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PL2709990T3 - Pochodne 1-((3-((1-piperazynylo)karbonylo)fenylo)metylo)-2,4(1H,3H)-chinazolinodionu jako inhibitory PARP do leczenia nowotworów - Google Patents

Pochodne 1-((3-((1-piperazynylo)karbonylo)fenylo)metylo)-2,4(1H,3H)-chinazolinodionu jako inhibitory PARP do leczenia nowotworów

Info

Publication number
PL2709990T3
PL2709990T3 PL12765230T PL12765230T PL2709990T3 PL 2709990 T3 PL2709990 T3 PL 2709990T3 PL 12765230 T PL12765230 T PL 12765230T PL 12765230 T PL12765230 T PL 12765230T PL 2709990 T3 PL2709990 T3 PL 2709990T3
Authority
PL
Poland
Prior art keywords
piperazinyl
carbonyl
phenyl
methyl
treating cancer
Prior art date
Application number
PL12765230T
Other languages
English (en)
Inventor
Sui Xiong Cai
Ye Edward Tian
Haijun Dong
Qingbing XU
Lizhen Wu
Lijun Liu
Yangzhen JIANG
Qingli BAO
Guoxiang WANG
Feng Yin
Chengyun GU
Xiuhua HU
Xiaozhu WANG
Sishun Kang
Shengzhi CHEN
Original Assignee
Impact Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN2011100824756A external-priority patent/CN102731416A/zh
Application filed by Impact Therapeutics, Inc. filed Critical Impact Therapeutics, Inc.
Publication of PL2709990T3 publication Critical patent/PL2709990T3/pl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL12765230T 2011-04-01 2012-03-31 Pochodne 1-((3-((1-piperazynylo)karbonylo)fenylo)metylo)-2,4(1H,3H)-chinazolinodionu jako inhibitory PARP do leczenia nowotworów PL2709990T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2011100824756A CN102731416A (zh) 2011-04-01 2011-04-01 1-(芳基甲基)-喹唑啉-2，4-二酮作为parp抑制剂及其应用
CN2011077034 2011-07-11
PCT/CN2012/073362 WO2012130166A1 (en) 2011-04-01 2012-03-31 1-(arylmethyl)quinazoline-2,4(1h,3h)-diones as parp inhibitors and the use thereof
EP12765230.3A EP2709990B1 (en) 2011-04-01 2012-03-31 1-((3-((1-Piperazinyl)carbonyl)phenyl)methyl)-2,4(1H,3H)-quinazolinedione derivatives as PARP inhibitors for treating cancer

Publications (1)

Publication Number Publication Date
PL2709990T3 true PL2709990T3 (pl) 2020-03-31

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PL12765230T PL2709990T3 (pl) 2011-04-01 2012-03-31 Pochodne 1-((3-((1-piperazynylo)karbonylo)fenylo)metylo)-2,4(1H,3H)-chinazolinodionu jako inhibitory PARP do leczenia nowotworów

Country Status (19)

