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PT1222159E - Intermediarios de fabricacao de um derivado de tipo benzofurano ou benzotiofeno nitrado em posicao 5 e as suas utilizacoes - Google Patents

Intermediarios de fabricacao de um derivado de tipo benzofurano ou benzotiofeno nitrado em posicao 5 e as suas utilizacoes

Info

Publication number
PT1222159E
PT1222159E PT00971474T PT00971474T PT1222159E PT 1222159 E PT1222159 E PT 1222159E PT 00971474 T PT00971474 T PT 00971474T PT 00971474 T PT00971474 T PT 00971474T PT 1222159 E PT1222159 E PT 1222159E
Authority
PT
Portugal
Prior art keywords
nitrated
benzofuran
benzoyophene
utilizations
intermediaries
Prior art date
Application number
PT00971474T
Other languages
English (en)
Inventor
Thierry Schlama
Armand Mettling
Philippe Karrer
Original Assignee
Rhodia Chimie Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodia Chimie Sa filed Critical Rhodia Chimie Sa
Publication of PT1222159E publication Critical patent/PT1222159E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06Preparation of nitro compounds
    • C07C201/12Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT00971474T 1999-10-21 2000-10-23 Intermediarios de fabricacao de um derivado de tipo benzofurano ou benzotiofeno nitrado em posicao 5 e as suas utilizacoes PT1222159E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9913250A FR2800067B1 (fr) 1999-10-21 1999-10-21 Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations

Publications (1)

Publication Number Publication Date
PT1222159E true PT1222159E (pt) 2005-08-31

Family

ID=9551278

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00971474T PT1222159E (pt) 1999-10-21 2000-10-23 Intermediarios de fabricacao de um derivado de tipo benzofurano ou benzotiofeno nitrado em posicao 5 e as suas utilizacoes

Country Status (15)

Country Link
US (2) US6855842B1 (pt)
EP (1) EP1222159B1 (pt)
JP (1) JP2003512347A (pt)
CN (1) CN1268601C (pt)
AT (1) ATE296795T1 (pt)
AU (1) AU1032401A (pt)
BR (1) BR0014808A (pt)
CA (1) CA2387713A1 (pt)
DE (1) DE60020587T2 (pt)
DK (1) DK1222159T3 (pt)
ES (1) ES2239623T3 (pt)
FR (1) FR2800067B1 (pt)
HU (1) HUP0203188A3 (pt)
PT (1) PT1222159E (pt)
WO (1) WO2001028974A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555697B1 (en) * 1999-10-21 2003-04-29 Rhodia Chimie Method of preparing a benzofuran or benzothiophene compound
IL146389A0 (en) 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
DE10237819A1 (de) * 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
TW201111354A (en) 2009-05-27 2011-04-01 Sanofi Aventis Process for the production of Dronedarone intermediates
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
CN101948455B (zh) * 2010-10-18 2012-11-14 山东邹平大展新材料有限公司 一种2-正丁基-3-(4-羟基苯甲酰基)-5-硝基苯并呋喃的制备方法
WO2012120544A2 (en) 2011-03-10 2012-09-13 Sun Pharmaceutical Industries Ltd. PROCESS FOR N-[2-n-BUTYL-3-[4-[3-(DI-n-BUTYLAMINO) PROPOXY]ENZOYL]BENZOFURAN-5-YL]METHANESULFONAMIDE HYDROCHLORIDE
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN115847629B (zh) * 2022-11-30 2023-09-29 江苏富乐徳石英科技有限公司 一种高效节能环保的石英环制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5659718A (en) * 1979-10-19 1981-05-23 Ihara Chem Ind Co Ltd Preparation of substituted phenoxycarboxylic acid derivative
DE3031738A1 (de) * 1980-08-22 1982-04-01 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur herstellung von benzo (b) thiophen-derivaten und ihre verwendung als zwischenprodukte
US4537984A (en) * 1983-05-19 1985-08-27 Nissan Chemical Industries Ltd. Process for producing 2-(4-hydroxyphenoxy) propionate derivatives
PL152990B1 (pl) * 1987-06-20 1991-02-28 Sposób wytwarzania kwasu 2-(o-formylofenoksy) heksanowego
FR2665444B1 (fr) * 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
KR19990076876A (ko) * 1995-12-29 1999-10-25 스티븐 베네티아너 비트로넥틴 수용체 길항제

Also Published As

Publication number Publication date
WO2001028974A3 (fr) 2001-12-06
CN1379754A (zh) 2002-11-13
US20050113596A1 (en) 2005-05-26
HUP0203188A3 (en) 2003-04-28
ATE296795T1 (de) 2005-06-15
WO2001028974A2 (fr) 2001-04-26
FR2800067A1 (fr) 2001-04-27
DE60020587D1 (de) 2005-07-07
DK1222159T3 (da) 2005-08-08
BR0014808A (pt) 2002-06-11
US6855842B1 (en) 2005-02-15
AU1032401A (en) 2001-04-30
CN1268601C (zh) 2006-08-09
EP1222159B1 (fr) 2005-06-01
ES2239623T3 (es) 2005-10-01
FR2800067B1 (fr) 2004-12-17
DE60020587T2 (de) 2005-11-10
CA2387713A1 (fr) 2001-04-26
JP2003512347A (ja) 2003-04-02
EP1222159A2 (fr) 2002-07-17
HUP0203188A2 (hu) 2003-03-28

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