PT2922576T - Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática - Google Patents
Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepáticaInfo
- Publication number
- PT2922576T PT2922576T PT138574553T PT13857455T PT2922576T PT 2922576 T PT2922576 T PT 2922576T PT 138574553 T PT138574553 T PT 138574553T PT 13857455 T PT13857455 T PT 13857455T PT 2922576 T PT2922576 T PT 2922576T
- Authority
- PT
- Portugal
- Prior art keywords
- administering
- treatment
- methods
- hepatic encephalopathy
- nitrogen scavenging
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261728967P | 2012-11-21 | 2012-11-21 | |
| US201361759292P | 2013-01-31 | 2013-01-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2922576T true PT2922576T (pt) | 2018-01-24 |
Family
ID=50728524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT138574553T PT2922576T (pt) | 2012-11-21 | 2013-11-21 | Métodos de administração e avaliação de fármacos sequestradores de azoto para o tratamento de encefalopatia hepática |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9289406B2 (pt) |
| EP (2) | EP2922576B1 (pt) |
| JP (1) | JP2016506378A (pt) |
| KR (1) | KR20150086510A (pt) |
| CN (1) | CN104797272A (pt) |
| AU (1) | AU2013347905B2 (pt) |
| BR (1) | BR112015011778A2 (pt) |
| CA (1) | CA2891657A1 (pt) |
| CY (1) | CY1120163T1 (pt) |
| DK (1) | DK2922576T3 (pt) |
| ES (1) | ES2654774T3 (pt) |
| HK (2) | HK1210699A1 (pt) |
| HR (1) | HRP20180041T1 (pt) |
| HU (1) | HUE036133T2 (pt) |
| LT (1) | LT2922576T (pt) |
| PL (1) | PL2922576T3 (pt) |
| PT (1) | PT2922576T (pt) |
| RS (1) | RS56757B1 (pt) |
| SI (1) | SI2922576T1 (pt) |
| WO (1) | WO2014081977A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6144488B2 (ja) | 2009-04-03 | 2017-06-07 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテートおよびその製造方法 |
| ES2517340T3 (es) | 2009-06-08 | 2014-11-03 | Ucl Business Plc | Tratamiento de la hipertensión portal usando L-ornitina y fenilacetato |
| BR112014007357B1 (pt) | 2011-09-30 | 2022-12-06 | Immedica Pharma Ab | Método para determinar o ajuste da dosagem de um fármaco de varredura de nitrogênio |
| LT2846791T (lt) | 2012-04-20 | 2017-04-10 | Horizon Therapeutics, Llc | Hpn-100, skirtas naudoti azoto susilaikymo sutrikimų gydymui |
| SI2922576T1 (en) * | 2012-11-21 | 2018-04-30 | Horizon Therapeutics, Llc | Procedures for the administration and evaluation of medicines for the elimination of nitrogen for the treatment of hepatitis encephalopathy |
| AU2015353703B2 (en) | 2014-11-24 | 2021-04-01 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| AU2016308641B2 (en) | 2015-08-18 | 2022-02-03 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
| EP3621947A4 (en) | 2017-05-11 | 2021-03-10 | Ocera Therapeutics, Inc. | L-ORNITHINE PHENYLACETATE MANUFACTURING PROCESSES |
| US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
| IL303100A (en) * | 2020-12-01 | 2023-07-01 | Wellstat Therapeutics Corp | 5'-O-phenylacetyluridine and therapeutic use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4284647A (en) | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
| US4457942A (en) | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
| US5635532A (en) | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| CA2212047C (en) | 1995-02-07 | 2010-11-16 | Saul W. Brusilow | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders |
| US6219567B1 (en) | 1999-06-21 | 2001-04-17 | Cardiox Corporation | Monitoring of total ammoniacal concentration in blood |
| US20030195255A1 (en) | 2002-04-12 | 2003-10-16 | Summar Marshall L. | Method for treating hepatic encephalopathies |
| US20040229948A1 (en) * | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
| US20050273359A1 (en) | 2004-06-03 | 2005-12-08 | Young David E | System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure |
| CN1778963A (zh) * | 2004-11-23 | 2006-05-31 | 苏州艾杰生物科技有限公司 | 血氨含量测定方法及血氨诊断试剂盒 |
| ES2448549T3 (es) | 2004-11-26 | 2014-03-14 | Ucl Business Plc | Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatía hepática |
| US20060135612A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
| US20070004805A1 (en) | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
| WO2007059031A2 (en) | 2005-11-10 | 2007-05-24 | Massachusetts Institute Of Technology | Methods and compositions for raising levels and release of gamma aminobutyric acid |
