PE20221283A1 - Compuestos triciclicos sustituidos - Google Patents
Compuestos triciclicos sustituidosInfo
- Publication number
- PE20221283A1 PE20221283A1 PE2022001331A PE2022001331A PE20221283A1 PE 20221283 A1 PE20221283 A1 PE 20221283A1 PE 2022001331 A PE2022001331 A PE 2022001331A PE 2022001331 A PE2022001331 A PE 2022001331A PE 20221283 A1 PE20221283 A1 PE 20221283A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- unsubstituted
- cycloalkyl
- alkyl
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- MEUGSNBOYROBOF-SNVBAGLBSA-N 4-[[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]amino]-2,6-dimethylpyrimido[5,4-g][1,4]benzoxazin-7-one Chemical compound NC=1C=C(C=C(C=1)C(F)(F)F)[C@@H](C)NC1=NC(=NC2=CC3=C(C=C12)N(C(CO3)=O)C)C MEUGSNBOYROBOF-SNVBAGLBSA-N 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 101100404726 Arabidopsis thaliana NHX7 gene Proteins 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- WKEUOIJSEBKOJQ-GFCCVEGCSA-N FC(C(C)(C)O)(F)C=1C(=C(C=CC=1)[C@@H](C)NC1=NC(=NC2=CC3=C(C=C12)N(C(CO3)=O)C)C)F Chemical compound FC(C(C)(C)O)(F)C=1C(=C(C=CC=1)[C@@H](C)NC1=NC(=NC2=CC3=C(C=C12)N(C(CO3)=O)C)C)F WKEUOIJSEBKOJQ-GFCCVEGCSA-N 0.000 abstract 1
- WFXAEYOBJFAFSJ-LLVKDONJSA-N FC(CO)(F)C=1C(=C(C=CC=1)[C@@H](C)NC1=NC(=NC2=CC3=C(C=C12)N(C(CO3)=O)C)C)F Chemical compound FC(CO)(F)C=1C(=C(C=CC=1)[C@@H](C)NC1=NC(=NC2=CC3=C(C=C12)N(C(CO3)=O)C)C)F WFXAEYOBJFAFSJ-LLVKDONJSA-N 0.000 abstract 1
- 102000057028 SOS1 Human genes 0.000 abstract 1
- 108700022176 SOS1 Proteins 0.000 abstract 1
- 101100197320 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RPL35A gene Proteins 0.000 abstract 1
- 101150100839 Sos1 gene Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- -1 perhaloalkyl Chemical group 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Referida a un compuesto de formula general (I), donde: el anillo A se selecciona entre arilo, heteroarilo y heterociclilo; el anillo B es un anillo carbociclico de 5 o 6 miembros 10 sustituido o no sustituido y un anillo heterociclico de 5 o 6 miembros sustituido o no sustituido que contiene de 1 a 3 heteroatomos seleccionados independientemente entre S, O y N; R1 es hidrogeno, alquilo sustituido o no sustituido y cicloalquilo sustituido o no sustituido; R2 y R3 son hidrogeno, halogeno, ciano, alquilo sustituido o no sustituido y cicloalquilo sustituido o no sustituido; R4 es halogeno, ciano, entre otros; "n" es un numero entero seleccionado entre 0, 1, 2 y 3; R5 es hidrogeno, alquilo, perhaloalquilo y cicloalquilo; R6 es hidrogeno, alquilo y cicloalquilo; o R6 junto con el nitrogeno al que estan unidos, forman un anillo de heterociclilo; y R7 es alquilo y cicloalquilo. Son compuestos preferidos: (R)-4-((1-(3-amino-5-(trifluorometil)fenil)etil)amino)-2,6-dimetil-6H- [1,4]oxazino[3,2-g]quinazolin-7(8H)-ona; (R)-4-((1-(3-(1,1-difluoro-2-hidroxietil)-2-fluorofenil)etil)amino)-2,6-dimetil6H-[1,4]oxazino[3,2-g]quinazolin-7(8H)-ona; (R)-4-((1-(3-(1,1-difluoro-2-hidroxi-2-metilpropil)-2-fluorofenil)etil)amino)- 2,6-dimetil-6H-[1,4]oxazino[3,2-g]quinazolin-7(8H)-ona; entre otros. Dichos compuestos son inhibidores de SOS1 y son utiles en el tratamiento de enfermedades o trastornos proliferativos, infecciosos y RASopatias.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201921054254 | 2019-12-27 | ||
| IN201921049099 | 2019-12-29 | ||
| IN202021022668 | 2020-05-29 | ||
| IN202021032769 | 2020-07-30 | ||
| IN202021035200 | 2020-08-14 | ||
