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PL1743027T3 - Zmutowane białka pneumolizyny - Google Patents

Zmutowane białka pneumolizyny

Info

Publication number
PL1743027T3
PL1743027T3 PL05742528T PL05742528T PL1743027T3 PL 1743027 T3 PL1743027 T3 PL 1743027T3 PL 05742528 T PL05742528 T PL 05742528T PL 05742528 T PL05742528 T PL 05742528T PL 1743027 T3 PL1743027 T3 PL 1743027T3
Authority
PL
Poland
Prior art keywords
mutant pneumolysin
pneumolysin proteins
proteins
mutant
pneumolysin
Prior art date
Application number
PL05742528T
Other languages
English (en)
Inventor
Lea-Ann Kirkham
Timothy John Mitchell
Original Assignee
Univ Glasgow Court
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow Court filed Critical Univ Glasgow Court
Publication of PL1743027T3 publication Critical patent/PL1743027T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL05742528T 2004-05-07 2005-05-09 Zmutowane białka pneumolizyny PL1743027T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56941504P 2004-05-07 2004-05-07
GBGB0410220.8A GB0410220D0 (en) 2004-05-07 2004-05-07 Mutant pneumolysin proteins
PCT/GB2005/001792 WO2005108580A1 (en) 2004-05-07 2005-05-09 Mutant pneumolysin proteins
EP05742528.2A EP1743027B1 (en) 2004-05-07 2005-05-09 Mutant pneumolysin proteins

Publications (1)

Publication Number Publication Date
PL1743027T3 true PL1743027T3 (pl) 2013-11-29

Family

ID=32482854

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05742528T PL1743027T3 (pl) 2004-05-07 2005-05-09 Zmutowane białka pneumolizyny

Country Status (15)

Country Link
US (1) US7820789B2 (pl)
EP (1) EP1743027B1 (pl)
JP (1) JP4848552B2 (pl)
KR (1) KR101191591B1 (pl)
CN (1) CN101018863B (pl)
AU (1) AU2005240835B2 (pl)
CA (1) CA2566344C (pl)
DK (1) DK1743027T3 (pl)
ES (1) ES2427978T3 (pl)
GB (1) GB0410220D0 (pl)
IL (2) IL178885A (pl)
PL (1) PL1743027T3 (pl)
PT (1) PT1743027E (pl)
SI (1) SI1743027T1 (pl)
WO (1) WO2005108580A1 (pl)

