diasterosselectivo para a preparação de ésteres de maitansinoides contendo tiol ou dissulfeto e seus intermediários

Country Status (12)

Country Link
US (1) US11420981B2 (pt)
EP (1) EP3956332B1 (pt)
JP (1) JP7568644B2 (pt)
CN (1) CN113710674B (pt)
DK (1) DK3956332T3 (pt)
ES (1) ES2942915T3 (pt)
FI (1) FI3956332T3 (pt)
HU (1) HUE061695T2 (pt)
PL (1) PL3956332T3 (pt)
PT (1) PT3956332T (pt)
SI (1) SI3956332T1 (pt)
WO (1) WO2020212256A1 (pt)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
US4151042A (en) 1977-03-31 1979-04-24 Takeda Chemical Industries, Ltd. Method for producing maytansinol and its derivatives
US4162940A (en) 1977-03-31 1979-07-31 Takeda Chemical Industries, Ltd. Method for producing Antibiotic C-15003 by culturing nocardia
JPS56102793A (en) 1979-12-28 1981-08-17 Takeda Chem Ind Ltd Preparation of antibiotic c-15003 p-3
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6573074B2 (en) 2000-04-12 2003-06-03 Smithkline Beecham Plc Methods for ansamitocin production
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
AR030612A1 (es) * 2000-09-12 2003-08-27 Smithkline Beecham Corp Procedimiento e intermedios
US6790954B2 (en) 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
PL1651162T3 (pl) * 2003-05-20 2016-04-29 Immunogen Inc Maitansynoidy w leczeniu nowotworów
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
US7301019B2 (en) 2005-01-21 2007-11-27 Immunogen, Inc. Method for the preparation of maytansinoid esters
CA2617953C (en) 2005-08-09 2013-12-17 Millennium Pharmaceuticals, Inc. Method of acylating maytansinol with chiral amino acids
DK1945647T3 (da) 2005-11-08 2012-05-07 Immunogen Inc Fremgangsmåder til fremstilling af maytansinol
NZ739573A (en) 2012-09-26 2019-11-29 Immunogen Inc Improved methods for the acylation of maytansinol
CN103254213B (zh) * 2012-12-21 2015-02-25 百奥泰生物科技(广州)有限公司 类美登素酯的制备方法及用于所述方法的组合物
CN105585579A (zh) * 2014-10-24 2016-05-18 南京联宁生物制药有限公司 一种化合物及其制备方法以及美登素dm1的制备方法

Also Published As

Publication number Publication date
EP3956332B1 (en) 2023-02-22
CN113710674A (zh) 2021-11-26
DK3956332T3 (da) 2023-05-01
WO2020212256A1 (en) 2020-10-22
SI3956332T1 (sl) 2023-05-31
HUE061695T2 (hu) 2023-08-28
FI3956332T3 (fi) 2023-05-09
JP2022529064A (ja) 2022-06-16
EP3956332A1 (en) 2022-02-23
US20220119408A1 (en) 2022-04-21
PL3956332T3 (pl) 2023-05-29
CN113710674B (zh) 2024-03-15
JP7568644B2 (ja) 2024-10-16
US11420981B2 (en) 2022-08-23
ES2942915T3 (es) 2023-06-07

Similar Documents

Publication Publication Date Title
IL292648A (en) A process for the preparation of glucuronide-drug binders and their intermediates
ZA202101214B (en) Process and intermediates for the preparation of bilastine
ZA202003590B (en) Process for the preparation of opicapone and intermediates thereof
EP3638239A4 (en) METHODS OF TREATMENT OF DISEASES ASSOCIATED WITH RBP4 USING TRIAZOLOPYRIDINES
EP3717456A4 (en) PROCESS FOR PREPARING ROXADUSTAT AND ITS INTERMEDIARIES
IL289904A (en) A process for preparing biphenylamines
IL276773A (en) Process and intermediates for the preparation of certain toxic pesticides
HUE058259T2 (hu) Eljárás lubiproszton és annak intermedierei elkészítésére
PL3737685T3 (pl) Sposób wytwarzania kryzaborolu i jego związków pośrednich
FI3830067T3 (fi) Menetelmä alkoholien hapettamiseksi
GB201915447D0 (en) Polymorphs of avapritinib and methods of preparing the polymorphs
SI3956332T1 (sl) Diasteroselektivni postopek za pripravo tiol- ali disulfid-vsebujočih majtansinoidnih estrov in njihovih intermediatov
ZA202107053B (en) Novel process for the preparation of filgotinib and intermediates thereof
EP3762356A4 (en) IMPROVED PROCESS FOR MANUFACTURING INTERMEDIATE PRODUCTS
IL290169A (en) Method and intermediates for the preparation of pyroxulfone
EP4064827A4 (en) TRANSFORMATION PROCESSES
EP3956317A4 (en) PROCESS FOR THE PREPARATION OF AZOXYSTROBINE AND INTERMEDIATE THEREOF
EP3917935A4 (en) SYNTHESIS PROCESS AND NEW INTERMEDIATES
PT3969459T (pt) Processo e intermediários para a preparação de eldecalcitol
EP3782469A4 (en) METHODS OF CONTROL OF SOIL DISEASES IN PLANTS
HUP2100077A1 (hu) Eljárás avapritinib és intermedierek elõállítására
ZA202110479B (en) Novel esters of medroxyprogesterone
HUE067201T2 (hu) Eljárás és intermedier oxetan-2-il-metánamin elõállítására
IL288393A (en) Methods for making thiazolylpyrazole carboxylic acids and intermediates therefor
EP4051681A4 (en) PROCESS FOR MANUFACTURE OF TOFACITINIB AND INTERMEDIATE THEREOF