| PCT/IB2020/062462 WO2021130731A1 (en) | 2019-12-27 | 2020-12-27 | Substituted tricyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20221283A1 true PE20221283A1 (es) | 2022-09-05 |
Family
ID=74184675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022001331A PE20221283A1 (es) | 2019-12-27 | 2020-12-27 | Compuestos triciclicos sustituidos |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20230119316A1 (es) |
| EP (1) | EP4081521A1 (es) |
| JP (1) | JP2023514019A (es) |
| KR (1) | KR20220132543A (es) |
| CN (1) | CN115605476B (es) |
| AU (1) | AU2020412429A1 (es) |
| BR (1) | BR112022012641A2 (es) |
| CA (1) | CA3165864A1 (es) |
| CL (1) | CL2022001739A1 (es) |
| CO (1) | CO2022010460A2 (es) |
| CR (1) | CR20220363A (es) |
| EC (1) | ECSP22058816A (es) |
| GE (1) | GEP20247653B (es) |
| IL (1) | IL294198A (es) |
| MX (1) | MX2022008066A (es) |
| PE (1) | PE20221283A1 (es) |
| PH (1) | PH12022551585A1 (es) |
| WO (1) | WO2021130731A1 (es) |
| ZA (1) | ZA202207722B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11883393B2 (en) | 2019-12-19 | 2024-01-30 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| CA3183100A1 (en) | 2020-05-29 | 2021-12-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelmintic heterocyclic compounds |
| IL301298A (en) | 2020-09-15 | 2023-05-01 | Revolution Medicines Inc | Indole derivatives as ras inhibitors in the treatment of cancer |
| TW202229291A (zh) * | 2020-12-07 | 2022-08-01 | 大陸商北京泰德製藥股份有限公司 | Ｓｏｓ１抑制劑、包含其的藥物組合物及其用途 |
| WO2022157629A1 (en) * | 2021-01-19 | 2022-07-28 | Lupin Limited | Pharmaceutical combinations of sos1 inhibitors for treating and/or preventing cancer |
| CN114835719A (zh) * | 2021-02-01 | 2022-08-02 | 苏州泽璟生物制药股份有限公司 | 取代双环并芳杂环胺类抑制剂及其制备方法和应用 |
| WO2022207673A1 (en) | 2021-03-31 | 2022-10-06 | Sevenless Therapeutics Limited | Sos1 inhibitors and ras inhibitors for use in the treatment of pain |
| CN117479942A (zh) | 2021-04-09 | 2024-01-30 | 勃林格殷格翰国际有限公司 | 抗癌疗法 |
| TWI807787B (zh) * | 2021-04-19 | 2023-07-01 | 大陸商昆藥集團股份有限公司 | 苯並嘧啶三環衍生物及製備方法和應用 |
| AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
| CN118339164A (zh) | 2021-11-01 | 2024-07-12 | 勃林格殷格翰动物保健有限公司 | 驱虫吡咯并哒嗪化合物 |
| CN115536660A (zh) * | 2021-11-04 | 2022-12-30 | 北京福元医药股份有限公司 | 苄氨基取代的杂多环化合物及其组合物、制剂和用途 |
| TW202340214A (zh) | 2021-12-17 | 2023-10-16 | 美商健臻公司 | 做為shp2抑制劑之吡唑并吡𠯤化合物 |
| KR20240122545A (ko) * | 2021-12-17 | 2024-08-12 | 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 | 항종양 활성을 갖는 헤테로고리 화합물 및 그 용도 |
| EP4463454A1 (en) | 2022-01-14 | 2024-11-20 | Jazz Pharmaceuticals Ireland Limited | Novel amine-substituted phthalazines and derivatives as sos1 inhibitors |
| KR20230121208A (ko) * | 2022-02-10 | 2023-08-18 | (주)파로스아이바이오 | Sos1 억제제 및 이의 유도체 |
| EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
| WO2023165438A1 (zh) * | 2022-03-03 | 2023-09-07 | 浙江海正药业股份有限公司 | 三环类衍生物及其制备方法和用途 |
| GB202203976D0 (en) | 2022-03-22 | 2022-05-04 | Jazz Pharmaceuticals Ireland Ltd | Tricyclic phthalazines and derivatives as sos1 inhibitors |
| AU2023276599A1 (en) | 2022-05-25 | 2024-12-05 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
| IL317476A (en) | 2022-06-10 | 2025-02-01 | Revolution Medicines Inc | Macrocyclic RAS inhibitors |
| WO2024211712A1 (en) | 2023-04-07 | 2024-10-10 | Revolution Medicines, Inc. | Condensed macrocyclic compounds as ras inhibitors |
| WO2024211663A1 (en) | 2023-04-07 | 2024-10-10 | Revolution Medicines, Inc. | Condensed macrocyclic compounds as ras inhibitors |
