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PL361424A1 - ß-THIO-AMINO ACIDS - Google Patents

ß-THIO-AMINO ACIDS

Info

Publication number
PL361424A1
PL361424A1 PL36142401A PL36142401A PL361424A1 PL 361424 A1 PL361424 A1 PL 361424A1 PL 36142401 A PL36142401 A PL 36142401A PL 36142401 A PL36142401 A PL 36142401A PL 361424 A1 PL361424 A1 PL 361424A1
Authority
PL
Poland
Prior art keywords
thio
amino acids
acids
amino
Prior art date
Application number
PL36142401A
Other languages
Polish (pl)
Inventor
Boris Chizh
Matthias Gerlach
Michael Haurand
Claudia Pütz
Gero Gaube
D. Enders
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10045831A external-priority patent/DE10045831A1/en
Priority claimed from DE10049484A external-priority patent/DE10049484A1/en
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of PL361424A1 publication Critical patent/PL361424A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/18Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
PL36142401A 2000-09-14 2001-09-11 ß-THIO-AMINO ACIDS PL361424A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10045831A DE10045831A1 (en) 2000-09-14 2000-09-14 Anticonvulsant, anxiolytic and especially analgesic medicaments, comprising new or known beta-thio-alpha-aminoacid compounds having strong affinity for gabapentin binding site
DE10049484A DE10049484A1 (en) 2000-09-29 2000-09-29 Anticonvulsant, anxiolytic and especially analgesic medicaments, comprising new or known beta-thio-alpha-aminoacid compounds having strong affinity for gabapentin binding site
PCT/EP2001/010488 WO2002022568A1 (en) 2000-09-14 2001-09-11 ss-THIO-AMINO ACIDS

Publications (1)

Publication Number Publication Date
PL361424A1 true PL361424A1 (en) 2004-10-04

Family

ID=26007074

Family Applications (1)

Application Number Title Priority Date Filing Date
PL36142401A PL361424A1 (en) 2000-09-14 2001-09-11 ß-THIO-AMINO ACIDS

Country Status (16)

