PH27182A - Perfusate for the preservation of organs - Google Patents

Perfusate for the preservation of organs Download PDF

Info

Publication number: PH27182A
Authority: PH; Philippines
Prior art keywords: preservation; composition according; solution; starch; organ
Prior art date: 1987-12-29

Application number

PH37988A

Other languages

English (en)

Inventor

Robert O Belzer

James H Southard

Original Assignee

Wisconsin Alumni Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-12-29

Filing date

1988-12-28

Publication date

1993-04-16

1988-12-28 Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found

1993-04-16 Publication of PH27182A publication Critical patent/PH27182A/en

Links

238000004321 preservation Methods 0.000 title claims description 38
210000000056 organ Anatomy 0.000 title claims description 31
238000003860 storage Methods 0.000 claims description 35
239000000203 mixture Substances 0.000 claims description 23
238000000034 method Methods 0.000 claims description 19
229920001612 Hydroxyethyl starch Polymers 0.000 claims description 17
229940050526 hydroxyethylstarch Drugs 0.000 claims description 17
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
239000008103 glucose Substances 0.000 claims description 13
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 8
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 7
238000002513 implantation Methods 0.000 claims description 6
MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims description 5
229920002472 Starch Polymers 0.000 claims description 5
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MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims description 5
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229960005404 sulfamethoxazole Drugs 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000004083 survival effect Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical group COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 1
229960001082 trimethoprim Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A01N1/02—
- A01N1/0226—

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Physiology (AREA)
Molecular Biology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PH37988A 1987-12-29 1988-12-28 Perfusate for the preservation of organs PH27182A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/139,530 US4879283A (en)	1985-10-03	1987-12-29	Solution for the preservation of organs

Publications (1)

Publication Number	Publication Date
PH27182A true PH27182A (en)	1993-04-16

Family

ID=22487110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH37988A PH27182A (en)	1987-12-29	1988-12-28	Perfusate for the preservation of organs

Country Status (17)

Country	Link
US (1)	US4879283A (fr)
JP (1)	JPH0768082B2 (fr)
KR (1)	KR950015064B1 (fr)
AU (1)	AU609236B2 (fr)
BE (1)	BE1003362A3 (fr)
CH (1)	CH678912A5 (fr)
DE (1)	DE3843958C2 (fr)
FR (1)	FR2625073B1 (fr)
GB (1)	GB2213362B (fr)
HU (1)	HU200885B (fr)
IT (1)	IT1227916B (fr)
NL (1)	NL193971C (fr)
NZ (1)	NZ227516A (fr)
PH (1)	PH27182A (fr)
RU (1)	RU2019965C1 (fr)
SE (1)	SE503182C2 (fr)
ZA (1)	ZA889683B (fr)

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CN105263321B (zh)	2013-03-28	2018-07-27	哥伦比亚大学纽约管理委员会	用omega-3甘油酯再灌注促进对用于移植的供体器官的保护
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1987
- 1987-12-29 US US07/139,530 patent/US4879283A/en not_active Expired - Lifetime
1988
- 1988-12-23 GB GB8830096A patent/GB2213362B/en not_active Expired - Lifetime
- 1988-12-24 DE DE3843958A patent/DE3843958C2/de not_active Expired - Lifetime
- 1988-12-27 SE SE8804661A patent/SE503182C2/sv not_active IP Right Cessation
- 1988-12-28 CH CH4832/88A patent/CH678912A5/de not_active IP Right Cessation
- 1988-12-28 IT IT8823136A patent/IT1227916B/it active
- 1988-12-28 JP JP63329506A patent/JPH0768082B2/ja not_active Expired - Lifetime
- 1988-12-28 PH PH37988A patent/PH27182A/en unknown
- 1988-12-28 NL NL8803186A patent/NL193971C/nl not_active IP Right Cessation
- 1988-12-28 RU SU884613281A patent/RU2019965C1/ru active
- 1988-12-28 FR FR8817334A patent/FR2625073B1/fr not_active Expired - Lifetime
- 1988-12-28 KR KR1019880017896A patent/KR950015064B1/ko not_active IP Right Cessation
- 1988-12-28 ZA ZA889683A patent/ZA889683B/xx unknown
- 1988-12-28 HU HU886634A patent/HU200885B/hu unknown
- 1988-12-29 BE BE8801448A patent/BE1003362A3/fr not_active IP Right Cessation
- 1988-12-29 AU AU27616/88A patent/AU609236B2/en not_active Expired
1989
- 1989-01-05 NZ NZ227516A patent/NZ227516A/xx unknown

Also Published As

Publication number	Publication date
HUT49782A (en)	1989-11-28
IT8823136A0 (it)	1988-12-28
GB2213362A (en)	1989-08-16
IT1227916B (it)	1991-05-14
DE3843958C2 (de)	1994-03-10
JPH01246201A (ja)	1989-10-02
FR2625073A1 (fr)	1989-06-30
NL193971B (nl)	2000-12-01
CH678912A5 (fr)	1991-11-29
RU2019965C1 (ru)	1994-09-30
BE1003362A3 (fr)	1992-03-10
DE3843958A1 (de)	1989-07-13
SE8804661D0 (sv)	1988-12-27
FR2625073B1 (fr)	1993-03-26
AU2761688A (en)	1989-06-29
KR950015064B1 (ko)	1995-12-21
AU609236B2 (en)	1991-04-26
ZA889683B (en)	1989-09-27
GB2213362B (en)	1992-04-22
JPH0768082B2 (ja)	1995-07-26
KR890009409A (ko)	1989-08-01
SE8804661L (sv)	1989-06-30
NL193971C (nl)	2001-04-03
GB8830096D0 (en)	1989-02-22
SE503182C2 (sv)	1996-04-15
NL8803186A (nl)	1989-07-17
HU200885B (en)	1990-09-28
NZ227516A (en)	1991-02-26
US4879283A (en)	1989-11-07

Publication	Publication Date	Title
US4879283A (en)	1989-11-07	Solution for the preservation of organs
US4873230A (en)	1989-10-10	Composition for the preservation of organs
US5145771A (en)	1992-09-08	Rinse solution for organs and tissues
AU2005302851B2 (en)	2012-02-23	Composition for cold preservation and perfusion of organs
US5200398A (en)	1993-04-06	Composition for the preservation of organs comprising glucuronic acid or a physiologically tolerated salt or ester thereof
US5306711A (en)	1994-04-26	Organ preservative solution
JP2003520859A (ja)	2003-07-08	器官および組織保存および低体温血液置換のためのシステム
US6641992B2 (en)	2003-11-04	Aqueous solution for preserving tissues and organs
JP2010180257A (ja)	2010-08-19	ドナー器官のためのフラッシュ保存溶液
CN113490414B (zh)	2023-04-21	干细胞的保存
EP0551359B1 (fr)	1994-08-10	Compositions chimiques
JPH0822801B2 (ja)	1996-03-06	臓器保存用溶液
CA1282342C (fr)	1991-04-02	Perfusat pour la conservation d'organes
KR100304594B1 (ko)	2001-09-13	이식용 장기 및 혈액세포 보존제의 조성물
AHLBERG et al.	1987	72-HOUR PRESERVA TION OF THE CANINE P ANCREAS1, 2
Jamieson	1997	Liver preservation: historical review of preservation techniques
Ploeg	2003	REQUIREMENTS FOR