PT2883966T - Impressão digital de mirna no diagnóstico de cancro do pulmão - Google Patents
Impressão digital de mirna no diagnóstico de cancro do pulmãoInfo
- Publication number
- PT2883966T PT2883966T PT141963108T PT14196310T PT2883966T PT 2883966 T PT2883966 T PT 2883966T PT 141963108 T PT141963108 T PT 141963108T PT 14196310 T PT14196310 T PT 14196310T PT 2883966 T PT2883966 T PT 2883966T
- Authority
- PT
- Portugal
- Prior art keywords
- diagnosis
- lung cancer
- mirna fingerprint
- mirna
- fingerprint
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/30—Unsupervised data analysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Data Mining & Analysis (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Software Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Databases & Information Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18445209P | 2009-06-05 | 2009-06-05 | |
US21397109P | 2009-08-03 | 2009-08-03 | |
US28752109P | 2009-12-17 | 2009-12-17 | |
EP09015668A EP2336353A1 (en) | 2009-12-17 | 2009-12-17 | miRNA fingerprints in the diagnosis of diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2883966T true PT2883966T (pt) | 2017-10-16 |
Family
ID=42470815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT141963108T PT2883966T (pt) | 2009-06-05 | 2010-06-07 | Impressão digital de mirna no diagnóstico de cancro do pulmão |
Country Status (10)
Country | Link |
---|---|
US (7) | US9758827B2 (pt) |
EP (9) | EP2336353A1 (pt) |
DK (1) | DK2883966T3 (pt) |
ES (1) | ES2642395T3 (pt) |
HK (1) | HK1252674A1 (pt) |
HU (1) | HUE035009T2 (pt) |
NO (1) | NO2883966T3 (pt) |
PL (1) | PL2883966T3 (pt) |
PT (1) | PT2883966T (pt) |
WO (3) | WO2010139811A1 (pt) |
Families Citing this family (84)
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US8415096B2 (en) | 2007-05-23 | 2013-04-09 | University Of South Florida | Micro-RNAs modulating immunity and inflammation |
WO2010099342A2 (en) * | 2009-02-25 | 2010-09-02 | Cepheid | Methods of detecting lung cancer |
WO2010124284A1 (en) * | 2009-04-24 | 2010-10-28 | Hemant Virkar | Methods for mapping data into lower dimensions |
EP2336353A1 (en) * | 2009-12-17 | 2011-06-22 | febit holding GmbH | miRNA fingerprints in the diagnosis of diseases |
CN102782155B (zh) * | 2009-12-24 | 2016-05-04 | 复旦大学 | 用于肺癌的血浆中微rna表达谱分析的组合物和方法 |
US20120015830A1 (en) * | 2010-06-21 | 2012-01-19 | Diogenix, Inc. | Microrna profiles for evaluating multiple sclerosis |
BR112013001136B1 (pt) | 2010-07-16 | 2020-12-15 | Stichting Vumc | Processos de análise para a presença de um marcador de câncer, do estágio da doença ou da eficácia de um tratamento de câncer, e dispositivo para diagnóstico de câncer |
US20120107825A1 (en) | 2010-11-01 | 2012-05-03 | Winger Edward E | Methods and compositions for assessing patients with reproductive failure using immune cell-derived microrna |
EP2655660A2 (en) * | 2010-12-22 | 2013-10-30 | Herlev Hospital | Microrna for diagnosis of pancreatic cancer |
CN102127548A (zh) * | 2010-12-28 | 2011-07-20 | 浙江大学 | 单链非编码MicroRNA二及其用途 |
EP2505663A1 (en) * | 2011-03-30 | 2012-10-03 | IFOM Fondazione Istituto Firc di Oncologia Molecolare | A method to identify asymptomatic high-risk individuals with early stage lung cancer by means of detecting miRNAs in biologic fluids |
CN103703142A (zh) | 2011-01-26 | 2014-04-02 | 西菲伊德公司 | 检测肺癌的方法 |
EP2668288B1 (en) * | 2011-01-28 | 2016-01-20 | Comprehensive Biomarker Center GmbH | Complex mirna sets as novel biomarkers for lung diseases |
US20120214682A1 (en) * | 2011-01-28 | 2012-08-23 | Bigwood Douglas W | Microrna signatures indicative of immunomodulating therapy for multiple sclerosis |
CN102643812B (zh) * | 2011-02-18 | 2016-02-10 | 中国科学院上海药物研究所 | 人miR-1227的反义寡聚核苷酸及其应用 |
