PT1028954E - Imidazoles substituidos uteis no tratamento de doencas inflamatorias - Google Patents
Imidazoles substituidos uteis no tratamento de doencas inflamatoriasInfo
- Publication number
- PT1028954E PT1028954E PT98918463T PT98918463T PT1028954E PT 1028954 E PT1028954 E PT 1028954E PT 98918463 T PT98918463 T PT 98918463T PT 98918463 T PT98918463 T PT 98918463T PT 1028954 E PT1028954 E PT 1028954E
- Authority
- PT
- Portugal
- Prior art keywords
- substituidos
- uteis
- imidazoles
- treatment
- inflammatory diseases
- Prior art date
Links
- 150000002460 imidazoles Chemical class 0.000 title 1
- 208000027866 inflammatory disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4425297P | 1997-04-24 | 1997-04-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1028954E true PT1028954E (pt) | 2003-11-28 |
Family
ID=21931339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98918463T PT1028954E (pt) | 1997-04-24 | 1998-04-17 | Imidazoles substituidos uteis no tratamento de doencas inflamatorias |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US5965583A (pt) |
| EP (1) | EP1028954B1 (pt) |
| JP (1) | JP2001522357A (pt) |
| KR (1) | KR100568438B1 (pt) |
| CN (1) | CN1211381C (pt) |
| AR (1) | AR012594A1 (pt) |
| AT (1) | ATE244234T1 (pt) |
| AU (1) | AU7138298A (pt) |
| BR (1) | BR9808998A (pt) |
| CA (1) | CA2297176A1 (pt) |
| DE (1) | DE69816109T2 (pt) |
| DK (1) | DK1028954T3 (pt) |
| ES (1) | ES2202840T3 (pt) |
| HU (1) | HUP0002842A3 (pt) |
| IL (1) | IL132318A0 (pt) |
| NO (1) | NO318937B1 (pt) |
| NZ (1) | NZ500447A (pt) |
| PL (1) | PL191111B1 (pt) |
| PT (1) | PT1028954E (pt) |
| RU (1) | RU2222534C2 (pt) |
| TR (1) | TR199902622T2 (pt) |
| UA (1) | UA65572C2 (pt) |
| WO (1) | WO1998047892A1 (pt) |
| ZA (1) | ZA983451B (pt) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
| EP0956018A4 (en) | 1996-08-21 | 2000-01-12 | Smithkline Beecham Corp | IMIDAZOLE COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE |
| DK1028954T3 (da) | 1997-04-24 | 2003-10-27 | Ortho Mcneil Pharm Inc | Substituerede imidazoler egnede til behandling af inflammatoriske sygdomme |
| JP2002504909A (ja) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | 新規な置換ピラゾールおよびピラゾリン化合物 |
| EP0994870A4 (en) | 1997-06-19 | 2002-10-23 | Smithkline Beecham | NEW IMIDAZOLE COMPOUNDS SUBSTITUTED BY AN ARYLOXYREST |
| GB9713726D0 (en) | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6251914B1 (en) | 1997-07-02 | 2001-06-26 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| JP2001518507A (ja) | 1997-10-08 | 2001-10-16 | スミスクライン・ビーチャム・コーポレイション | 新規シクロアルケニル置換化合物 |
| DE69821132T2 (de) * | 1997-10-27 | 2004-10-21 | Takeda Chemical Industries Ltd | 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes |
| WO1999032121A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
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| CA2949004A1 (en) | 2014-05-16 | 2015-11-19 | Atriva Therapeutics Gmbh | Novel anti-infective strategy against influenza virus and s. aureus coinfections |
| CN107074831B (zh) | 2014-08-25 | 2020-12-08 | 永辉药业 | Mapk抑制剂 |
| MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| KR20200066655A (ko) | 2017-10-05 | 2020-06-10 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | DUX4의 발현을 저감시키기 위한 p38 저해제의 용도 |
| TW201936190A (zh) | 2017-10-30 | 2019-09-16 | 加拿大商艾普托斯生物科學公司 | 用於治療癌症之芳基咪唑 |
| WO2020035482A1 (en) | 2018-08-13 | 2020-02-20 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
| AR123011A1 (es) | 2020-07-20 | 2022-10-19 | Annexon Inc | Inhibidores de factores del complemento y usos de los mismos |
| WO2023280911A1 (en) | 2021-07-06 | 2023-01-12 | Westfälische Wilhelms-Universität Münster | P38-inhibitors for the treatment of coronavirus infections and/or covid-19 cytokine storm |
| WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2963572D1 (en) * | 1978-04-11 | 1982-10-21 | Ciba Geigy Ag | Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions |
