PT2435410T - Resumo - Google Patents

Resumo

Info

Publication number: PT2435410T
Authority: PT; Portugal
Prior art keywords: lxr modulators; lxr; modulators
Prior art date: 2009-05-28

Application number

PT107219024T

Other languages

English (en)

Inventor

B Busch Brett

C Stevens William Jr

K Kick Ellen

Zhang Haiying

Bollu Venkataiah

Martin Richard

Mohan Raju

Original Assignee

Bristol Myers Squibb Co

Exelixis Patent Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-05-28

Filing date

2010-05-26

Publication date

2017-05-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43223342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2435410(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-05-26 Application filed by Bristol Myers Squibb Co, Exelixis Patent Co Llc filed Critical Bristol Myers Squibb Co

2017-05-03 Publication of PT2435410T publication Critical patent/PT2435410T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Toxicology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT107219024T 2009-05-28 2010-05-26 Resumo PT2435410T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US18173609P	2009-05-28	2009-05-28

Publications (1)

Publication Number	Publication Date
PT2435410T true PT2435410T (pt)	2017-05-03

Family

ID=43223342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT107219024T PT2435410T (pt)	2009-05-28	2010-05-26	Resumo

Country Status (30)

Country	Link
US (4)	US8618154B2 (pt)
EP (1)	EP2435410B1 (pt)
JP (1)	JP5625050B2 (pt)
KR (1)	KR101676704B1 (pt)
CN (1)	CN102648184B (pt)
AR (1)	AR078049A1 (pt)
AU (1)	AU2010254082B2 (pt)
BR (1)	BRPI1013259B8 (pt)
CA (1)	CA2761934C (pt)
CL (1)	CL2011002972A1 (pt)
CO (1)	CO6470826A2 (pt)
CY (1)	CY1119407T1 (pt)
DK (1)	DK2435410T3 (pt)
EA (1)	EA019960B1 (pt)
ES (1)	ES2620451T3 (pt)
HR (1)	HRP20170194T1 (pt)
IL (1)	IL216176A (pt)
LT (1)	LT2435410T (pt)
MX (1)	MX2011012559A (pt)
MY (1)	MY153958A (pt)
NZ (1)	NZ596330A (pt)
PE (1)	PE20120797A1 (pt)
PL (1)	PL2435410T3 (pt)
PT (1)	PT2435410T (pt)
SG (1)	SG176247A1 (pt)
SI (1)	SI2435410T1 (pt)
TN (1)	TN2011000585A1 (pt)
TW (1)	TWI488844B (pt)
WO (1)	WO2010138598A2 (pt)
ZA (1)	ZA201108181B (pt)

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CN102648184B (zh) *	2009-05-28	2015-09-30	埃克塞利希斯专利有限责任公司	Lxr调节剂
TW201242953A (en)	2011-03-25	2012-11-01	Bristol Myers Squibb Co	Imidazole prodrug LXR modulators
EP2820013B9 (en)	2012-03-02	2019-01-09	Ralexar Therapeutics, Inc.	Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
AU2013302861A1 (en)	2012-08-13	2015-03-05	The Rockefeller University	Treatment and diagnosis of melanoma
CN105209039B (zh) *	2013-03-15	2018-06-22	百时美施贵宝公司	Lxr调节剂
US9751869B2 (en)	2013-03-15	2017-09-05	Bristol-Myers Squibb Company	LXR modulators
CA2923178A1 (en)	2013-09-04	2015-03-12	Alexar Therapeutics, Inc.	Liver x receptor (lxr) modulators for the treatment of dermal diseases, disorders and conditions
NZ717688A (en)	2013-09-04	2021-07-30	Ellora Therapeutics Inc	Liver x receptor (lxr) modulators
AU2015204572B2 (en)	2014-01-10	2020-07-30	Inspirna, Inc.	LXR agonists and uses thereof
KR101815734B1 (ko)	2015-05-29	2018-01-05	가톨릭대학교 산학협력단	ｍｉＲ－７, ｍｉＲ－１８ａ 또는 ｍｉＲ－１８ｂ를 유효성분으로 포함하는 대사성 질환의 예방 또는 치료용 약학적 조성물
AU2017207291B2 (en)	2016-01-11	2023-06-15	The Rockefeller University	Methods for the treatment of myeloid derived suppressor cells related disorders
WO2019104062A1 (en)	2017-11-21	2019-05-31	Rgenix, Inc.	Polymorphs and uses thereof
EP3999055A1 (en)	2019-07-15	2022-05-25	Novartis AG	Methods for treating meibomian gland dysfunction with liver x receptor agonists
CN110305141B (zh) *	2019-07-18	2022-01-11	深圳市三启药物开发有限公司	一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用
US11174220B2 (en)	2019-12-13	2021-11-16	Inspirna, Inc.	Metal salts and uses thereof

