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PE20110845A1 - Nuevos compuestos heterociclicos nitrogenados, preparacion de los mismos y utilizacion de los mismos como medicamentos antibacterianos - Google Patents

Nuevos compuestos heterociclicos nitrogenados, preparacion de los mismos y utilizacion de los mismos como medicamentos antibacterianos

Info

Publication number
PE20110845A1
PE20110845A1 PE2011000827A PE2011000827A PE20110845A1 PE 20110845 A1 PE20110845 A1 PE 20110845A1 PE 2011000827 A PE2011000827 A PE 2011000827A PE 2011000827 A PE2011000827 A PE 2011000827A PE 20110845 A1 PE20110845 A1 PE 20110845A1
Authority
PE
Peru
Prior art keywords
same
nitrogenated
preparation
new
antibacterial drugs
Prior art date
Application number
PE2011000827A
Other languages
English (en)
Inventor
Maxime Lampilas
David Alun Rowlans
Marie-Edith Gourdel
Emilie Renaud
Camille Pierres
Adel Kebsi
Benoît Ledoussal
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40548019&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20110845(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel filed Critical Novexel
Publication of PE20110845A1 publication Critical patent/PE20110845A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES UN RADICAL (CH2)n-NH2 SIENDO n DE 1-2; R2 ES H; R3 Y R4 FORMAN UN RADICAL PIRAZOLILO SUSTITUIDO POR UN GRUPO (CH2)m-(C(O))p-R5 SIENDO m DE 0-3, p ES 0-1 Y R5 ES HIDROXI. SON COMPUESTOS PREFERIDOS: TRANS 8-(AMINOMETIL)-2-CARBAMOIL-4,8-DIHIDRO-5-(SULFOOXI)-4,7-METANO-7H-PIRAZOLO[3,4-E][1,3] DIACEPIN-6-(5H)-ONA; TRANS 8-(AMINOMETIL)-5,6-DIHIDRO-6-OXO-5-(SULFOOXI)-4H-4,7-METANOPIRAZOLO[3,4-e][1,3]DIACEPIN-2(8H)-ACETAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON HETEROCICLICOS NITROGENADOS UTILES COMO ANTIBACTERIANOS
PE2011000827A 2008-10-03 2009-08-03 Nuevos compuestos heterociclicos nitrogenados, preparacion de los mismos y utilizacion de los mismos como medicamentos antibacterianos PE20110845A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0805472A FR2936798B1 (fr) 2008-10-03 2008-10-03 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.

Publications (1)

Publication Number Publication Date
PE20110845A1 true PE20110845A1 (es) 2011-11-17

Family

ID=40548019

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000827A PE20110845A1 (es) 2008-10-03 2009-08-03 Nuevos compuestos heterociclicos nitrogenados, preparacion de los mismos y utilizacion de los mismos como medicamentos antibacterianos

Country Status (18)

