PL299929A1 - Quinoxaline derivatives, method of obtaining sames and their use in drugs - Google Patents

Quinoxaline derivatives, method of obtaining sames and their use in drugs

Info

Publication number: PL299929A1
Authority: PL; Poland
Prior art keywords: drugs; quinoxaline derivatives; sames; obtaining; obtaining sames
Prior art date: 1991-10-26

Application number

PL92299929A

Other versions

PL171125B1 (en

Inventor

Andreas Huth

Ralph Schmiechen

Ilse Beetz

Ingrid Schumann

Lechoslaw Turski

Peter Andreas Loeschmann

David Norman Stephens

Dieter Seidelmann

Martin Krueger

Dieter Rahtz

Peter Hoelscher

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-26

Filing date

1992-10-25

Publication date

1994-04-05

1991-10-26 Priority claimed from DE4135871A external-priority patent/DE4135871A1/en

1992-10-25 Application filed by Schering Ag filed Critical Schering Ag

1994-04-05 Publication of PL299929A1 publication Critical patent/PL299929A1/en

1997-03-28 Publication of PL171125B1 publication Critical patent/PL171125B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Psychology (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL92299929A 1991-10-26 1992-10-25 Quinoxaline derivatives, method of obtaining sames and their use in drugs PL171125B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4135871A DE4135871A1 (en)	1991-10-26	1991-10-26	New quinoxaline derivs.
DE4224200		1992-07-17
PCT/DE1992/000895 WO1993008173A1 (en)	1991-10-26	1992-10-25	Quinoxaline derivates with affinity for quisqualate-receptors

Publications (2)

Publication Number	Publication Date
PL299929A1 true PL299929A1 (en)	1994-04-05
PL171125B1 PL171125B1 (en)	1997-03-28

Family

ID=25908683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL92299929A PL171125B1 (en)	1991-10-26	1992-10-25	Quinoxaline derivatives, method of obtaining sames and their use in drugs

Country Status (17)

