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PT3227294T - 1-[2-(aminometil)benzil]-2-tioxo-1,2,3,s-tetra-hidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inibidores de mieloperoxidase - Google Patents

1-[2-(aminometil)benzil]-2-tioxo-1,2,3,s-tetra-hidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inibidores de mieloperoxidase

Info

Publication number
PT3227294T
PT3227294T PT158020750T PT15802075T PT3227294T PT 3227294 T PT3227294 T PT 3227294T PT 158020750 T PT158020750 T PT 158020750T PT 15802075 T PT15802075 T PT 15802075T PT 3227294 T PT3227294 T PT 3227294T
Authority
PT
Portugal
Prior art keywords
myeloperoxidase
thioxo
pyrrolo
pyrimidin
aminomethyl
Prior art date
Application number
PT158020750T
Other languages
English (en)
Inventor
Bertil Inghardt Tord
Tomkinson Nicholas
Gan Li-Ming
Paul Stonehouse Jeffrey
Johannesson Petra
Jurva Ulrik
Erik Michaëlsson
Lindstedt-Alstermark Eva-Lotte
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PT3227294T publication Critical patent/PT3227294T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT158020750T 2014-12-01 2015-11-30 1-[2-(aminometil)benzil]-2-tioxo-1,2,3,s-tetra-hidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inibidores de mieloperoxidase PT3227294T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462085722P 2014-12-01 2014-12-01
US201562166808P 2015-05-27 2015-05-27

Publications (1)

Publication Number Publication Date
PT3227294T true PT3227294T (pt) 2019-10-28

Family

ID=54754631

Family Applications (1)

Application Number Title Priority Date Filing Date
PT158020750T PT3227294T (pt) 2014-12-01 2015-11-30 1-[2-(aminometil)benzil]-2-tioxo-1,2,3,s-tetra-hidro-4h-pirrolo[3,2-d]pirimidin-4-onas como inibidores de mieloperoxidase

Country Status (38)

Country Link
US (5) US9616063B2 (pt)
EP (1) EP3227294B1 (pt)
JP (1) JP6616417B2 (pt)
KR (1) KR102543404B1 (pt)
CN (1) CN107001374B (pt)
AU (1) AU2015357290B2 (pt)
BR (1) BR112017011124B1 (pt)
CA (1) CA2968449C (pt)
CL (1) CL2017001380A1 (pt)
CO (1) CO2017006658A2 (pt)
CY (1) CY1122587T1 (pt)
DK (1) DK3227294T3 (pt)
DO (1) DOP2017000129A (pt)
EA (1) EA030805B1 (pt)
ES (1) ES2751690T3 (pt)
GT (1) GT201700114A (pt)
HK (1) HK1245270A1 (pt)
HR (1) HRP20191744T1 (pt)
HU (1) HUE045606T2 (pt)
IL (1) IL252436B (pt)
LT (1) LT3227294T (pt)
ME (1) ME03568B (pt)
MX (1) MX370492B (pt)
MY (1) MY195816A (pt)
NI (1) NI201700065A (pt)
NZ (1) NZ732164A (pt)
PE (1) PE20170914A1 (pt)
PH (1) PH12017500977A1 (pt)
PL (1) PL3227294T3 (pt)
PT (1) PT3227294T (pt)
RS (1) RS59375B1 (pt)
SG (1) SG11201703961UA (pt)
SI (1) SI3227294T1 (pt)
SV (1) SV2017005451A (pt)
TN (1) TN2017000208A1 (pt)
TW (1) TWI681963B (pt)
UY (1) UY36416A (pt)
WO (1) WO2016087338A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
MA49618A (fr) 2017-07-17 2020-05-27 Astrazeneca Ab Inhibiteurs de la mpo destinés à être utilisés en médecine
CN112151111B (zh) * 2020-08-27 2022-10-11 上海大学 基于多元线性回归快速预测黄嘌呤衍生物抑制活性的qsar方法
CN115403584B (zh) * 2021-05-26 2024-04-02 长春金赛药业有限责任公司 2-硫代-2,3-二氢嘧啶-4-酮衍生物、药物组合物及其制备方法和应用
US20240166642A1 (en) 2022-08-18 2024-05-23 Astrazeneca Ab Inhibitors of myeloperoxidase
US20240092787A1 (en) 2022-08-24 2024-03-21 Astrazeneca Ab Pharmaceutical process and intermediates
US20240091231A1 (en) 2022-08-31 2024-03-21 Astrazeneca Ab Pharmaceutical formulations
WO2024120457A1 (zh) * 2022-12-09 2024-06-13 深圳信立泰药业股份有限公司 一种吡咯并[3,2-d]嘧啶-4-酮类衍生物及其制备方法和医药用途
WO2024209075A1 (en) * 2023-04-06 2024-10-10 Astrazeneca Ab Method of treatment with mpo inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR039385A1 (es) 2002-04-19 2005-02-16 Astrazeneca Ab Derivados de tioxantina como inhibidores de la mieloperoxidasa
US20050130983A1 (en) * 2002-05-02 2005-06-16 Dae-Kee Kim Pyrrolopyrimidinone derivatives, process for preparation thereof, and method of using and composition comprising them
SE0302756D0 (sv) 2003-10-17 2003-10-17 Astrazeneca Ab Novel Compounds
GB0401269D0 (en) * 2004-01-21 2004-02-25 Astrazeneca Ab Compounds
MY140748A (en) * 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
ATE501148T1 (de) * 2004-12-14 2011-03-15 Astrazeneca Ab Pyrazolopyrimidinverbindungen als antitumormittel
US20090286813A1 (en) 2006-04-13 2009-11-19 Astrazeneca Ab Thioxanthine Derivatives and Their Use as Inhibitors of MPO
TW200806667A (en) 2006-04-13 2008-02-01 Astrazeneca Ab New compounds
TW200804383A (en) 2006-06-05 2008-01-16 Astrazeneca Ab New compounds
CN101460501A (zh) 2006-06-05 2009-06-17 阿斯利康(瑞典)有限公司 作为髓过氧化物酶抑制剂的吡咯并[3，2-d]嘧啶-4-酮衍生物
US20090054468A1 (en) * 2007-08-23 2009-02-26 Astrazeneca Ab New Use 938
USRE47009E1 (en) 2011-02-01 2018-08-28 The Children's Hospital Of Philadelphia HDAC inhibitors and therapeutic methods using the same
AU2012335220B2 (en) 2011-11-11 2017-06-01 Pfizer Inc. 2-thiopyrimidinones
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase

