PL2771342T3 - Nowe pochodne puryny i ich zastosowanie w leczeniu chorób - Google Patents
Nowe pochodne puryny i ich zastosowanie w leczeniu choróbInfo
- Publication number
- PL2771342T3 PL2771342T3 PL12798854.1T PL12798854T PL2771342T3 PL 2771342 T3 PL2771342 T3 PL 2771342T3 PL 12798854 T PL12798854 T PL 12798854T PL 2771342 T3 PL2771342 T3 PL 2771342T3
- Authority
- PL
- Poland
- Prior art keywords
- disease
- treatment
- purine derivatives
- purine
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161552746P | 2011-10-28 | 2011-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2771342T3 true PL2771342T3 (pl) | 2016-11-30 |
Family
ID=47326252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL12798854.1T PL2771342T3 (pl) | 2011-10-28 | 2012-10-26 | Nowe pochodne puryny i ich zastosowanie w leczeniu chorób |
Country Status (21)
Country | Link |
---|---|
US (1) | US9334271B2 (pl) |
EP (1) | EP2771342B1 (pl) |
JP (1) | JP6059731B2 (pl) |
KR (1) | KR20140090218A (pl) |
CN (1) | CN104039790B (pl) |
AP (1) | AP2014007601A0 (pl) |
AU (1) | AU2012327954B2 (pl) |
BR (1) | BR112014009890A2 (pl) |
CA (1) | CA2853256C (pl) |
CL (1) | CL2014001049A1 (pl) |
CO (1) | CO6950473A2 (pl) |
CU (1) | CU20140048A7 (pl) |
EA (1) | EA023935B1 (pl) |
ES (1) | ES2587533T3 (pl) |
IL (1) | IL232256A0 (pl) |
MX (1) | MX340452B (pl) |
PL (1) | PL2771342T3 (pl) |
PT (1) | PT2771342T (pl) |
SG (1) | SG11201401716XA (pl) |
TN (1) | TN2014000175A1 (pl) |
WO (1) | WO2013061305A1 (pl) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
EA025011B1 (ru) | 2011-01-31 | 2016-11-30 | Новартис Аг | ПУРИНЫ, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR КИНАЗЫ, ИХ ИСПОЛЬЗОВАНИЕ И ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201209613D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
GB201307577D0 (en) | 2013-04-26 | 2013-06-12 | Astex Therapeutics Ltd | New compounds |
SI3122359T1 (sl) | 2014-03-26 | 2021-05-31 | Astex Therapeutics Ltd. | Kombinacije inhibitorja FGFR in inhibitorja IGF1R |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
MA39784B1 (fr) | 2014-03-26 | 2021-03-31 | Astex Therapeutics Ltd | Combinaisons des inhibiteurs du fgfr et du cmet destinées au traitement du cancer |
JP6427599B2 (ja) * | 2014-05-19 | 2018-11-21 | チャンスー ヘンルイ メディシン カンパニー,リミテッド | チロシンキナーゼ阻害剤としての置換エチニルヘテロ二環式化合物 |
JP6782701B2 (ja) | 2014-12-30 | 2020-11-11 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 脳疾患を処置するための方法および組成物 |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
US10478494B2 (en) | 2015-04-03 | 2019-11-19 | Astex Therapeutics Ltd | FGFR/PD-1 combination therapy for the treatment of cancer |
JP6896711B2 (ja) | 2015-09-23 | 2021-06-30 | ヤンセン ファーマシューティカ エヌ.ベー. | ビヘテロアリール置換1,4−ベンゾジアゼピン及び癌の治療のためのその使用 |
CA2996857C (en) | 2015-09-23 | 2024-05-21 | Janssen Pharmaceutica Nv | Quinoxaline, quinoline and quinazolinone derivative compounds for the treatment of cancer |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2018033455A1 (de) | 2016-08-15 | 2018-02-22 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
JP2022519271A (ja) * | 2019-02-06 | 2022-03-22 | シンソークス, インコーポレイテッド | Il-2コンジュゲートおよびその使用方法 |
