PT1988910T - Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação - Google Patents
Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparaçãoInfo
- Publication number
- PT1988910T PT1988910T PT77520963T PT07752096T PT1988910T PT 1988910 T PT1988910 T PT 1988910T PT 77520963 T PT77520963 T PT 77520963T PT 07752096 T PT07752096 T PT 07752096T PT 1988910 T PT1988910 T PT 1988910T
- Authority
- PT
- Portugal
- Prior art keywords
- acryloyloxyethylphosphorylcholine
- preparation
- containing polymer
- polymer conjugates
- conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77691606P | 2006-02-28 | 2006-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1988910T true PT1988910T (pt) | 2018-02-07 |
Family
ID=38459678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT77520963T PT1988910T (pt) | 2006-02-28 | 2007-02-28 | Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação |
Country Status (9)
Country | Link |
---|---|
US (5) | US20100166700A1 (pt) |
EP (2) | EP1988910B1 (pt) |
JP (2) | JP5528710B2 (pt) |
DK (1) | DK1988910T3 (pt) |
ES (1) | ES2657628T3 (pt) |
LT (1) | LT1988910T (pt) |
PT (1) | PT1988910T (pt) |
SI (1) | SI1988910T1 (pt) |
WO (2) | WO2007100905A2 (pt) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
DK1988910T3 (en) | 2006-02-28 | 2018-01-22 | Kodiak Sciences Inc | ACRYLOYLOXYETHYLPHOSPHORYLCHOLINE-CONTAINING POLYMER CONJUGATES AND PREPARATION thereof |
EP2334334A1 (en) | 2008-09-19 | 2011-06-22 | Nektar Therapeutics | Polymer conjugates of nesiritide peptides |
EP2260873B1 (en) * | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylation of proteins |
WO2011075185A1 (en) * | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
KR20170137938A (ko) * | 2010-04-15 | 2017-12-13 | 올리가시스 | 고분자량 쌍성이온-함유 중합체 |
CN101870735B (zh) * | 2010-06-02 | 2013-06-12 | 北京精益泰翔技术发展有限公司 | 一种新型高糖基化促红细胞生成素免疫融合蛋白 |
WO2012061165A2 (en) * | 2010-10-25 | 2012-05-10 | Lu Xiandan Sharon | Methods and compositions for improving admet properties |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
KR20190112175A (ko) | 2010-12-01 | 2019-10-02 | 앨더바이오 홀딩스 엘엘씨 | 항―ngf 조성물 및 그의 용도 |
BR112014003240A2 (pt) * | 2011-08-12 | 2017-03-01 | Ascendis Pharma As | composição de prostaciclina com liberação sustentada |
JP6195848B2 (ja) * | 2012-01-27 | 2017-09-13 | ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアThe Regents Of The University Of California | 糖ポリマーを用いた生体分子の安定化 |
JP6542128B2 (ja) | 2013-01-11 | 2019-07-10 | コルセア ファーマ インコーポレイテッド | トレプロスチニルのプロドラッグ |
US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
PT3041513T (pt) | 2013-09-08 | 2020-09-07 | Kodiak Sciences Inc | Conjugados de polímeros zwiteriónicos com fator viii |
US9840553B2 (en) * | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
WO2016061562A2 (en) | 2014-10-17 | 2016-04-21 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
JP6802157B2 (ja) | 2014-11-26 | 2020-12-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | タンパク質送達のためのステルス性ナノカプセル |
US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
EP4056590A1 (en) | 2015-08-24 | 2022-09-14 | GlaxoSmithKline Intellectual Property (No.2) Limited | Biopharmaceutical compositions |
KR20180104635A (ko) * | 2015-12-30 | 2018-09-21 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
US9695138B1 (en) | 2016-10-17 | 2017-07-04 | Acenda Pharma, Inc. | Phenothiazine derivatives and methods of use thereof |
WO2018191548A2 (en) | 2017-04-14 | 2018-10-18 | Kodiak Sciences Inc. | Complement factor d antagonist antibodies and conjugates thereof |
WO2019169341A1 (en) * | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
WO2020176547A1 (en) | 2019-02-25 | 2020-09-03 | Ginkgo Bioworks, Inc. | Biosynthesis of cannabinoids and cannabinoid precursors |
CN110627937B (zh) * | 2019-09-27 | 2021-03-30 | 西北大学 | 仿细胞膜聚合物的制备方法、及其修饰壳聚糖-金自组装载药纳米粒子的制备方法和应用 |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
CN111978390B (zh) * | 2020-08-31 | 2022-10-14 | 上海景泽生物技术有限公司 | 聚乙二醇修饰的rhBNP及其用途 |
WO2022255479A1 (ja) * | 2021-06-04 | 2022-12-08 | タグシクス・バイオ株式会社 | 中分子化合物の血中動態改善のための中分子化合物コンジュゲート体およびその製造方法 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5162218A (en) | 1988-11-18 | 1992-11-10 | The Regents Of The University Of California | Conjugated polypeptides and methods for their preparation |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
