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PT2755483T - Indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização de wnt/β-catenina - Google Patents

Indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização de wnt/β-catenina

Info

Publication number
PT2755483T
PT2755483T PT12830938T PT12830938T PT2755483T PT 2755483 T PT2755483 T PT 2755483T PT 12830938 T PT12830938 T PT 12830938T PT 12830938 T PT12830938 T PT 12830938T PT 2755483 T PT2755483 T PT 2755483T
Authority
PT
Portugal
Prior art keywords
wnt
carboxamides
indazole
signaling pathway
pathway inhibitors
Prior art date
Application number
PT12830938T
Other languages
English (en)
Inventor
Hood John
Kumar Kc Sunil
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of PT2755483T publication Critical patent/PT2755483T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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PT12830938T 2011-09-14 2012-09-13 Indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização de wnt/β-catenina PT2755483T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161534601P 2011-09-14 2011-09-14
US201261624646P 2012-04-16 2012-04-16

Publications (1)

Publication Number Publication Date
PT2755483T true PT2755483T (pt) 2019-02-18

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PT12830938T PT2755483T (pt) 2011-09-14 2012-09-13 Indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização de wnt/β-catenina

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Country Link
US (6) US9221793B2 (pt)
EP (2) EP2755483B1 (pt)
JP (2) JP2014526510A (pt)
KR (1) KR102010611B1 (pt)
CN (2) CN109705097B (pt)
AU (2) AU2012308570B2 (pt)
BR (1) BR112014006127A2 (pt)
CA (1) CA2848659C (pt)
CL (1) CL2014000642A1 (pt)
CO (1) CO6940416A2 (pt)
CY (1) CY1122795T1 (pt)
DK (1) DK2755483T3 (pt)
ES (1) ES2711777T3 (pt)
HR (1) HRP20190281T1 (pt)
HU (1) HUE041576T2 (pt)
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