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PT1960352E - Derivados de 2-adamantilureia como inibidores seletivos de 11â-hsd1 - Google Patents

Derivados de 2-adamantilureia como inibidores seletivos de 11â-hsd1

Info

Publication number
PT1960352E
PT1960352E PT68187095T PT06818709T PT1960352E PT 1960352 E PT1960352 E PT 1960352E PT 68187095 T PT68187095 T PT 68187095T PT 06818709 T PT06818709 T PT 06818709T PT 1960352 E PT1960352 E PT 1960352E
Authority
PT
Portugal
Prior art keywords
hsd1 inhibitors
adamantylurea
derivatives
selective
disorders
Prior art date
Application number
PT68187095T
Other languages
English (en)
Inventor
Denis Carniato
Christine Charon
Bjoern Hock
Johannes Gleitz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PT1960352E publication Critical patent/PT1960352E/pt

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    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
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    • C07C2603/58—Ring systems containing bridged rings containing three rings
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PT68187095T 2005-12-16 2006-11-22 Derivados de 2-adamantilureia como inibidores seletivos de 11â-hsd1 PT1960352E (pt)

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AU2006326703A1 (en) 2007-06-21
EA017923B1 (ru) 2013-04-30
JP5356825B2 (ja) 2013-12-04
KR101394586B1 (ko) 2014-05-12
AR058546A1 (es) 2008-02-13
EP1960352B1 (en) 2013-08-07
US8466200B2 (en) 2013-06-18
ZA200806148B (en) 2009-06-24
PL1960352T3 (pl) 2013-12-31
CY1114660T1 (el) 2016-10-05
US20090227631A1 (en) 2009-09-10
CN101331114B (zh) 2013-08-07
CN101331114A (zh) 2008-12-24
DK1960352T3 (da) 2013-10-28
AU2006326703B2 (en) 2012-02-23
KR20080079317A (ko) 2008-08-29
BRPI0619839B1 (pt) 2021-01-12
ES2434077T3 (es) 2013-12-13
US8188288B2 (en) 2012-05-29
IL192053A0 (en) 2008-12-29
SI1960352T1 (sl) 2013-12-31
WO2007068330A1 (en) 2007-06-21
BRPI0619839B8 (pt) 2021-05-25
BRPI0619839A2 (pt) 2011-10-18
EP1960352A1 (en) 2008-08-27
EA200801426A1 (ru) 2008-10-30
CA2633186C (en) 2014-08-12
IL192053A (en) 2014-01-30

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