Country	Link
EP (1)	EP0565683A1 (en)
JP (1)	JP3258008B2 (en)
KR (1)	KR100262371B1 (en)
CN (1)	CN1038840C (en)
AU (1)	AU664212B2 (en)
CA (1)	CA2099270A1 (en)
CZ (1)	CZ286351B6 (en)
FI (1)	FI932959A (en)
HU (1)	HUT64756A (en)
IL (1)	IL103538A (en)
NO (1)	NO304693B1 (en)
NZ (1)	NZ244896A (en)
PL (1)	PL171125B1 (en)
PT (1)	PT101004B (en)
RU (1)	RU2117663C1 (en)
SK (1)	SK281518B6 (en)
WO (1)	WO1993008173A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK162491D0 (en) *	1991-09-20	1991-09-20	Novo Nordisk As	Heterocyclic compounds, their preparation and pharmaceutical preparations containing the compounds
CA2138026C (en) *	1992-06-22	2003-09-09	Eckard Weber	Novel 1,4-dihydroquinoxaline-2,3-diones and uses therefor as glycine receptor antagonists
DE4314592A1 (en) *	1993-04-28	1994-11-03	Schering Ag	Benzo (f) quinoxalinedione derivatives, their production and use in medicinal products
IL109397A0 (en) *	1993-04-28	1994-07-31	Schering Ag	Quinoxalinedione derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE4428152A1 (en) *	1994-06-22	1996-01-04	Basf Ag	New amido-quinoxalinediones, their production and use
GB9419318D0 (en) *	1994-09-24	1994-11-09	Pfizer Ltd	Therapeutic agents
UA44283C2 (en) *	1994-09-27	2002-02-15	Яманоуті Фармасьютікал Ко., Лтд.	1,2,3,4, -TETRAHYDROCHINOXALINDION DERIVATIVES AND PHARMACEUTICAL COMPOSITION BASED ON THEM
DE4439493A1 (en) *	1994-10-25	1996-05-02	Schering Ag	New quinoxalinedione derivatives, their production and use in pharmaceuticals
DE4439492A1 (en) *	1994-10-25	1996-05-02	Schering Ag	New quinoxalinedione derivatives, their production and use in pharmaceuticals
US6110911A (en) *	1995-06-07	2000-08-29	Warner-Lambert Company	Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
DE19521058A1 (en) *	1995-06-09	1996-12-12	Basf Ag	Process for the preparation of aromatic-containing polyether polyols
DE19545251A1 (en) *	1995-11-24	1997-05-28	Schering Ag	New quinoxalinedione derivatives, their production and use in pharmaceuticals
TW448171B (en) *	1996-06-06	2001-08-01	Yamanouchi Pharma Co Ltd	Imidazole-substituted quinoxalinedione derivatives
DE19624808A1 (en)	1996-06-21	1998-01-02	Basf Ag	Pyrrolylquinoxalinediones, their preparation and use
DE19728326A1 (en) *	1997-06-27	1999-01-07	Schering Ag	New quinoxalinedione derivatives, their production and use in pharmaceuticals
US6015800A (en) *	1997-09-03	2000-01-18	Warner-Lambert Company	Substituted quinoxaline-2-ones as glutamate receptor antagonists
EP0900567A3 (en) *	1997-09-05	2001-05-02	Pfizer Products Inc.	Quinazoline-4-one AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy
IL125950A0 (en) *	1997-09-05	1999-04-11	Pfizer Prod Inc	Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy
FR2769309B1 (en)	1997-10-08	2001-06-15	Oreal	KERATINIC FIBER OXIDATION DYE COMPOSITION COMPRISING AN AMINO ACID DERIVATIVE AS AN OXIDATION BASE AND NOVEL AMINO ACID DERIVATIVES
GB0311406D0 (en) *	2003-05-17	2003-06-25	Queen Mary & Westfield College	Substituted phosphonate fluorescent sensors,and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0118982A1 (en) *	1983-02-01	1984-09-19	Sumitomo Chemical Company, Limited	Organic phosphorous quinoxalinone and their production and use
NO179551C (en) *	1987-11-10	1996-10-30	Novo Nordisk As	Analogous Process for Preparing Therapeutically Effective Quinoxaline Compounds
DK69790D0 (en) *	1990-03-16	1990-03-16	Novo Nordisk As	HETEROCYCLIC COMPOUNDS, THEIR PREPARATION OF USE

1992
- 1992-10-23 PT PT101004A patent/PT101004B/en not_active IP Right Cessation
- 1992-10-25 WO PCT/DE1992/000895 patent/WO1993008173A1/en not_active Application Discontinuation
- 1992-10-25 CA CA002099270A patent/CA2099270A1/en not_active Abandoned
- 1992-10-25 EP EP92922676A patent/EP0565683A1/en not_active Withdrawn
- 1992-10-25 CZ CZ19931387A patent/CZ286351B6/en not_active IP Right Cessation
- 1992-10-25 RU RU93044489A patent/RU2117663C1/en active
- 1992-10-25 IL IL10353892A patent/IL103538A/en not_active IP Right Cessation
- 1992-10-25 JP JP50735393A patent/JP3258008B2/en not_active Expired - Fee Related
- 1992-10-25 HU HU9301877A patent/HUT64756A/en unknown
- 1992-10-25 SK SK727-93A patent/SK281518B6/en unknown
- 1992-10-25 AU AU28894/92A patent/AU664212B2/en not_active Ceased
- 1992-10-25 KR KR1019930701948A patent/KR100262371B1/en not_active IP Right Cessation
- 1992-10-25 PL PL92299929A patent/PL171125B1/en unknown
- 1992-10-26 CN CN92113338A patent/CN1038840C/en not_active Expired - Fee Related
- 1992-10-27 NZ NZ244896A patent/NZ244896A/en unknown
1993
- 1993-06-24 FI FI932959A patent/FI932959A/en unknown
- 1993-06-25 NO NO932116A patent/NO304693B1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO932344D0 (en)	1993-06-25
SK281518B6 (en)	2001-04-09
PL171125B1 (en)	1997-03-28
FI932959A0 (en)	1993-06-24
SK72793A3 (en)	1993-10-06
WO1993008173A1 (en)	1993-04-29
KR930703271A (en)	1993-11-29
HUT64756A (en)	1994-02-28
IL103538A (en)	2001-07-24
PT101004A (en)	1994-01-31
NO932344L (en)	1993-06-25
JPH06503583A (en)	1994-04-21
NO304693B1 (en)	1999-02-01
RU2117663C1 (en)	1998-08-20
PT101004B (en)	1999-10-29
CA2099270A1 (en)	1993-04-27
NZ244896A (en)	1995-07-26
KR100262371B1 (en)	2000-08-01
EP0565683A1 (en)	1993-10-20
AU2889492A (en)	1993-05-21
CZ138793A3 (en)	1994-01-19
CZ286351B6 (en)	2000-03-15
HU9301877D0 (en)	1993-09-28
IL103538A0 (en)	1993-03-15
FI932959A (en)	1993-06-24
AU664212B2 (en)	1995-11-09
JP3258008B2 (en)	2002-02-18
CN1072929A (en)	1993-06-09
CN1038840C (en)	1998-06-24

