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PE20121358A1 - Derivados de indol como inhibidores itk - Google Patents

Derivados de indol como inhibidores itk

Info

Publication number
PE20121358A1
PE20121358A1 PE2012000713A PE2012000713A PE20121358A1 PE 20121358 A1 PE20121358 A1 PE 20121358A1 PE 2012000713 A PE2012000713 A PE 2012000713A PE 2012000713 A PE2012000713 A PE 2012000713A PE 20121358 A1 PE20121358 A1 PE 20121358A1
Authority
PE
Peru
Prior art keywords
alcoxy
alkyl
indol
derivatives
compounds
Prior art date
Application number
PE2012000713A
Other languages
English (en)
Inventor
Teruhiko Inoue
Tetsudo Kaya
Shinichi Kikuchi
Koji Matsumura
Ritsuki Masuo
Motoya Suzuki
Michihide Maekawa
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20121358A1 publication Critical patent/PE20121358A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE INDOL DE FORMULA (I) DONDE R1 ES H, HIDROXI O ALCOXI(C1-C6) OPCIONALMENTE SUSTITUIDO CON ARILO(C6-C10); R2 Y R3 SON CADA UNO H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HIDROXI O ALCOXI(C1-C6); R4 ES -C(O)NR5R6 O -NR7C(O)R8, EN DONDE R5 ES H O ALQUILO(C1-C6); R6 ES H, ALCOXI(C1-C6), ARILO(C6-C10), ENTRE OTROS; R7 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO; R8 ES ALQUILO(C1-C6), ALCOXI(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (i), (ii), ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA DE LAS CELULAS T INDUCIBLE (ITK) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE
PE2012000713A 2009-11-25 2010-11-25 Derivados de indol como inhibidores itk PE20121358A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009268040 2009-11-25

Publications (1)

Publication Number Publication Date
PE20121358A1 true PE20121358A1 (es) 2012-10-23

Family

ID=44066507

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000713A PE20121358A1 (es) 2009-11-25 2010-11-25 Derivados de indol como inhibidores itk

Country Status (31)

Country Link
US (6) US8299070B2 (es)
EP (3) EP3059234A1 (es)
JP (6) JP5734628B2 (es)
KR (1) KR101766502B1 (es)
CN (1) CN102712624B (es)
AR (1) AR079164A1 (es)
AU (1) AU2010323579C1 (es)
BR (1) BR112012012529B1 (es)
CA (1) CA2781660C (es)
CL (1) CL2012001328A1 (es)
CO (1) CO6541645A2 (es)
CY (1) CY1117559T1 (es)
DK (1) DK2505586T3 (es)
ES (1) ES2572935T3 (es)
HK (1) HK1174025A1 (es)
HR (1) HRP20160579T1 (es)
HU (1) HUE028016T2 (es)
IL (1) IL220009A (es)
ME (1) ME02447B (es)
MX (1) MX2012006017A (es)
MY (1) MY161095A (es)
NZ (1) NZ600840A (es)
PE (1) PE20121358A1 (es)
PL (1) PL2505586T3 (es)
PT (1) PT2505586E (es)
RS (1) RS54910B1 (es)
RU (1) RU2556216C2 (es)
SI (1) SI2505586T1 (es)
SM (1) SMT201600258B (es)
TW (1) TWI491591B (es)
WO (1) WO2011065402A1 (es)

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CN103804363A (zh) * 2012-11-14 2014-05-21 韩冰 一类具有神经保护作用的化合物及其用途
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EP3801546B1 (en) * 2018-05-25 2024-07-17 Japan Tobacco Inc. Indole compound for treating interstitial cystitis
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Also Published As

Publication number Publication date
CO6541645A2 (es) 2012-10-16
US20170267662A1 (en) 2017-09-21
CN102712624A (zh) 2012-10-03
EP2505586B1 (en) 2016-03-02
PL2505586T3 (pl) 2016-12-30
TWI491591B (zh) 2015-07-11
TW201124378A (en) 2011-07-16
PT2505586E (pt) 2016-06-03
AU2010323579C1 (en) 2016-11-03
US20180362506A1 (en) 2018-12-20
SMT201600258B (it) 2016-08-31
IL220009A (en) 2017-08-31
KR101766502B1 (ko) 2017-08-08
MY161095A (en) 2017-04-14
HUE028016T2 (en) 2016-11-28
HRP20160579T1 (hr) 2016-07-29
RS54910B1 (sr) 2016-10-31
EP3766877A1 (en) 2021-01-20
ME02447B (me) 2016-09-20
IL220009A0 (en) 2012-07-31
US20110306599A1 (en) 2011-12-15
JP2020079276A (ja) 2020-05-28
CA2781660A1 (en) 2011-06-03
HK1174025A1 (zh) 2013-05-31
BR112012012529A2 (pt) 2016-05-03
JP2021091718A (ja) 2021-06-17
WO2011065402A1 (ja) 2011-06-03
CA2781660C (en) 2018-06-26
RU2012126129A (ru) 2013-12-27
KR20120096540A (ko) 2012-08-30
MX2012006017A (es) 2012-06-25
EP3059234A1 (en) 2016-08-24
AU2010323579A1 (en) 2012-07-19
EP2505586A1 (en) 2012-10-03
NZ600840A (en) 2014-01-31
CY1117559T1 (el) 2017-04-26
CL2012001328A1 (es) 2012-10-05
EP2505586A4 (en) 2013-05-15
US20200255408A1 (en) 2020-08-13
JP2018158935A (ja) 2018-10-11
AU2010323579B2 (en) 2016-05-19
CN102712624B (zh) 2014-06-04
JP5734628B2 (ja) 2015-06-17
JP2015172051A (ja) 2015-10-01
SI2505586T1 (sl) 2016-08-31
AR079164A1 (es) 2011-12-28
RU2556216C2 (ru) 2015-07-10
BR112012012529B1 (pt) 2021-10-26
JP2011132222A (ja) 2011-07-07
US8299070B2 (en) 2012-10-30
US20130116240A1 (en) 2013-05-09
US20210284627A1 (en) 2021-09-16
ES2572935T3 (es) 2016-06-03
DK2505586T3 (en) 2016-05-30
JP2017039761A (ja) 2017-02-23

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