Country Link
US (1) US6846843B2 (en)
EP (1) EP1317426B1 (en)
JP (1) JP2004509101A (en)
AR (1) AR030662A1 (en)
AT (1) ATE309983T1 (en)
AU (2) AU1497802A (en)
CA (1) CA2421990C (en)
DE (1) DE50108104D1 (en)
DK (1) DK1317426T3 (en)
ES (1) ES2252310T3 (en)
HU (1) HUP0302912A3 (en)
MX (1) MXPA03002090A (en)
NZ (1) NZ525143A (en)
PE (1) PE20020426A1 (en)
PL (1) PL361424A1 (en)
WO (1) WO2002022568A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NI200300043A (en) 2002-03-28 2003-11-05 Warner Lambert Co AMINO ACIDS WITH AFFINITY FOR THE PROTEIN a2DELTA.
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
EP1572173B1 (en) 2002-12-13 2010-04-28 Warner-Lambert Company LLC Alpha-2-delta ligand to treat lower urinary tract symptoms
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
DE602004024317D1 (en) 2003-09-12 2010-01-07 Pfizer COMBINATIONS OF ALPHA-2-DELTA LIGANDS AND SEROTONINE / NORADRENALINE RECOVERY INHIBITORS
BRPI0414819A (en) 2003-09-25 2006-11-14 Warner Lambert Co affinity amino acid prodrugs for alpha2delta protein
DK2125021T3 (en) 2006-12-22 2011-09-19 Recordati Ireland Ltd Combination therapy of lower urinary tract diseases with alpha2 delta ligands and NSAIDs
US20090041806A1 (en) * 2007-06-15 2009-02-12 Xenoport, Inc. Use of prodrugs of gaba analogs, antispasticity agents, and prodrugs of gaba b receptor agonists for treating spasticity
US8785370B2 (en) 2007-10-05 2014-07-22 Keratin Complex Holdings, Inc. Reactive keratin protein formulations and methods of using for revitalizing hair
AU2008307477A1 (en) * 2007-10-05 2009-04-09 Vito Biage Bucario Treatment method for revitalizing hair and method of producing keratin protein treatment solution
US8969275B2 (en) 2009-06-30 2015-03-03 Basf Se Aqueous alkaline cleaning compositions and methods of their use
US8927476B2 (en) 2010-07-19 2015-01-06 Basf Se Aqueous alkaline cleaning compositions and methods of their use
WO2015064453A1 (en) * 2013-11-01 2015-05-07 株式会社糖鎖工学研究所 Method for producing d-form or l-form amino acid derivative having thiol group
WO2024022998A1 (en) * 2022-07-26 2024-02-01 Inke, S.A. Process for preparing daprodustat and cocrystals thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091569A (en) 1960-08-26 1963-05-28 Mead Johnson & Co Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus
NL144484B (en) 1967-07-26 1975-01-15 Merck & Co Inc PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTI-ANFLAMMATORY ACTION AND A PROCESS FOR THE PREPARATION OF THE ANTI-INFLAMMATORY ACTIVE ARALKYL MERCAPTOAMINO ACIDS.
DE2460891C2 (en) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-aminomethyl-1-cycloalkaneacetic acids and their esters, processes for their preparation and medicaments containing these compounds
HUT40447A (en) 1984-03-29 1986-12-28 Sandoz Ag Process for preparing substituted alpha-amino acids and pharmaceutical compositions containing such compounds
DE3727897A1 (en) 1987-08-21 1989-03-02 Degussa METHOD FOR PRODUCING N-ACYLATED MERCAPTO (ALPHA) AMINO ACIDS
DE3821540A1 (en) 1988-06-25 1989-12-28 Boehringer Mannheim Gmbh NEW SULFONAMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICAL PRODUCTS CONTAINING SULFONAMIDES
JPH0659399A (en) * 1992-08-10 1994-03-04 Konica Corp Color development processing tablet for silver halide photographic color sensitive material
US5401839A (en) * 1993-03-23 1995-03-28 Lever Brothers Company, Division Of Conopco, Inc. Process of preparing N-substituted aldonamides having improved color and color stability
US6620848B2 (en) * 1997-01-13 2003-09-16 Smithkline Beecham Corporation Nitric oxide synthase inhibitors
GB9808667D0 (en) * 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic compounds
AU5478799A (en) * 1998-09-14 2000-04-03 Warner-Lambert Company Branched alkyl pyrrolidine-3-carboxylic acids
WO2000031020A1 (en) * 1998-11-25 2000-06-02 Warner-Lambert Company Improved gamma amino butyric acid analogs
US6225311B1 (en) * 1999-01-27 2001-05-01 American Cyanamid Company Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
ATE278664T1 (en) * 1999-02-18 2004-10-15 Hoffmann La Roche THIOAMIDE DERIVATIVES
WO2000074705A1 (en) * 1999-06-08 2000-12-14 Peter Prehm Rheumatic autoimmune disease antigen
US6642398B2 (en) * 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
CA2384911C (en) * 1999-09-16 2008-07-22 Warner-Lambert Company Method for the screening of .alpha.2. delta.-1 subunit binding ligands

Also Published As

Publication number Publication date
HUP0302912A2 (en) 2003-12-29
EP1317426A1 (en) 2003-06-11
PE20020426A1 (en) 2002-05-18
DK1317426T3 (en) 2006-01-09
JP2004509101A (en) 2004-03-25
WO2002022568A1 (en) 2002-03-21
NZ525143A (en) 2005-12-23
ES2252310T3 (en) 2006-05-16
US20030236253A1 (en) 2003-12-25
AR030662A1 (en) 2003-08-27
AU2002214978B2 (en) 2006-08-31
EP1317426B1 (en) 2005-11-16
DE50108104D1 (en) 2005-12-22
CA2421990C (en) 2009-11-03
HUP0302912A3 (en) 2005-05-30
MXPA03002090A (en) 2003-06-19
ATE309983T1 (en) 2005-12-15
US6846843B2 (en) 2005-01-25
AU1497802A (en) 2002-03-26
CA2421990A1 (en) 2003-03-12

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Legal Events

Date Code Title Description
DISC Decisions on discontinuance of the proceedings (taken after the publication of the particulars of the applications)