| US20240352036A1 (en) | 2023-04-14 | 2024-10-24 | Revolution Medicines, Inc. | Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof |
| US20240352038A1 (en) | 2023-04-14 | 2024-10-24 | Revolution Medicines, Inc. | Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| CA2148082A1 (en) * | 1993-09-03 | 1995-03-09 | Daisuke Machii | Imidazoquinazoline derivatives |
| TW372967B (en) | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
| AU2003256323A1 (en) | 2002-06-26 | 2004-01-19 | Chiron Corporation | Sos1 inhibitors |
| JP2010513562A (ja) | 2006-12-20 | 2010-04-30 | ブリストル−マイヤーズ スクイブ カンパニー | 抗凝血剤として有用な二環状ラクタム第ｖｉｉａ因子阻害剤 |
| KR20100095605A (ko) | 2007-12-19 | 2010-08-31 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 바이시클릭 헤테로시클릭 유도체 |
| WO2009106599A2 (en) | 2008-02-29 | 2009-09-03 | Novartis Ag | Substituted piperidines as therapeutic compounds |
| CN102633812B (zh) * | 2012-04-06 | 2014-11-12 | 中国药科大学 | 噁唑酮并喹唑啉衍生物、制备方法及用途 |
| US10087215B2 (en) | 2013-03-15 | 2018-10-02 | Dana-Farber Cancer Institute, Inc. | Stabilized SOS1 peptides |
| TWI735002B (zh) | 2014-04-23 | 2021-08-01 | 美商英塞特公司 | 作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮 |
| WO2016077793A1 (en) | 2014-11-14 | 2016-05-19 | Children's Hospital Medical Center | Sos1 inhibitors for cancer treatment |
| JP6959650B2 (ja) * | 2015-08-21 | 2021-11-02 | アルデイラ セラピューティクス， インコーポレイテッド | アルデヒドコンジュゲートおよびその使用 |
| TW201711999A (zh) | 2015-09-03 | 2017-04-01 | 佛瑪治療公司 | ﹝６，６﹞稠合雙環組蛋白脫乙醯基酶８（ｈｄａｃ８）抑制劑 |
| EP3558979B1 (en) * | 2016-12-22 | 2021-02-17 | Boehringer Ingelheim International GmbH | Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors |
| US20220235013A1 (en) | 2017-03-21 | 2022-07-28 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| JOP20190221A1 (ar) | 2017-04-05 | 2019-09-23 | Seal Rock Therapeutics Inc | مركبات مثبطات كيناز منظم لإشارات الاستماتة 1 (ask1) واستخداماتها |
| HRP20230400T1 (hr) * | 2017-12-21 | 2023-06-23 | Boehringer Ingelheim International Gmbh | Benzilamino supstituirani piridopirimidinoni i derivati kao inhibitori sos1 |
| US20220274979A1 (en) | 2018-04-18 | 2022-09-01 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-quinazolines |
| WO2019243823A1 (en) | 2018-06-21 | 2019-12-26 | Curadev Pharma Limited | Azaheterocyclic small molecule modulators of human sting |
| CA3130080A1 (en) | 2019-03-01 | 2020-09-10 | Revolution Medicines, Inc. | Bicyclic heteroaryl compounds and uses thereof |
| EP3930845A1 (en) | 2019-03-01 | 2022-01-05 | Revolution Medicines, Inc. | Bicyclic heterocyclyl compounds and uses thereof |
-
2020
- 2020-12-27 MX MX2022008066A patent/MX2022008066A/es unknown
- 2020-12-27 CA CA3165864A patent/CA3165864A1/en active Pending
- 2020-12-27 EP EP20842043.0A patent/EP4081521A1/en active Pending
- 2020-12-27 JP JP2022539232A patent/JP2023514019A/ja active Pending
- 2020-12-27 CN CN202080097766.XA patent/CN115605476B/zh active Active
- 2020-12-27 AU AU2020412429A patent/AU2020412429A1/en active Pending
- 2020-12-27 CR CR20220363A patent/CR20220363A/es unknown
- 2020-12-27 IL IL294198A patent/IL294198A/en unknown
- 2020-12-27 GE GEAP202016015A patent/GEP20247653B/en unknown
- 2020-12-27 BR BR112022012641A patent/BR112022012641A2/pt unknown
- 2020-12-27 KR KR1020227026096A patent/KR20220132543A/ko unknown
- 2020-12-27 PH PH1/2022/551585A patent/PH12022551585A1/en unknown
- 2020-12-27 PE PE2022001331A patent/PE20221283A1/es unknown
