PL376821A1 - Sposoby zwiększania produkcji polipeptydów - Google Patents
Sposoby zwiększania produkcji polipeptydówInfo
- Publication number
- PL376821A1 PL376821A1 PL376821A PL37682103A PL376821A1 PL 376821 A1 PL376821 A1 PL 376821A1 PL 376821 A PL376821 A PL 376821A PL 37682103 A PL37682103 A PL 37682103A PL 376821 A1 PL376821 A1 PL 376821A1
- Authority
- PL
- Poland
- Prior art keywords
- methods
- polypeptide production
- increasing polypeptide
- increasing
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36824802P | 2002-03-27 | 2002-03-27 | |
US36824602P | 2002-03-27 | 2002-03-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL376821A1 true PL376821A1 (pl) | 2006-01-09 |
Family
ID=28678222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL376821A PL376821A1 (pl) | 2002-03-27 | 2003-03-27 | Sposoby zwiększania produkcji polipeptydów |
Country Status (9)
Country | Link |
---|---|
US (2) | US6872549B2 (pl) |
EP (1) | EP1497444B1 (pl) |
JP (3) | JP2005521401A (pl) |
AU (1) | AU2003220529B2 (pl) |
CA (1) | CA2480121C (pl) |
ES (1) | ES2557741T3 (pl) |
MX (1) | MXPA04009381A (pl) |
PL (1) | PL376821A1 (pl) |
WO (1) | WO2003083066A2 (pl) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050005310A1 (en) * | 1999-07-12 | 2005-01-06 | Genentech, Inc. | Expression vectors and methods |
MXPA04009381A (es) * | 2002-03-27 | 2005-01-25 | Immunex Corp | Metodos para incrementar la produccion de polipeptidos. |
EP1567658A2 (en) * | 2002-11-14 | 2005-08-31 | Genentech, Inc. | Intron fusion construct and method of using for selecting high-expressing production cell lines |
US20040265964A1 (en) * | 2003-04-25 | 2004-12-30 | Martin Allen | Inducers of recombinant protein expression |
US20050112194A1 (en) * | 2003-08-21 | 2005-05-26 | Duchesnay Inc. | Micronutrient supplement dispensing package |
WO2005018652A1 (en) * | 2003-08-21 | 2005-03-03 | Duchesnay Inc. | Micronutrient supplement |
EP1697414A2 (en) * | 2003-12-23 | 2006-09-06 | Applied Research Systems ARS Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
US20080311078A1 (en) | 2005-06-14 | 2008-12-18 | Gokarn Yatin R | Self-Buffering Protein Formulations |
WO2007049567A1 (ja) * | 2005-10-24 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 物質の製造方法 |
BRPI0622251A2 (pt) | 2005-12-20 | 2011-07-19 | Bristol-Myers Squibb Company | método para obtenção de uma composição compreendendo uma população isolada de moléculas de ctla4-ig de um meio de cultura lìquido e para isolamento de uma composição compreendendo moléculas de ctla4-ig e composição |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
EP3438131B1 (en) * | 2006-02-10 | 2022-03-16 | Life Technologies Corporation | Oligosaccharide modification and labeling of proteins |
WO2008082436A2 (en) * | 2006-08-14 | 2008-07-10 | Biocontrol Systems, Inc. | Method for detecting pathogens |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
AU2007294731B2 (en) | 2006-09-13 | 2014-04-17 | Abbvie Inc. | Cell culture improvements |
US8357514B2 (en) * | 2007-03-28 | 2013-01-22 | Medarex, Inc. | Methods of gene amplification and expression |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
US20090023186A1 (en) * | 2007-07-22 | 2009-01-22 | Excellgene Sa | Use of valproic acid for enhancing production of recombinant proteins in mammalian cells |
JP2011512877A (ja) * | 2008-03-12 | 2011-04-28 | ワイス・エルエルシー | 組換えタンパク質の大スケール産生に適した細胞を同定する方法 |
IN2012DN05169A (pl) * | 2009-12-02 | 2015-10-23 | Acceleron Pharma Inc | |
CN103080221B (zh) | 2010-09-30 | 2015-11-25 | 大金工业株式会社 | 防熔滴剂以及树脂组合物 |