CA2830461C (en) * | 2011-03-18 | 2021-06-29 | Thomas Wurdinger | A method of analysing a blood sample of a subject for the presence of a disease marker |
US20140031258A1 (en) * | 2011-03-28 | 2014-01-30 | The Johns Hopkins University | Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac) |
JP6011945B2 (ja) * | 2011-05-20 | 2016-10-25 | 公一 中城 | マイクロrna又はその発現系を含む組成物 |
WO2012168448A2 (en) * | 2011-06-08 | 2012-12-13 | Febit Holding Gmbh | Complex sets of mirnas as non-invasive biomarkers for dilated cardiomyopathy |
CN102851282B (zh) * | 2011-06-30 | 2014-10-08 | 上海市肿瘤研究所 | 用于区分原发性肺癌与癌旁组织的microRNA标志物 |
CN102250904B (zh) * | 2011-07-13 | 2013-11-13 | 中国科学技术大学 | 一种预防和/或治疗黑色素瘤的药物 |
DE102011108254A1 (de) * | 2011-07-22 | 2013-01-24 | RUHR-UNIVERSITäT BOCHUM | Pantumormarker |
US20130059753A1 (en) * | 2011-09-01 | 2013-03-07 | Holy and Undivided Trinity of Queen Elizabeth, near Dublin | Global Analysis of Serum microRNAs as Potential Biomarkers for Lung Adenocarcinoma |
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US9745578B2 (en) | 2011-11-30 | 2017-08-29 | Cedars-Sinai Medical Center | Targeting microRNA miR-409-3P to treat prostate cancer |
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US9447471B2 (en) | 2011-12-29 | 2016-09-20 | Quest Diagnostics Investments Incorporated | Microrna profiling for diagnosis of dysplastic nevi and melanoma |
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CN102676526B (zh) * | 2012-05-16 | 2013-05-29 | 北京旷博生物技术有限公司 | 乳腺癌分子标志物miR-30c-1-3p |
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CN103045597B (zh) * | 2013-01-11 | 2014-06-11 | 南京大学 | 微小核苷酸hsa-miR-1909及其应用 |
CN103305602A (zh) * | 2013-03-08 | 2013-09-18 | 深圳市人民医院 | 一种基于液相芯片检测痰液microRNAs用于早期肺癌诊断的方法 |
KR20150069375A (ko) * | 2013-12-13 | 2015-06-23 | 연세대학교 산학협력단 | 줄기세포로부터 연골세포로의 분화 촉진용 조성물 |
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PL406989A1 (pl) | 2014-01-29 | 2015-08-03 | Gdański Uniwersytet Medyczny | Profil mikro RNA we krwi jako test wykrywania raka płuca |
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KR20180132748A (ko) * | 2016-04-01 | 2018-12-12 | 도레이 카부시키가이샤 | 악성 뇌종양의 검출 키트 또는 디바이스 및 검출 방법 |
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KR101721811B1 (ko) * | 2016-12-28 | 2017-03-30 | 경북대학교 산학협력단 | microRNA-30b, microRNA-133a 또는 microRNA-202-5p의 억제제를 포함하는 항암용 약학적 조성물 |
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CN111096639B (zh) * | 2018-10-10 | 2021-10-15 | 童小鸾 | 一种服装用的机械衣架 |
CN109207599A (zh) * | 2018-11-12 | 2019-01-15 | 觅瑞(杭州)生物科技有限公司 | 一种用于非小细胞肺癌诊断的外周血miRNA标志物 |
CN109224076B (zh) * | 2018-11-14 | 2021-11-19 | 苏州吉玛基因股份有限公司 | 与肺癌诊疗相关的基因miR-140-3P及其mimics和应用 |
CN111197070A (zh) * | 2018-11-16 | 2020-05-26 | 南京迈西可生物科技有限公司 | 鉴定rna分子中2`-o-甲基化修饰的方法及其应用 |
US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
EP4022094A4 (en) * | 2019-08-26 | 2022-11-30 | Liquid Lung DX | BIOMARKERS FOR DIAGNOSIS OF LUNG CANCER |
JP7473941B2 (ja) * | 2019-11-07 | 2024-04-24 | 学校法人産業医科大学 | 中皮腫の診断補助方法及び診断用キット |
KR102288359B1 (ko) * | 2019-12-06 | 2021-08-10 | 주식회사 레피겐엠디 | 면역력 감소에 의한 질병의 발병 위험 예측용 다중 유전자 마커 및 이를 이용한 질병의 발병 위험 예측 방법 |
EP3862441A3 (en) * | 2020-02-04 | 2021-10-27 | Artemisia S.p.A. | Method for the early diagnosis of cancer by means of ddpcr analysis of mirna and protein markers in liquid biopsy |
EP3862442A3 (en) * | 2020-02-04 | 2021-10-27 | Artemisia S.p.A. | Method for the early diagnosis of cancer by means of ddpcr analysis of mirna in liquid biopsy |
CN112501295B (zh) * | 2020-12-01 | 2023-03-31 | 上海米然生物科技有限公司 | miRNA组合、含其的试剂盒及在肺癌诊断中的应用 |
CN111793692A (zh) * | 2020-08-04 | 2020-10-20 | 中国科学院昆明动物研究所 | 一种特征miRNA表达谱组合及肺鳞癌早期预测方法 |
US20220073992A1 (en) * | 2020-11-24 | 2022-03-10 | Hossein Abdul Tehrani Abdul Tehrani | Diagnosis of chronic kidney disease (ckd) and its subgroups |
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