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PE20091929A1 - Procedimientos para la sintesis selectiva del acetato de 3alfa-hidroxicloromadinona - Google Patents

Procedimientos para la sintesis selectiva del acetato de 3alfa-hidroxicloromadinona

Info

Publication number
PE20091929A1
PE20091929A1 PE2009000698A PE2009000698A PE20091929A1 PE 20091929 A1 PE20091929 A1 PE 20091929A1 PE 2009000698 A PE2009000698 A PE 2009000698A PE 2009000698 A PE2009000698 A PE 2009000698A PE 20091929 A1 PE20091929 A1 PE 20091929A1
Authority
PE
Peru
Prior art keywords
acetate
hydroxychloromadinone
beta
component
hydroxyclor
Prior art date
Application number
PE2009000698A
Other languages
English (en)
Inventor
Thomas Otten
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE20091929A1 publication Critical patent/PE20091929A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA UN PROCEDIMIENTO PARA LA OBTENCION DE ACETATO DE 3 ALFA-HIDROXICLOROMADINONA, DONDE DICHO PROCEDIMIENTO CONSISTE EN REDUCIR EL ACETATO DE CLOROMADINONA CON UN COMPONENTE HIDRURO METALICO PARA OBTENER EL ACETATO 3 BETA-HIDROXICLOROMADINONA E INVERTIR LA CONFIGURACION DE LA POSICION 3 DEL ACETATO 3 BETA-HIDROXICLOROMADINONA PARA OBTENER EL ACETATO DE 3 ALFA-HIDROXICLOROMADINONA. LA INVERSION CONSISTE EN HACER REACCIONAR EL ACETATO 3 BETA-HIDROXICLOROMADINONA CON UN ACIDO CARBOXILICO EN PRESENCIA DE UN COMPONENTE FOSFINA Y UN COMPONENTE AZOICO O UN COMPONENTE FOSFORANO PARA OBTENER UN ESTER DE FORMULA (IV), DONDE R ES UN HIDROCARBURO C1-C12, Y DESCOMPONER EL ESTER (IV) PARA OBTENER EL ACETATO DE 3 ALFA-HIDROXICLOROMADINONA
PE2009000698A 2008-05-21 2009-05-19 Procedimientos para la sintesis selectiva del acetato de 3alfa-hidroxicloromadinona PE20091929A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08009329 2008-05-21

Publications (1)

Publication Number Publication Date
PE20091929A1 true PE20091929A1 (es) 2010-01-09

Family

ID=40285894

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000698A PE20091929A1 (es) 2008-05-21 2009-05-19 Procedimientos para la sintesis selectiva del acetato de 3alfa-hidroxicloromadinona

Country Status (5)

Country Link
US (1) US20090318720A1 (es)
AR (1) AR071843A1 (es)
CL (1) CL2009001233A1 (es)
PE (1) PE20091929A1 (es)
WO (1) WO2009141110A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4094654B1 (ja) * 2007-01-31 2008-06-04 東洋化成工業株式会社 アゾジカルボン酸ビス（２−アルコキシエチル）エステル化合物、その製造中間体
CN107698645A (zh) * 2017-10-25 2018-02-16 湖南科瑞生物制药股份有限公司 醋酸氯地孕酮的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1222922B (de) * 1963-04-25 1966-08-18 Merck Ag E Verfahren zur Herstellung 6-substituierter 4, 6-Pregnadienderivate
GB1054290A (es) * 1963-05-01
US20030045514A1 (en) * 2001-05-03 2003-03-06 Louis Monti 17-Methyleneandrostan-3alpha-ol analogs as CRH inhibitors
DE102006003508A1 (de) * 2006-01-24 2007-07-26 Grünenthal GmbH Arzneimittel umfassend eine Hormonkombination
DE102006003509A1 (de) * 2006-01-24 2007-07-26 Grünenthal GmbH Kontrazeptivum

Also Published As

Publication number Publication date
CL2009001233A1 (es) 2009-08-07
AR071843A1 (es) 2010-07-21
WO2009141110A1 (de) 2009-11-26
US20090318720A1 (en) 2009-12-24

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