PE20212247A1 - Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos - Google Patents
Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estosInfo
- Publication number
- PE20212247A1 PE20212247A1 PE2021000924A PE2021000924A PE20212247A1 PE 20212247 A1 PE20212247 A1 PE 20212247A1 PE 2021000924 A PE2021000924 A PE 2021000924A PE 2021000924 A PE2021000924 A PE 2021000924A PE 20212247 A1 PE20212247 A1 PE 20212247A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- alkyl
- amino
- unsubstituted
- aminophenyl
- Prior art date
Links
- HWWKOVGSUZFLBU-UHFFFAOYSA-N NC1=CC=CC(NC2C(NC(=O)CC2)=O)=C1 Chemical class NC1=CC=CC(NC2C(NC(=O)CC2)=O)=C1 HWWKOVGSUZFLBU-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Chemical class 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 102000001307 androgen receptors Human genes 0.000 abstract 3
- 108010080146 androgen receptors Proteins 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001721 carbon Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/94—Oxygen atom, e.g. piperidine N-oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La invencion se refiere a compuestos derivados de 3-((3-aminofenil)amino)piperidina-2,6-diona de formula (IA); en donde RN es H; cada R1 se selecciona de halogeno, CN y C1-3 alquilo; cada R2 y R3 se selecciona independientemente de H y C1-3 alquilo, o R2 y R3 y el carbono al que estan unidos forman un C3-6 cicloalquilo sustituido o no sustituido; cada R4 es C1-3 alquilo sustituido o no sustituido, o dos grupos R4, junto con el mismo atomo de carbono o atomo o atomos de carbono adyacentes a los que estan unidos, forman un C3-6 cicloalquilo sustituido o no sustituido, o dos grupos R4 junto con los atomos de carbono no adyacentes a los que estan unidos forman un heterociclilo de 4-7 miembros sustituido o no sustituido; X es N; L es -O(C1-6 alquilo)- o -(C1-9 alquilo)-; n es 0-4; m es 0-8. Un compuesto seleccionado es formiato de 2-(4-(2-(4-(3-(6-ciano-5-(trifluorometil)piridin-3-il)-5,5-dimetil-4- oxo-2-tioxoimidazolidin-1-il)fenoxi)etil)piperazin-1-il)-N-(3-((2,6-dioxopiperidin-3- il)amino)fenil)acetamida. Dichos compuestos son mediadores de los receptores androgenico (AR), siendo utiles para el tratamiento de enfermedades mediadas por AR, tal como el cancer de prostata.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862782298P | 2018-12-19 | 2018-12-19 | |
| US201962879900P | 2019-07-29 | 2019-07-29 | |
| PCT/US2019/067088 WO2020132014A1 (en) | 2018-12-19 | 2019-12-18 | Substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds, compositions thereof, and methods of treatment therewith |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20212247A1 true PE20212247A1 (es) | 2021-11-24 |
Family
ID=71098067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2021000924A PE20212247A1 (es) | 2018-12-19 | 2019-12-18 | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US11149007B2 (es) |
| EP (1) | EP3897636A4 (es) |
| JP (2) | JP7494181B2 (es) |
| KR (1) | KR20210118816A (es) |
| CN (1) | CN113453681B (es) |
| AU (1) | AU2019403207A1 (es) |
| BR (1) | BR112021011968A2 (es) |
| CA (1) | CA3124130A1 (es) |
| CL (1) | CL2021001665A1 (es) |
| CO (1) | CO2021007973A2 (es) |
| IL (1) | IL284223A (es) |
| MX (1) | MX2021007473A (es) |
| PE (1) | PE20212247A1 (es) |
| SG (1) | SG11202106507RA (es) |
| TW (1) | TWI820276B (es) |
| WO (1) | WO2020132014A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20212247A1 (es) * | 2018-12-19 | 2021-11-24 | Celgene Corp | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos |
| MX2021007475A (es) | 2018-12-19 | 2021-08-05 | Celgene Corp | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos. |
| MX2022007678A (es) | 2019-12-19 | 2022-09-19 | Arvinas Operations Inc | Compuestos y metodos para la degradacion dirigida del receptor de androgenos. |
| IL297762A (en) | 2020-05-09 | 2022-12-01 | Arvinas Operations Inc | Methods for producing a bifunctional compound, ultrapure forms of the bifunctional compound, and dosage forms including it |
