PL440687A1 - Low molecular weight compound for use in treatment of spinocerebellar ataxia type 3 - Google Patents
Low molecular weight compound for use in treatment of spinocerebellar ataxia type 3Info
- Publication number
- PL440687A1 PL440687A1 PL440687A PL44068722A PL440687A1 PL 440687 A1 PL440687 A1 PL 440687A1 PL 440687 A PL440687 A PL 440687A PL 44068722 A PL44068722 A PL 44068722A PL 440687 A1 PL440687 A1 PL 440687A1
- Authority
- PL
- Poland
- Prior art keywords
- treatment
- molecular weight
- spinocerebellar ataxia
- low molecular
- ataxia type
- Prior art date
Links
- 208000002569 Machado-Joseph Disease Diseases 0.000 title abstract 2
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 title abstract 2
- 150000003384 small molecules Chemical class 0.000 title 1
- SCKXBVLYWLLALY-CZCYGEDCSA-N (3e,5e)-3,5-bis[(4-fluoro-3-nitrophenyl)methylidene]-1-prop-2-enoylazepan-4-one Chemical compound C1=C(F)C([N+](=O)[O-])=CC(\C=C/2C(C(=C/C=3C=C(C(F)=CC=3)[N+]([O-])=O)/CN(CC\2)C(=O)C=C)=O)=C1 SCKXBVLYWLLALY-CZCYGEDCSA-N 0.000 abstract 1
- 108010064641 ONX 0912 Proteins 0.000 abstract 1
- 229960001467 bortezomib Drugs 0.000 abstract 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 abstract 1
- 229960002438 carfilzomib Drugs 0.000 abstract 1
- 108010021331 carfilzomib Proteins 0.000 abstract 1
- BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- SWZXEVABPLUDIO-WSZYKNRRSA-N n-[(2s)-3-methoxy-1-[[(2s)-3-methoxy-1-[[(2s)-1-[(2r)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide Chemical compound N([C@@H](COC)C(=O)N[C@@H](COC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)[C@]1(C)OC1)C(=O)C1=CN=C(C)S1 SWZXEVABPLUDIO-WSZYKNRRSA-N 0.000 abstract 1
- 229950005750 oprozomib Drugs 0.000 abstract 1
- -1 small molecule compound Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Przedmiotem zgłoszenia jest związek niskocząsteczkowy do zastosowania w leczeniu ataksji rdzeniowo-móżdżkowej typu 3, przy czym związek ten jest wybrany spośród bortezomibu, karfilzomibu, VLX1570 lub oprozomibu.The subject of the application is a small molecule compound for use in the treatment of spinocerebellar ataxia type 3, the compound being selected from bortezomib, carfilzomib, VLX1570 or oprozomib.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440687A PL440687A1 (en) | 2022-03-18 | 2022-03-18 | Low molecular weight compound for use in treatment of spinocerebellar ataxia type 3 |
| EP23722102.3A EP4493205A1 (en) | 2022-03-18 | 2023-03-17 | A low molecular weight compound for use in the treatment of spinocerebellar ataxia type 3 |
| PCT/PL2023/050017 WO2023177314A1 (en) | 2022-03-18 | 2023-03-17 | A low molecular weight compound for use in the treatment of spinocerebellar ataxia type 3 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL440687A PL440687A1 (en) | 2022-03-18 | 2022-03-18 | Low molecular weight compound for use in treatment of spinocerebellar ataxia type 3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL440687A1 true PL440687A1 (en) | 2023-09-25 |
Family
ID=86329479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL440687A PL440687A1 (en) | 2022-03-18 | 2022-03-18 | Low molecular weight compound for use in treatment of spinocerebellar ataxia type 3 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4493205A1 (en) |
| PL (1) | PL440687A1 (en) |
| WO (1) | WO2023177314A1 (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8999289B2 (en) * | 2005-03-22 | 2015-04-07 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
-
2022
- 2022-03-18 PL PL440687A patent/PL440687A1/en unknown
-
2023
- 2023-03-17 EP EP23722102.3A patent/EP4493205A1/en active Pending
- 2023-03-17 WO PCT/PL2023/050017 patent/WO2023177314A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP4493205A1 (en) | 2025-01-22 |
| WO2023177314A1 (en) | 2023-09-21 |
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