CZ308800B6 (cs) * | 2019-02-12 | 2021-05-26 | Univerzita Palackého v Olomouci | Heterocyklické dusíkaté deriváty purinu, farmaceutické přípravky obsahující tyto deriváty a jejich použití při neuroprotekci |
US20220144838A1 (en) * | 2019-03-13 | 2022-05-12 | Nanjing Immunophage Biotech Co., Ltd. | Compounds as Inhibitors of Macrophage Migration Inhibitory Factor |
EP4161519A4 (en) * | 2020-06-03 | 2024-07-17 | Yumanity Therapeutics Inc | PURINES AND METHODS OF USE |
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-
2012
- 2012-10-26 AP AP2014007601A patent/AP2014007601A0/xx unknown
- 2012-10-26 AU AU2012327954A patent/AU2012327954B2/en not_active Ceased
- 2012-10-26 CN CN201280064734.5A patent/CN104039790B/zh not_active Expired - Fee Related
- 2012-10-26 JP JP2014537802A patent/JP6059731B2/ja not_active Expired - Fee Related
- 2012-10-26 PT PT127988541T patent/PT2771342T/pt unknown
- 2012-10-26 ES ES12798854.1T patent/ES2587533T3/es active Active
- 2012-10-26 KR KR1020147013841A patent/KR20140090218A/ko active IP Right Grant
- 2012-10-26 EA EA201490888A patent/EA023935B1/ru not_active IP Right Cessation
- 2012-10-26 PL PL12798854.1T patent/PL2771342T3/pl unknown
- 2012-10-26 CA CA2853256A patent/CA2853256C/en not_active Expired - Fee Related
- 2012-10-26 MX MX2014005132A patent/MX340452B/es active IP Right Grant
- 2012-10-26 EP EP12798854.1A patent/EP2771342B1/en not_active Not-in-force
- 2012-10-26 SG SG11201401716XA patent/SG11201401716XA/en unknown
- 2012-10-26 BR BR112014009890-5A patent/BR112014009890A2/pt not_active Application Discontinuation
- 2012-10-26 WO PCT/IB2012/055929 patent/WO2013061305A1/en active Application Filing
- 2012-10-26 US US14/353,950 patent/US9334271B2/en not_active Expired - Fee Related
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2014
- 2014-04-24 TN TNP2014000175A patent/TN2014000175A1/en unknown
- 2014-04-24 CL CL2014001049A patent/CL2014001049A1/es unknown
- 2014-04-24 IL IL232256A patent/IL232256A0/en unknown
- 2014-04-28 CU CU2014000048A patent/CU20140048A7/es unknown
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Also Published As
Publication number | Publication date |
---|---|
CA2853256C (en) | 2019-05-14 |
MX340452B (es) | 2016-07-08 |
PT2771342T (pt) | 2016-08-17 |
EP2771342A1 (en) | 2014-09-03 |
EA201490888A1 (ru) | 2014-09-30 |
EP2771342B1 (en) | 2016-05-18 |
AU2012327954B2 (en) | 2015-11-26 |
AP2014007601A0 (en) | 2014-04-30 |
SG11201401716XA (en) | 2014-05-29 |
CL2014001049A1 (es) | 2014-10-24 |
ES2587533T3 (es) | 2016-10-25 |
NZ624366A (en) | 2015-12-24 |
US9334271B2 (en) | 2016-05-10 |
KR20140090218A (ko) | 2014-07-16 |
CN104039790B (zh) | 2016-04-13 |
CA2853256A1 (en) | 2013-05-02 |
WO2013061305A1 (en) | 2013-05-02 |
JP2014530903A (ja) | 2014-11-20 |
IL232256A0 (en) | 2014-06-30 |
EA023935B1 (ru) | 2016-07-29 |
CN104039790A (zh) | 2014-09-10 |
MX2014005132A (es) | 2014-10-06 |
AU2012327954A1 (en) | 2014-06-19 |
BR112014009890A2 (pt) | 2020-10-27 |
US20140336166A1 (en) | 2014-11-13 |
JP6059731B2 (ja) | 2017-01-11 |
TN2014000175A1 (en) | 2015-09-30 |
CU20140048A7 (es) | 2014-12-26 |
CO6950473A2 (es) | 2014-05-20 |
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