| CA3182325A1 (en) | 2020-06-24 | 2021-12-30 | Matthew D. Alexander | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| WO2021262815A1 (en) * | 2020-06-24 | 2021-12-30 | Celgene Corporation | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| CN115955979A (zh) * | 2020-06-24 | 2023-04-11 | 新基公司 | Cereblon结合化合物、其组合物及其用于治疗的方法 |
| CA3186548A1 (en) | 2020-07-21 | 2022-01-27 | Song Hee Lee | Compound for androgen receptor degradation, and pharmaceutical use thereof |
| WO2022061348A1 (en) | 2020-09-16 | 2022-03-24 | Biotheryx, Inc. | Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| WO2022087335A1 (en) | 2020-10-23 | 2022-04-28 | Biotheryx, Inc. | Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications |
| US20240124418A1 (en) | 2020-12-14 | 2024-04-18 | Biotheryx, Inc. | Pde4 degraders, pharmaceutical compositions, and therapeutic applications |
| WO2022272074A1 (en) * | 2021-06-25 | 2022-12-29 | Celgene Corporation | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| WO2022272053A1 (en) * | 2021-06-25 | 2022-12-29 | Celgene Corporation | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| WO2024102706A1 (en) * | 2022-11-09 | 2024-05-16 | Bristol-Myers Squibb Company | Combination therapy with substituted 3-((3-aminophenyl)amino)piperidine-2,6-dione compounds |
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| MX2021007475A (es) | 2018-12-19 | 2021-08-05 | Celgene Corp | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos. |
| PE20212247A1 (es) * | 2018-12-19 | 2021-11-24 | Celgene Corp | Compuestos de 3-((3-aminofenil)amino)piperidina-2,6-diona sustituida, composiciones de estos y metodos de tratamiento con estos |
-
2019
- 2019-12-18 PE PE2021000924A patent/PE20212247A1/es unknown
- 2019-12-18 TW TW108146514A patent/TWI820276B/zh active
- 2019-12-18 EP EP19901383.0A patent/EP3897636A4/en active Pending
- 2019-12-18 WO PCT/US2019/067088 patent/WO2020132014A1/en active Application Filing
- 2019-12-18 US US16/719,171 patent/US11149007B2/en active Active
- 2019-12-18 CA CA3124130A patent/CA3124130A1/en active Pending
- 2019-12-18 BR BR112021011968-0A patent/BR112021011968A2/pt unknown
- 2019-12-18 MX MX2021007473A patent/MX2021007473A/es unknown
- 2019-12-18 KR KR1020217019479A patent/KR20210118816A/ko unknown
- 2019-12-18 CN CN201980092358.2A patent/CN113453681B/zh active Active
- 2019-12-18 SG SG11202106507RA patent/SG11202106507RA/en unknown
- 2019-12-18 AU AU2019403207A patent/AU2019403207A1/en active Pending
- 2019-12-18 JP JP2021535539A patent/JP7494181B2/ja active Active
-
2021
- 2021-06-18 CO CONC2021/0007973A patent/CO2021007973A2/es unknown
- 2021-06-18 CL CL2021001665A patent/CL2021001665A1/es unknown
- 2021-06-20 IL IL284223A patent/IL284223A/en unknown
- 2021-08-16 US US17/403,742 patent/US11873283B2/en active Active
-
2023
- 2023-11-28 US US18/521,663 patent/US20240368083A1/en active Pending
-
2024
- 2024-05-22 JP JP2024083009A patent/JP2024109765A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022514344A (ja) | 2022-02-10 |
| BR112021011968A2 (pt) | 2021-09-08 |
| IL284223A (en) | 2021-08-31 |
| US20230002321A1 (en) | 2023-01-05 |
| US11873283B2 (en) | 2024-01-16 |
| EP3897636A1 (en) | 2021-10-27 |
| JP7494181B2 (ja) | 2024-06-03 |
| AU2019403207A1 (en) | 2021-07-15 |
| EP3897636A4 (en) | 2022-09-07 |
| JP2024109765A (ja) | 2024-08-14 |
| CN113453681A (zh) | 2021-09-28 |
| MX2021007473A (es) | 2021-08-05 |
| KR20210118816A (ko) | 2021-10-01 |
| US11149007B2 (en) | 2021-10-19 |
| TWI820276B (zh) | 2023-11-01 |
| TW202039435A (zh) | 2020-11-01 |
| US20200199073A1 (en) | 2020-06-25 |
| US20240368083A1 (en) | 2024-11-07 |
| CN113453681B (zh) | 2024-10-11 |
| CL2021001665A1 (es) | 2022-01-14 |
| WO2020132014A1 (en) | 2020-06-25 |
| SG11202106507RA (en) | 2021-07-29 |
| CO2021007973A2 (es) | 2021-09-09 |
| CA3124130A1 (en) | 2020-06-25 |
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