JP6001456B2 (ja) * | 2010-12-28 | 2016-10-05 | 中外製薬株式会社 | 動物細胞の培養方法 |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
CA2952347A1 (en) | 2011-07-01 | 2013-01-10 | Amgen Inc. | Mammalian cell culture |
EP2653548A1 (de) | 2012-04-17 | 2013-10-23 | Greenovation Biotech GmbH | Verfahren zur Erhöhung der Sekretion rekombinanter Proteine |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
WO2014035475A1 (en) | 2012-09-02 | 2014-03-06 | Abbvie Inc. | Methods to control protein heterogeneity |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
EP2970888A4 (en) * | 2013-03-15 | 2017-04-12 | Theocorp Holding Co., LLC | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
AU2017345490B2 (en) | 2016-10-21 | 2022-07-07 | Amgen Inc. | Pharmaceutical formulations and methods of making the same |
KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
EP3702365A4 (en) * | 2017-10-23 | 2021-11-10 | Progen Co., Ltd. | MODIFIED EGF PROTEIN, ITS PRODUCTION PROCESS AND ITS USE |
WO2022140389A1 (en) | 2020-12-22 | 2022-06-30 | Amgen Inc. | Cell culture method |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3824286A (en) * | 1970-07-07 | 1974-07-16 | Lever Brothers Ltd | Preparation of polyacetylalkylene diamines |
EP0005476B1 (de) * | 1978-05-17 | 1981-12-30 | Dr. Karl Thomae GmbH | Verfahren zur Herstellung von Humaninterferon |
US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
US4357422A (en) * | 1980-08-14 | 1982-11-02 | Massachusetts Institute Of Technology | Method of enhancing interferon production |
US4416986A (en) * | 1981-01-16 | 1983-11-22 | Merck & Co., Inc. | Methods of producing HBsAg |
US4473647A (en) * | 1981-02-27 | 1984-09-25 | Amf Inc. | Tissue culture medium |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
US4992472A (en) * | 1987-06-16 | 1991-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | Chemical differentiating agents |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
AU643427B2 (en) | 1988-10-31 | 1993-11-18 | Immunex Corporation | Interleukin-4 receptors |
US5330744A (en) * | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
ZA899421B (en) | 1988-12-14 | 1990-09-26 | Merrell Dow Pharma | Method of potentiating natural killer cell activity |
IL94611A (en) * | 1989-06-05 | 1994-12-29 | Organogenesis Inc | Medium for cell cultures containing insulin or growth factor similar to insulin, transferrin or iron ion, triiodothyronine or thyroxine and method of use |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
EP0417563B1 (de) | 1989-09-12 | 2000-07-05 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
CA2146559A1 (en) | 1992-10-23 | 1994-05-11 | Melanie K. Spriggs | Methods of preparing soluble, oligomeric proteins |
US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US20010010922A1 (en) | 1994-06-09 | 2001-08-02 | Riccardo Dalla-Favera | Cloning and uses of the genetic locus bcl-6 |
US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
DK1666591T3 (da) | 1995-06-29 | 2011-05-23 | Immunex Corp | Cytokin der inducerer apoptose |
JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
WO1998028010A2 (en) | 1996-12-24 | 1998-07-02 | Hyal Pharmaceutical Corporation | Use of moieties for binding to hyaluronan and icam-1 |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
AU1663599A (en) | 1997-12-19 | 1999-07-12 | Novo Nordisk A/S | Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents |
US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
WO2000020576A2 (en) | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Methods and compositions for inducing differentiation and apotosis in cells that overexpess the notch protein |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