Country Link
US (4) US9290460B2 (pl)
EP (1) EP2709990B1 (pl)
JP (1) JP6270713B2 (pl)
CN (2) CN104230827B (pl)
AU (1) AU2012237776B2 (pl)
CA (1) CA2831015C (pl)
CY (1) CY1121847T1 (pl)
DK (1) DK2709990T3 (pl)
ES (1) ES2736299T3 (pl)
HR (1) HRP20191273T1 (pl)
HU (1) HUE046121T2 (pl)
PL (1) PL2709990T3 (pl)
PT (1) PT2709990T (pl)
RS (1) RS59091B1 (pl)
SG (1) SG193599A1 (pl)
SI (1) SI2709990T1 (pl)
TR (1) TR201910675T4 (pl)
TW (1) TWI527800B (pl)
WO (1) WO2012130166A1 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103443085B (zh) 2011-03-14 2016-03-23 南京英派药业有限公司 喹唑啉二酮及其应用
TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用
US9102631B2 (en) 2011-11-01 2015-08-11 Impact Therapeutics, Inc. 1-(arylmethyl)-5,6,7,8-tetrahydroquinazoline-2,4-diones and analogs and the use thereof
WO2013161853A1 (ja) 2012-04-24 2013-10-31 中外製薬株式会社 キナゾリンジオン誘導体
CN104379560A (zh) 2012-04-24 2015-02-25 中外制药株式会社 苯甲酰胺衍生物
CU24341B1 (es) 2013-03-13 2018-05-08 Forma Therapeutics Inc Compuestos y composiciones orgánicas inhibidores del ácido graso sintetasa (fasn) útiles para el tratamiento del cáncer, infecciones virales, obesidad y diabetes
TW201605805A (zh) 2013-10-23 2016-02-16 Chugai Pharmaceutical Co Ltd 喹唑啉酮及異喹啉酮衍生物
WO2016016268A1 (de) * 2014-07-28 2016-02-04 Technische Universität Dresden Thymin- und chinazolin-dion-derivate zur hemmung von hsp27
ES2922637T3 (es) * 2015-04-03 2022-09-19 Impact Therapeutics Shanghai Inc Forma de dosificación farmacéutica sólida de inhibidor de PARP y aplicación de forma de dosificación farmacéutica sólida de inhibidor de PARP
CN106083741A (zh) * 2016-02-22 2016-11-09 南京中医药大学 2‑硫代喹唑啉二酮衍生物
CN107098886B (zh) * 2016-02-26 2020-07-14 中国医学科学院药物研究所 含有哌嗪酮的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
WO2017167251A1 (zh) * 2016-04-01 2017-10-05 上海瑛派药业有限公司 1-(芳基甲基)喹唑啉-2,4(1h,3h)-二酮的制备工艺
CN108727343A (zh) * 2017-04-21 2018-11-02 中国医学科学院药物研究所 含有3-氨基四氢吡咯的喹唑啉酮类parp-1/2抑制剂及其制备方法、药物组合物和用途
TWI767148B (zh) 2018-10-10 2022-06-11 美商弗瑪治療公司 抑制脂肪酸合成酶(fasn)
US10793554B2 (en) 2018-10-29 2020-10-06 Forma Therapeutics, Inc. Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
CN111269216A (zh) * 2018-12-05 2020-06-12 中国医学科学院药物研究所 含有哌嗪酮的喹唑啉二酮盐类化合物、其制备方法、药物组合物和用途
ES2966719T3 (es) * 2019-05-14 2024-04-23 Suzhou Four Health Pharmaceuticals Co Ltd Derivados de quinazolina-2,4-diona como inhibidores de PARP
US20230263801A1 (en) * 2020-07-24 2023-08-24 Impact Therapeutics (Shanghai), Inc Combination therapy of parp inhibitors
WO2022099442A1 (zh) * 2020-11-10 2022-05-19 上海瑛派药业有限公司 5-氟-1-(4-氟-3-(4-(嘧啶-2-基)哌嗪-1-羰基)苄基)喹唑啉-2,4(1h,3h)-二酮的结晶形式及其制备
MX2023011331A (es) * 2021-03-26 2023-10-03 Impact Therapeutics Shanghai Inc Capsula oral de inhibidor de parp y metodo de preparacion de la misma.
WO2023138667A1 (zh) * 2022-01-21 2023-07-27 上海瑛派药业有限公司 Senaparib和替莫唑胺的复方制剂及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
DE2652144A1 (de) 1976-11-16 1978-05-18 Merck Patent Gmbh Neue chinazolindione
US4444762A (en) 1980-04-04 1984-04-24 Nelson Research & Development Company Vehicle composition containing 1-substituted azacyclopentan-2-ones
CA1161036A (en) 1980-05-15 1984-01-24 Masayuki Ishikawa Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
MX7829A (es) 1986-08-21 1993-08-01 Pfizer Quinazolindionas y piridopirimindionas y procedimiento para su preparacion
JP3992291B2 (ja) 1995-09-28 2007-10-17 アスビオファーマ株式会社 キナゾリン誘導体
US6201121B1 (en) 1995-12-28 2001-03-13 Fuji Chemical Industry Co., Ltd. Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
AU1743997A (en) 1996-12-20 1998-07-17 Geron Corporation Poly(adp-ribose) polymerase inhibitors to treat diseases associated with cellular senescence
AUPO440496A0 (en) * 1996-12-30 1997-01-23 Fujisawa Pharmaceutical Co., Ltd. Quinazoline derivatives
US6344559B1 (en) 1997-03-17 2002-02-05 Fujisawa Pharmaceutical Co., Ltd. Process for producing quinazoline derivatives
JP2001302515A (ja) 2000-04-18 2001-10-31 Sumitomo Pharmaceut Co Ltd ポリ（ａｄｐ−リボース）ポリメラーゼ阻害剤
JP2002284699A (ja) * 2001-03-28 2002-10-03 Sumitomo Pharmaceut Co Ltd 視細胞変性疾患治療剤
CA2446963A1 (en) * 2001-06-19 2002-12-27 Warner-Lambert Company Llc Quinazolinediones as antibacterial agents
DE10201240A1 (de) 2002-01-15 2003-07-24 Bayer Ag Substituierte Alkyluracile und ihre Verwendung
CA2569827C (en) 2004-06-30 2013-04-09 Janssen Pharmaceutica N.V. Quinazolinedione derivatives as parp inhibitors
JP2007137818A (ja) 2005-11-17 2007-06-07 Taisho Pharmaceut Co Ltd ８−ヒドロキシ−２，４（１ｈ，３ｈ）−キナゾリンジオン誘導体
ES2422603T3 (es) 2007-05-31 2013-09-12 Shionogi & Co Compuestos oxiimino y el uso de estos
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2716088C (en) 2008-03-27 2017-03-07 Eddy Jean Edgard Freyne Quinazolinone derivatives as tubulin polymerization inhibitors
US20140018376A1 (en) * 2009-10-20 2014-01-16 Hans Allgeier Use of 1H-Quinazoline-2,4-Diones
CN103443085B (zh) 2011-03-14 2016-03-23 南京英派药业有限公司 喹唑啉二酮及其应用
TWI527800B (zh) 2011-04-01 2016-04-01 南京英派藥業有限公司 作為聚（二磷酸腺苷酸－核醣）聚合酶（ｐａｒｐ）之抑制劑之１－（芳基甲基）喹唑啉－２，４（１ｈ，３ｈ）－二酮及其應用

