PE20151654A1 - Inhibidores de cdc7 - Google Patents
Inhibidores de cdc7Info
- Publication number
- PE20151654A1 PE20151654A1 PE2015001925A PE2015001925A PE20151654A1 PE 20151654 A1 PE20151654 A1 PE 20151654A1 PE 2015001925 A PE2015001925 A PE 2015001925A PE 2015001925 A PE2015001925 A PE 2015001925A PE 20151654 A1 PE20151654 A1 PE 20151654A1
- Authority
- PE
- Peru
- Prior art keywords
- cdc7 inhibitors
- cdc7
- inhibitors
- isoindolinone
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
Abstract
La presente invencion se refiere a compuestos de 5 isoindolinona, o una sal del mismo farmaceuticamente aceptable, que inhiben CDC7 Y, por lo tanto pueden ser utiles en el tratamiento de cancer
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782798P | 2013-03-14 | 2013-03-14 | |
| US201361789108P | 2013-03-15 | 2013-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20151654A1 true PE20151654A1 (es) | 2015-11-12 |
Family
ID=50382704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2015001925A PE20151654A1 (es) | 2013-03-14 | 2014-03-07 | Inhibidores de cdc7 |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US9156824B2 (es) |
| EP (1) | EP2970221B1 (es) |
| JP (1) | JP6064079B2 (es) |
| KR (1) | KR101718645B1 (es) |
| CN (1) | CN105008351B (es) |
| AP (1) | AP2015008734A0 (es) |
| AU (1) | AU2014228374B2 (es) |
| BR (1) | BR112015020466B1 (es) |
| CA (1) | CA2900773C (es) |
| CL (1) | CL2015002530A1 (es) |
| CR (1) | CR20150416A (es) |
| CY (1) | CY1119199T1 (es) |
| DK (1) | DK2970221T3 (es) |
| EA (1) | EA027012B1 (es) |
| ES (1) | ES2639793T3 (es) |
| GT (1) | GT201500263A (es) |
| HK (1) | HK1212696A1 (es) |
| HR (1) | HRP20171151T1 (es) |
| HU (1) | HUE033482T2 (es) |
| IL (1) | IL240962B (es) |
| JO (1) | JO3383B1 (es) |
| LT (1) | LT2970221T (es) |
| ME (1) | ME02805B (es) |
| MX (1) | MX363438B (es) |
| MY (1) | MY188145A (es) |
| NZ (1) | NZ710392A (es) |
| PE (1) | PE20151654A1 (es) |
| PH (1) | PH12015502091A1 (es) |
| PL (1) | PL2970221T3 (es) |
| PT (1) | PT2970221T (es) |
| RS (1) | RS56122B1 (es) |
| SG (1) | SG11201507541PA (es) |
| SI (1) | SI2970221T1 (es) |
| TN (1) | TN2015000349A1 (es) |
| TW (1) | TWI622396B (es) |
| UA (1) | UA116125C2 (es) |
| WO (1) | WO2014143601A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2906555T (pt) * | 2012-10-15 | 2017-02-15 | Pfizer Ireland Pharmaceuticals | Processo para a preparação de voriconazol e análogos do mesmo |
| US9278950B2 (en) | 2013-01-14 | 2016-03-08 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| RS60244B1 (sr) | 2013-01-15 | 2020-06-30 | Incyte Holdings Corp | Jedinjenja tiazolkarboksamida i piridinkarboksamida korisna kao inhibitori pim kinaze |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | Ｐ２ｘ７調節劑 |
| ES2654288T3 (es) | 2013-03-14 | 2018-02-13 | Janssen Pharmaceutica, N.V. | Moduladores de P2X7 |
| US10053463B2 (en) | 2013-03-14 | 2018-08-21 | Janssen Pharmaceutica Nv | Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators |
| JO3509B1 (ar) | 2013-03-14 | 2020-07-05 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| TW201522307A (zh) | 2013-03-14 | 2015-06-16 | 百靈佳殷格翰國際股份有限公司 | 經取代２－氮雜－雙環［２．２．１］庚烷－３－羧酸（苄基－氰基－甲基）－醯胺組織蛋白酶ｃ抑制劑 |
