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PT3250610T - Fcrn antibodies and methods of use thereof - Google Patents

Fcrn antibodies and methods of use thereof

Info

Publication number
PT3250610T
PT3250610T PT167442045T PT16744204T PT3250610T PT 3250610 T PT3250610 T PT 3250610T PT 167442045 T PT167442045 T PT 167442045T PT 16744204 T PT16744204 T PT 16744204T PT 3250610 T PT3250610 T PT 3250610T
Authority
PT
Portugal
Prior art keywords
methods
fcrn antibodies
fcrn
antibodies
Prior art date
Application number
PT167442045T
Other languages
Portuguese (pt)
Original Assignee
Momenta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Momenta Pharmaceuticals Inc filed Critical Momenta Pharmaceuticals Inc
Publication of PT3250610T publication Critical patent/PT3250610T/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
PT167442045T 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof PT3250610T (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562110071P 2015-01-30 2015-01-30
US201562258082P 2015-11-20 2015-11-20

Publications (1)

Publication Number Publication Date
PT3250610T true PT3250610T (en) 2023-11-13

Family

ID=56544538

Family Applications (1)

Application Number Title Priority Date Filing Date
PT167442045T PT3250610T (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof

Country Status (21)

Country Link
US (3) US10676526B2 (en)
EP (2) EP3250610B1 (en)
JP (2) JP6853178B2 (en)
KR (2) KR102483016B1 (en)
CN (13) CN118638230A (en)
AU (1) AU2016211280B2 (en)
CA (1) CA2972822A1 (en)
DK (1) DK3250610T3 (en)
ES (1) ES2962824T3 (en)
FI (1) FI3250610T3 (en)
HR (1) HRP20231399T1 (en)
HU (1) HUE063778T2 (en)
IL (1) IL252837B (en)
LT (1) LT3250610T (en)
NZ (1) NZ733097A (en)
PL (1) PL3250610T3 (en)
PT (1) PT3250610T (en)
RS (1) RS64768B1 (en)
SG (2) SG10202007232WA (en)
SI (1) SI3250610T1 (en)
WO (1) WO2016123521A2 (en)

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EA035324B1 (en) 2013-12-24 2020-05-28 Ардженкс Бвба NEONATAL Fc RECEPTOR (FcRn) ANTAGONISTS AND METHODS OF USE THEREOF
US20170211876A1 (en) * 2014-06-12 2017-07-27 Hoffmann-La Roche Inc. Method for selecting antibodies with modified fcrn interaction
HUE063778T2 (en) * 2015-01-30 2024-01-28 Momenta Pharmaceuticals Inc Fcrn antibodies and methods of use thereof
JP7094941B2 (en) * 2016-07-29 2022-07-04 モメンタ ファーマシューティカルズ インコーポレイテッド FCRN antibody and how to use it
CN110785186A (en) * 2017-06-15 2020-02-11 Ucb生物制药有限责任公司 Method for treating immune thrombocytopenia
US11773168B2 (en) * 2017-12-13 2023-10-03 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
MX2020013195A (en) 2018-06-08 2021-02-26 Argenx Bvba Compositions and methods for treating immune thrombocytopenia.
JOP20210014A1 (en) * 2018-07-20 2021-01-19 Zhongli Zhang Compositions of fcrn antibodies and methods of use thereof
KR20210105873A (en) * 2018-07-20 2021-08-27 모멘타 파머슈티컬스 인코포레이티드 FCRN Antibody Composition
SG11202103801UA (en) 2018-10-16 2021-05-28 UCB Biopharma SRL Method for the treatment of myasthenia gravis
KR20220019018A (en) 2019-06-07 2022-02-15 아르제넥스 비브이비에이 Pharmaceutical formulations of FcRn inhibitors suitable for subcutaneous administration
MX2022001380A (en) * 2019-08-01 2022-03-25 Momenta Pharmaceuticals Inc Fcrn antibodies and methods of use thereof.
WO2021101975A1 (en) * 2019-11-19 2021-05-27 Immunovant Sciences Gmbh Methods of treating warm autoimmune hemolytic anemia using anti-fcrn antibodies
AU2021376364A1 (en) * 2020-11-06 2023-06-22 Momenta Pharmaceuticals, Inc. Fcrn antibodies and methods of use thereof
EP4287828A1 (en) * 2021-02-02 2023-12-13 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric fcrn
WO2023030501A1 (en) * 2021-09-03 2023-03-09 舒泰神(北京)生物制药股份有限公司 Antibody capable of specifically recognizing fcrn and use thereof
AU2023281650A1 (en) 2022-05-30 2024-10-17 Hanall Biopharma Co., Ltd. Anti-fcrn antibody or antigen binding fragment thereof with improved stability
WO2024163894A1 (en) 2023-02-04 2024-08-08 Momenta Pharmaceuticals, Inc. Compositions and methods for treating hemolytic disease of the fetus and newborn

