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PT2656843E - Ésteres de bendamustina e compostos relacionados e a sua utilização médica - Google Patents

Ésteres de bendamustina e compostos relacionados e a sua utilização médica Download PDF

Info

Publication number
PT2656843E
PT2656843E PT121657282T PT12165728T PT2656843E PT 2656843 E PT2656843 E PT 2656843E PT 121657282 T PT121657282 T PT 121657282T PT 12165728 T PT12165728 T PT 12165728T PT 2656843 E PT2656843 E PT 2656843E
Authority
PT
Portugal
Prior art keywords
bendamustine
esters
related compounds
medical use
medical
Prior art date
Application number
PT121657282T
Other languages
English (en)
Inventor
Günther Bernhardt
Helmut Schickaneder
Armin Buschauer
Christian Schickaneder
Michael Limmert
Stefan Huber
Original Assignee
Helmut Schickaneder
Christians Schickaneder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmut Schickaneder, Christians Schickaneder filed Critical Helmut Schickaneder
Publication of PT2656843E publication Critical patent/PT2656843E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
PT121657282T 2012-04-26 2012-04-26 Ésteres de bendamustina e compostos relacionados e a sua utilização médica PT2656843E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12165728.2A EP2656843B1 (en) 2012-04-26 2012-04-26 Esters of bendamustine and related compounds, and medical use thereof

Publications (1)

Publication Number Publication Date
PT2656843E true PT2656843E (pt) 2015-04-14

Family

ID=46045872

Family Applications (1)

Application Number Title Priority Date Filing Date
PT121657282T PT2656843E (pt) 2012-04-26 2012-04-26 Ésteres de bendamustina e compostos relacionados e a sua utilização médica

Country Status (8)

Country Link
US (1) US8809549B2 (pt)
EP (1) EP2656843B1 (pt)
DK (1) DK2656843T3 (pt)
ES (1) ES2535511T3 (pt)
HR (1) HRP20150436T1 (pt)
PL (1) PL2656843T3 (pt)
PT (1) PT2656843E (pt)
SI (1) SI2656843T1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2875455C (en) * 2012-06-19 2020-03-10 Helmut Schickaneder Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy
WO2014075035A1 (en) * 2012-11-12 2014-05-15 Cephalon, Inc. Bendamustine derivatives and methods of using same
PT3130592T (pt) 2014-04-10 2019-11-21 Hubei Bio Pharmaceutical Industrial Tech Institute Inc Análogos do composto 4h-pirazolo[1,5-]benzimidazole como inibidores de parp
CA3013237A1 (en) * 2016-02-24 2017-08-31 Acesion Pharma Aps Novel potassium channel inhibitors
WO2019068904A1 (en) 2017-10-05 2019-04-11 Tube Pharmaceuticals Gmbh ORAL ADMINISTRATION OF BENDAMUSTINE FORMULATIONS

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
NZ592626A (en) * 2008-10-08 2013-03-28 Cephalon Inc Processes for the preparation of bendamustine
JP5778037B2 (ja) 2008-12-03 2015-09-16 アステラス ドイチュランド ゲゼルシャフト ミット ベシュレンクテルハフツング ベンダムスチンの経口投与剤
CN101691359B (zh) 2009-09-30 2011-04-13 深圳万乐药业有限公司 一种高纯度的盐酸苯达莫司汀的合成方法
WO2011079193A2 (en) * 2009-12-23 2011-06-30 Dr. Reddy's Laboratories Ltd. Preparation of bendamustine and its salts
JO3659B1 (ar) 2010-06-02 2020-08-27 Astellas Deutschland Gmbh أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية
DE102010055499A1 (de) 2010-12-22 2011-06-16 W.C. Heraeus Gmbh Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon

Also Published As

Publication number Publication date
EP2656843B1 (en) 2015-03-18
US8809549B2 (en) 2014-08-19
PL2656843T3 (pl) 2015-08-31
HRP20150436T1 (hr) 2015-05-22
EP2656843A1 (en) 2013-10-30
US20130289032A1 (en) 2013-10-31
DK2656843T3 (en) 2015-04-20
ES2535511T3 (es) 2015-05-12
SI2656843T1 (sl) 2015-06-30

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