PL2242749T3 - Nowe pirydynony i pirydazynony - Google Patents

Nowe pirydynony i pirydazynony

Info

Publication number: PL2242749T3
Authority: PL; Poland
Prior art keywords: pyridazinones; pyridinones; novel; novel pyridinones
Prior art date: 2008-02-05

Application number

PL09709135T

Other languages

English (en)

Inventor

Nolan James Dewdney

Joshua Kennedy-Smith

Rama K Kondru

Bradley E Loe

Yan Lou

Joel Mcintosh

Timothy D Owens

Michael Soth

Zachary Kevin Sweeney

Joshua Paul Gergely Taygerly

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-02-05

Filing date

2009-01-27

Publication date

2013-09-30

2009-01-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2013-09-30 Publication of PL2242749T3 publication Critical patent/PL2242749T3/pl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL09709135T 2008-02-05 2009-01-27 Nowe pirydynony i pirydazynony PL2242749T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US2620408P	2008-02-05	2008-02-05
US12251008P	2008-12-15	2008-12-15
EP09709135.9A EP2242749B1 (en)	2008-02-05	2009-01-27	Novel pyridinones and pyridazinones
PCT/EP2009/050875 WO2009098144A1 (en)	2008-02-05	2009-01-27	Novel pyridinones and pyridazinones

Publications (1)

Publication Number	Publication Date
PL2242749T3 true PL2242749T3 (pl)	2013-09-30

Family

ID=40413736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL09709135T PL2242749T3 (pl)	2008-02-05	2009-01-27	Nowe pirydynony i pirydazynony

Country Status (30)

Country	Link
EP (1)	EP2242749B1 (pl)
JP (1)	JP5259739B2 (pl)
KR (1)	KR101308803B1 (pl)
CN (1)	CN101932573B (pl)
AR (1)	AR070408A1 (pl)
AU (1)	AU2009211514B2 (pl)
BR (1)	BRPI0907915A2 (pl)
CA (1)	CA2710462C (pl)
CL (1)	CL2009000229A1 (pl)
CO (1)	CO6290767A2 (pl)
CR (1)	CR11598A (pl)
CY (1)	CY1114114T1 (pl)
DK (1)	DK2242749T3 (pl)
EC (1)	ECSP10010384A (pl)
ES (1)	ES2420846T3 (pl)
HK (1)	HK1146826A1 (pl)
HR (1)	HRP20130615T1 (pl)
IL (1)	IL206357A (pl)
MA (1)	MA32064B1 (pl)
MX (1)	MX2010008197A (pl)
MY (1)	MY158411A (pl)
NZ (1)	NZ586916A (pl)
PE (1)	PE20091484A1 (pl)
PL (1)	PL2242749T3 (pl)
PT (1)	PT2242749E (pl)
RU (1)	RU2505538C2 (pl)
SI (1)	SI2242749T1 (pl)
TW (1)	TWI382024B (pl)
WO (1)	WO2009098144A1 (pl)
ZA (1)	ZA201005539B (pl)

