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PT2516434E - Pirrolidinonas heteroaromáticas fundidas como inibidores de syk - Google Patents

Pirrolidinonas heteroaromáticas fundidas como inibidores de syk Download PDF

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Publication number
PT2516434E
PT2516434E PT108008350T PT10800835T PT2516434E PT 2516434 E PT2516434 E PT 2516434E PT 108008350 T PT108008350 T PT 108008350T PT 10800835 T PT10800835 T PT 10800835T PT 2516434 E PT2516434 E PT 2516434E
Authority
PT
Portugal
Prior art keywords
fused heteroaromatic
syk inhibitors
pyrrolidinones
heteroaromatic pyrrolidinones
syk
Prior art date
Application number
PT108008350T
Other languages
English (en)
Inventor
Qing Dong
Yasuyoshi Arikawa
Benjamin Jones
Betty Lam
Zhe Nie
Christopher Smith
Masashi Takahashi
Victoria Feher
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43618073&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2516434(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PT2516434E publication Critical patent/PT2516434E/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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  • Pain & Pain Management (AREA)
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  • Transplantation (AREA)
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  • Ophthalmology & Optometry (AREA)
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PT108008350T 2009-12-23 2010-12-17 Pirrolidinonas heteroaromáticas fundidas como inibidores de syk PT2516434E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28996909P 2009-12-23 2009-12-23
US38696410P 2010-09-27 2010-09-27

Publications (1)

Publication Number Publication Date
PT2516434E true PT2516434E (pt) 2015-10-05

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PT108008350T PT2516434E (pt) 2009-12-23 2010-12-17 Pirrolidinonas heteroaromáticas fundidas como inibidores de syk

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US (7) US9181255B2 (pt)
EP (4) EP3489236B1 (pt)
JP (7) JP5658274B2 (pt)
KR (1) KR101790255B1 (pt)
CN (1) CN102753548B (pt)
AR (1) AR081797A1 (pt)
AU (1) AU2010333804B2 (pt)
BR (1) BR112012015651B1 (pt)
CA (1) CA2786950C (pt)
CL (1) CL2012001745A1 (pt)
CO (1) CO6592058A2 (pt)
CR (1) CR20120392A (pt)
CY (1) CY1116736T1 (pt)
DK (1) DK2516434T3 (pt)
DO (1) DOP2012000180A (pt)
EA (1) EA021568B1 (pt)
EC (1) ECSP12012057A (pt)
ES (1) ES2545616T3 (pt)
GE (1) GEP20156243B (pt)
HK (1) HK1176054A1 (pt)
HR (1) HRP20150878T1 (pt)
HU (1) HUE025177T2 (pt)
IL (1) IL220509A (pt)
JO (1) JO3108B1 (pt)
MA (1) MA33909B1 (pt)
ME (1) ME02186B (pt)
MX (1) MX2012007402A (pt)
MY (1) MY159257A (pt)
NZ (1) NZ601267A (pt)
PE (1) PE20130188A1 (pt)
PL (1) PL2516434T3 (pt)
PT (1) PT2516434E (pt)
RS (1) RS54180B1 (pt)
SG (1) SG181857A1 (pt)
SI (1) SI2516434T1 (pt)
SM (1) SMT201500199B (pt)
TN (1) TN2012000316A1 (pt)
TW (1) TWI457339B (pt)
UA (1) UA107100C2 (pt)
UY (1) UY33151A (pt)
WO (1) WO2011079051A1 (pt)
ZA (1) ZA201205428B (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3489236B1 (en) 2009-12-23 2020-09-30 Takeda Pharmaceutical Company Limited Process for the preparation of fused heteroaromatic pyrrolidinones
KR20140020972A (ko) * 2011-03-28 2014-02-19 에프. 호프만-라 로슈 아게 티아졸로피리미딘 화합물
WO2012177714A1 (en) 2011-06-22 2012-12-27 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
EP2900243A4 (en) * 2012-09-27 2016-04-13 Portola Pharm Inc BICYCLIC OXA LACTAM KINASE HEMMER
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