| AU2014308703A1 (en) | 2013-08-23 | 2016-03-24 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US10150766B2 (en) | 2014-09-12 | 2018-12-11 | Janssen Pharmaceutica Nv | P2X7 modulators |
| HUE047208T2 (hu) | 2014-09-12 | 2020-04-28 | Boehringer Ingelheim Int | A katepszin-C spirociklikus inhibitorai |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Ｐｉｍ激酶抑制劑之鹽 |
| US9920032B2 (en) | 2015-10-02 | 2018-03-20 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| AU2017332839B2 (en) * | 2016-09-22 | 2021-11-11 | Cancer Research Technology Limited | Preparation and uses of pyrimidinone derivatives |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| CN108383771A (zh) * | 2018-01-08 | 2018-08-10 | 华东师范大学 | 手性3,3-二取代异吲哚啉-1-酮衍生物及其合成方法和应用 |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| AU2019349962A1 (en) | 2018-09-28 | 2021-03-18 | Janssen Pharmaceutica Nv | Monoacylglycerol lipase modulators |
| KR20210069080A (ko) | 2018-09-28 | 2021-06-10 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
| US20220220125A1 (en) * | 2019-04-16 | 2022-07-14 | Janssen Pharmaceutica Nv | Fused isoindolin-1-one derivatives useful as grk2 inhibitors |
| US11839663B2 (en) | 2019-09-30 | 2023-12-12 | Janssen Pharmaceutica Nv | Radiolabelled MGL pet ligands |
| MX2022011902A (es) | 2020-03-26 | 2023-01-04 | Janssen Pharmaceutica Nv | Moduladores de la monoacilglicerol lipasa. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0400970D0 (sv) * | 2004-04-14 | 2004-04-14 | Astrazeneca Ab | Nicotinic acetylcholine receptor ligands |
| TW200639163A (en) * | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| US7576082B2 (en) * | 2005-06-24 | 2009-08-18 | Hoffman-La Roche Inc. | Oxindole derivatives |
| EP2073806B1 (en) * | 2006-10-12 | 2012-02-15 | Xenon Pharmaceuticals Inc. | Use of spiro-oxindole compounds as therapeutic agents |
| US8648069B2 (en) * | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| WO2008154241A1 (en) * | 2007-06-08 | 2008-12-18 | Abbott Laboratories | 5-heteroaryl substituted indazoles as kinase inhibitors |
-
2014
- 2014-03-04 JO JOP/2014/0067A patent/JO3383B1/ar active
- 2014-03-05 TW TW103107546A patent/TWI622396B/zh active
- 2014-03-07 LT LTEP14712966.2T patent/LT2970221T/lt unknown
- 2014-03-07 SI SI201430280T patent/SI2970221T1/sl unknown
- 2014-03-07 AP AP2015008734A patent/AP2015008734A0/xx unknown
- 2014-03-07 HU HUE14712966A patent/HUE033482T2/en unknown
- 2014-03-07 MX MX2015012583A patent/MX363438B/es unknown
- 2014-03-07 CA CA2900773A patent/CA2900773C/en active Active
- 2014-03-07 PE PE2015001925A patent/PE20151654A1/es active IP Right Grant
- 2014-03-07 SG SG11201507541PA patent/SG11201507541PA/en unknown
- 2014-03-07 CN CN201480011202.4A patent/CN105008351B/zh active Active
- 2014-03-07 JP JP2016500764A patent/JP6064079B2/ja active Active
- 2014-03-07 WO PCT/US2014/021466 patent/WO2014143601A1/en active Application Filing
- 2014-03-07 PL PL14712966T patent/PL2970221T3/pl unknown
- 2014-03-07 NZ NZ710392A patent/NZ710392A/en unknown