US6506598B1 (en) * | 1999-04-26 | 2003-01-14 | Genentech, Inc. | Cell culture process |
DK1222298T3 (da) | 1999-10-13 | 2006-04-10 | Immunex Corp | Vektorer og fremgangsmåder til rekombinant proteinekspression |
WO2001036637A1 (en) | 1999-11-17 | 2001-05-25 | Immunex Corporation | Receptor activator of nf-kappa b |
WO2001083525A2 (en) | 2000-05-03 | 2001-11-08 | Amgen Inc. | Modified peptides, comprising an fc domain, as therapeutic agents |
MXPA04009381A (es) * | 2002-03-27 | 2005-01-25 | Immunex Corp | Metodos para incrementar la produccion de polipeptidos. |
-
2003
- 2003-03-27 MX MXPA04009381A patent/MXPA04009381A/es active IP Right Grant
- 2003-03-27 WO PCT/US2003/009266 patent/WO2003083066A2/en active IP Right Grant
- 2003-03-27 US US10/400,334 patent/US6872549B2/en not_active Expired - Lifetime
- 2003-03-27 JP JP2003580502A patent/JP2005521401A/ja active Pending
- 2003-03-27 CA CA2480121A patent/CA2480121C/en not_active Expired - Fee Related
- 2003-03-27 EP EP03716840.8A patent/EP1497444B1/en not_active Expired - Lifetime
- 2003-03-27 PL PL376821A patent/PL376821A1/pl unknown
- 2003-03-27 AU AU2003220529A patent/AU2003220529B2/en not_active Expired
- 2003-03-27 ES ES03716840.8T patent/ES2557741T3/es not_active Expired - Lifetime
-
2005
- 2005-02-04 US US11/051,149 patent/US7452695B2/en not_active Expired - Lifetime
-
2008
- 2008-02-04 JP JP2008024395A patent/JP4414466B2/ja not_active Expired - Lifetime
- 2008-11-26 JP JP2008301520A patent/JP4414472B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20050233415A1 (en) | 2005-10-20 |
JP2008167760A (ja) | 2008-07-24 |
US7452695B2 (en) | 2008-11-18 |
MXPA04009381A (es) | 2005-01-25 |
AU2003220529A1 (en) | 2003-10-13 |
JP4414466B2 (ja) | 2010-02-10 |
US20030211579A1 (en) | 2003-11-13 |
ES2557741T3 (es) | 2016-01-28 |
EP1497444A2 (en) | 2005-01-19 |
CA2480121A1 (en) | 2003-10-09 |
JP2005521401A (ja) | 2005-07-21 |
AU2003220529B2 (en) | 2006-09-07 |
EP1497444A4 (en) | 2006-08-30 |
EP1497444B1 (en) | 2015-11-04 |
JP2009082138A (ja) | 2009-04-23 |
US6872549B2 (en) | 2005-03-29 |
WO2003083066A3 (en) | 2004-02-26 |
WO2003083066A2 (en) | 2003-10-09 |
JP4414472B2 (ja) | 2010-02-10 |
CA2480121C (en) | 2012-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL376821A1 (pl) | Sposoby zwiększania produkcji polipeptydów | |
HUS1500016I1 (hu) | Tiacumicin elõállítása | |
AU2003283174A8 (en) | Method for protein production | |
AU2003206684A8 (en) | Plant polypeptide production | |
PL377943A1 (pl) | Sposób wytwarzania benzofenonów | |
IL162780A0 (en) | Method for producing modified peptide | |
GB0201505D0 (en) | Process | |
EP1539982A4 (en) | glutathione | |
EP1614695A4 (en) | POLYPEPTIDE | |
PL372214A1 (pl) | Nowy sposób | |
GB0218977D0 (en) | Polypeptide | |
GB0201378D0 (en) | Process | |
HK1082000A1 (en) | Method for producing cephalexin | |
GB0202563D0 (en) | Process | |
GB0223193D0 (en) | Polypeptide | |
GB0229967D0 (en) | Protein production | |
GB0218030D0 (en) | Multi-submit protein production system | |
GB0208925D0 (en) | Polypeptide | |
PL374000A1 (pl) | Ulepszony sposób wytwarzania hydroksyazapironów | |
GB0229476D0 (en) | Novel process | |
GB0206655D0 (en) | Novel process | |
EP1477559A4 (en) | NEW POLYPEPTIDE | |
GB0202221D0 (en) | Novel polypeptide | |
PL377523A1 (pl) | Sposób wytwarzania zrekombinowanej heterokarpiny | |
GB0222616D0 (en) | Novel method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
DISC | Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications) |