| DD201677A5 (de) * | 1980-07-25 | 1983-08-03 | Ciba Geigy | Verfahren zur herstellung von trisubstituierten imidazolderivaten |
| US4503065A (en) * | 1982-08-03 | 1985-03-05 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl 1-2-halo imidazoles |
| US5646281A (en) * | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Certain 4-piperidino- and piperazinomethyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
| IL104369A0 (en) * | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| DK1028954T3 (da) | 1997-04-24 | 2003-10-27 | Ortho Mcneil Pharm Inc | Substituerede imidazoler egnede til behandling af inflammatoriske sygdomme |
-
1998
- 1998-04-17 DK DK98918463T patent/DK1028954T3/da active
- 1998-04-17 AU AU71382/98A patent/AU7138298A/en not_active Abandoned
- 1998-04-17 AT AT98918463T patent/ATE244234T1/de not_active IP Right Cessation
- 1998-04-17 CN CNB988045230A patent/CN1211381C/zh not_active Expired - Fee Related
- 1998-04-17 KR KR1019997009785A patent/KR100568438B1/ko not_active IP Right Cessation
- 1998-04-17 RU RU99122164/04A patent/RU2222534C2/ru not_active IP Right Cessation
- 1998-04-17 PT PT98918463T patent/PT1028954E/pt unknown
- 1998-04-17 WO PCT/US1998/007910 patent/WO1998047892A1/en not_active Application Discontinuation
- 1998-04-17 US US09/062,304 patent/US5965583A/en not_active Expired - Lifetime
- 1998-04-17 HU HU0002842A patent/HUP0002842A3/hu unknown
- 1998-04-17 IL IL13231898A patent/IL132318A0/xx not_active IP Right Cessation
- 1998-04-17 NZ NZ500447A patent/NZ500447A/en unknown
- 1998-04-17 EP EP98918463A patent/EP1028954B1/en not_active Expired - Lifetime
- 1998-04-17 BR BR9808998-6A patent/BR9808998A/pt not_active Application Discontinuation
- 1998-04-17 PL PL336758A patent/PL191111B1/pl not_active IP Right Cessation
- 1998-04-17 JP JP54623198A patent/JP2001522357A/ja not_active Withdrawn
- 1998-04-17 TR TR1999/02622T patent/TR199902622T2/xx unknown
- 1998-04-17 ES ES98918463T patent/ES2202840T3/es not_active Expired - Lifetime
- 1998-04-17 UA UA99105811A patent/UA65572C2/uk unknown
- 1998-04-17 DE DE69816109T patent/DE69816109T2/de not_active Expired - Fee Related
- 1998-04-17 CA CA002297176A patent/CA2297176A1/en not_active Abandoned
- 1998-04-23 ZA ZA9803451A patent/ZA983451B/xx unknown
- 1998-04-23 AR ARP980101886A patent/AR012594A1/es not_active Application Discontinuation
-
1999
- 1999-04-20 US US09/295,156 patent/US6214830B1/en not_active Expired - Lifetime
- 1999-10-19 NO NO19995095A patent/NO318937B1/no unknown
-
2000
- 2000-11-03 US US09/705,508 patent/US6521655B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1028954B1 (en) | 2003-07-02 |
| PL336758A1 (en) | 2000-07-17 |
| CN1253558A (zh) | 2000-05-17 |
| DK1028954T3 (da) | 2003-10-27 |
| ATE244234T1 (de) | 2003-07-15 |
| US6214830B1 (en) | 2001-04-10 |
| TR199902622T2 (xx) | 2000-05-22 |
| ES2202840T3 (es) | 2004-04-01 |
| NZ500447A (en) | 2001-09-28 |
| BR9808998A (pt) | 2000-08-08 |
| RU2222534C2 (ru) | 2004-01-27 |
| DE69816109D1 (de) | 2003-08-07 |
| WO1998047892A1 (en) | 1998-10-29 |
| KR100568438B1 (ko) | 2006-04-07 |
| UA65572C2 (en) | 2004-04-15 |
| DE69816109T2 (de) | 2004-04-22 |
| NO318937B1 (no) | 2005-05-30 |
| EP1028954A1 (en) | 2000-08-23 |
| ZA983451B (en) | 1999-10-25 |
| NO995095D0 (no) | 1999-10-19 |
| HUP0002842A2 (hu) | 2001-06-28 |
| KR20010020204A (ko) | 2001-03-15 |
| CA2297176A1 (en) | 1998-10-29 |
| AR012594A1 (es) | 2000-11-08 |
| CN1211381C (zh) | 2005-07-20 |
| NO995095L (no) | 1999-12-09 |
| PL191111B1 (pl) | 2006-03-31 |
| US6521655B1 (en) | 2003-02-18 |
| AU7138298A (en) | 1998-11-13 |
| IL132318A0 (en) | 2001-03-19 |
| US5965583A (en) | 1999-10-12 |
| HUP0002842A3 (en) | 2002-01-28 |
| JP2001522357A (ja) | 2001-11-13 |
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