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EP1660128A4 (en) * 2003-08-08 2009-01-21 Univ New York State Res Found Anti-fcrn antibodies for treatment of auto/allo immune conditions
US7662928B2 (en) 2003-08-08 2010-02-16 The Research Foundation Of State University Of New York Anti-FcRn antibodies for treatment of auto/allo immune conditions
CN101124245A (en) * 2003-11-12 2008-02-13 比奥根艾迪克Ma公司 Neonatal Fc receptor (FcRn)-binding polypeptide variants, dimeric Fc binding proteins and methods related thereto
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EP1986690A4 (en) 2006-01-25 2009-05-13 Univ New York State Res Found ANTI-FcRn ANTIBODIES FOR TREATEMENT OF AUTO/ALLO IMMUNE CONDITIONS
CN101421297A (en) * 2006-02-17 2009-04-29 森托尼克斯制药有限公司 Peptides that block the binding of igg to fcrn
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CN102149729B (en) * 2008-04-25 2014-08-20 戴埃克斯有限公司 Antibodies against FcRn and use thereof
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KR101815265B1 (en) 2013-06-20 2018-01-04 한올바이오파마주식회사 FcRn specific human antibody and composition for treatment of autoimmune diseases
HUE063778T2 (en) 2015-01-30 2024-01-28 Momenta Pharmaceuticals Inc Fcrn antibodies and methods of use thereof
EP3268391B1 (en) 2015-03-09 2021-08-11 argenx BVBA Methods of reducing serum levels of fc-containing agents using fcrn antagonsits
KR20180023900A (en) 2015-05-12 2018-03-07 신티뮨, 인크. Humanized affinity matured anti-FcRn antibodies
JP7094941B2 (en) 2016-07-29 2022-07-04 モメンタ ファーマシューティカルズ インコーポレイテッド FCRN antibody and how to use it
SG11202003944WA (en) 2017-12-08 2020-06-29 Argenx Bvba Use of fcrn antagonists for treatment of generalized myasthenia gravis
US11773168B2 (en) 2017-12-13 2023-10-03 Momenta Pharmaceuticals, Inc. FcRn antibodies and methods of use thereof
JOP20210014A1 (en) 2018-07-20 2021-01-19 Zhongli Zhang Compositions of fcrn antibodies and methods of use thereof
KR20210105873A (en) 2018-07-20 2021-08-27 모멘타 파머슈티컬스 인코포레이티드 FCRN Antibody Composition

Also Published As

Publication number Publication date
NZ733097A (en) 2024-07-05
PL3250610T3 (en) 2024-01-29
CN118667012A (en) 2024-09-20
HUE063778T2 (en) 2024-01-28
CN113384693A (en) 2021-09-14
CN118638229A (en) 2024-09-13
EP4286011A2 (en) 2023-12-06
DK3250610T3 (en) 2023-10-30
CN118667009A (en) 2024-09-20
IL252837A0 (en) 2017-08-31
FI3250610T3 (en) 2023-11-01
HRP20231399T1 (en) 2024-02-16
AU2022201145A1 (en) 2022-03-17
CN118667015A (en) 2024-09-20
SG10202007232WA (en) 2020-09-29
CN118638230A (en) 2024-09-13
SI3250610T1 (en) 2023-11-30
SG11201705475QA (en) 2017-08-30
US11732047B2 (en) 2023-08-22
AU2016211280A1 (en) 2017-07-13
LT3250610T (en) 2023-09-25
KR20230007545A (en) 2023-01-12
US10676526B2 (en) 2020-06-09
BR112017015287A2 (en) 2018-01-16
WO2016123521A3 (en) 2016-09-22
US20240158508A1 (en) 2024-05-16
CN118667011A (en) 2024-09-20
EP3250610A4 (en) 2018-08-22
WO2016123521A2 (en) 2016-08-04
KR20170109020A (en) 2017-09-27
US20200299382A1 (en) 2020-09-24
CN118562003A (en) 2024-08-30
EP4286011A3 (en) 2024-02-14
EP3250610B1 (en) 2023-08-09
CN118652337A (en) 2024-09-17
CN118667010A (en) 2024-09-20
ES2962824T3 (en) 2024-03-21
CN118667013A (en) 2024-09-20
KR102483016B1 (en) 2023-01-03
US20180016334A1 (en) 2018-01-18
JP2021061854A (en) 2021-04-22
AU2016211280B2 (en) 2021-11-25
CN107567460A (en) 2018-01-09
JP6853178B2 (en) 2021-03-31
JP7224382B2 (en) 2023-02-17
CN118667014A (en) 2024-09-20
EP3250610A2 (en) 2017-12-06
CA2972822A1 (en) 2016-08-04
IL252837B (en) 2021-10-31
CN107567460B (en) 2021-04-23
JP2018504907A (en) 2018-02-22
RS64768B1 (en) 2023-11-30

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