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SG162803A1 (en) *	2005-06-27	2010-07-29	Exelixis Inc	Imidazole based lxr modulators
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CN102648184B (zh) *	2009-05-28	2015-09-30	埃克塞利希斯专利有限责任公司	Lxr调节剂

2010
- 2010-05-26 CN CN201080033601.2A patent/CN102648184B/zh active Active
- 2010-05-26 AU AU2010254082A patent/AU2010254082B2/en active Active
- 2010-05-26 KR KR1020117031397A patent/KR101676704B1/ko active IP Right Grant
- 2010-05-26 WO PCT/US2010/036211 patent/WO2010138598A2/en active Application Filing
- 2010-05-26 BR BRPI1013259A patent/BRPI1013259B8/pt active IP Right Grant
- 2010-05-26 SG SG2011087459A patent/SG176247A1/en unknown
- 2010-05-26 LT LTEP10721902.4T patent/LT2435410T/lt unknown
- 2010-05-26 PT PT107219024T patent/PT2435410T/pt unknown
- 2010-05-26 ES ES10721902.4T patent/ES2620451T3/es active Active
- 2010-05-26 SI SI201031427A patent/SI2435410T1/sl unknown
- 2010-05-26 US US13/319,937 patent/US8618154B2/en active Active
- 2010-05-26 EA EA201171488A patent/EA019960B1/ru not_active IP Right Cessation
- 2010-05-26 MX MX2011012559A patent/MX2011012559A/es active IP Right Grant
- 2010-05-26 PE PE2011002005A patent/PE20120797A1/es active IP Right Grant
- 2010-05-26 EP EP10721902.4A patent/EP2435410B1/en active Active
- 2010-05-26 PL PL10721902T patent/PL2435410T3/pl unknown
- 2010-05-26 NZ NZ596330A patent/NZ596330A/xx unknown
- 2010-05-26 DK DK10721902.4T patent/DK2435410T3/da active
- 2010-05-26 CA CA2761934A patent/CA2761934C/en active Active
- 2010-05-26 MY MYPI2011006278A patent/MY153958A/en unknown
- 2010-05-26 JP JP2012513215A patent/JP5625050B2/ja active Active
- 2010-05-28 TW TW099117252A patent/TWI488844B/zh active
- 2010-05-28 AR ARP100101870A patent/AR078049A1/es not_active Application Discontinuation
2011
- 2011-11-07 IL IL216176A patent/IL216176A/en active IP Right Grant
- 2011-11-08 ZA ZA2011/08181A patent/ZA201108181B/en unknown
- 2011-11-16 TN TNP2011000585A patent/TN2011000585A1/en unknown
- 2011-11-24 CL CL2011002972A patent/CL2011002972A1/es unknown
- 2011-11-25 CO CO11161736A patent/CO6470826A2/es active IP Right Grant
2013
- 2013-11-21 US US14/085,926 patent/US20140163081A1/en not_active Abandoned
2015
- 2015-05-04 US US14/703,247 patent/US20150299136A1/en not_active Abandoned
2016
- 2016-06-07 US US15/175,425 patent/US20160280661A1/en not_active Abandoned
2017
- 2017-02-06 HR HRP20170194TT patent/HRP20170194T1/hr unknown
- 2017-04-05 CY CY20171100403T patent/CY1119407T1/el unknown