Publication	Publication Date	Title
PL299929A1 (en)	1994-04-05	Quinoxaline derivatives, method of obtaining sames and their use in drugs
CS189391A3 (en)	1992-06-17	Dialkoxypiridylbenzimidazole derivatives, process of their preparation and their pharmaceutical use
IL88182A0 (en)	1989-06-30	Derivatives of 1-desoxynojirimicyin and 1-desoxymannonojirimycin,their preparation and their use in medicaments
IS4839A (en)	1998-08-28	New benzazepine derivatives, medicinal products containing them and their use in the preparation of medicinal products
OA09964A (en)	1995-12-11	1,5- Benzodiazepine derivatives and their use in medicine
ZA923516B (en)	1993-02-24	New thiopyranopyrrole derivatives and their preparation
PL321003A1 (en)	1997-11-24	Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
EP0498268A3 (en)	1993-12-08	5-oxo-l-proline derivatives and pharmaceutical use thereof
EP0237073A3 (en)	1989-11-15	Il-1alpha derivatives and drugs
ZA917853B (en)	1992-07-29	2-aminopyrimidine-4-carboxamide derivatives,their preparation and their use in therapy
IL116525A0 (en)	1996-03-31	Piperazinedione derivatives their preparation and use
IL87089A0 (en)	1988-12-30	N-aminobutyl-n-phenylarylamide derivatives,their preparation and their application in therapy
AU2557892A (en)	1993-04-27	New beta -carbolin derivatives, their preparation and their use in drugs
PL299754A1 (en)	1994-03-21	Benzimidazoles, therapeutic agent containing them and method of obtaining the sames
IL107133A0 (en)	1993-12-28	Piperidine derivatives,their preparation and their application in therapy
IL101617A0 (en)	1992-12-30	2-aminopyrimidine-4-carboxamide derivatives,their preparation and their application in therapy
PL297839A1 (en)	1993-11-02	Novel hetaryloxy-beta-carbolines, method of obtaining them and their use in drugs
IL90000A0 (en)	1989-12-15	Benzothiazepin-4-one derivatives,their preparation and their application in therapy
IL97859A0 (en)	1992-06-21	1,5-benzothiazepinone derivatives,their preparation and pharmaceutical use
ZA92357B (en)	1993-07-19	Amide derivatives and their therapeutic use.
GB2253851B (en)	1993-10-06	Pyridine derivatives,their preparation and pharmaceutical use
EP0352083A3 (en)	1990-05-30	Alkenyltetrazole derivatives, their preparation and use
ZA907628B (en)	1992-06-24	3-isoxazolone derivatives,their preparation and their therapeutic uses
GB2272647B (en)	1995-06-28	Apparatus and method for use in the administration of medication
GB2266887B (en)	1996-04-17	Substituted pyridines,their preparation and pharmaceutical use