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PE20121584A1 - Composiciones y metodos para el diagnostico y el tratamiento de tumores - Google Patents

Composiciones y metodos para el diagnostico y el tratamiento de tumores

Info

Publication number
PE20121584A1
PE20121584A1 PE2012000729A PE2012000729A PE20121584A1 PE 20121584 A1 PE20121584 A1 PE 20121584A1 PE 2012000729 A PE2012000729 A PE 2012000729A PE 2012000729 A PE2012000729 A PE 2012000729A PE 20121584 A1 PE20121584 A1 PE 20121584A1
Authority
PE
Peru
Prior art keywords
seq
nos
sequence
cdr
antibody
Prior art date
Application number
PE2012000729A
Other languages
English (en)
Inventor
Mark Dennis
Paul Polakis
Bonnee Rubinfeld
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43856230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20121584(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20121584A1 publication Critical patent/PE20121584A1/es

Links

Classifications

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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Abstract

SE REFIERE A UN ANTICUERPO QUIMERICO, HUMANIZADO O FRAGMENTO DE ANTICUERPO, QUE SE UNE A TAT211 QUE COMPRENDE: a) UNA SECUENCIA CDR-L1 SELECCIONADA DE SEQ ID NOS: 21-34, b) UNA SECUENCIA CDR-L2 SELECCIONADA DE SEQ ID NOS: 35-38, c) UNA SECUENCIA CDR-L3 SELECCIONADA DE SEQ ID NOS: 39-41, d) UNA SECUENCIA CDR-H1 SELECCIONADA DE SEQ ID NOS: 42-45, e) UNA SECUENCIA CDR-H2 SELECCIONADA DE SEQ ID NOS: 46-60, Y f) UNA SECUENCIA CDR-H3 SELECCIONADA DE SEQ ID NOS: 61-65; COMPRENDE TAMBIEN UNA SECUENCIA DE MARCO DE CONSENSO HUMANA DEL ACEPTOR VH DE SEQ ID NOS: 66-75 Y VL DE SEQ ID NOS: 76-79. ADEMAS DICHO ANTICUERPO ESTA CONJUGADO A UN AGENTE INHIBIDOR DEL CRECIMIENTO O CITOTOXICO. DICHO ANTICUERPO INHIBE EL CRECIMIENTO DE CELULAS CANCEROSAS DE CANCER DE OVARIO Y PULMON
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KR20200055770A (ko) * 2017-09-20 2020-05-21 메르사나 테라퓨틱스, 인코포레이티드 Napi2b 표적 요법에 대한 반응을 예측하기 위한 조성물 및 방법
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