Also Published As

Publication number	Publication date
US20140163081A1 (en)	2014-06-12
ZA201108181B (en)	2013-01-30
IL216176A (en)	2015-10-29
CO6470826A2 (es)	2012-06-29
HRP20170194T1 (hr)	2017-05-19
CY1119407T1 (el)	2018-03-07
US20150299136A1 (en)	2015-10-22
TN2011000585A1 (en)	2013-05-24
MX2011012559A (es)	2012-06-08
SG176247A1 (en)	2012-01-30
CL2011002972A1 (es)	2012-08-17
EA201171488A1 (ru)	2012-07-30
KR20120047868A (ko)	2012-05-14
CN102648184B (zh)	2015-09-30
CN102648184A (zh)	2012-08-22
CA2761934C (en)	2018-01-09
BRPI1013259B1 (pt)	2021-04-13
BRPI1013259A2 (pt)	2016-04-05
KR101676704B1 (ko)	2016-11-16
LT2435410T (lt)	2017-04-10
IL216176A0 (en)	2012-01-31
EA019960B1 (ru)	2014-07-30
WO2010138598A3 (en)	2011-07-28
BRPI1013259B8 (pt)	2021-05-25
JP2012528180A (ja)	2012-11-12
TW201109308A (en)	2011-03-16
WO2010138598A2 (en)	2010-12-02
EP2435410B1 (en)	2017-01-18
US20120071534A1 (en)	2012-03-22
EP2435410A2 (en)	2012-04-04
PE20120797A1 (es)	2012-07-08
US8618154B2 (en)	2013-12-31
TWI488844B (zh)	2015-06-21
PL2435410T3 (pl)	2017-07-31
JP5625050B2 (ja)	2014-11-12
SI2435410T1 (sl)	2017-06-30
AR078049A1 (es)	2011-10-12
CA2761934A1 (en)	2010-12-02
DK2435410T3 (da)	2017-04-10
AU2010254082B2 (en)	2015-01-29
AU2010254082A1 (en)	2011-12-08
ES2620451T3 (es)	2017-06-28
MY153958A (en)	2015-04-30
US20160280661A1 (en)	2016-09-29
NZ596330A (en)	2013-07-26

Publication	Publication Date	Title
IL218770A0 (en)	2012-06-28	Novel modulators
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EP2452438A4 (en)	2013-10-23	DELTA-SIGMA-DELTA MODULATOR
EP2414891A4 (en)	2013-02-27	ELECTROCHROME DEVICES
EP2453295A4 (en)	2012-09-26	OPTICAL MODULATOR
GB0922066D0 (en)	2010-02-03	Modulator
DK2464943T3 (en)	2020-07-13	Systemintegration
GB0906217D0 (en)	2009-05-20	Footbaths
GB2485290B (en)	2016-04-20	Gear set
GB0902147D0 (en)	2009-03-25	NMNAT2 modulator
GB0916889D0 (en)	2009-11-11	Splice variants
AU4924P (en)	2014-09-22	Bonscablue Scaevola aemula
GB0900167D0 (en)	2009-02-11	B b
GB0903335D0 (en)	2009-04-08	Concept three
PL117926U1 (pl)	2010-07-19	Książka edukacyjna-zeszyt
GB0902441D0 (en)	2009-04-01	Corcost-t11
GB0909471D0 (en)	2009-07-15	DoorDevelopment2
GB0900672D0 (en)	2009-02-25	Clip-m
GB0901192D0 (en)	2009-03-11	Seaid
GB0902739D0 (en)	2009-04-01	Kayline
GB0916629D0 (en)	2009-11-04	Balloon-grip
GB0903732D0 (en)	2009-04-15	Switchcase
GB0903794D0 (en)	2009-04-15	Scopesights
GB0904107D0 (en)	2009-04-22	WebHook
GB0905422D0 (en)	2009-05-13	Cushchair