PL2242752T3 - Imidazolilobifenyloimidazole jako inhibitory wirusa zapalenia wątroby typu c - Google Patents
Imidazolilobifenyloimidazole jako inhibitory wirusa zapalenia wątroby typu cInfo
- Publication number
- PL2242752T3 PL2242752T3 PL08768910T PL08768910T PL2242752T3 PL 2242752 T3 PL2242752 T3 PL 2242752T3 PL 08768910 T PL08768910 T PL 08768910T PL 08768910 T PL08768910 T PL 08768910T PL 2242752 T3 PL2242752 T3 PL 2242752T3
- Authority
- PL
- Poland
- Prior art keywords
- hepatitis
- virus inhibitors
- imidazolyl
- imidazoles
- biphenyl imidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08768910A EP2242752B1 (en) | 2008-02-13 | 2008-02-13 | Imidazolyl biphenyl imidazoles as hepatitis c virus inhibitors |
PCT/US2008/053779 WO2009102325A1 (en) | 2008-02-13 | 2008-02-13 | Imidazolyl biphenyl imidazoles as hepatitis c virus inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PL2242752T3 true PL2242752T3 (pl) | 2012-12-31 |
Family
ID=39661448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL08768910T PL2242752T3 (pl) | 2008-02-13 | 2008-02-13 | Imidazolilobifenyloimidazole jako inhibitory wirusa zapalenia wątroby typu c |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP2242752B1 (pl) |
JP (1) | JP5312486B2 (pl) |
KR (1) | KR101492672B1 (pl) |
CN (1) | CN102007122B (pl) |
AU (1) | AU2008350334B2 (pl) |
BR (1) | BRPI0822323A2 (pl) |
CA (1) | CA2715839C (pl) |
CY (1) | CY1113259T1 (pl) |
DK (1) | DK2242752T3 (pl) |
EA (1) | EA018088B1 (pl) |
ES (1) | ES2391600T3 (pl) |
HK (1) | HK1144194A1 (pl) |
HR (1) | HRP20120706T1 (pl) |
IL (1) | IL207469A (pl) |
MX (1) | MX2010008863A (pl) |
NZ (1) | NZ587557A (pl) |
PL (1) | PL2242752T3 (pl) |
PT (1) | PT2242752E (pl) |
SI (1) | SI2242752T1 (pl) |
WO (1) | WO2009102325A1 (pl) |
ZA (1) | ZA201005573B (pl) |
Families Citing this family (94)
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US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8383094B2 (en) | 2008-10-01 | 2013-02-26 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
SG172353A1 (en) | 2008-12-23 | 2011-07-28 | Abbott Lab | Anti-viral compounds |
CA2740193A1 (en) | 2008-12-23 | 2010-07-01 | Abbott Laboratories | Anti-viral compounds |
TWI438200B (zh) | 2009-02-17 | 2014-05-21 | 必治妥美雅史谷比公司 | C型肝炎病毒抑制劑 |
US8188132B2 (en) | 2009-02-17 | 2012-05-29 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8242156B2 (en) | 2009-02-17 | 2012-08-14 | Enanta Pharmaceuticals, Inc. | Linked dibenzimidazole derivatives |
US8394968B2 (en) | 2009-02-17 | 2013-03-12 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9765087B2 (en) | 2009-02-27 | 2017-09-19 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
SG174146A1 (en) | 2009-02-27 | 2011-10-28 | Enanta Pharm Inc | Hepatitis c virus inhibitors |
US8673954B2 (en) | 2009-02-27 | 2014-03-18 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
US8507522B2 (en) | 2009-03-06 | 2013-08-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US20190127365A1 (en) | 2017-11-01 | 2019-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of hepatitis c virus replication |
DK2410844T3 (en) | 2009-03-27 | 2016-07-04 | Merck Sharp & Dohme | Inhibitors of hepatitis C virus replication |
US8796466B2 (en) | 2009-03-30 | 2014-08-05 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
TW201038559A (en) | 2009-04-09 | 2010-11-01 | Bristol Myers Squibb Co | Hepatitis C virus inhibitors |
US8143414B2 (en) | 2009-04-13 | 2012-03-27 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010120935A1 (en) | 2009-04-15 | 2010-10-21 | Abbott Laboratories | Anti-viral compounds |
NZ596444A (en) | 2009-05-13 | 2014-01-31 | Gilead Sciences Inc | Antiviral compounds |
US8138215B2 (en) | 2009-05-29 | 2012-03-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8211928B2 (en) | 2009-05-29 | 2012-07-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8716454B2 (en) | 2009-06-11 | 2014-05-06 | Abbvie Inc. | Solid compositions |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
EP2337781B1 (en) | 2009-06-11 | 2014-07-23 | AbbVie Bahamas Ltd. | Anti-viral compounds to treat hcv infection |