- 2014-03-07 KR KR1020157024644A patent/KR101718645B1/ko not_active Application Discontinuation
- 2014-03-07 EP EP14712966.2A patent/EP2970221B1/en active Active
- 2014-03-07 US US14/200,141 patent/US9156824B2/en active Active
- 2014-03-07 PT PT147129662T patent/PT2970221T/pt unknown
- 2014-03-07 RS RS20170791A patent/RS56122B1/sr unknown
- 2014-03-07 ES ES14712966.2T patent/ES2639793T3/es active Active
- 2014-03-07 EA EA201591509A patent/EA027012B1/ru not_active IP Right Cessation
- 2014-03-07 BR BR112015020466-0A patent/BR112015020466B1/pt active IP Right Grant
- 2014-03-07 MY MYPI2015703062A patent/MY188145A/en unknown
- 2014-03-07 DK DK14712966.2T patent/DK2970221T3/en active
- 2014-03-07 AU AU2014228374A patent/AU2014228374B2/en active Active
- 2014-03-07 ME MEP-2017-173A patent/ME02805B/me unknown
- 2014-03-07 UA UAA201508675A patent/UA116125C2/uk unknown
-
2015
- 2015-08-12 TN TN2015000349A patent/TN2015000349A1/en unknown
- 2015-08-14 CR CR20150416A patent/CR20150416A/es unknown
- 2015-08-31 IL IL240962A patent/IL240962B/en active IP Right Grant
- 2015-09-09 CL CL2015002530A patent/CL2015002530A1/es unknown
- 2015-09-09 GT GT201500263A patent/GT201500263A/es unknown
- 2015-09-14 PH PH12015502091A patent/PH12015502091A1/en unknown
-
2016
- 2016-01-21 HK HK16100636.2A patent/HK1212696A1/zh unknown
-
2017
- 2017-07-27 HR HRP20171151TT patent/HRP20171151T1/hr unknown
- 2017-08-10 CY CY20171100861T patent/CY1119199T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20151654A1 (es) | Inhibidores de cdc7 | |
| CO2018013293A2 (es) | Derivados de pirazolopirimidina como inhibidor de quinasa | |
| CL2019000844A1 (es) | Compuesto de piridina. | |
| AR110381A2 (es) | Inhibidores biarilo de tirosina cinasa de bruton | |
| ECSP14017584A (es) | Compuestos inhibidores de raf | |
| CR20150078A (es) | Análogos de piridazina 1,4-disustituida y métodos para el tratamiento de condiciones relacionadas con la deficiencia de smn | |
| MX2020004932A (es) | Compuestos utiles para inhibir a cdk7. | |
| ES2721001T3 (es) | Derivado de isoindolina, y composiciones y métodos para tratar una enfermedad neurodegenerativa | |
| CO2020007156A2 (es) | Derivado de amino-metil piperidina como inhibidor de quinasa | |
| CL2016002971A1 (es) | Combinación. | |
| PA8850801A1 (es) | Compuestos útiles para inhibir chk1 | |
| CR20140036A (es) | Compuesto inhibidor de la señalización de la trayectoria notch | |
| UY36075A (es) | Derivados de tubulisina | |
| ECSP17029203A (es) | Inhibidor de cinasa aurora a | |
| CO2020007162A2 (es) | Derivado de oxi-fluoropiperidina como inhibidor de quinasa | |
| BR112017000730A2 (pt) | derivados de pirrolidinona como inibidores de metap-2 | |
| DOP2019000194A (es) | Derivados de pirrolotriazina como inhibidor de cinasas | |
| EA201691036A1 (ru) | Новое соединение для лечения тяжелой гипогликемии | |
| PE20151587A1 (es) | Composicion farmaceutica que comprende al 3-carboxi-n-etil-n,n-dimetilpropein-1-aminio o una sal farmaceuticamente aceptable del mismo | |
| AR094662A1 (es) | Compuesto útil para el tratamiento de enfermedades degenerativas e inflamatorias |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |