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PH12016500749B1 - A method for preparing an intermediate of iopromide - Google Patents

A method for preparing an intermediate of iopromide

Info

Publication number
PH12016500749B1
PH12016500749B1 PH12016500749A PH12016500749A PH12016500749B1 PH 12016500749 B1 PH12016500749 B1 PH 12016500749B1 PH 12016500749 A PH12016500749 A PH 12016500749A PH 12016500749 A PH12016500749 A PH 12016500749A PH 12016500749 B1 PH12016500749 B1 PH 12016500749B1
Authority
PH
Philippines
Prior art keywords
iopromide
preparing
solvent
dioxane
reaction
Prior art date
Application number
PH12016500749A
Other versions
PH12016500749A1 (en
Inventor
Yong Suk Jin
Wol Young Kim
Joon Hwan Lee
Seung Tae Kim
Sang Hyun Kim
Hee Kyoon Yoon
Original Assignee
Daewong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewong Pharmaceutical Co Ltd filed Critical Daewong Pharmaceutical Co Ltd
Publication of PH12016500749B1 publication Critical patent/PH12016500749B1/en
Publication of PH12016500749A1 publication Critical patent/PH12016500749A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to a method for preparing an intermediate of iopromide, and more particularly, to a method for preparing an intermediate of iopromide, in which 5-methoxyacetylamino-2,4,6-triiodoisophthalic acid dichloride is produced using 1,4-dioxane as a reaction solvent, and then reacted with 3-amino-1,2-propanediol using a solvent mixture of 1,4-dioxane or tetrahydrofuran (THF) and isopropanol as a reaction solvent to obtain the intermediate of iopromide with a faster reaction time, a smaller amount of solvent, and a higher yield.
PH12016500749A 2013-10-25 2016-04-21 A method for preparing an intermediate of iopromide PH12016500749A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020130128154A KR101520187B1 (en) 2013-10-25 2013-10-25 A method for preparation of an intermediate of iopromide
PCT/KR2014/009991 WO2015060657A1 (en) 2013-10-25 2014-10-23 A method for preparing an intermediate of iopromide

Publications (2)

Publication Number Publication Date
PH12016500749B1 true PH12016500749B1 (en) 2016-06-13
PH12016500749A1 PH12016500749A1 (en) 2016-06-13

Family

ID=52993179

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12016500749A PH12016500749A1 (en) 2013-10-25 2016-04-21 A method for preparing an intermediate of iopromide

Country Status (7)

Country Link
KR (1) KR101520187B1 (en)
CN (1) CN105636933B (en)
EA (1) EA031801B1 (en)
PH (1) PH12016500749A1 (en)
SA (1) SA516370977B1 (en)
UA (1) UA114158C2 (en)
WO (1) WO2015060657A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110078636B (en) * 2019-05-23 2022-05-17 浙江海洲制药有限公司 Method for preparing iopromide intermediate
CN114436880B (en) * 2020-11-03 2023-04-28 成都倍特药业股份有限公司 Preparation method of iopromide intermediate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
AU5093993A (en) * 1992-09-02 1994-03-29 Mallinckrodt Medical, Inc. Nonionic X-ray contrast agents compositions and methods
IT1286522B1 (en) 1996-12-04 1998-07-15 Dibra Spa PROCESS FOR THE PREPARATION OF DERIVATIVES OF 5-AMINO-2,4,6- TRIIODO-1,3-BENZENEDICICARBOXYLIC ACID
IT1292037B1 (en) 1997-05-30 1999-01-25 Bracco Spa PROCESS FOR THE PREPARATION OF 5- (ACETYL 62,3-DIIDROXYPROPYL) - AMINO) -N, N'-BIS (2,3-DIIDROXYPROPYL) -2,4,6-TRIIODE-1,3-BENZEN-
KR100286639B1 (en) * 1999-03-31 2001-04-16 강재헌 Process for preparing iopromide
EP2231200A1 (en) * 2007-12-05 2010-09-29 GE Healthcare AS Contrast agents
KR101098553B1 (en) * 2008-04-30 2011-12-26 주식회사 엘지생명과학 Novel Process for Preparation of Iopromide

Also Published As

Publication number Publication date
CN105636933B (en) 2017-12-15
EA201690757A1 (en) 2016-10-31
CN105636933A (en) 2016-06-01
WO2015060657A1 (en) 2015-04-30
SA516370977B1 (en) 2017-08-21
EA031801B1 (en) 2019-02-28
PH12016500749A1 (en) 2016-06-13
KR20150047997A (en) 2015-05-06
KR101520187B1 (en) 2015-05-13
UA114158C2 (en) 2017-04-25

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