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PT3199537T - Processos e intermediários para preparar agentes anti-hiv - Google Patents

Processos e intermediários para preparar agentes anti-hiv

Info

Publication number
PT3199537T
PT3199537T PT16204289T PT16204289T PT3199537T PT 3199537 T PT3199537 T PT 3199537T PT 16204289 T PT16204289 T PT 16204289T PT 16204289 T PT16204289 T PT 16204289T PT 3199537 T PT3199537 T PT 3199537T
Authority
PT
Portugal
Prior art keywords
intermediates
processes
preparing anti
hiv agents
hiv
Prior art date
Application number
PT16204289T
Other languages
English (en)
Inventor
R Graetz Benjamin
Hung Chiu Yu Richard
P Polniaszek Richard
Heath Brown Brandon
Sujino Keiko
Duc-Phi Tran Duong
Scott Triman Alan
M Kent Kenneth
Pfeiffer Steven
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of PT3199537T publication Critical patent/PT3199537T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4071Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075Esters with hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44Amides thereof
    • C07F9/4434Amides thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4449Esters with hydroxyaryl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/173Purine radicals with 2-deoxyribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT16204289T 2011-05-19 2012-05-18 Processos e intermediários para preparar agentes anti-hiv PT3199537T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161488133P 2011-05-19 2011-05-19

Publications (1)

Publication Number Publication Date
PT3199537T true PT3199537T (pt) 2019-01-17

Family

ID=46208163

Family Applications (2)

Application Number Title Priority Date Filing Date
PT16204289T PT3199537T (pt) 2011-05-19 2012-05-18 Processos e intermediários para preparar agentes anti-hiv
PT127255701T PT2710019T (pt) 2011-05-19 2012-05-18 Processos e intermediários para preparar agentes anti-hiv

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT127255701T PT2710019T (pt) 2011-05-19 2012-05-18 Processos e intermediários para preparar agentes anti-hiv

Country Status (10)

Country Link
US (5) US8987437B2 (pt)
EP (3) EP3450438A1 (pt)
JP (4) JP5951757B2 (pt)
AR (1) AR086492A1 (pt)
AU (4) AU2012255029B2 (pt)
CA (1) CA2835932C (pt)
ES (2) ES2700470T3 (pt)
PT (2) PT3199537T (pt)
TW (1) TWI635093B (pt)
WO (1) WO2012159047A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5951757B2 (ja) 2011-05-19 2016-07-13 ギリアード サイエンシーズ, インコーポレイテッド 抗hiv剤を調製するためのプロセスおよび中間体
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
EP3518935A1 (en) 2016-09-27 2019-08-07 Gilead Sciences, Inc. Therapeutic compositions for treatment of human immunodeficiency virus
PT3661937T (pt) 2017-08-01 2021-09-24 Gilead Sciences Inc Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais
US10836769B2 (en) 2018-02-26 2020-11-17 Gilead Sciences, Inc. Substituted pyrrolizine compounds and uses thereof
CN112175003B (zh) * 2019-07-01 2022-02-15 上海医药工业研究院 一种苯基氢膦酸酯及其中间体的制备方法
JP7022970B1 (ja) 2021-06-09 2022-02-21 株式会社エクセノヤマミズ 船舶

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US599431A (en) 1898-02-22 Clothes-wringer
GB835785A (en) 1956-04-30 1960-05-25 Victor Chemical Works Method of making diaryl phosphites
MX3898E (es) * 1975-12-29 1981-09-10 Monsanto Co Procedimiento mejorado para la preparacion de triesteres de n-fosfonometilglicina
US4198355A (en) 1977-03-28 1980-04-15 Mobil Oil Corporation Preparation of tertiary alkylphosphorodichloridite derivatives
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
HU906976D0 (en) 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
KR100767432B1 (ko) 2000-07-21 2007-10-17 길리애드 사이언시즈, 인코포레이티드 포스포네이트 뉴클레오티드 유사체의 전구 약물과 그것의 선택 및 제조 방법
JP2005523922A (ja) * 2002-04-26 2005-08-11 ギリアード サイエンシーズ, インコーポレイテッド 非ヌクレオシド逆転写酵素阻害剤
ATE490788T1 (de) * 2003-04-25 2010-12-15 Gilead Sciences Inc Antivirale phosphonate analoge
JP2010535701A (ja) * 2003-04-25 2010-11-25 ギリアード サイエンシーズ, インコーポレイテッド 抗癌ホスホネートアナログ
PL382845A1 (pl) 2004-07-16 2008-01-21 Gilead Sciences, Inc. Związki przeciwwirusowe
EP1778251B1 (en) * 2004-07-27 2011-04-13 Gilead Sciences, Inc. Nucleoside phosphonate conjugates as anti hiv agents
WO2007014352A2 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
KR20080104315A (ko) * 2006-03-17 2008-12-02 인비스타 테크놀러지스 에스.에이.알.엘 염기성 첨가제를 사용한 처리에 의한 트리오르가노포스파이트의 정제 방법
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
ES2393962T3 (es) 2008-07-08 2013-01-03 Gilead Sciences, Inc. Sales de compuestos inhibidores del VIH.
WO2011003018A2 (en) 2009-07-01 2011-01-06 Cornell University Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof
JP5951757B2 (ja) 2011-05-19 2016-07-13 ギリアード サイエンシーズ, インコーポレイテッド 抗hiv剤を調製するためのプロセスおよび中間体

Also Published As

Publication number Publication date
EP2710019B1 (en) 2017-05-03
AU2012255029B2 (en) 2016-04-28
EP3450438A1 (en) 2019-03-06
AU2018200776A1 (en) 2018-02-22
JP2019089808A (ja) 2019-06-13
JP5951757B2 (ja) 2016-07-13
JP2017110025A (ja) 2017-06-22
JP2016128459A (ja) 2016-07-14
AU2019226278A1 (en) 2019-09-26
TW201309715A (zh) 2013-03-01
AU2016208292A1 (en) 2016-08-11
AU2016208292B2 (en) 2018-02-22
US9783567B2 (en) 2017-10-10
NZ618939A (en) 2015-11-27
CA2835932C (en) 2020-03-24
US20160340379A1 (en) 2016-11-24
ES2629913T3 (es) 2017-08-16
JP2014516968A (ja) 2014-07-17
AR086492A1 (es) 2013-12-18
US8987437B2 (en) 2015-03-24
US20150203525A1 (en) 2015-07-23
US20180079773A1 (en) 2018-03-22
AU2018200776B2 (en) 2019-10-03
AU2012255029A1 (en) 2013-05-02
TWI635093B (zh) 2018-09-11
PT2710019T (pt) 2017-07-21
JP6621772B2 (ja) 2019-12-18
WO2012159047A1 (en) 2012-11-22
ES2700470T3 (es) 2019-02-15
US10196419B2 (en) 2019-02-05
US9296779B2 (en) 2016-03-29
CA2835932A1 (en) 2012-11-22
EP3199537B1 (en) 2018-10-17
JP6282295B2 (ja) 2018-02-21
US20120296076A1 (en) 2012-11-22
EP2710019A1 (en) 2014-03-26
EP3199537A1 (en) 2017-08-02
US20190359644A1 (en) 2019-11-28

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