| US8094521B2 (en) | 2007-02-28 | 2012-01-10 | Nightingale Products LLC | Caregiver personal alert device |
| WO2009087474A2 (en) | 2008-01-08 | 2009-07-16 | Akthelia Pharmaceuticals | Agonists for antimicrobial peptide systems |
| EP2330892B1 (en) | 2008-04-29 | 2016-06-29 | Horizon Therapeutics, Inc. | Methods of treatment using ammonia-scavenging drugs |
| TR201816616T4 (tr) * | 2008-08-29 | 2018-11-21 | Horizon Therapeutics Llc | Amonyak temizleyici ilaçlar kullanılan tedavi metotları. |
| EP2338050A1 (en) | 2008-08-29 | 2011-06-29 | Ucyclyd Pharma, Inc. | Dosing and monitoring patients on nitrogen-scavenging drugs |
| ES2546526T3 (es) * | 2009-07-24 | 2015-09-24 | Baylor College Of Medicine | Métodos de modulación de ácidos de cadena ramificada y usos de los mismos |
| US20130224277A1 (en) | 2010-08-31 | 2013-08-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation |
| BR112014007357B1 (pt) * | 2011-09-30 | 2022-12-06 | Immedica Pharma Ab | Método para determinar o ajuste da dosagem de um fármaco de varredura de nitrogênio |
| LT2846791T (lt) | 2012-04-20 | 2017-04-10 | Horizon Therapeutics, Llc | Hpn-100, skirtas naudoti azoto susilaikymo sutrikimų gydymui |
| SI2922576T1 (en) * | 2012-11-21 | 2018-04-30 | Horizon Therapeutics, Llc | Procedures for the administration and evaluation of medicines for the elimination of nitrogen for the treatment of hepatitis encephalopathy |
| US20150094278A1 (en) | 2013-09-30 | 2015-04-02 | Hyperion Therapeutics, Inc. | Methods of diagnosing, grading, monitoring, and treating hepatic encephalopathy |
| WO2015057747A1 (en) | 2013-10-14 | 2015-04-23 | Hyperion Therapeutics, Inc. | Methods of treating urea cycle disorders |
-
2013
- 2013-11-21 SI SI201330898T patent/SI2922576T1/en unknown
- 2013-11-21 JP JP2015544137A patent/JP2016506378A/ja active Pending
- 2013-11-21 ES ES13857455.3T patent/ES2654774T3/es active Active
- 2013-11-21 DK DK13857455.3T patent/DK2922576T3/en active
- 2013-11-21 EP EP13857455.3A patent/EP2922576B1/en active Active
- 2013-11-21 PT PT138574553T patent/PT2922576T/pt unknown
- 2013-11-21 HU HUE13857455A patent/HUE036133T2/hu unknown
- 2013-11-21 LT LTEP13857455.3T patent/LT2922576T/lt unknown
- 2013-11-21 EP EP17200153.9A patent/EP3335735A1/en not_active Withdrawn
- 2013-11-21 CA CA2891657A patent/CA2891657A1/en not_active Withdrawn
- 2013-11-21 CN CN201380061003.XA patent/CN104797272A/zh active Pending
- 2013-11-21 US US14/086,870 patent/US9289406B2/en active Active
- 2013-11-21 PL PL13857455T patent/PL2922576T3/pl unknown
- 2013-11-21 WO PCT/US2013/071333 patent/WO2014081977A1/en active Application Filing
- 2013-11-21 BR BR112015011778A patent/BR112015011778A2/pt not_active IP Right Cessation
- 2013-11-21 KR KR1020157016078A patent/KR20150086510A/ko not_active Application Discontinuation
- 2013-11-21 AU AU2013347905A patent/AU2013347905B2/en not_active Ceased
- 2013-11-21 RS RS20180035A patent/RS56757B1/sr unknown
-
2015
- 2015-11-19 HK HK15111438.0A patent/HK1210699A1/xx unknown
-
2016
- 2016-02-15 US US15/043,859 patent/US20160223520A1/en not_active Abandoned
- 2016-02-18 HK HK16101726.1A patent/HK1213778A1/zh not_active IP Right Cessation
-
2017
- 2017-08-08 US US15/672,196 patent/US20180017546A1/en not_active Abandoned
-
2018
- 2018-01-09 HR HRP20180041TT patent/HRP20180041T1/hr unknown
- 2018-01-25 CY CY20181100103T patent/CY1120163T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104797272A (zh) | 2015-07-22 |
| KR20150086510A (ko) | 2015-07-28 |
| WO2014081977A1 (en) | 2014-05-30 |
| CA2891657A1 (en) | 2014-05-30 |
| LT2922576T (lt) | 2018-02-12 |
| US9289406B2 (en) | 2016-03-22 |
| EP2922576A4 (en) | 2016-05-04 |
| RS56757B1 (sr) | 2018-04-30 |
| EP2922576A1 (en) | 2015-09-30 |
| EP2922576B1 (en) | 2017-11-08 |
| US20140142186A1 (en) | 2014-05-22 |
| ES2654774T3 (es) | 2018-02-15 |
| HK1213778A1 (zh) | 2016-07-15 |
| EP3335735A1 (en) | 2018-06-20 |
| SI2922576T1 (en) | 2018-04-30 |
| CY1120163T1 (el) | 2018-12-12 |
| HK1210699A1 (en) | 2016-05-06 |
| US20160223520A1 (en) | 2016-08-04 |
| AU2013347905A1 (en) | 2015-04-30 |
| PL2922576T3 (pl) | 2018-08-31 |
| JP2016506378A (ja) | 2016-03-03 |
| DK2922576T3 (en) | 2018-01-15 |
| HUE036133T2 (hu) | 2018-06-28 |
| AU2013347905B2 (en) | 2018-10-04 |
| BR112015011778A2 (pt) | 2017-07-11 |
| HRP20180041T1 (hr) | 2018-06-01 |
| US20180017546A1 (en) | 2018-01-18 |
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