- 2020-12-27 US US17/789,293 patent/US20230119316A1/en active Pending
- 2020-12-27 WO PCT/IB2020/062462 patent/WO2021130731A1/en active Application Filing
-
2022
- 2022-06-23 CL CL2022001739A patent/CL2022001739A1/es unknown
- 2022-07-12 ZA ZA2022/07722A patent/ZA202207722B/en unknown
- 2022-07-26 CO CONC2022/0010460A patent/CO2022010460A2/es unknown
- 2022-07-26 EC ECSENADI202258816A patent/ECSP22058816A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP22058816A (es) | 2022-08-31 |
| KR20220132543A (ko) | 2022-09-30 |
| JP2023514019A (ja) | 2023-04-05 |
| EP4081521A1 (en) | 2022-11-02 |
| CA3165864A1 (en) | 2021-07-01 |
| CR20220363A (es) | 2022-09-23 |
| US20230119316A1 (en) | 2023-04-20 |
| MX2022008066A (es) | 2022-08-15 |
| GEP20247653B (en) | 2024-08-12 |
| CN115605476A (zh) | 2023-01-13 |
| ZA202207722B (en) | 2023-03-29 |
| IL294198A (en) | 2022-08-01 |
| CN115605476B (zh) | 2024-05-24 |
| BR112022012641A2 (pt) | 2022-09-06 |
| CL2022001739A1 (es) | 2023-03-31 |
| WO2021130731A1 (en) | 2021-07-01 |
| CO2022010460A2 (es) | 2022-08-09 |
| PH12022551585A1 (en) | 2023-11-29 |
| AU2020412429A1 (en) | 2022-08-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20221283A1 (es) | Compuestos triciclicos sustituidos | |
| MY140012A (en) | Heterocylic substituted phenyl methanones | |
| AR038341A1 (es) | Compuestos que son agonistas de receptores alfa-1 preferentemente agonistas de receptores alfa-1a/l | |
| ATE293101T1 (de) | Piperidine zur verwendung als orexin rezeptor antagonisten | |
| PE20060664A1 (es) | Amidas biciclicas como inhibidores de cinasa | |
| CO5611147A2 (es) | Derivados de nicotinamida utiles como inhibidores p38 | |
| CO5640117A2 (es) | Derivados de 2,4-diamonopirimidina | |
| AR062125A1 (es) | Compuestos que modulan el receptor cb2 y su utilizacion como medicamentos | |
| EA200300777A1 (ru) | N-фенпропилциклопентил-замещенные производные глутарамида в качестве nep ингибиторов для fsad | |
| PE20230854A1 (es) | Compuestos de tetrahidropirazolo-pirazinil-dihidroimidazolona o tetrahidropirazolo-piridinil-dihidroimidazolona y metodos de uso de los mismos | |
| BR0209334A (pt) | Aminas n-aroil cìclicas | |
| AR076415A1 (es) | Compuestos heterociclicos nitrogenados fusionados y su uso en el control de artropodos | |
| CO4940442A1 (es) | Derivados de 4-bromo o 4-yodo fenilamino acido benzhidroxamico | |
| ATE454375T1 (de) | 1-phenyl-benzimidazolverbindungen und ihre verwendung als modulatoren des gaba-a-rezeptors | |
| CO6260074A2 (es) | Compuestos de 5-(4-(halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa | |
| PE20041078A1 (es) | Derivados heterociclicos inhibidores de la elastasa leucocitica humana (elh) | |
| AR074466A1 (es) | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. | |
| CY1116391T1 (el) | Αιθινυλο παραγωγα ως θετικοι αλλοστερικοι ρυθμιστες του mglur5 | |
| AR053340A1 (es) | Derivados de trifluormetilbenzamida y sus usos terapeuticos | |
| SE0101579D0 (sv) | New compounds | |
| CY1116388T1 (el) | 5-(φαινυλο/πυριδινυλο-αιθινυλο)-2-πυριδινο/2-πυριμιδινο-καρβοξαμιδια ως mglur5 ρυθμιστες | |
| WO2005070919A8 (en) | N-type calcium channel blockers | |
| AR072118A1 (es) | Derivados de pirrolidina como antagonistas de receptor de nk2 | |
| AR034585A1 (es) | Nuevos compuestos de dihidropirimidina ciano substituidos y su uso para tratar padecimientos | |
| CO5700831A2 (es) | Compuestos de silicio con actividad microbiocida |