GB9324033D0 (en) | 1993-11-23 | 1994-01-12 | Biocompatibles Ltd | Ethylenically unsaturated compounds |
US6541580B1 (en) | 1995-03-31 | 2003-04-01 | Carnegie Mellon University | Atom or group transfer radical polymerization |
US5763548A (en) | 1995-03-31 | 1998-06-09 | Carnegie-Mellon University | (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization |
US5807937A (en) | 1995-11-15 | 1998-09-15 | Carnegie Mellon University | Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties |
US5789487A (en) | 1996-07-10 | 1998-08-04 | Carnegie-Mellon University | Preparation of novel homo- and copolymers using atom transfer radical polymerization |
US7125938B2 (en) | 1997-03-11 | 2006-10-24 | Carnegie Mellon University | Atom or group transfer radical polymerization |
EP2133421A1 (en) | 1997-10-16 | 2009-12-16 | University Of Georgia Research Foundation, Inc. | Transgenic birds and protein production in the egg white |
DE69932320T2 (de) | 1998-01-30 | 2007-07-12 | Albemarle Corp. | Maleimide enthaltende fotopolymerisierbare zusammensetzungen und verfahren zu deren verwendung |
US6121371A (en) | 1998-07-31 | 2000-09-19 | Carnegie Mellon University | Application of atom transfer radical polymerization to water-borne polymerization systems |
US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
AU4195100A (en) * | 1999-04-05 | 2000-10-23 | Research Foundation Of State University Of New York, The | Graft, graft-block, block-graft, and star-shaped copolymers and methods of making them |
CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
US7049373B2 (en) | 1999-08-06 | 2006-05-23 | Carnegie Mellon University | Process for preparation of graft polymers |
GB9928956D0 (en) * | 1999-12-07 | 2000-02-02 | Malik Navid | Internally supported biomimetic coating systems |
IL144815A (en) | 2000-08-11 | 2005-07-25 | Sumitomo Chemical Co | Process for producing carbonyl or hydroxy compound |
AU2002211467A1 (en) | 2000-10-06 | 2002-04-15 | Carnegie-Mellon University | Preparation of nanocomposite structures by controlled polymerization |
US6852816B2 (en) | 2000-10-06 | 2005-02-08 | Biocompatibles Uk Limited | Zwitterionic polymers |
AU2001296670A1 (en) | 2000-10-06 | 2002-04-15 | Carnegie-Mellon University | A catalyst system for controlled polymerization |
WO2002028913A2 (en) | 2000-10-06 | 2002-04-11 | Carnegie Mellon University | Polymerization process for ionic monomers |
WO2002060978A1 (fr) * | 2001-01-30 | 2002-08-08 | Kyowa Hakko Kogyo Co., Ltd. | Polyalkylene glycols ramifies |
ATE470647T1 (de) | 2001-04-06 | 2010-06-15 | Univ Carnegie Mellon | Verfahren zur herstellung von nanostrukturierten materialien |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US20040253596A1 (en) | 2001-08-27 | 2004-12-16 | Michael Pawlak | Bioanalytical recognition surface with optimized recognition element density |
WO2003031480A2 (en) | 2001-10-12 | 2003-04-17 | Carnegie Mellon University | Process for monomer sequence control in polymerizations |
US6759491B2 (en) | 2001-10-12 | 2004-07-06 | Carnegie Mellon University | Simultaneous reverse and normal initiation of ATRP |
WO2003033521A1 (en) | 2001-10-16 | 2003-04-24 | Massachusetts Institute Of Technology | Inppressor trna system in mammalian cells for the introduction of unnatural amino acids in polypeptides. |
WO2003040211A2 (en) * | 2001-11-07 | 2003-05-15 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
EP1465933B1 (en) | 2002-01-16 | 2007-08-29 | Biocompatibles UK Limited | Polymer conjugates |
EP1480680B1 (en) * | 2002-03-07 | 2010-11-03 | Biocompatibles UK Limited | Block copolymers complexed with nucleic acids |
AU2003214387A1 (en) * | 2002-03-07 | 2003-09-16 | Biocompatibles Uk Limited | Drug carriers comprising amphiphilic block copolymers |
JP4248189B2 (ja) | 2002-04-09 | 2009-04-02 | 株式会社資生堂 | ホスホリルコリン基含有多糖類及びその製造方法 |
US20050180945A1 (en) | 2002-05-21 | 2005-08-18 | Chaikof Elliot L. | Multivalent polymers with chan-terminating binding groups |
WO2004014963A2 (en) | 2002-08-09 | 2004-02-19 | Carnegie Mellon University | Polymers, supersoft elastomers and methods for preparing the same |
EP1556090A1 (en) | 2002-09-25 | 2005-07-27 | Biocompatibles UK Limited | Polymer compositions for administration to animals |