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US10316027B2 (en) 2019-06-11
EP2709990A1 (en) 2014-03-26
JP2014509615A (ja) 2014-04-21
CY1121847T1 (el) 2020-07-31
AU2012237776B2 (en) 2016-09-15
CA2831015A1 (en) 2012-10-04
CA2831015C (en) 2020-03-24
CN103097361B (zh) 2014-08-06
US9290460B2 (en) 2016-03-22
HUE046121T2 (hu) 2020-02-28
DK2709990T3 (da) 2019-07-29
US20180215741A1 (en) 2018-08-02
EP2709990B1 (en) 2019-06-12
US20190270732A1 (en) 2019-09-05
US9926304B2 (en) 2018-03-27
ES2736299T3 (es) 2019-12-27
RS59091B1 (sr) 2019-09-30
JP6270713B2 (ja) 2018-01-31
PT2709990T (pt) 2019-07-24
TWI527800B (zh) 2016-04-01
SG193599A1 (en) 2013-10-30
US20140023642A1 (en) 2014-01-23
CN104230827A (zh) 2014-12-24
CN104230827B (zh) 2016-10-26
EP2709990A4 (en) 2014-11-26
TW201245161A (en) 2012-11-16
US11358955B2 (en) 2022-06-14
HRP20191273T1 (hr) 2019-10-18
AU2012237776A1 (en) 2013-10-10
WO2012130166A1 (en) 2012-10-04
US20160237070A1 (en) 2016-08-18
SI2709990T1 (sl) 2019-09-30
CN103097361A (zh) 2013-05-08
TR201910675T4 (tr) 2019-08-21

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