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GB0714963D0 (en) 2007-08-01 2007-09-12 Novartis Ag Compositions comprising antigens
RU2498994C2 (ru) * 2007-12-21 2013-11-20 Новартис Аг Мутантные формы стрептолизина о
US9125863B2 (en) * 2008-05-22 2015-09-08 Children's Medical Center Corporation Synergistic immunogenic fusion protein-polysaccharide conjugate
US8758766B2 (en) * 2008-12-24 2014-06-24 The Kingdom of The Netherlands, Represented by The Mininster of Health, Welfare and Sport, on Behalf of The Minster The National Institute of Public Health and The Environment Modified Streptococcus pneumoniae pneumolysin (PLY) polypeptides
EP2411045A1 (en) 2009-03-24 2012-02-01 Novartis AG Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates
CN102413838A (zh) * 2009-04-30 2012-04-11 科勒制药集团有限公司 肺炎球菌疫苗及其用途
US20120237536A1 (en) 2009-09-10 2012-09-20 Novartis Combination vaccines against respiratory tract diseases
EP2515938A4 (en) * 2009-12-22 2013-08-28 Sanofi Pasteur Ltd IMMUNOGENIC COMPOSITIONS
US9649372B2 (en) 2009-12-22 2017-05-16 Sanofi Pasteur Limited Immunogenic compositions and related methods
DK3246044T4 (da) 2010-08-23 2024-05-21 Wyeth Llc Stabile formuleringer af Neisseria-meningitidis-RLP2086-antigener
NZ607224A (en) 2010-09-10 2014-11-28 Wyeth Llc Non-lipidated variants of neisseria meningitidis orf2086 antigens
WO2012072769A1 (en) 2010-12-01 2012-06-07 Novartis Ag Pneumococcal rrgb epitopes and clade combinations
WO2012134975A1 (en) 2011-03-28 2012-10-04 St. Jude Children's Research Hospital Methods and compositions employing immunogenic fusion proteins
US20130164774A9 (en) 2011-04-08 2013-06-27 University Of Massachusetts Methods, compositions and kits for assaying mitochondrial function
ES2682670T3 (es) * 2011-04-21 2018-09-21 The Rockefeller University Lisinas de bacteriófagos de Streptococcus para la detección y tratamiento de bacterias gram positivas
EP2709603B1 (en) 2011-05-11 2021-03-24 Children's Medical Center Corporation Modified biotin-binding protein, fusion proteins thereof and applications
AU2012257771C1 (en) 2011-05-17 2015-12-03 Glaxosmithkline Biologicals S.A. Vaccine against Streptococcus pneumoniae
ITMI20111182A1 (it) 2011-06-28 2012-12-29 Canio Buonavoglia Vaccino per coronavirus canino
CN104519910B (zh) 2012-03-07 2017-05-03 诺华股份有限公司 肺炎链球菌抗原的含佐剂制剂
BR112014021658A2 (pt) 2012-03-09 2017-07-11 Pfizer composições de neisseria meningitidis e métodos das mesmas
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
US11576958B2 (en) 2013-02-07 2023-02-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
US9802987B2 (en) 2013-03-08 2017-10-31 Pfizer Inc. Immunogenic fusion polypeptides
WO2014186796A1 (en) 2013-05-17 2014-11-20 The Board Of Regents Of The University Of Texas System Immunization to protect against adverse cardiac events relating to pneumococcal infection
AU2014316722B2 (en) 2013-09-08 2017-09-07 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN103936842B (zh) * 2014-04-30 2016-03-23 重庆医科大学 肺炎链球菌溶血素突变体及其作为粘膜免疫佐剂的应用
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
US10562941B2 (en) 2014-11-21 2020-02-18 The Board Of Regents Of The University Of Oklahoma Pneumolysin mutants and methods of use thereof
AU2016221318B2 (en) 2015-02-19 2020-06-25 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
CA3051801A1 (en) 2017-01-31 2018-08-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
WO2018183475A1 (en) 2017-03-28 2018-10-04 Children's Medical Center Corporation A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
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EP4317182A1 (en) * 2021-03-22 2024-02-07 Starmab Biologics (Suzhou) Co., Ltd Antigen-binding protein targeting streptococcus pneumoniae hemolysin protein and use thereof
CN113264999B (zh) * 2021-04-29 2023-02-28 星济生物(苏州)有限公司 中和肺炎链球菌溶血素蛋白的抗原结合蛋白及其用途
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Also Published As

Publication number Publication date
EP1743027B1 (en) 2013-07-10
GB0410220D0 (en) 2004-06-09
IL203479A (en) 2013-04-30
CN101018863B (zh) 2012-01-04
SI1743027T1 (sl) 2013-10-30
IL178885A0 (en) 2007-03-08
KR20070073602A (ko) 2007-07-10
JP2008505617A (ja) 2008-02-28
PT1743027E (pt) 2013-10-08
DK1743027T3 (da) 2013-09-30
ES2427978T3 (es) 2013-11-05
AU2005240835B2 (en) 2011-12-01
JP4848552B2 (ja) 2011-12-28
EP1743027A1 (en) 2007-01-17
CN101018863A (zh) 2007-08-15
KR101191591B1 (ko) 2012-10-15
IL178885A (en) 2011-11-30
WO2005108580A1 (en) 2005-11-17
US20080112964A1 (en) 2008-05-15
AU2005240835A1 (en) 2005-11-17
CA2566344A1 (en) 2005-11-17
US7820789B2 (en) 2010-10-26
CA2566344C (en) 2015-07-07

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