US9394279B2 (en) | 2009-06-11 | 2016-07-19 | Abbvie Inc. | Anti-viral compounds |
US8221737B2 (en) | 2009-06-16 | 2012-07-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8609648B2 (en) | 2009-07-02 | 2013-12-17 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
MX2012000695A (es) | 2009-07-16 | 2012-06-12 | Vertex Pharma | Análogos de bencimidazol para el tratamiento o la prevención de infecciones por flavivirus. |
PE20120993A1 (es) | 2009-09-04 | 2012-08-22 | Janssen Pharmaceuticals Inc | Derivados bifenilicos como antivirales |
EP2475256A4 (en) | 2009-09-11 | 2013-06-05 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
US8703938B2 (en) | 2009-09-11 | 2014-04-22 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8759332B2 (en) | 2009-09-11 | 2014-06-24 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8815928B2 (en) | 2009-09-11 | 2014-08-26 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8927709B2 (en) | 2009-09-11 | 2015-01-06 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8415374B2 (en) | 2009-10-12 | 2013-04-09 | Bristol-Myers Squibb Company | Combinations of hepatitis C virus inhibitors |
UA108211C2 (uk) | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
US20110269956A1 (en) | 2009-11-11 | 2011-11-03 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110274648A1 (en) | 2009-11-11 | 2011-11-10 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US20110281910A1 (en) | 2009-11-12 | 2011-11-17 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US8653070B2 (en) | 2009-12-14 | 2014-02-18 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
US8377980B2 (en) * | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8362020B2 (en) | 2009-12-30 | 2013-01-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011091417A1 (en) | 2010-01-25 | 2011-07-28 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8178531B2 (en) | 2010-02-23 | 2012-05-15 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
BR112012022311A2 (pt) | 2010-03-04 | 2016-08-23 | Enanta Pharm Inc | agentes farmacêuticos de combinação como inibidores da replicação de hcv. |
EP2550267A1 (en) | 2010-03-24 | 2013-01-30 | Vertex Pharmaceuticals Incorporated | Analogues for the treatment or prevention of flavivirus infections |
US9127021B2 (en) | 2010-04-09 | 2015-09-08 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
WO2011153396A1 (en) | 2010-06-04 | 2011-12-08 | Enanta Pharmaceuticals, Inc | Hepatitis c virus inhibitors |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
EP2585448A1 (en) | 2010-06-28 | 2013-05-01 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flavivirus infections |
AU2011276526A1 (en) | 2010-06-28 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
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EP2606041A2 (en) | 2010-08-17 | 2013-06-26 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of flaviviridae viral infections |
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EP2621279B1 (en) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
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WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
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EP2771319B1 (en) | 2011-10-27 | 2022-03-02 | Massachusetts Institute of Technology | Amino acid derivatives functionalized on the n- terminal capable of forming drug incapsulating microspheres |
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BR112014016157A8 (pt) | 2011-12-28 | 2017-07-04 | Janssen R&D Ireland | derivados heterobicíclicos como inibidores de vhc |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
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CN103304551B (zh) * | 2012-03-14 | 2017-06-13 | 北京凯因科技股份有限公司 | 丙肝聚合酶抑制剂 |
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KR102239196B1 (ko) | 2013-08-27 | 2021-04-12 | 길리애드 파마셋 엘엘씨 | 2종의 항바이러스 화합물의 조합 제제 |
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WO2015184644A1 (zh) * | 2014-06-06 | 2015-12-10 | 爱博新药研发(上海)有限公司 | 抑制丙肝病毒的化合物、药物组合物及其应用 |