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US8299077B2 (en) *	2009-03-02	2012-10-30	Roche Palo Alto Llc	Inhibitors of Bruton's tyrosine kinase
EP2421854B1 (en) *	2009-04-24	2014-07-23	F.Hoffmann-La Roche Ag	Inhibitors of bruton's tyrosine kinase
DK2473049T3 (en)	2009-09-04	2019-04-01	Biogen Ma Inc	INHIBITORS OF BRUTON'S TYROSINKINASE
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AR082590A1 (es)	2010-08-12	2012-12-19	Hoffmann La Roche	Inhibidores de la tirosina-quinasa de bruton
EP2709997B1 (en)	2011-05-17	2016-06-29	F.Hoffmann-La Roche Ag	Inhibitors of bruton's tyrosine kinase
CN103748088A (zh) *	2011-08-17	2014-04-23	弗·哈夫曼-拉罗切有限公司	酪氨酸激酶抑制剂
UA111756C2 (uk) *	2011-11-03	2016-06-10	Ф. Хоффманн-Ля Рош Аг	Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
WO2013148603A1 (en)	2012-03-27	2013-10-03	Takeda Pharmaceutical Company Limited	Cinnoline derivatives as as btk inhibitors
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AR091273A1 (es)	2012-06-08	2015-01-21	Biogen Idec Inc	Inhibidores de pirimidinil tirosina quinasa
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BR112015010693A2 (pt) *	2012-11-16	2017-07-11	Hoffmann La Roche	inibidores de tirosina quinase de bruton
US20150290192A1 (en) *	2012-11-30	2015-10-15	Hoffmann-La Roche Inc.	Inhibitors of bruton's tyrosine kinase
CN105051028B (zh) *	2013-03-05	2017-06-09	豪夫迈·罗氏有限公司	布鲁顿氏酪氨酸激酶抑制剂
WO2014135474A1 (en) *	2013-03-05	2014-09-12	F. Hoffmann-La Roche Ag	Inhibitors of bruton's tyrosine kinase
JO3377B1 (ar)	2013-03-11	2019-03-13	Takeda Pharmaceuticals Co	مشتقات بيريدينيل وبيريدينيل مندمج
JP6204568B2 (ja)	2013-04-25	2017-09-27	ベイジーン，リミテッド	タンパク質キナーゼ阻害剤としての縮合複素環化合物
CN104177338B (zh) *	2013-05-22	2018-04-03	南京勇山生物科技有限公司	一类布鲁顿激酶抑制剂
KR101815360B1 (ko) *	2013-07-03	2018-01-04	에프. 호프만-라 로슈 아게	헤테로아릴 피리돈 및 아자-피리돈 아마이드 화합물
KR102100419B1 (ko)	2013-09-13	2020-04-14	베이진 스위찰랜드 게엠베하	항-pd1 항체 및 이의 치료 및 진단 용도
JP6275846B2 (ja) *	2013-12-05	2018-02-07	エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト	求電子性官能基を有するヘテロアリールピリドン及びアザ−ピリドン化合物
JP6526189B2 (ja)	2014-07-03	2019-06-05	ベイジーンリミテッド	抗ｐｄ−ｌ１抗体並びにその治療及び診断のための使用
CN106922146B (zh) *	2014-10-02	2020-05-26	豪夫迈·罗氏有限公司	用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
WO2017123695A1 (en) *	2016-01-13	2017-07-20	Boehringer Ingelheim International Gmbh	Isoquinolones as btk inhibitors
US20190105407A1 (en)	2016-03-31	2019-04-11	Takeda Pharmaceutical Company Limited	Isoquinolinyl triazolone complexes
JP6993056B2 (ja)	2016-07-05	2022-02-15	ベイジーンリミテッド	癌治療のためのｐｄ－１アンタゴニスト及びｒａｆ阻害剤の組合せ
US11174243B2 (en)	2016-07-21	2021-11-16	Sunesis Pharmaceuticals, Inc.	Succinate forms and compositions of Bruton's tyrosine kinase inhibitors
MX2019001900A (es)	2016-08-16	2019-07-01	Beigene Ltd	Forma cristalina de (s)-7-(1-acriloilpiperidin-4-il)-2-(4-fenoxife nil)-4,5,6,7-tetra-hidropirazolo[1,5-a]pirimidin-3-carboxamida, preparacion y usos de la misma.
HUE065528T2 (hu)	2016-08-19	2024-06-28	Beigene Switzerland Gmbh	Zanubrutinib kombinációja anti-CD20 vagy anti-PD-1 antitesttel rák kezelésében történõ alkalmazásra
EP3515414B1 (en)	2016-09-19	2022-11-30	MEI Pharma, Inc.	Combination therapy
CN110461847B (zh)	2017-01-25	2022-06-07	百济神州有限公司	(S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途
CN106967073A (zh) *	2017-04-24	2017-07-21	刘双伟	一种治疗类风湿性关节炎的药物
CN106946891B (zh) *	2017-05-08	2018-07-13	宿州市徽腾知识产权咨询有限公司	一种用于治疗类风湿性关节炎的药物
JP2020525411A (ja)	2017-06-26	2020-08-27	ベイジーンリミテッド	肝細胞癌のための免疫療法
CN110997677A (zh)	2017-08-12	2020-04-10	百济神州有限公司	具有改进的双重选择性的Btk抑制剂
US11786529B2 (en)	2017-11-29	2023-10-17	Beigene Switzerland Gmbh	Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
BR122023024103A2 (pt)	2018-10-15	2024-02-20	Nurix Therapeutics, Inc.	Compostos bifuncionais para degradação de btk por meio da via de proteossoma de ubiquitina, composição farmacêutica compreendendo os mesmos, e seus usos
EP3942045A1 (en)	2019-03-21	2022-01-26	Onxeo	A dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2020210508A1 (en)	2019-04-09	2020-10-15	Nurix Therapeutics, Inc.	3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
CN114206855A (zh)	2019-05-17	2022-03-18	紐力克斯治疗公司	用于Cbl-b抑制的氰基环丁基类化合物及其用途
JP2023500906A (ja)	2019-11-08	2023-01-11	インサーム（インスティテュナシオナルドゥラサンテエドゥラルシェルシェメディカル）	キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021091575A1 (en) *	2019-11-08	2021-05-14	Nurix Therapeutics, Inc.	Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
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2009
- 2009-01-27 PL PL09709135T patent/PL2242749T3/pl unknown
- 2009-01-27 MX MX2010008197A patent/MX2010008197A/es active IP Right Grant
- 2009-01-27 MY MYPI2010003693A patent/MY158411A/en unknown
- 2009-01-27 ES ES09709135T patent/ES2420846T3/es active Active
- 2009-01-27 RU RU2010136665/04A patent/RU2505538C2/ru not_active IP Right Cessation
- 2009-01-27 AU AU2009211514A patent/AU2009211514B2/en not_active Expired - Fee Related
- 2009-01-27 EP EP09709135.9A patent/EP2242749B1/en not_active Not-in-force
- 2009-01-27 NZ NZ586916A patent/NZ586916A/en not_active IP Right Cessation
- 2009-01-27 DK DK09709135.9T patent/DK2242749T3/da active
- 2009-01-27 CA CA2710462A patent/CA2710462C/en not_active Expired - Fee Related
- 2009-01-27 JP JP2010545433A patent/JP5259739B2/ja not_active Expired - Fee Related
- 2009-01-27 PT PT97091359T patent/PT2242749E/pt unknown
- 2009-01-27 CN CN200980103857.3A patent/CN101932573B/zh not_active Expired - Fee Related
- 2009-01-27 SI SI200930630T patent/SI2242749T1/sl unknown
- 2009-01-27 WO PCT/EP2009/050875 patent/WO2009098144A1/en active Application Filing
- 2009-01-27 BR BRPI0907915-7A patent/BRPI0907915A2/pt not_active IP Right Cessation
- 2009-01-27 KR KR1020107016014A patent/KR101308803B1/ko not_active IP Right Cessation
- 2009-02-03 CL CL2009000229A patent/CL2009000229A1/es unknown
- 2009-02-03 TW TW098103399A patent/TWI382024B/zh not_active IP Right Cessation
- 2009-02-03 AR ARP090100345A patent/AR070408A1/es not_active Application Discontinuation
- 2009-02-04 PE PE2009000169A patent/PE20091484A1/es not_active Application Discontinuation
2010
- 2010-06-14 IL IL206357A patent/IL206357A/en not_active IP Right Cessation
- 2010-07-26 CO CO10090865A patent/CO6290767A2/es active IP Right Grant
- 2010-07-27 CR CR11598A patent/CR11598A/es not_active Application Discontinuation
- 2010-08-03 ZA ZA2010/05539A patent/ZA201005539B/en unknown
- 2010-08-05 EC EC2010010384A patent/ECSP10010384A/es unknown
- 2010-08-06 MA MA33066A patent/MA32064B1/fr unknown
2011
- 2011-01-28 HK HK11100915.9A patent/HK1146826A1/xx not_active IP Right Cessation
2013
- 2013-07-02 HR HRP20130615AT patent/HRP20130615T1/hr unknown
- 2013-07-08 CY CY20131100576T patent/CY1114114T1/el unknown