Also Published As

Publication number Publication date
US20240335446A1 (en) 2024-10-10
CN107001374B (zh) 2019-06-14
EP3227294A1 (en) 2017-10-11
TN2017000208A1 (en) 2018-10-19
US20210228585A1 (en) 2021-07-29
CY1122587T1 (el) 2021-01-27
WO2016087338A1 (en) 2016-06-09
SI3227294T1 (sl) 2019-11-29
CO2017006658A2 (es) 2017-10-20
JP2017535588A (ja) 2017-11-30
MY195816A (en) 2023-02-22
SV2017005451A (es) 2017-10-12
AU2015357290A1 (en) 2017-06-15
HUE045606T2 (hu) 2020-01-28
IL252436A0 (en) 2017-07-31
PL3227294T3 (pl) 2020-04-30
TWI681963B (zh) 2020-01-11
NI201700065A (es) 2018-01-04
ES2751690T3 (es) 2020-04-01
PE20170914A1 (es) 2017-07-12
TW201639846A (zh) 2016-11-16
SG11201703961UA (en) 2017-06-29
IL252436B (en) 2021-05-31
US11975004B2 (en) 2024-05-07
DOP2017000129A (es) 2017-09-15
KR102543404B1 (ko) 2023-06-14
HRP20191744T1 (hr) 2019-12-27
CA2968449C (en) 2023-02-28
MX2017007322A (es) 2018-02-19
CA2968449A1 (en) 2016-06-09
KR20170088900A (ko) 2017-08-02
BR112017011124B1 (pt) 2022-11-16
NZ732164A (en) 2018-02-23
CL2017001380A1 (es) 2018-01-12
LT3227294T (lt) 2019-10-25
US9616063B2 (en) 2017-04-11
US11000525B2 (en) 2021-05-11
CN107001374A (zh) 2017-08-01
MX370492B (es) 2019-12-16
UY36416A (es) 2016-06-01
RS59375B1 (sr) 2019-11-29
JP6616417B2 (ja) 2019-12-04
US20160152623A1 (en) 2016-06-02
HK1245270A1 (zh) 2018-08-24
DK3227294T3 (da) 2019-10-21
US10016430B2 (en) 2018-07-10
EA030805B1 (ru) 2018-09-28
US20190076432A1 (en) 2019-03-14
AU2015357290B2 (en) 2018-03-29
US20170173025A1 (en) 2017-06-22
PH12017500977A1 (en) 2017-11-27
EA201791021A1 (ru) 2017-11-30
BR112017011124A2 (pt) 2017-12-26
EP3227294B1 (en) 2019-08-14
GT201700114A (es) 2019-08-12
ME03568B (me) 2020-07-20

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