TWI721947B (zh) | 2014-06-11 | 2021-03-21 | 美商基利法瑪席特有限責任公司 | 抗病毒化合物的固態形式 |
HUE062274T2 (hu) | 2015-06-19 | 2023-10-28 | Massachusetts Inst Technology | Alkenil-szubsztituált 2,5-piperazindionok és alkalmazásuk hatóanyag alanyba vagy sejtbe történõ célbajuttatására szolgáló készítményekben |
CN106008316B (zh) * | 2016-06-17 | 2018-04-27 | 成都百事兴科技实业有限公司 | 一种合成雷迪帕韦手性中间体的方法 |
CN105967990A (zh) * | 2016-07-05 | 2016-09-28 | 南京红杉生物科技有限公司 | 一种4,4’-二(2-溴乙酰基)联苯的合成方法 |
US20190256498A1 (en) * | 2016-07-08 | 2019-08-22 | Lupin Limited | Crystalline forms of daclatasvir dihydrochloride |
CN113167802A (zh) | 2018-12-04 | 2021-07-23 | 百时美施贵宝公司 | 通过多同位素体反应监测使用样品内校准曲线的分析方法 |
CN111825659A (zh) * | 2019-04-19 | 2020-10-27 | 扬子江药业集团有限公司 | 一种盐酸达拉他韦杂质盐酸盐及其制备方法和用途 |
US12037340B2 (en) | 2021-05-21 | 2024-07-16 | Gilead Sciences, Inc. | Pentacyclic derivatives as Zika virus inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6080870A (en) * | 1996-04-03 | 2000-06-27 | Merck & Co., Inc. | Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors |
EP1532118A2 (en) * | 2002-07-05 | 2005-05-25 | Axxima Pharmaceuticals Aktiengesellschaft | Imidazole compounds for the treatment of hepatitis c virus infections |
GB0416396D0 (en) * | 2004-07-22 | 2004-08-25 | Angeletti P Ist Richerche Bio | Therapeutic agents |
US8143288B2 (en) * | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
US7759495B2 (en) * | 2006-08-11 | 2010-07-20 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8329159B2 (en) * | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2008
- 2008-02-13 PL PL08768910T patent/PL2242752T3/pl unknown
- 2008-02-13 AU AU2008350334A patent/AU2008350334B2/en not_active Ceased
- 2008-02-13 MX MX2010008863A patent/MX2010008863A/es active IP Right Grant
- 2008-02-13 EP EP08768910A patent/EP2242752B1/en not_active Not-in-force
- 2008-02-13 BR BRPI0822323-8A patent/BRPI0822323A2/pt not_active IP Right Cessation
- 2008-02-13 KR KR20107020264A patent/KR101492672B1/ko not_active IP Right Cessation
- 2008-02-13 JP JP2010546739A patent/JP5312486B2/ja not_active Expired - Fee Related
- 2008-02-13 EA EA201001274A patent/EA018088B1/ru not_active IP Right Cessation
- 2008-02-13 DK DK08768910.5T patent/DK2242752T3/da active
- 2008-02-13 ES ES08768910T patent/ES2391600T3/es active Active
- 2008-02-13 CA CA2715839A patent/CA2715839C/en not_active Expired - Fee Related
- 2008-02-13 SI SI200830809T patent/SI2242752T1/sl unknown
- 2008-02-13 NZ NZ587557A patent/NZ587557A/en not_active IP Right Cessation
- 2008-02-13 CN CN2008801286329A patent/CN102007122B/zh not_active Expired - Fee Related
- 2008-02-13 WO PCT/US2008/053779 patent/WO2009102325A1/en active Application Filing
- 2008-02-13 PT PT08768910T patent/PT2242752E/pt unknown
-
2010
- 2010-08-04 ZA ZA2010/05573A patent/ZA201005573B/en unknown
- 2010-08-08 IL IL207469A patent/IL207469A/en not_active IP Right Cessation
- 2010-11-08 HK HK10110401.0A patent/HK1144194A1/xx not_active IP Right Cessation
-
2012
- 2012-09-05 HR HRP20120706AT patent/HRP20120706T1/hr unknown
- 2012-10-26 CY CY20121101023T patent/CY1113259T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2008350334A1 (en) | 2009-08-20 |
EP2242752A1 (en) | 2010-10-27 |
CA2715839A1 (en) | 2009-08-20 |
CN102007122B (zh) | 2013-09-04 |
BRPI0822323A2 (pt) | 2015-06-16 |
SI2242752T1 (sl) | 2013-03-29 |
IL207469A (en) | 2016-03-31 |
EA201001274A1 (ru) | 2011-06-30 |
WO2009102325A1 (en) | 2009-08-20 |
IL207469A0 (en) | 2010-12-30 |
AU2008350334B2 (en) | 2013-10-17 |
KR20100113629A (ko) | 2010-10-21 |
JP2011511833A (ja) | 2011-04-14 |
ES2391600T3 (es) | 2012-11-28 |
ZA201005573B (en) | 2012-01-25 |
DK2242752T3 (da) | 2012-11-19 |
PT2242752E (pt) | 2012-10-29 |
HRP20120706T1 (hr) | 2012-09-30 |
KR101492672B1 (ko) | 2015-02-16 |
EP2242752B1 (en) | 2012-08-08 |
HK1144194A1 (en) | 2011-02-02 |
EA018088B1 (ru) | 2013-05-30 |
JP5312486B2 (ja) | 2013-10-09 |
CN102007122A (zh) | 2011-04-06 |
MX2010008863A (es) | 2010-09-07 |
CY1113259T1 (el) | 2016-04-13 |
NZ587557A (en) | 2012-04-27 |
CA2715839C (en) | 2014-12-09 |
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