Also Published As

Publication number	Publication date
PT2242749E (pt)	2013-07-16
AR070408A1 (es)	2010-04-07
SI2242749T1 (sl)	2013-07-31
IL206357A0 (en)	2010-12-30
HRP20130615T1 (en)	2013-08-31
CN101932573B (zh)	2014-06-11
CN101932573A (zh)	2010-12-29
CA2710462A1 (en)	2009-08-13
EP2242749A1 (en)	2010-10-27
NZ586916A (en)	2012-06-29
ECSP10010384A (es)	2010-09-30
RU2505538C2 (ru)	2014-01-27
DK2242749T3 (da)	2013-06-17
CO6290767A2 (es)	2011-06-20
MA32064B1 (fr)	2011-02-01
TW200938538A (en)	2009-09-16
AU2009211514A1 (en)	2009-08-13
KR101308803B1 (ko)	2013-09-13
MY158411A (en)	2016-10-14
CY1114114T1 (el)	2016-07-27
JP2011511027A (ja)	2011-04-07
WO2009098144A1 (en)	2009-08-13
EP2242749B1 (en)	2013-04-10
CL2009000229A1 (es)	2010-06-04
CA2710462C (en)	2015-11-24
MX2010008197A (es)	2010-08-23
BRPI0907915A2 (pt)	2015-07-28
JP5259739B2 (ja)	2013-08-07
HK1146826A1 (en)	2011-07-15
KR20100093130A (ko)	2010-08-24
CR11598A (es)	2010-10-27
ZA201005539B (en)	2011-04-28
ES2420846T3 (es)	2013-08-27
TWI382024B (zh)	2013-01-11
PE20091484A1 (es)	2009-10-03
RU2010136665A (ru)	2012-03-20
IL206357A (en)	2013-12-31
AU2009211514B2 (en)	2014-02-20

Publication	Publication Date	Title
HRP20130615T1 (en)	2013-08-31	Novel pyridinones and pyridazinones
HRP20180718T1 (hr)	2018-07-13	Oligopeptidni spojevi i njihova upotreba
HK1196358A1 (en)	2014-12-12	Substituted pyridin-2-ones and pyridazin-3-ones -2--3-
IL210804A (en)	2015-06-30	Benzylidenehydrazides and their uses
IL205571A0 (en)	2010-12-30	4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroarylpyrimidin
ZA201100372B (en)	2011-10-26	Wounddressing and headgear
GB0808575D0 (en)	2008-06-18	Compilign and linking
ZA201103456B (en)	2012-08-29	Leukolectins and uses thereof
EP2291377A4 (en)	2011-10-05	IMIDAZOPYRIMIDINONE AND ITS USES
GB0903299D0 (en)	2009-04-08	Composition and methods
PL2247601T3 (pl)	2013-09-30	Tiazopirymidynony i ich zastosowanie
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