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PL2635563T3 - Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1 - Google Patents

Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1

Info

Publication number
PL2635563T3
PL2635563T3 PL11785232T PL11785232T PL2635563T3 PL 2635563 T3 PL2635563 T3 PL 2635563T3 PL 11785232 T PL11785232 T PL 11785232T PL 11785232 T PL11785232 T PL 11785232T PL 2635563 T3 PL2635563 T3 PL 2635563T3
Authority
PL
Poland
Prior art keywords
benzoimidazole
indeno
hsd
carbonitrile
hexahydro
Prior art date
Application number
PL11785232T
Other languages
English (en)
Inventor
Matthias Eckhardt
Hans-Juergen Martin
Martin Schuehle
Sandra Sick
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2635563(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PL2635563T3 publication Critical patent/PL2635563T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL11785232T 2010-11-05 2011-11-04 Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1 PL2635563T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2010/055586 WO2011057054A1 (en) 2009-11-06 2010-11-05 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P 2011-05-11 2011-05-11
EP11785232.7A EP2635563B1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors
PCT/US2011/059331 WO2012061708A1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (1)

Publication Number Publication Date
PL2635563T3 true PL2635563T3 (pl) 2015-06-30

Family

ID=44999935

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11785232T PL2635563T3 (pl) 2010-11-05 2011-11-04 Postacie krystaliczne soli chlorowodorkowej (4a-r,9a-s)-1-(1h-benzoimidazolo-5-karbonylo)-2,3,4,4a,9,9a-heksahydro-1h-indeno[2,1-b]pirydyno-6-karbonitrylu i ich zastosowanie jako inhibitory hsd 1

Country Status (36)

Country Link
US (2) US8686149B2 (pl)
EP (1) EP2635563B1 (pl)
JP (1) JP2013541592A (pl)
KR (1) KR20130119939A (pl)
CN (1) CN103228642B (pl)
AP (1) AP3521A (pl)
AR (1) AR083678A1 (pl)
AU (1) AU2011323164B2 (pl)
BR (1) BR112013011095A2 (pl)
CA (1) CA2816136A1 (pl)
CL (1) CL2013001221A1 (pl)
CO (1) CO6781480A2 (pl)
CY (1) CY1116043T1 (pl)
DK (1) DK2635563T3 (pl)
EA (1) EA022406B1 (pl)
EC (2) ECSP12011788A (pl)
ES (1) ES2533833T3 (pl)
GE (1) GEP20166481B (pl)
HK (1) HK1184144A1 (pl)
HR (1) HRP20150327T1 (pl)
IL (1) IL225647A0 (pl)
ME (1) ME02066B (pl)
MX (1) MX2013005069A (pl)
NZ (1) NZ609281A (pl)
PE (1) PE20140123A1 (pl)
PL (1) PL2635563T3 (pl)
PT (1) PT2635563E (pl)
RS (1) RS53900B1 (pl)
SG (1) SG189859A1 (pl)
SI (1) SI2635563T1 (pl)
SM (1) SMT201500095B (pl)
TN (1) TN2012000117A1 (pl)
TW (1) TWI537258B (pl)
UA (1) UA110807C2 (pl)
UY (1) UY33701A (pl)
WO (1) WO2012061708A1 (pl)

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WO2010139673A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2011011123A1 (en) 2009-06-11 2011-01-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
BR112014027884A2 (pt) * 2012-05-09 2017-06-27 Boehringer Ingelheim Int combinações farmacêuticas para tratamento de distúrbios metabólicos
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
CN118206529A (zh) 2017-09-04 2024-06-18 C4医药公司 二氢苯并咪唑酮
WO2020181232A1 (en) 2019-03-06 2020-09-10 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment

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Also Published As

Publication number Publication date
US20140249174A1 (en) 2014-09-04
AP2013006902A0 (en) 2013-06-30
EA022406B1 (ru) 2015-12-30
UY33701A (es) 2012-05-31
CA2816136A1 (en) 2012-05-10
KR20130119939A (ko) 2013-11-01
SI2635563T1 (sl) 2015-04-30
JP2013541592A (ja) 2013-11-14
EP2635563B1 (en) 2015-01-14
TN2012000117A1 (en) 2013-09-19
UA110807C2 (uk) 2016-02-25
PE20140123A1 (es) 2014-03-02
CY1116043T1 (el) 2017-01-25
BR112013011095A2 (pt) 2016-08-02
NZ609281A (en) 2015-02-27
EP2635563A1 (en) 2013-09-11
US8686149B2 (en) 2014-04-01
CL2013001221A1 (es) 2013-11-08
ME02066B (me) 2015-05-20
MX2013005069A (es) 2013-08-29
AP3521A (en) 2016-01-11
ES2533833T3 (es) 2015-04-15
ECSP13012664A (es) 2013-08-30
AR083678A1 (es) 2013-03-13
CN103228642B (zh) 2015-02-18
RS53900B1 (en) 2015-08-31
CN103228642A (zh) 2013-07-31
EA201390643A1 (ru) 2013-11-29
TW201242960A (en) 2012-11-01
ECSP12011788A (es) 2012-10-30
CO6781480A2 (es) 2013-10-31
HRP20150327T1 (hr) 2015-04-24
TWI537258B (zh) 2016-06-11
IL225647A0 (en) 2013-06-27
SMT201500095B (it) 2015-07-09
PT2635563E (pt) 2015-04-13
US20120157488A1 (en) 2012-06-21
AU2011323164B2 (en) 2015-07-23
HK1184144A1 (en) 2014-01-17
WO2012061708A1 (en) 2012-05-10
GEP20166481B (en) 2016-05-25
SG189859A1 (en) 2013-06-28
DK2635563T3 (en) 2015-02-02
AU2011323164A1 (en) 2013-05-02
US9120769B2 (en) 2015-09-01

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