Country Link
US (1) US8067435B2 (es)
EP (2) EP2845855A1 (es)
JP (1) JP5555240B2 (es)
KR (1) KR20110067137A (es)
CN (1) CN102203094B (es)
AU (1) AU2009299511A1 (es)
BR (1) BRPI0919810A8 (es)
CA (1) CA2739503A1 (es)
CL (1) CL2011000729A1 (es)
CO (1) CO6361957A2 (es)
EA (1) EA021799B1 (es)
EC (1) ECSP11010946A (es)
FR (1) FR2936798B1 (es)
IL (1) IL212059A0 (es)
MX (1) MX2011003573A (es)
PE (1) PE20110845A1 (es)
WO (1) WO2010038115A1 (es)
ZA (1) ZA201102429B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772490B2 (en) 2010-12-22 2014-07-08 Meiji Seika Pharma Co., Ltd. Optically active diazabicyclooctane derivatives and process for preparing the same
ES2606059T3 (es) * 2011-08-30 2017-03-17 Wockhardt Limited Derivados de 1,6-diazabiciclo[3,2,1]octan-7-ona y su uso en el tratamiento de infecciones bacterianas
KR101680933B1 (ko) * 2011-09-13 2016-11-29 욱크하르트 리미티드 질소 함유 화합물 및 이의 용도
EP2831069B1 (en) * 2012-03-30 2017-07-12 Merck Sharp & Dohme Corp. Isoxazole beta-lactamase inhibitors
AR090539A1 (es) * 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
SG10201605368UA (en) 2012-05-30 2016-08-30 Meiji Seika Pharma Co Ltd NOVEL β-LACTAMASE INHIBITOR AND PROCESS FOR PREPARING THE SAME
AU2013308127B2 (en) 2012-08-25 2015-08-13 Wockhardt Limited 1,6- Diazabicyclo [3,2,1] octan- 7- one derivatives and their use in the treatment of bacterial infections
KR102239725B1 (ko) 2013-09-24 2021-04-12 메이지 세이카 파루마 가부시키가이샤 디아자비시클로옥탄 유도체의 제조법과 그의 중간체
SG11201602723RA (en) 2013-10-08 2016-05-30 Meiji Seika Pharma Co Ltd Crystals of diazabicyclooctane derivative and production method for crystals of diazabicyclooctane derivative
JP6411482B2 (ja) * 2013-10-11 2018-10-24 ウォックハート リミテッド 窒素含有化合物およびその使用
MY196240A (en) 2014-11-17 2023-03-24 Entasis Therapeutics Ltd Combination Therapy for Treatment Of Resistant Bacterial Infections
CA2969192C (en) 2014-12-05 2023-02-28 Meiji Seika Pharma Co., Ltd. A process for producing crystals of a diazabicylooctane derivative and a stable lyophilized composition thereof
EP3075733A1 (en) * 2015-03-31 2016-10-05 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
EP3277686B1 (en) * 2015-03-31 2020-07-22 Mutabilis Novel heterocyclic compounds and their use in preventing or treating bacterial infections
US10501481B2 (en) * 2015-04-03 2019-12-10 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
TW201725205A (zh) 2015-10-02 2017-07-16 樂高化學生物科學股份有限公司 用於抑制β-內醯胺酶之組合物及方法
EP3512851B1 (en) 2016-09-16 2022-07-06 Entasis Therapeutics Limited Beta-lactamase inhibitor compounds
MY201377A (en) 2017-05-08 2024-02-21 Entasis Therapeutics Inc Compounds and methods for treating bacterial infections
EP3604315A1 (en) * 2018-07-30 2020-02-05 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
CN1264837C (zh) 1997-09-15 2006-07-19 普罗克特和甘保尔公司 喹诺酮抗微生物剂、其组合物和应用
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
NZ525571A (en) 2000-12-14 2004-09-24 Procter & Gamble Antimicrobial quinolones
AU3089302A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial 2-pyridones, their compositions and uses
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844268B1 (fr) 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Also Published As

Publication number Publication date
EA021799B1 (ru) 2015-09-30
US20100087648A1 (en) 2010-04-08
IL212059A0 (en) 2011-06-30
EA201170522A1 (ru) 2011-12-30
MX2011003573A (es) 2011-08-12
EP2845855A1 (fr) 2015-03-11
AU2009299511A1 (en) 2010-04-08
JP5555240B2 (ja) 2014-07-23
JP2012504593A (ja) 2012-02-23
CN102203094A (zh) 2011-09-28
FR2936798A1 (fr) 2010-04-09
ZA201102429B (en) 2012-05-30
CO6361957A2 (es) 2012-01-20
EP2344499A1 (fr) 2011-07-20
ECSP11010946A (es) 2011-05-31
CN102203094B (zh) 2014-04-02
KR20110067137A (ko) 2011-06-21
BRPI0919810A2 (pt) 2017-10-31
WO2010038115A1 (fr) 2010-04-08
US8067435B2 (en) 2011-11-29
FR2936798B1 (fr) 2012-09-28
CL2011000729A1 (es) 2012-07-06
BRPI0919810A8 (pt) 2017-12-12
CA2739503A1 (fr) 2010-04-08

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