BR0316048B1 (pt) | 2002-11-07 | 2014-01-28 | Copolímero com estrutura controlada e utilização de um copolímero | |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
US9040664B2 (en) * | 2003-04-11 | 2015-05-26 | Antriabio, Inc. | Materials and methods for preparing protein-polymer conjugates |
GB0314472D0 (en) * | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
KR20120073370A (ko) * | 2003-09-17 | 2012-07-04 | 넥타르 테라퓨틱스 | 다분지형 고분자 전구약물 |
CA2549730C (en) | 2003-12-16 | 2012-02-14 | Nektar Therapeutics Al, Corporation | Chemically modified small molecules |
US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
US7214759B2 (en) | 2004-11-24 | 2007-05-08 | Advanced Cardiovascular Systems, Inc. | Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same |
US20070005130A1 (en) * | 2005-06-29 | 2007-01-04 | Thierry Glauser | Biodegradable polymer for coating |
JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Glp−1のポリマ複合体 |
US7906134B2 (en) | 2005-12-21 | 2011-03-15 | Abbott Laboratories | Room temperature-curable polymers |
DK1988910T3 (en) | 2006-02-28 | 2018-01-22 | Kodiak Sciences Inc | ACRYLOYLOXYETHYLPHOSPHORYLCHOLINE-CONTAINING POLYMER CONJUGATES AND PREPARATION thereof |
WO2008064058A2 (en) | 2006-11-21 | 2008-05-29 | Abbott Laboratories | Use of a terpolymer of tetrafluoroethylene, hexafluoropropylene, and vinylidene fluoride in drug eluting coatings |
WO2008098930A1 (en) * | 2007-02-14 | 2008-08-21 | Biocompatibes Uk Limited | Derivatisation of biological molecules |
AU2008226823B2 (en) | 2007-03-12 | 2014-03-13 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
AU2008226791B2 (en) | 2007-03-12 | 2014-01-16 | Nektar Therapeutics | Oligomer-antihistamine conjugates |
JP2010117189A (ja) | 2008-11-12 | 2010-05-27 | Sumitomo Bakelite Co Ltd | 生理活性物質固定化用基板 |
CA2745302A1 (en) | 2008-12-12 | 2010-06-17 | University Of Massachusetts | Zwitterionic polymers with therapeutic moieties |
US20100158850A1 (en) | 2008-12-23 | 2010-06-24 | The Regents Of The University Of Michigan | Dendrimer based modular platforms |
EP2260873B1 (en) * | 2009-06-08 | 2019-07-24 | Biocompatibles UK Limited | Pcylation of proteins |
WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
KR20170137938A (ko) | 2010-04-15 | 2017-12-13 | 올리가시스 | 고분자량 쌍성이온-함유 중합체 |
WO2013059137A1 (en) | 2011-10-17 | 2013-04-25 | Oligasis | High molecular weight zwitterion-containing polymers |
-
2007
- 2007-02-28 DK DK07752096.3T patent/DK1988910T3/en active
- 2007-02-28 SI SI200731999T patent/SI1988910T1/en unknown
- 2007-02-28 JP JP2008557399A patent/JP5528710B2/ja active Active
- 2007-02-28 ES ES07752096.3T patent/ES2657628T3/es active Active
- 2007-02-28 WO PCT/US2007/005381 patent/WO2007100905A2/en active Application Filing
- 2007-02-28 EP EP07752096.3A patent/EP1988910B1/en active Active
- 2007-02-28 EP EP17165316.5A patent/EP3222142A1/en active Pending
- 2007-02-28 PT PT77520963T patent/PT1988910T/pt unknown
- 2007-02-28 US US12/281,071 patent/US20100166700A1/en not_active Abandoned
- 2007-02-28 WO PCT/US2007/005372 patent/WO2007100902A2/en active Application Filing
- 2007-02-28 LT LTEP07752096.3T patent/LT1988910T/lt unknown
-
2013
- 2013-08-05 US US13/959,563 patent/US8846021B2/en active Active
- 2013-11-13 JP JP2013235314A patent/JP5745009B2/ja active Active
-
2014
- 2014-08-11 US US14/456,875 patent/US20150050714A1/en not_active Abandoned
-
2019
- 2019-05-28 US US16/424,265 patent/US20200000930A1/en not_active Abandoned
-
2021
- 2021-12-16 US US17/553,605 patent/US20220096643A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK1988910T3 (en) | 2018-01-22 |
SI1988910T1 (en) | 2018-02-28 |
EP1988910A2 (en) | 2008-11-12 |
LT1988910T (lt) | 2018-01-10 |
JP2009532330A (ja) | 2009-09-10 |
US20150050714A1 (en) | 2015-02-19 |
US8846021B2 (en) | 2014-09-30 |
WO2007100902A3 (en) | 2008-11-20 |
WO2007100902A2 (en) | 2007-09-07 |
WO2007100905A2 (en) | 2007-09-07 |
JP5528710B2 (ja) | 2014-06-25 |
US20130337534A1 (en) | 2013-12-19 |
WO2007100905A3 (en) | 2008-10-16 |
EP1988910A4 (en) | 2013-03-06 |
EP3222142A1 (en) | 2017-09-27 |
US20200000930A1 (en) | 2020-01-02 |
JP5745009B2 (ja) | 2015-07-08 |
EP1988910B1 (en) | 2017-12-06 |
JP2014043456A (ja) | 2014-03-13 |
ES2657628T3 (es) | 2018-03-06 |
US20100166700A1 (en) | 2010-07-01 |
US20220096643A1 (en) | 2022-03-31 |
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